An interventional study of glycine and placebo in Obsessive Compulsive Disorder, sponsored by Nathan Kline Institute for Psychiatric Research. Completed at 1 site in United States. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2016-12-16.
Sponsored by Nathan Kline Institute for Psychiatric Research · Not applicable, Interventional, and Treatment
The purpose of this study is to determine whether individuals with obsessive compulsive disorder who will take a preparation of the amino acid glycine in addition to their current treatment, may experience improvement in their symptoms.
Individuals with obsessive compulsive disorder (OCD) often find inadequate relief, even with the best of currently available treatments. Some evidence suggests the the neurotransmitter glutamate may be a useful target for new treatments for OCD. The amino acid glycine, if given orally in adequate dosages, can have specific effects on one particular glutamate receptor molecule in the brain, that might be helpful with OC symptoms. This randomized, double-blind protocol will have study participants who suffer with OCD take either a glycine preparation or placebo for 12 weeks. Clinical measures (e.g., Y-BOCS, NIMH-OC) will be recorded at each visit to determine whether those taking the glycine experience clinical benefit.
367 studies on the registry are indexed under Compulsive Personality Disorder; 67 are open to participants now.
This study's enrollment of 24 is below the median of 37 across 306 interventional studies indexed under Compulsive Personality Disorder.
Browse Compulsive Personality Disorder studies →Nathan Kline Institute for Psychiatric Research is the lead sponsor of 22 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
glycine powder
Drug: glycine
placebo powder
Other: placebo
Y-BOCS (Yale-Brown Obsessive Compulsive Scale)
Time frame: 12 weeks after baseline
NIMC-OC scale
Time frame: 12 weeks after baseline
CGI-Improvement
Time frame: 12 weeks after baseline
QLS(Quality of Life Scale)
Time frame: 12 weeks after baseline
Sheehan Disability Scale
Time frame: 12 weeks after baseline
This study is completed, as verified in Dec 2016. You cannot join it, but the record below documents what was studied.
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Compulsive Personality Disorder→
Nathan Kline Institute for Psychiatric Research