ClinicalTrials.gg
CompletedNCT00225745Updated Oct 14, 2015

Ghrelin Levels in Pancreatic Cancer Patients

An observational study in Pancreatic Cancer, sponsored by Dartmouth-Hitchcock Medical Center. Completed at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-10-14.

Sponsored by Dartmouth-Hitchcock Medical Center · Observational

Study type
Observational
Model
Case-control
Time perspective
Retrospective
Enrollment
72
Ages
18 Years and older
Sex
All
01

Study summary

The primary outcome measure for this study is plasma ghrelin level.

Read the detailed description

The primary outcome measure for this study is plasma ghrelin level, and the two primary comparison are:

  • Patients with cachexia versus patients without cachexia
  • Patients with cachexia versus healthy controls
02

Conditions studied

  • Pancreatic Cancer

Keywords

  • Ghrelin
03

In context

Pancreatic Neoplasms

3,310 studies on the registry are indexed under Pancreatic Neoplasms; 910 are open to participants now.

This study's enrollment of 72 is below the median of 200 across 636 observational studies indexed under Pancreatic Neoplasms.

Browse Pancreatic Neoplasms studies →

Lead sponsor

Dartmouth-Hitchcock Medical Center is the lead sponsor of 486 studies on the registry; 69 are open to participants now.

Of its 31 completed or terminated interventional studies of FDA-regulated products, 21 (68%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Pancreatic cancer patients who have not received treatment. Healthy age-matched controls.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Histological or cytological proof of pancreatic adenocarcinoma
  • The control are will include healthy age-matched patients without cancer
  • The test arm will include patients with pancreatic cancer and they will divided into two groups: those with and without weight loss
  • Patients must have recovered from any major infections and/or surgical procedures

Exclusion criteria

Exclusion Criteria:

  • Patients with other serious medical illness like congestive heart failure, thyroid disease,liver disease or renal failure - conditions that will alter their nutritional state
  • Patients on appetite stimulant and those receiving total parenteral nutrition
  • Patients who have undergone gastrectomy or those who have gastric ulcers
  • Patients receiving active chemotherapy
  • No prior malignancy except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer or for which patient has been disease free for at least five years.
05

Study design

Observational model
Case-control
Time perspective
Retrospective
Enrollment
72 participants (actual)
Biospecimen retention
Samples without dna

Groups and cohorts

  • 1

    Pancreatic cancer patients

    Procedure: Blood draw

  • 2

    Healthy controls

    Procedure: Blood draw

Interventions

  • ProcedureBlood draw

    One blood draw prior to first treatment

06

What researchers measure

Primary outcomes

  1. To evaluate plasma ghrelin levels in patients with pancreatic cancer and compare with age matched controls

    Time frame: prior to treatment

Secondary outcomes

  1. To investigate the role of ghrelin in pathophysiology of cancer cachexia

    Time frame: prior to treatment

  2. To generate hypotheses for future studies and treatment based on the findings

    Time frame: prior to treatment

07

Study locations

1 site
  • Dartmouth Hitchcock Medical Center/Norris Cotton Cancer Center
    Lebanon, New Hampshire 03756, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 14, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00225745
Responsible party
Sponsor
First posted
Sep 26, 2005
Start date
Apr 2004
Primary completion
Oct 2013
Completion
Sep 2015
Last update
Oct 14, 2015

Study contacts

J Marc Pipas, MD
principal investigator · Dartmouth-Hitchcock Medical Center

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2015. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion