M.D. Anderson Cancer Center: Carcinoma, Non-Small-Cell Lung trials

The registry lists 83 Carcinoma, Non-Small-Cell Lung studies with M.D. Anderson Cancer Center as lead sponsor. 8 are open to participants now and 26 have results posted.

Phase 1 32Phase 2 48Phase 3 2No phase 16(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Ph1/2 Trial Of Navlimetostat With Pumitamig In MTAP-Deficient Advanced Non-Small Cell Lung CancerRecruitingNCT07579221Phase 1/2
• Phase 1 Study Of Izalontamab Brengitecan + Adagrasib In NSCLC - The IZA-A TrialRecruitingNCT07382726Phase 1
• A Phase 2 Platform Study of Immunomodulatory Compounds in ICI-refractory Non-small Cell Lung CancerRecruitingNCT07133425Phase 2
• Dyadic Yoga Program for Patients Undergoing Thoracic Radiotherapy and Their Family Caregivers: The Testing of a Mobile Application DeliveryRecruitingNCT06919874Not applicable
• Predictive Biomarkers for Pneumonitis After Chemoradiotherapy and Immunotherapy in Patients With Non-small Cell Lung CancerRecruitingNCT04913311
• Dyadic Yoga Intervention in Improving Physical Performance and Quality of Life in Patients With Stage I-IV Non-small Cell Lung or Esophageal Cancer Undergoing Radiotherapy and Their CaregiversRecruitingNCT03948100Not applicable
• Role of Gut Microbiome and Fecal Transplant on Medication-Induced GI Complications in Patients With CancerRecruitingNCT03819296Phase 1
• Couple-Based Meditation for Metastatic Lung Cancer Patients and Their PartnersRecruitingNCT02596490Not applicable
• Bintrafusp Alfa and Pimasertib for the Treatment of Patients With Brain MetastasesTerminatedNCT04789668Phase 1/2Results posted
• Bintrafusp Alfa Before Surgery for the Treatment of Untreated Resectable Non-small Cell Lung CancerTerminatedNCT04560686Phase 2Results posted
• Bronchoscopic Laser Ablation of Peripheral Lung TumorsTerminatedNCT03707925Not applicableResults posted
• Pembrolizumab in Preventing Lung Cancer in Patients With Stage I-II Non-Small Cell Lung Cancer or High-Risk Pulmonary Nodules, the IMPRINT-Lung StudyCompletedNCT03634241Phase 2Results posted
• Durvalumab, Tremelimumab, and Selumetinib in Treating Participants With Recurrent or Stage IV Non-small Cell Lung CancerCompletedNCT03581487Phase 1/2Results posted
• Nivolumab With or Without Ipilimumab or Chemotherapy in Treating Patients With Previously Untreated Stage I-IIIA Non-small Cell Lung CancerCompletedNCT03158129Phase 2Results posted
• Pembrolizumab and Stereotactic Body Radiation Therapy or Non-Stereotactic Wide-Field Radiation Therapy in Treating Patients With Non-small Cell Lung CancerCompletedNCT02444741Phase 1/2Results posted
• Lung Cancer STARS Trial - STARS Revised Clinical Trial Protocol: Stereotactic Ablative Radiotherapy (SABR) in Stage I Non-small Cell Lung Cancer Patients Who Can Undergo LobectomyCompletedNCT02357992Not applicableResults posted
• A Phase I/II Study of Ibrutinib in Previously Treated Epidermal Growth Factor Receptor (EGFR) Mutant Non-Small Cell Lung CancerCompletedNCT02321540Phase 1/2Results posted
• Metformin in Non Small Cell Lung Cancer (NSCLC)TerminatedNCT02285855Phase 2Results posted
• Surgery and/or Radiation Therapy or Standard Therapy and/or Clinical Observation in Treating Patients With Previously Treated Stage IV Non-small Cell Lung CancerCompletedNCT01725165Phase 2Results posted
• Minocycline Study in Non Small Cell Lung Cancer (NSCLC) Patients for Chemoradiation TherapyCompletedNCT01636934Phase 2Results posted
• A Prospective Study Using Implanted Fiducial Markers to Assess Treatment Accuracy and Esophageal Toxicity in Spinal Stereotactic Body Radiation TherapyCompletedNCT01624220Not applicableResults posted
• Stereotactic Body Radiotherapy (SBRT) Versus Stereotactic Body Proton Therapy (SBPT)TerminatedNCT01511081Phase 2Results posted
• A Study for Reducing Symptom Burden Produced by Chemoradiation Treatment for Non Small Cell Lung Cancer by Minocycline and ArmodafinilCompletedNCT01317550Not applicableResults posted
• BATTLE-FL: Front-Line Biomarker-Integrated Treatment Study in Non Small Cell Lung CancerCompletedNCT01263782Phase 2Results posted
• BATTLE-2 Program: A Biomarker-Integrated Targeted Therapy Study in Previously Treated Patients With Advanced Non-Small Cell Lung CancerCompletedNCT01248247Phase 2Results posted
