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CompletedNCT00005352Updated Feb 18, 2016

Chronic Stress as a Risk Factor in the Etiology of Coronary Heart Disease

An observational study in Cardiovascular Diseases, Coronary Disease and Heart Diseases, sponsored by National Heart, Lung, and Blood Institute (NHLBI). Completed. Open to male participants aged Up to 100 Years. Per ClinicalTrials.gov, last updated 2016-02-18.

Sponsored by National Heart, Lung, and Blood Institute (NHLBI) · Observational

Study type
Observational
Ages
Up to 100 Years
Sex
Male
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Study summary

To conduct a prospective, longitudinal, analysis of the psychophysiological effects of chronic exposure to environmental stress. The study took advantage of a unique, naturally occurring experiment caused by the relocation of a major international airport.

Read the detailed description

DESIGN NARRATIVE:

Studies were conducted on blood pressure and the neuroendocrine effects of noise resulting from the relocation of the Munich International Airport. At the former airport site the investigators monitored people exposed to high levels of noise and then tracked these same individuals as their ambient environment became normal following the shutdown of the airport. At the new airport site, the opposite situation occurred: Individuals living in normal, quiet ambient conditions became exposed to loud aircraft noise. At both sites, control groups were formed who were not exposed to aircraft noise. The study piggybacked onto a German sponsored grant. NIH funds covered the costs of cardiovascular and psycho-physiological data analysis. Measures included biochemical assays of chronic neuroendocrine markers of stress, resting blood pressure, and reactivity of blood pressure during cognitive tasks. Perceptions of community noise levels were also assessed as possible mediators of the stressful effects of chronic exposure to ambient, environmental noise.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

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Conditions studied

  • Cardiovascular Diseases
  • Coronary Disease
  • Heart Diseases
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In context

Cardiovascular Diseases

4,904 studies on the registry are indexed under Cardiovascular Diseases; 920 are open to participants now.

Browse Cardiovascular Diseases studies →

Lead sponsor

National Heart, Lung, and Blood Institute (NHLBI) is the lead sponsor of 1,117 studies on the registry; 71 are open to participants now.

Of its 57 completed or terminated interventional studies of FDA-regulated products, 49 (86%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Up to 100 Years
Sexes eligible
Male
Accepts healthy volunteers
No

Eligibility criteria

No eligibility criteria

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Study design

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Study locations

No study locations are listed for this record.

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References and documents

Publications

  • Tafalla RJ, Evans GW. Noise, physiology, and human performance: the potential role of effort. J Occup Health Psychol. 1997 Apr;2(2):148-55. doi: 10.1037//1076-8998.2.2.148. PubMed 9552287 ↗
  • Bullinger M, Hygge S, Evans GW, Meis M, von Mackensen S. The psychological cost of aircraft noise for children. Zentralbl Hyg Umweltmed. 1999 Aug;202(2-4):127-38. PubMed 10507123 ↗
  • Hygge S, Evans GW, Bullinger M. A prospective study of some effects of aircraft noise on cognitive performance in schoolchildren. Psychol Sci. 2002 Sep;13(5):469-74. doi: 10.1111/1467-9280.00483. PubMed 12219816 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 18, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00005352
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
First posted
May 26, 2000
Start date
Sep 1992
Completion
Aug 1996
Last update
Feb 18, 2016

Study contacts

Gary Evans
Cornell University
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2004. You cannot join it, but the record below documents what was studied.

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