An observational study in Pulmonary Disease, Chronic Obstructive and Lung Diseases, Obstructive, sponsored by University of Pittsburgh. Completed at 1 site in Costa Rica. Open to participants aged 21 Years to 65 Years. Per ClinicalTrials.gov, last updated 2012-12-17.
Sponsored by University of Pittsburgh · Observational
The purpose of this study is to examine genetic factors that influence the development of chronic obstructive pulmonary disease (COPD) in Hispanics, a minority group at high risk for the disease.
DESIGN NARRATIVE:
This study will concentrate on a genetically isolated Hispanic population with a high prevalence of COPD living in the Central Valley of Costa Rica. Nine hundred individuals from descendants of the Costa Rican Central Valley founder population will be enrolled. To identify regions of the genome that are likely to contain genetic determinants of COPD-related phenotypes in this population, the study will collect phenotypic and genotypic data on 30 large families with a history of moderate to severe COPD that have multiple individuals affected with smoking-related airflow obstruction. A genome scan will be conducted on these individuals using short-tandem repeat (STR) markers. Linkage analysis will be performed on 6 COPD-related phenotypes, which will include the following: 1) chronic bronchitis; 2) airflow obstruction; 3) forced expiratory volume in one second (FEV1); 4) FEV1/FVC[forced vital capacity];5) bronchodilator responsiveness; and 6) total serum immunoglobulin E. Within genomic regions demonstrating linkage to COPD-related phenotypes in the genome scan, narrowly spaced STR markers will be genotyped and tested for linkage between these markers and COPD-related phenotypes. Within selected genomic regions, the association will be tested between single nucleotide polymorphisms (SNPs) in candidate genes and COPD-related phenotypes. By enrolling a large number of participants of a genetically isolated population and utilizing a family-based study design, this study should be able to address an important yet unstudied issue: the genetic influences on the expression of the COPD phenotype in Hispanics.
3,303 studies on the registry are indexed under Lung Diseases; 355 are open to participants now.
This study's enrollment of 679 is above the median of 157 across 929 observational studies indexed under Lung Diseases.
Browse Lung Diseases studies →University of Pittsburgh is the lead sponsor of 1,384 studies on the registry; 166 are open to participants now.
Of its 8 completed or terminated interventional studies of FDA-regulated products, 4 (50%) have results posted.
Counted across the registry records on this site, refreshed daily.
Families of individuals with physician-diagnosed COPD and smoking-related airflow obstruction who are younger than 71 years.
Exclusion Criteria:
Genetic factors that influence the development of COPD in Hispanics.
Time frame: Measured through the use of genetic samples
This study is completed, as verified in Dec 2012. You cannot join it, but the record below documents what was studied.
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