A Phase 4 interventional study of Sulfadoxine-pyrimethamine (Fansidar) in Malaria, Falciparum, sponsored by Bandim Health Project. Completed at 1 site in Guinea-Bissau. Open to participants aged Up to 15 Years. Per ClinicalTrials.gov, last updated 2010-03-16.
Sponsored by Bandim Health Project · Phase 4, Interventional, and Treatment
Children participating in a study evaluating the efficacy of chloroquine and amodiaquine for the treatment of malaria will, if getting malaria during follow-up, be re-treated with sulfadoxine-pyrimethamine (SP) in accordance with the recommendations of the National Malaria Programme.
To compare the actual efficacy of SP with that in 1995 - 1996 we, the investigators of the Bandim Health Project, will visit these children once a week for 5 weeks. A finger prick blood sample will be collected for a malaria test.
Children with malaria during follow-up will be treated according to the guidelines of the Bandim Health Centre.
The Bandim Health Project studies the efficacy of different treatment regimens for malaria in children. If the included children during follow-up get malaria again they are, according to the recommendations of the National Malaria Programme, treated with sulfadoxine-pyrimethamine (SP).
In 1995 - 1996 the efficacy of this re-treatment regimen was evaluated in the same area.
To evaluate if treatment with SP is still efficient we want to follow children included in a study comparing treatment with chloroquine and amodiaquine having recrudescent malaria for 35 days following the re-treatment with SP.
Children with reappearing parasitaemia will be treated with SP. If accepting to participate in this study the children will be visited once a week and a capillary blood sample will be drawn. The blood sample taken on the day of reappearing parasitaemia in the chloroquine/amodiaquine study will be used as the day 0 blood sample in the SP-study.
If the child gets malaria during the follow-up he will be treated according to the guidelines of the Bandim Health Centre. All treatment during follow-up will be free.
1,299 studies on the registry are indexed under Malaria; 86 are open to participants now.
This study's enrollment of 60 is below the median of 220 across 1,027 interventional studies indexed under Malaria.
Browse Malaria studies →Bandim Health Project is the lead sponsor of 59 studies on the registry; 5 are open to participants now.
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Exclusion Criteria:
Re-appearing parasitaemia
This study is completed, as verified in Mar 2010. You cannot join it, but the record below documents what was studied.
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Bandim Health Project