A Phase 2 interventional study of 20% N2O and 30% N2O in Opioid-Related Disorders and Substance-Related Disorders, sponsored by University of Chicago. Completed at 1 site in United States. Open to participants aged 21 Years to 37 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-05-28.
Sponsored by University of Chicago · Phase 2, Interventional, and Treatment
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine effects of subanesthetic concentrations of nitrous oxide on cold-pressor pain in humans.
2,124 studies on the registry are indexed under Substance-Related Disorders; 393 are open to participants now.
This study's enrollment of 10 is below the median of 108 across 1,727 interventional studies indexed under Substance-Related Disorders.
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Of its 99 completed or terminated interventional studies of FDA-regulated products, 68 (69%) have results posted.
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Subject inhaled 0% N2O for 40 minutes with cold immersion at 10 and 30 minutes
Subject inhaled 20% N2O for 40 minutes with cold immersion at 10 \& 30 minutes
Drug: 20% N2O
Subject inhaled 30% N2O for 40 minutes with cold immersion at 10 and 30 minutes
Drug: 30% N2O
Subject inhaled 40% N2O for 40 minutes with cold immersion at 10 and 30 minutes
Drug: 40% N2O
20% inhaled N2O
30% inhaled N2O
40% inhaled N2O
Pain intensity
Subjects immersed non-dominant arm for 3 minutes twice in 2-3 degree C water while inhaling 0 (placebo), 20, 30, or 40% N2O for a total of 40 minutes
Time frame: during cold test at 10 min & 30 min of inhalation
This study is completed, as verified in May 2015. You cannot join it, but the record below documents what was studied.
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University of Chicago