ClinicalTrials.gg
CompletedNCT00104195Updated Apr 16, 2014

A Research Study of How Teens With and Without an Anxiety Disorder Make Decisions

An observational study in Anxiety Disorders, Separation Anxiety Disorder and Phobic Disorders, sponsored by NYU Langone Health. Completed at 1 site in United States. Open to participants aged 13 Years to 17 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-04-16.

Sponsored by NYU Langone Health · Observational

Study type
Observational
Model
Case-control
Enrollment
127
Ages
13 Years to 17 Years
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 21 studies in Anxiety Disorders by NYU Langone Health — 4 open to participants now, 4 under way, none of them phase 3. Anxiety Disorders · NYU Langone Health.

Started
2004
the only one that year
Observational
2 of 21
none open now
Registered
1st of 21
by date

Among the 21 studies in Anxiety Disorders by NYU Langone Health, this one is the only one that started in 2004, is one of 2 observational ones, and was the 1st registered.

By phase

21 studies; the count open now beside each. This study's row is marked.

No phase17 · 3 open
Observationalthis study2 · 0 open
Phase 11 · 0 open
Phase 21 · 1 open

By the year they started

First in 2004; this study’s year is marked. 1 started in 2004.

What they test

Size and results

Median enrollment 60 across the 19 interventional studies, 82 across the 2 observational. Of the 17 that completed or were terminated, 2 (12%) have results posted.

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Watch this landscapeDownload CSVWith an account: a weekly mail of what changed among 21 studies in Anxiety Disorders by NYU Langone Health, or all of them as a file.
02

Study summary

The purpose of this trial is to study how teens with and without an anxiety disorder make decisions.

This is a brain imaging study using functional magnetic resonance imaging (fMRI) in adolescents between the ages of 13 and 17.

Read the detailed description

Preliminary analyses of behavioral data showed no group differences in response times during the decision-making games. However, behavioral ratings of certainty during the task showed differences between groups. Anxiety-disordered participants indicated lower levels of certainty during the most uncertain conditions of the task (p \< .05). This difference was consistent with the study hypothesis. Within-subjects analyses of the decision-making tasks showed that subjects responded as expected. Reaction times (RT) during uncertain conditions of the HiLo-Game were significantly longer than during more certain conditions (p = .001). Diary Task RTs for rating ambiguous situations were significantly longer than ratings of unambiguous situations (p = .019). Preliminary Analyses showed a significant correlation between Intolerance of Uncertainty (IU) and RT during the Marble Task (r = -0.54, p \< .05). Preliminary analysis also showed significant correlation between ratings of level of anxiety during the diary task and IU, IS, MASC and the child version of the SCARED. These preliminary results were not submitted for publication.

03

Conditions studied

  • Anxiety Disorders
  • Separation Anxiety Disorder
  • Phobic Disorders

Keywords

  • Anxiety
  • Adolescence
  • Generalized Anxiety Disorder
04

Who can participate

Ages eligible
13 Years to 17 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Anxious and healthy adolescents

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Must meet diagnostic criteria for Generalized Anxiety Disorder, Separation Anxiety Disorder or Social Phobia, OR must be free of medical, psychiatric, neurologic conditions and learning disorders (healthy controls)
  • Sufficient intelligence to understand the study and provide truly ; will be determined by educational history

Exclusion criteria

Exclusion Criteria:

  • Having any major medical conditions that may interfere with interpretation of results or be associated with risk in an MRI environment (history of metal implants, or to MRI scanning for research purposes, including pregnancy)
  • Current evidence of Autism, Major Depression, Substance Abuse, Obsessive Compulsive Disorder, Post-traumatic Stress Disorder, Panic Disorder, Tic Disorders, significant suicidality, lifetime history of psychosis or mania.
  • Estimated Full-Scale IQ below 80
  • Inability or unwillingness to remain still during scanning
  • Inability or unwillingness to provide assent
  • Absence of signed consent by parent or legal guardian
  • Current history of sexual or physical abuse in the family, or past sexual or physical abuse if there is ongoing Department of Social Services (DSS) involvement
Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

Contraindication

A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.

05

Study design

Observational model
Case-control
Enrollment
127 participants (actual)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Intolerance of Uncertainty

    Time frame: at time of assessment/enrollment

07

Study locations

1 site
  • New York University's Child Study Center
    New York, New York 10016, United States
08

Timeline

Tracking since Sep 25, 2026
Not marked actual or estimatedDates not marked actual or estimated

The record gives a start of Feb 2004, a primary completion of Apr 2014 and a completion of Apr 2014. It does not say whether these dates are actual or estimated.

How these figures are worked out, and which studies are left out of them.

Registered
Feb 23, 2005
First posted
Feb 24, 2005
Start
Feb 2004
Primary completionActual
Apr 2014
CompletionActual
Apr 2014
Last update
Apr 16, 2014
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Apr 16, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00104195
Lead sponsor
NYU Langone Health
Responsible party
F. Xavier Castellanos (Professor, NYU Langone Health) — Principal investigator
First posted
Feb 24, 2005
Start date
Feb 2004
Primary completion
Apr 2014
Completion
Apr 2014
Last update
Apr 16, 2014

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2014. You cannot join it, but the record below documents what was studied.

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Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

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