Merck Healthcare KGaA, Darmstadt, Germany clinical trials

A subsidiary of Merck KGaA, Darmstadt, Germany

The registry lists 55 studies whose lead sponsor is Merck Healthcare KGaA, Darmstadt, Germany. 4 are recruiting or about to start. Per ClinicalTrials.gov, last updated Oct 23, 2026.

Studies

Recruiting first, then most recently updated. Showing 50 of 55. List all 55 → · All Merck KGaA, Darmstadt, Germany studies →

• Study of Pimicotinib in Japanese Participants With Tenosynovial Giant Cell Tumor (TGCT) (J-MANEUVER)RecruitingNCT07499362Phase 2

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Efficacy and Safety of a New Formulation of Oral Cladribine Compared With Placebo in Participants With Generalized Myasthenia Gravis (MyClad)RecruitingNCT06463587Phase 3

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• A Study to Assess the Effects of Probenecid on the Pharmacokinetics of Mirdametinib and Its Metabolites in Healthy ParticipantsRecruitingNCT07840612Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• A Study to Compare the Efficacy and Safety of Follitropin Alfa/Lutropin Alfa Versus hMG in Japanese Participants With LH and FSH Deficiency Undergoing ART (HINATA)RecruitingNCT07340827Phase 3

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Phase 1 Single Ascending Doses (SAD) of M5542 in Healthy ParticipantsSuspendedNCT06577337Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• The Willow LTE Study With M5049 in Participants With SCLE, DLE and/or SLE (WILLOW LTE)Active, not recruitingNCT05540327Phase 2

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• JAVEMACS: Japan AVElumab Maintenance And Continuous Treatment StudyCompletedNCT06412848

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Anti-CEACAM5 ADC Precemtabart Tocentecan (M9140) in Chinese Participants With Solid TumorsActive, not recruitingNCT06806046Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Cladribine Tablets Level of Response Predictors in Clinical Practice (CLODINA)Active, not recruitingNCT05797740

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• An Observational Study to Evaluate the Efficacy and Safety of Avelumab + Axitinib Combination in Participants With aRCC (AVION)CompletedNCT04941768

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Effect of Renal Impairment on Enpatoran PharmacokineticsCompletedNCT06589713Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Tuvusertib (M1774) Human Mass Balance and Absolute Bioavailability Study (DDRIVER Solid Tumors 303)CompletedNCT06308263Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• An Ethno-bridging Study of Pergoveris in Healthy Premenopausal Participants of Japanese or Caucasian OriginCompletedNCT07269327Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Efficacy, Safety, and PK of M5717 in Combination With Pyronaridine as Chemoprevention in Adults and Adolescents With Asymptomatic Plasmodium Falciparum Infection (CAPTURE-2)CompletedNCT05974267Phase 2

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• A Study to Investigate the Association of Real-world Sensor-derived Biometric Data With Clinical Parameters and Patient-reported Outcomes for Monitoring Disease Activity in Patients With COPDCompletedNCT05655832Not applicable

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• DDI Study of Evobrutinib and CarbamazepineCompletedNCT05248945Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Relative Bioavailability of Evobrutinib Tablet BatchesCompletedNCT07214922Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Drug-Drug Interaction Study of Evobrutinib and Transporter SubstratesCompletedNCT05064488Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• A Study to Learn About the Study Medicine (Called Avelumab) in People With Advanced Urothelial Cancer After ChemotherapyCompletedNCT05366725

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Effect of Evobrutinib on Pharmacokinetics of a Combined Oral ContraceptiveCompletedNCT07215806Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• A TQT Study of Effect of M2951 on Cardiac RepolarizationCompletedNCT07214935Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Effect of Hepatic Impairment on M2951 (BTK Inhibitor) PKCompletedNCT04546789Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Phase IIa Proof of Concept Study of M5717-Pyronaridine in Adults and Adolescents With Acute Uncomplicated Plasmodium Falciparum Malaria (CAPTURE 1)CompletedNCT05689047Phase 2

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• PK Study of Xevinapant (Debio 1143) in Healthy East Asian ParticipantsCompletedNCT05519540Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Prospective Effectiveness and Safety Study of Cladribine in Participants Who Change First-line DMD Treatments for Multiple Sclerosis (CLAD CROSS)CompletedNCT04934800

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Study of Evobrutinib in Participants With RMS (evolutionRMS 1)TerminatedNCT04338022Phase 3

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• A Study to Learn About the Study Medicine (Avelumab) in Japanese Patients With Urothelial Carcinoma That Has SpreadCompletedNCT05431777

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Treatment Outcomes in Japanese RCC Patients Treated With Avelumab Plus Axitinib as First-line Therapy: Retrospective Study (J-DART2)CompletedNCT05650164

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Study of Evobrutinib in Participants With RMS (evolutionRMS 2)TerminatedNCT04338061Phase 3

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Extension to the MAGNIFY MS Trial on Mavenclad® (Magnify MS Extension)CompletedNCT04783935Phase 4

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• A TQT Study to Investigate the Effect of Enpatoran on Cardiac Repolarization in Healthy ParticipantsCompletedNCT06589726Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Effectiveness of Cladribine Tablets in Participants With Highly-active Relapsing Multiple Sclerosis (CAMELOT-MS)CompletedNCT04997148

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Berzosertib Human Mass Balance Study (DDRiver Solid Tumors 208)CompletedNCT05246111Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Cognition and HRQoL in Adults With Highly-active RMS in Year 3 and 4 After Initial Mavenclad® Dose (CLARIFY MS Extension)CompletedNCT04776213Phase 4

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Chemoprophylactic Activity of M5717 in PfSPZ Challenge ModelCompletedNCT04250363Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Tepotinib Drug-Drug Interaction Study With Carbamazepine in Healthy ParticipantsCompletedNCT05213481Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Study of M5049 in CLE and SLE ParticipantsCompletedNCT04647708Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Tepotinib Drug-Drug Interaction Study With Itraconazole in Healthy ParticipantsCompletedNCT05203822Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• GXR RM (Glucophage® Extended Release Reduced Mass) 500 Milligram (mg) Korea Bioequivalence (BE) StudyCompletedNCT04684420Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Bioequivalence of 5 Tablets of 100 mg Versus 2 Tablets of 250 mg TF3 of TepotinibCompletedNCT04204902Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Concor® Bioequivalence Study in Chinese Participants (Darmstadt-Nantong)CompletedNCT05930808Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• GXR RM China BE Study (Darmstadt - Jiangsu)CompletedNCT05463094Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Study Comparing Pharmacokinetics of Different Formulations of Evobrutinib in Healthy ParticipantsCompletedNCT05245396Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• BE of Euthyrox® Tablets (Merck Nantong Versus Merck Darmstadt Sites)CompletedNCT05174000Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Pergoveris FD and Liquid China BE StudyCompletedNCT04899193Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Study of M5049 in Healthy Japanese and Caucasian ParticipantsCompletedNCT04880213Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Enpatoran Human Mass Balance and Absolute Bioavailability StudyCompletedNCT05110027Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Bioequivalence Study of Coated Cesol Tablet Formulation Versus BiltricideCompletedNCT04314037Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Effect of Food on Peposertib PKCompletedNCT04702698Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

• Drug-drug Interaction Study of Evobrutinib With Midazolam in Healthy ParticipantsCompletedNCT04697511Phase 1

  Sponsor listed in the registry: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany