A Phase 2 interventional study of Aerobic endurance exercise training (ergometer) in Heart Failure, sponsored by University of Leipzig. Completed at 1 site in Germany. Open to male participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2007-08-01.
Sponsored by University of Leipzig · Phase 2 and Interventional
Patients with heart failure are limited in their exercise capacity due to skeletal muscle alteration and an impairment of peripheral perfusion. Regular physical exercise training has been shown to partially correct these peripheral maladaptations in patients with stable heart failure, which was associated with an improvement in exercise capacity. However, it is unknown so far, whether regular physical activity also exerts beneficial effects in patients with severe chronic heart failure.
Aim of the trial is therefore to assess the effects of aerobic exercise training on exercise capacity, muscle maladaptations and peripheral perfusion in patients with severe chronic heart failure according to NYHA class III b.
A total of 36 patients with severe chronic heart failure are prospectively randomized to either 3 months of aerobic ergometer training or a sedentary control group.
Before and after the intervention period maximal exercise capacity is assessed by ergospirometry, endothelial function is determined by high-resolution A-mode ultrasound, and muscle mass is determined by CT. Skeletal muscle biopsies are obtained at begin and after 3 months and are analyzed for markers of muscle catabolism/anabolism.
5,701 studies on the registry are indexed under Heart Failure; 1,220 are open to participants now.
This study's enrollment of 36 is below the median of 72 across 3,736 interventional studies indexed under Heart Failure.
Browse Heart Failure studies →University of Leipzig is the lead sponsor of 147 studies on the registry; 24 are open to participants now.
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Exclusion Criteria:
Peak oxygen uptake
Endothelial function
Skeletal muscle mass
Markers of muscle anabolism / catabolism
This study is completed, as verified in Jul 2007. You cannot join it, but the record below documents what was studied.
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University of Leipzig