UCB S.A.: Epilepsy trials

The registry lists 132 Epilepsy studies with UCB S.A. as lead sponsor. 2 are open to participants now and 90 have results posted.

Phase 1 6Phase 2 29Phase 3 74Phase 4 11No phase 14(a study in two phases counts in both)

Studies

Page 1 of 2. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy))RecruitingNCT05135091Phase 3
• A Study to Test the Safety and Tolerability of Brivaracetam in Children and Adolescents With SeizuresRecruitingNCT04715646Phase 3
• A Study to Test the Long-term Safety, Tolerability and Efficacy of Brivaracetam in Study Participants 2 to 26 Years of Age With Childhood Absence Epilepsy or Juvenile Absence EpilepsyCompletedNCT05109234Phase 3Results posted
• A Study to Test the Long-term Use of Oral Lacosamide in Pediatric Study Participants Who Completed NCT01964560 (EP0034) or NCT00938912 (SP848) and Received Lacosamide TreatmentCompletedNCT04627285Phase 3Results posted
• A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Lacosamide in Neonates With Repeated Electroencephalographic Neonatal SeizuresTerminatedNCT04519645Phase 2Results posted
• A Study to Test the Efficacy and Safety of Padsevonil as Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant EpilepsyTerminatedNCT03739840Phase 3Results posted
• A Study in Participants With Epilepsy, to Evaluate the Pharmacokinetics, Safety and Tolerability of Oxcarbazepine on PadsevonilCompletedNCT03695094Phase 1Results posted
• Inpatient, Dose-Ranging Study of Staccato Alprazolam in Epilepsy With Predictable Seizure PatternCompletedNCT03478982Phase 2Results posted
• A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Intravenous Brivaracetam in Subjects >= 1 Month to < 16 Years of Age With EpilepsyCompletedNCT03405714Phase 2Results posted
• Study to Test the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adults With Drug-resistant EpilepsyCompletedNCT03373383Phase 2Results posted
• Study to Test the Safety and Efficacy of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant EpilepsyTerminatedNCT03370120Phase 2Results posted
• A Study to Test the Safety/ Efficacy of Brivaracetam (BRV) Used as Adjunctive Treatment in Subjects >=16 Years of Age With Partial Seizures With or Without Secondary GeneralizationCompletedNCT03250377Phase 3Results posted
• A Study to Evaluate the Efficacy and Safety of Brivaracetam in Study Participants (>=16 to 80 Years of Age) With EpilepsyCompletedNCT03083665Phase 3Results posted
• A Study to Assess the Efficacy and Safety of Brivaracetam as Treatment for Increased Seizure Activity in an Epilepsy Monitoring Unit SettingCompletedNCT03021018Phase 2Results posted
• An Open-Label Extension Trial to Assess the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride HCl) Oral Solution in Children and Young Adults With Dravet SyndromeCompletedNCT02823145Phase 3Results posted
• Study to Investigate Safety and Tolerability of Intravenous Lacosamide in Children.CompletedNCT02710890Phase 2/3Results posted
• Study to Look at How Effective Briviact is as add-on Treatment for Patients With Epilepsy With Partial Onset SeizuresCompletedNCT02687711Results posted
• A Trial of Two Fixed Doses of ZX008 (Fenfluramine HCl) in Children and Young Adults With Dravet SyndromeCompletedNCT02682927Phase 3Results posted
• An Open-label Extension Study of UCB0942 in Adult Patients With Highly Drug-resistant Focal EpilepsyTerminatedNCT02625090Phase 2Results posted
• A Clinical Study to Investigate the Long-term Use of Lacosamide as Monotherapy in Subjects Who Completed Study SP0994CompletedNCT02582866Phase 3Results posted
• A Study of UCB0942 in Adult Patients With Highly Drug-resistant Focal EpilepsyCompletedNCT02495844Phase 2Results posted
• Efficacy and Safety of Lacosamide as Adjunctive Therapy in Subjects ≥1 Month to <4 Years With Partial-onset SeizuresCompletedNCT02477839Phase 3Results posted
• Safety and Efficacy of Lacosamide as Additional Therapy in Patients Suffering From Epileptic Tonic-Clonic SeizuresCompletedNCT02408549Phase 3Results posted