• Trial of Image-Guided Adaptive Conformal Photon vs Proton Therapy, With Concurrent Chemotherapy, for Locally Advanced Non-Small Cell Lung Carcinoma: Treatment Related Pneumonitis and Locoregional RecurrenceCompletedNCT00915005Phase 2Results posted
• Tarceva With Whole Brain Radiation Therapy - Brain Mets From Non-Small Cell Lung CancerCompletedNCT00871923Phase 2Results posted
• Dasatinib and Erlotinib in Non-Small Cell Lung Cancer (NSCLC)CompletedNCT00826449Phase 1/2Results posted
• TARCEVA (Erlotinib) in Combination With Chemoradiation in Patients With Stage IIIA/B Non-Small Cell Lung Cancer (NSCLC)CompletedNCT00563784Phase 2Results posted
• Single Agent Alimta in Poor Performance Status in Non-small Cell Lung CancerCompletedNCT00508144Phase 2Results posted
• Concurrent Proton and Chemotherapy in Locally Advanced Stage IIIA/B Non-Small Cell Lung Cancer (NSCLC)CompletedNCT00495170Phase 2Results posted
• Proton Radiotherapy for Patients With Non-Small Cell Lung Cancer (NSCLC)CompletedNCT00495040Phase 2Results posted
• BATTLE Program: Tarceva and Targretin in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)CompletedNCT00411632Phase 2Results posted
• Avastin/Docetaxel/Carboplatin in Non-Small Cell Lung CancerCompletedNCT00271505Phase 2Results posted
• Feasibility Testing of a Dyadic Exercise Program for Patients Undergoing Thoracic Radiotherapy and Their Family CaregiversSuspendedNCT07234799Not applicable
• Brigatinib Plus Chemotherapy or Local Consolidation Therapy in ALK Positive Advanced Non-small Cell Lung Cancer (BrightStar-2)WithdrawnNCT06522360Phase 2
• PhI/II Study of Amivantamab and Tepotinib Combo in MET-altered Non-small Cell Lung CancerActive, not recruitingNCT06083857Phase 1/2
• Perceptions on Expected Outcomes of Immunotherapy in Advanced Cancer Patients With Poor Performance StatusCompletedNCT05634551
• Poziotinib and Ramucirumab for the Treatment of EGFR Exon 20 Mutant Stage IV Non-small Cell Lung CancerWithdrawnNCT05045404Phase 2
• Sapanisertib and Nivolumab for the Treatment of Stage I-IV Non-small Cell Lung Cancer in Patients Who Have Progressed on Prior PD-1/PD-L1 Inhibitor Therapy, I-OVERCOME StudyWithdrawnNCT05022394Phase 1/2
• Robotic Bronchoscopy With Cone CT and Indocyanine Green to Aid Removal of Lung Lesions in Patients With Stage I Non-small Cell Lung Cancer or Lung Metastases, REPLACING StudyWithdrawnNCT04987281Phase 2
• Tocilizumab, Ipilimumab, and Nivolumab for the Treatment of Advanced Melanoma, Non-Small Cell Lung Cancer, or Urothelial CarcinomaActive, not recruitingNCT04940299Phase 2
• Ensartinib, Carboplatin, Pemetrexed and Bevacizumab for the Treatment of Stage IIIC or IV or Recurrent ALK-Positive Non-small Cell Lung CancerActive, not recruitingNCT04837716Phase 1
• NBTXR3 and Radiation Therapy for the Treatment of Inoperable Recurrent Non-small Cell Lung CancerActive, not recruitingNCT04505267Phase 1
• Osimertinib in Combination With Alisertib or Sapanisertib for the Treatment of Osimertinib-Resistant EGFR Mutant Stage IIIB or IV Non-Small Cell Lung CancerCompletedNCT04479306Phase 1
• Microwave Ablation or Wedge Resection for the Treatment of Lung, Sarcoma and Colorectal Lesions, ALLUME StudyActive, not recruitingNCT04430725
• Infliximab or Vedolizumab in Treating Immune Checkpoint Inhibitor-Related Colitis in Patients With Genitourinary Cancer or MelanomaActive, not recruitingNCT04407247Phase 1/2
• Ipilimumab and Nivolumab in Combination With Radiation Therapy in Treating Patients With Stage 2-3 Non-small Lung CancerActive, not recruitingNCT04013542Phase 1
• Online Psychosocial Intervention in Improving Social Well-Being and Support in Women With Stage I-IV Non-small Cell Lung Cancer Undergoing TreatmentActive, not recruitingNCT03731585Not applicable
• Local Consolidative Therapy and Brigatinib in Treating Patients With Stage IV or Recurrent Non-small Cell Lung CancerActive, not recruitingNCT03707938Phase 1
• Anamorelin Hydrochloride in Reducing Anorexia in Patients With Advanced Non-small Cell Lung CancerActive, not recruitingNCT03637816Phase 2/3
