An interventional study of Walking exercise and Cycling Exercise in Osteoarthritis, sponsored by Mayo Clinic. Completed at 1 site in United States. Open to participants aged 30 Years and older. Per ClinicalTrials.gov, last updated 2013-05-17.
Sponsored by Mayo Clinic · Not applicable, Interventional, and Treatment
This trial will test if walking or bicycling exercise is effective as a non-surgical treatment option for patients with knee osteoarthritis.
Traditional, conservative medical treatment of osteoarthritis has been directed at improving functional status through reducing joint pain and inflammation and maintaining or restoring joint function. Exercise is an adjunct therapy in the clinical management of patients with osteoarthritis of the knee. However, it is not uniformly accepted. The central hypothesis of this work is that the Surgeon General's exercise guidelines can be successfully implemented as an effective nonsurgical option for treatment of patients with early stages of knee osteoarthritis.
Patients with knee osteoarthritis will be randomized into a control group, a walking exercise group, and a stationary cycling exercise group. The individuals in the exercise groups will be required to exercise three times per week for one year using emerging public health recommendations for aerobic exercise in the adult and aging population. Patient outcome will be assessed using objective gait analysis measurements, knee radiographs to quantify joint space narrowing, magnetic resonance imaging, a general health questionnaire (SF-36), a disease/site specific questionnaire (WOMAC), and a visual-analog pain scale. All subjects will be studied at 0 and 52 weeks.
4,397 studies on the registry are indexed under Osteoarthritis; 581 are open to participants now.
This study's enrollment of 306 is above the median of 70 across 3,440 interventional studies indexed under Osteoarthritis.
Browse Osteoarthritis studies →Mayo Clinic is the lead sponsor of 3,218 studies on the registry; 669 are open to participants now.
Of its 445 completed or terminated interventional studies of FDA-regulated products, 313 (70%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria
Participants will receive no intervention and will act as the control group.
Participants will partake in a walking exercise program.
Behavioral: Walking exercise
Participants will partake in a cycling exercise program.
Behavioral: Cycling Exercise
30 minutes/day, 3 times/week for 52 weeks
30 minutes/day, 3 times/week for 52 weeks
VAS, SF-36, WOMAC, and Activity Index questionnaires
Time frame: Week 52
Weight-bearing anterior-posterior (AP) and lateral x-rays of the knee
Time frame: Week 52
MRI imaging of the knee
Time frame: Week 52
Measurements of gait during level walking and stair climbing
Time frame: Week 52
Change in consumption of analgesics, reflecting the level of joint pain
Time frame: Week 52
This study is completed, as verified in May 2013. You cannot join it, but the record below documents what was studied.
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