• A Study to Assess the Safety and Efficacy of Lacosamide Versus Placebo (a Pill Without Active Medication) in Patients With Idiopathic Generalised Epilepsy Who Are Already Taking Anti-epileptic MedicationsCompletedNCT02408523Phase 3Results posted
• Study of Lacosamide as an Adjunctive Drug Treatment for Epilepsy in Patients With Brain TumorsCompletedNCT02276053Results posted
• Open-label Study to Evaluate the Safety and Tolerability of iv Lacosamide in Japanese Adults With Partial-onset SeizuresCompletedNCT02192814Phase 3Results posted
• A Long-term Safety and Tolerability Study of USL261 in Patients With Seizure ClustersTerminatedNCT02161185Phase 3Results posted
• A Trial to Evaluate the Long Term Safety and Tolerability of Lacosamide Taken as Monotherapy in Adults With Partial-onset SeizuresCompletedNCT02124564Phase 3Results posted
• Study to Evaluate the Safety and Efficacy of USL261 in Patients With Increased Bouts of Seizure Activity in the EMUCompletedNCT01999777Phase 3Results posted
• A Study to Investigate the Safety and Efficacy of Lacosamide Added to the Patients Current Therapy in Patients Aged 1 Month to Less Than 18 Years Old With Epilepsy Syndromes Associated With Generalized Seizures.CompletedNCT01969851Phase 2Results posted
• A Clinical Study to Investigate the Efficacy and Safety of Lacosamide as an Add on Therapy in Children With Epilepsy With Partial-onset SeizuresCompletedNCT01964560Phase 3Results posted
• Open-label, Randomized, Active-controlled Study of LEV Used as Monotherapy in Patients With Partial-Onset SeizuresCompletedNCT01954121Phase 3Results posted
• Study to Investigate Lacosamide as Add-on Therapy in Subjects ≥4 Years to <17 Years of Age With Partial Onset SeizuresCompletedNCT01921205Phase 3Results posted
• Study to Evaluate the Safety, Tolerability, and Efficacy of Long-term Adjunctive Therapy With Lacosamide in Adults With Partial-onset SeizuresCompletedNCT01832038Phase 3Results posted
• Evaluation of Long-term Safety, and Efficacy of Brivaracetam (BRV) Used as Adjunctive Treatment in Subjects With EpilepsyCompletedNCT01728077Phase 3Results posted
• A Trial to Evaluate the Efficacy and Safety of Adjunctive Therapy With Lacosamide in Adults With Partial-Onset SeizuresCompletedNCT01710657Phase 3Results posted
• Study Evaluating Changes in Total Drug Load and Seizure Frequency Using Vimpat® (Lacosamide) in Combination TherapyCompletedNCT01673282Results posted
• Effect of Brivaracetam (BRV) on Nonpsychotic Behavioral Side Effects in Subjects Treated Previously With Levetiracetam (LEV)CompletedNCT01653262Phase 3Results posted
• Study to Evaluate the Long-term Safety and Tolerability of USL261 in Patients With Seizure ClustersTerminatedNCT01529034Phase 3Results posted
• An Open Label Study of Levetiracetam Monotherapy in Patients With Newly Diagnosed Focal EpilepsyCompletedNCT01506882Phase 3Results posted
• Levetiracetam Versus Oxcarbazepine as Monotherapy to Evaluate Efficacy and Safety in Subjects With Newly or Recently Diagnosed Partial EpilepsyCompletedNCT01498822Phase 4Results posted
• eValuation of the Efficacy and toleRability of Vimpat When Added to lEvetiracetamCompletedNCT01484977Phase 3Results posted
• Evaluating Long Term Safety of Lacosamide (LCM) to Carbamazepine Controlled-release (CBZ-CR); Initial Monotherapy in Epilepsy Subjects 16 Years and OlderCompletedNCT01465997Phase 3Results posted
• An Open Label Study of L059 Intravenous (IV) in Japanese Epilepsy Subjects With Partial Onset SeizuresCompletedNCT01407523Phase 2Results posted
• Safety and Tolerability of Intravenous Brivaracetam (Infusion or Bolus) as Adjunctive Antiepileptic TherapyCompletedNCT01405508Phase 3Results posted
• An Open Label Study of L059 (Levetiracetam) in Japanese Epilepsy Subjects With Generalized Tonic-clonic SeizuresCompletedNCT01398956Phase 3Results posted
• Study to Evaluate the Safety and Efficacy of USL261 (Intranasal Midazolam) in Patients With Seizure ClustersTerminatedNCT01390220Phase 3Results posted
• Open-label Long-term Study of Adjunctive Brivaracetam in Pediatric Subjects With EpilepsyCompletedNCT01364597Phase 3Results posted