• Osimertinib, Surgery, and Radiation Therapy in Treating Patients With Stage IIIB or IV Non-small Cell Lung Cancer With EGFR Mutations, NORTHSTAR StudyActive, not recruitingNCT03410043Phase 2
• Nivolumab and Ipilimumab With or Without Local Consolidation Therapy in Treating Patients With Stage IV Non-Small Cell Lung CancerActive, not recruitingNCT03391869Phase 3
• Trametinib and Pembrolizumab in Treating Patients With Recurrent Non-small Cell Lung Cancer That Is Metastatic, Unresectable, or Locally AdvancedActive, not recruitingNCT03225664Phase 1/2
• Stereotactic Body Radiation Therapy With or Without Nivolumab in Treating Patients With Stage I-IIA or Recurrent Non-small Cell Lung CancerActive, not recruitingNCT03110978Phase 2
• Poziotinib in EGFR Exon 20 Mutant Advanced NSCLCTerminatedNCT03066206Phase 2
• Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal DiseaseActive, not recruitingNCT03025256Phase 1
• MEDI4736 With Selumetinib for KRAS Mutant Non-Small Cell Lung Cancer (NSCLC)WithdrawnNCT03004105Phase 2
• Danvatirsen and Durvalumab in Treating Patients With Advanced and Refractory Pancreatic, Non-Small Cell Lung Cancer, and Mismatch Repair Deficient Colorectal CancerActive, not recruitingNCT02983578Phase 2
• Study of Ibrutinib Followed by Ibrutinib in Combination With Nivolumab in Non-Small Cell Lung Cancer (NSCLC)WithdrawnNCT02950038Phase 2
• Nivolumab and Radiation Therapy With or Without Ipilimumab in Treating Patients With Brain Metastases From Non-small Cell Lung CancerActive, not recruitingNCT02696993Phase 1/2
• MPDL3280A With Chemoradiation for Lung CancerActive, not recruitingNCT02525757Phase 2
• Phase IB Study to Evaluate the Safety of Selinexor (KPT-330) in Combination With Multiple Standard Chemotherapy or Immunotherapy Agents in Patients With Advanced MalignanciesTerminatedNCT02419495Phase 1
• Cisplatin, Docetaxel, and Nintedanib Before Surgery in Treating Patients With Previously Untreated Stage IB-IIIA Non-small Cell Lung CancerCompletedNCT02225405Phase 1
• Registry Study of Thoracic Reirradiation for Non-Small Cell Lung Cancer (NSCLC) Utilizing Proton Beam Therapy or Intensity Modulated Radiation TherapyCompletedNCT01808677
• Image-Guided, Intensity-Modulated Photon or Proton Beam Radiation Therapy in Treating Patients With Stage II-IIIB Non-small Cell Lung CancerActive, not recruitingNCT01629498Phase 1/2
• Sublingual Anvirzel in Advance Non-Small Cell Lung Cancer (NSCLC)WithdrawnNCT01562301Phase 1
• Study of Hypofractionated Proton Radiation Therapy in Thoracic MalignanciesTerminatedNCT01165658Phase 1
• Imatinib Mesylate and Docetaxel in Non-Small Cell Lung Cancer (NSCLC)CompletedNCT01083589Phase 2
• Reducing Symptom Burden - Non Small Cell Lung Cancer (NSCLC)WithdrawnNCT01048983Phase 1/2
• Utility of Endobronchial Ultrasound Guided Needle Biopsy in Early Stage Non- Small Cell Lung Cancer (NSCLC)CompletedNCT00832715Phase 1/2
• Topical Cyclosporine vs. Placebo for Epiphora Associated With DocetaxelWithdrawnNCT00824811Phase 2
• Radiation Therapy (XRT) and ZD6474 in Non-Small Cell Lung Cancer (NSCLC)TerminatedNCT00745732Phase 1
• Sorafenib and Thoracic Radiation for Patients With Non-Small Cell Lung CancerTerminatedNCT00543335Phase 1
• BAY 43-9006 in Previously Untreated Patients With Non-Small Cell Lung Cancer (NSCLC)CompletedNCT00533585Phase 1
• Measurement of Pain and Other Symptoms of Non-Small Cell Lung Cancer (NSCLC) Patients Following Thoracic SurgeryCompletedNCT00501319
• BATTLE Program: Umbrella Protocol for Patients With Non-Small Cell Lung Cancer (NSCLC)CompletedNCT00409968
• Vanguard Study for Head and Neck Cancer or Non-Small Cell Lung Cancer (NSCLC) PatientsCompletedNCT00352391
• CPT-11/Cisplatin and Celecoxib With Radiation Therapy for Patients With Unresectable Non-Small Cell Lung Cancer (NSCLC)CompletedNCT00346801Phase 1
• Docetaxel, Cisplatin, and Erlotinib Hydrochloride in Treating Patients With Stage I-III Non-small Cell Lung Cancer Following SurgeryCompletedNCT00254384Phase 1
• Phase I Study of IV DOTAP: Cholesterol-Fus1 in Non-Small-Cell Lung CancerCompletedNCT00059605Phase 1
• Iressa/Docetaxel in Non-Small-Cell Lung CancerWithdrawnNCT00048087Phase 2
• Cisplatin and Gemcitabine Plus Trastuzumab in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung CancerCompletedNCT00016367Phase 2