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CompletedNCT00367094Updated Jul 9, 2007

Combination of Benazepril Plus Hydrochlorothiazide in Chinese Patients With Mild to Moderate Essential Hypertension

A Phase 3 interventional study of Benazepril plus hydrochlorothiazide in Hypertension, sponsored by Novartis. Completed at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2007-07-09.

Sponsored by Novartis · Phase 3, Interventional, and Treatment

Phase
Phase 3
Study type
Interventional
Enrollment
296
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

This study will evaluate efficacy and safety data for benazepril/hydrochlorothiazide in adult Chinese patients with mild to moderate essential hypertension. Patients whose blood pressure is not adequately controlled with benazepril monotherapy during a 4 week run-in period will be randomly allocated to double blind treatment over 8 weeks with either a combination of benazepril/hydrochlorothiazide per day or continuation of benazepril per day.

02

Conditions studied

  • Hypertension

Keywords

  • Hypertension, benazepril, hydrochlorothiazide, fixed combination
03

In context

Hypertension

6,689 studies on the registry are indexed under Hypertension; 965 are open to participants now.

This study's enrollment of 296 is above the median of 90 across 4,995 interventional studies indexed under Hypertension.

Browse Hypertension studies →

Lead sponsor

Novartis is the lead sponsor of 703 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Male or female patients, age 18 or older
  • Given informed consent
  • Diagnosed as having mild to moderate essential hypertension

Exclusion criteria

Exclusion Criteria:

  • Severe hypertension
  • Significant preexisting cardiovascular and cerebrovascular disease
  • Diabetes mellitus type 1 or poorly controlled diabetes mellitus type II
  • Advanced renal impairment

Other protocol-defined inclusion/exclusion criteria may apply.

05

Study design

Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double
Enrollment
296 participants

Interventions

  • DrugBenazepril plus hydrochlorothiazide
06

What researchers measure

Primary outcomes

  1. Change in diastolic blood pressure from baseline to week 8

Secondary outcomes

  1. Change in systolic blood pressure from baseline to week 8

  2. Proportion of patients with blood pressure less than 140/90 mmHg at week 8

  3. Ambulant blood pressure monitoring profiles at baseline and week 8

07

Study locations

1 site
  • Novartis
    Beijing, China
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 9, 2007, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00367094
Lead sponsor
Novartis
First posted
Aug 22, 2006
Start date
Jul 2006
Last update
Jul 9, 2007

Study contacts

Novartis Pharmaceuticals
principal investigator · Novartis Pharmaceuticals
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2007. You cannot join it, but the record below documents what was studied.

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