• Brivaracetam Safety and Efficacy Follow-up Study in Subjects With EpilepsyCompletedNCT01339559Phase 3Results posted
• A Study of Levetiracetam in Japanese Pediatric Patients With Generalized Tonic-clonic SeizuresCompletedNCT01292837Phase 3Results posted
• Brivaracetam Efficacy and Safety Study in Subjects With Partial Onset SeizuresCompletedNCT01261325Phase 3Results posted
• Trial Comparing the Efficacy and Safety of Lacosamide (LCM) to Carbamazepine Controlled-Release (CBZ-CR); Initial Monotherapy in Epilepsy; Subjects Aged 16 and OlderCompletedNCT01243177Phase 3Results posted
• Trial to Assess Optimized Dosage of Lacosamide as add-on Therapy in Patients With Partial Onset SeizureCompletedNCT01235403Phase 4Results posted
• Levetiracetam Versus Topiramate as Adjunctive Therapy to Evaluate Efficacy and Safety in Subjects With Refractory Partial Onset SeizuresCompletedNCT01229735Phase 4Results posted
• A Double-blind, Placebo-controlled Study of Levetiracetam in Epilepsy Patients With Generalized Tonic-clonic Seizures (Except Partial Seizures Evolving to Secondarily Generalized Seizures)CompletedNCT01228747Phase 3Results posted
• Observational Study in Infants Who Are Prescribed Treatment With Keppra® (Levetiracetam) Oral SolutionCompletedNCT01210690Results posted
• Open-Label Extension Study to Assess the Safety and Seizure Frequency Associated With Lacosamide for Primary Generalized Tonic-Clonic Seizures in Subjects With EpilepsyCompletedNCT01118962Phase 2Results posted
• Open-Label Study to Assess Lacosamide Safety as Add-on Therapy for Primary Generalized Tonic-Clonic Seizures in Subjects With EpilepsyCompletedNCT01118949Phase 2Results posted
• Vimpat® Added as Adjunctive Therapy to One Baseline Antiepileptic DrugCompletedNCT01098162Results posted
• An Open Label Study of Levetiracetam in Japanese Pediatric Patients With Partial SeizuresCompletedNCT01063764Phase 3Results posted
• Study Evaluating the Pharmacokinetics of Keppra Extended Release (XR) in Children and Adults With EpilepsyCompletedNCT00961441Phase 2Results posted
• Trial to Assess Lacosamide as the First add-on Anti-epileptic Drug Treatment in Patients With Partial-onset SeizuresCompletedNCT00955357Phase 4Results posted
• An Open-Label Study to Determine Safety , Tolerability, and Efficacy of Oral Lacosamide in Children With EpilepsyCompletedNCT00938912Phase 2Results posted
• A Multicenter, Open-Label Study To Investigate The Safety And Pharmacokinetics Of Lacosamide In Children With Partial SeizuresCompletedNCT00938431Phase 2Results posted
• Post-Authorization Safety Study to Assess the Safety of Vimpat as add-on Therapy in Patients With Partial-onset SeizuresCompletedNCT00771927Results posted
• An Open-label, Multinational, Multicenter, Follow-up Study to Evaluate the Long-term Safety and Efficacy of BrivaracetamCompletedNCT00761774Phase 3Results posted
• A Double-blind, Randomized Conversion to Monotherapy Study to Evaluate the Efficacy and Safety of Brivaracetam in Subjects (≥ 16 to 75 Years Old) With Partial Onset SeizuresTerminatedNCT00699283Phase 3Results posted
• A Double-blind, Randomized Conversion to Monotherapy Study to Evaluate the Efficacy and Safety of Brivaracetam in Subjects (≥ 16 to 75 Years Old) With Partial Onset SeizuresTerminatedNCT00698581Phase 3Results posted
• Safety of Intravenous Lacosamide Dose Followed by Twice Daily Oral Lacosamide in Subjects With Partial-onset SeizuresCompletedNCT00655551Phase 3Results posted
• Study to Assess the Long-term Safety of Oral Lacosamide in Subjects With Partial-onset SeizuresCompletedNCT00655486Phase 3Results posted
• Open-label Study of Levetiracetam Intravenous Infusion in Children (4-16 Years Old) With EpilepsyCompletedNCT00535392Phase 2Results posted
• Trial to Assess Long-term Lacosamide (LCM) Monotherapy Use and Safety of LCM Monotherapy and Adjunctive Therapy for Partial-onset SeizuresCompletedNCT00530855Phase 3Results posted
• Determine Safety and Efficacy of Long-term Oral Lacosamide in Patients With Partial SeizuresCompletedNCT00522275Phase 3Results posted
• Trial to Demonstrate the Efficacy and Safety of Conversion to Lacosamide Monotherapy for Partial-onset SeizuresCompletedNCT00520741Phase 3Results posted
