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CompletedNCT00000262Updated May 27, 2015

Effects of Combined Sevoflurane and Nitrous Oxide Inhalation - 14

An interventional study of 30% Nitrous oxide and 0.4% Sevoflurane in Opioid-Related Disorders and Substance-Related Disorders, sponsored by University of Chicago. Completed at 1 site in United States. Per ClinicalTrials.gov, last updated 2015-05-27.

Sponsored by University of Chicago · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
20
Allocation
Randomized
Sex
All
01

Study summary

The purpose of this study is to determine the effects of combined sevoflurane and nitrous oxide inhalation on mood, psychomotor performance, and the pain response in humans.

02

Conditions studied

  • Opioid-Related Disorders
  • Substance-Related Disorders

Keywords

  • nitrous oxide
  • sevoflurane
  • drug interaction
  • subjective effects
  • analgesia
  • healthy volunteers
03

In context

Substance-Related Disorders

2,124 studies on the registry are indexed under Substance-Related Disorders; 393 are open to participants now.

This study's enrollment of 20 is below the median of 108 across 1,727 interventional studies indexed under Substance-Related Disorders.

Browse Substance-Related Disorders studies →

Lead sponsor

University of Chicago is the lead sponsor of 907 studies on the registry; 182 are open to participants now.

Of its 99 completed or terminated interventional studies of FDA-regulated products, 68 (69%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

Please contact site for information.

05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Double (Participant, Care provider)
Enrollment
20 participants (actual)

Study arms

  • Placebo comparator
    Placebo +/- 30% Nitrous oxide

    Drug: 30% Nitrous oxide · Other: Placebo

  • Active comparator
    Sevoflurane 0.2% +/- 30% Nitrous oxide

    Drug: 30% Nitrous oxide · Drug: 0.2% sevoflurane

  • Active comparator
    Sevoflurane 0.4% +/- 30% Nitrous oxide

    Drug: 30% Nitrous oxide · Drug: 0.4% Sevoflurane

Interventions

  • Drug30% Nitrous oxide
  • Drug0.4% Sevoflurane
  • Drug0.2% sevoflurane
  • OtherPlacebo
06

What researchers measure

Primary outcomes

  1. Pain intensity, pain bothersomeness

    Inhalation was for 68 min divided into 4 blocks with nitrous oxide added during either block 2 or block 4

    Time frame: During inhalation

  2. Mood

    Inhalation was for 68 min divided into 4 blocks with nitrous oxide added during either block 2 or block 4

    Time frame: During inhalation

  3. Psychomotor performance

    Inhalation was for 68 min divided into 4 blocks with nitrous oxide added during either block 2 or block 4

    Time frame: During inhalation

07

Study locations

1 site
  • University of Chicago, Anesthesia & Critical Care
    Chicago, Illinois 60637, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 27, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00000262
Lead sponsor
University of Chicago
Collaborators
National Institute on Drug Abuse (NIDA)
Responsible party
Sponsor
First posted
Sep 21, 1999
Start date
Nov 1996
Primary completion
Feb 1999
Completion
Feb 1999
Last update
May 27, 2015

Study contacts

James Zacny, Ph.D.
principal investigator · University of Chicago
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2015. You cannot join it, but the record below documents what was studied.

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