• Open-label Study of Levetiracetam Intravenous Infusion in Children (1 Month-4 Years Old) With EpilepsyCompletedNCT00505934Phase 2Results posted
• Brivaracetam as add-on Treatment in Adolescents and Adults Suffering From EpilepsyCompletedNCT00504881Phase 3Results posted
• Double-blind, Randomized Study Evaluating the Efficacy and Safety of Brivaracetam in Adults With Partial Onset SeizuresCompletedNCT00490035Phase 3Results posted
• Double-blind, Randomized Study Evaluating the Efficacy and Safety of Brivaracetam in Adults With Partial Onset SeizuresCompletedNCT00464269Phase 3Results posted
• Open-label, Pharmacokinetic, Safety and Efficacy Study of Adjunctive Brivaracetam in Children With Epilepsy.CompletedNCT00422422Phase 2Results posted
• A Study to Look at the Efficacy and Safety of Keppra® Extended Release Formulation - XRCompletedNCT00368069Phase 3Results posted
• A Long Term Follow up Administration Study of L059 (Levetiracetam) in Epilepsy Patients With Partial Onset SeizuresCompletedNCT00367432Phase 3Results posted
• Follow up Trial for Keppra (Levetiracetam) as Monotherapy in Patients With Newly Diagnosed Epilepsy Coming From N01175 (NCT00175903).CompletedNCT00291655Phase 3Results posted
• Follow-up Trial to Evaluate Long-term Safety and Efficacy of Brivaracetam in Subjects Suffering From EpilepsyCompletedNCT00175916Phase 3Results posted
• A Dose-ranging Study With Brivaracetam in Patients From 16 to 65 Years With Refractory Partial Onset Seizures.CompletedNCT00175825Phase 2Results posted
• Open Label Safety and Efficacy Study of Levetiracetam in Patients With EpilepsyCompletedNCT00160654Phase 4Results posted
• Follow-up Study of L059 (Levetiracetam) in Epileptic Patients With Partial Onset Seizures by Open Label MethodCompletedNCT00160615Phase 3Results posted
• Long-Term, Follow-Up Study Of the Safety And Efficacy Of Levetiracetam In Children With Partial Onset SeizuresCompletedNCT00152516Phase 3Results posted
• Study With Subjects 18-65 Years Old With Partial Onset Seizures Who Are Currently Taking LevetiracetamCompletedNCT00152503Phase 2Results posted
• Study With Seletracetam (Ucb 44212) in Adult Subjects (18 to 65 Years) With Partial Onset SeizuresCompletedNCT00152451Phase 2Results posted
• Monotherapy With Levetiracetam in Patients Suffering From Epilepsy.CompletedNCT00150813Phase 3Results posted
• This Trial, Evaluating the Long-term Safety and Tolerability of Brivaracetam Will Provide Subjects Suffering From Epilepsy, Who May Have Benefited From Brivaracetam as Adjunctive Treatment, the Opportunity to Receive Open Label Brivaracetam TreatmentCompletedNCT00150800Phase 3Results posted
• A Study Of The Safety And Efficacy Of Levetiracetam (Keppra®) (Ucb L059) In Children With EpilepsyCompletedNCT00150709Phase 3Results posted
• A Study to Assess the Pharmacokinetics (PK) and Safety of Staccato Alprazolam in Adolescent Study Participants With EpilepsyCompletedNCT04857307Phase 1
• A Study to Evaluate the Efficacy, Safety, and Tolerability of Brivaracetam as Monotherapy in Patients 2 to 25 Years of Age With Childhood Absence Epilepsy or Juvenile Absence EpilepsyCompletedNCT04666610Phase 3
• European Non-interventional Study on Refractory Epilepsy With Developmental DelayTerminatedNCT04398667
• A Study to Test the Blood Concentration of 4 Padsevonil Product Variants and the Effect of Food on PadsevonilWithdrawnNCT04283136Phase 1
• A Study to Evaluate the Safety and Tolerability of Intravenous Brivaracetam (BRV) as Replacement for Oral Brivaracetam in Japanese Subjects >=16 Years of Age With Partial Seizures With or Without Secondary GeneralizationCompletedNCT03685630Phase 3
• Compassionate Use Program With Brivaracetam for the Treatment of Patients With EpilepsyNo longer availableNCT03532516
• To Evaluate the Pharmacokinetics and Safety/Tolerability of Lacosamide in 3 Dosages in Healthy Male Korean SubjectsCompletedNCT01450111Phase 1
• A Trial to Investigate the Safety, Tolerability and Pharmacokinetics of Intravenous SPM 927CompletedNCT00800215Phase 2