Hoffmann-La Roche: Arthritis, Rheumatoid trials

The registry lists 219 Arthritis, Rheumatoid studies with Hoffmann-La Roche as lead sponsor. 2 are open to participants now and 139 have results posted.

Phase 1 6Phase 2 22Phase 3 85Phase 4 28No phase 80(a study in two phases counts in both)

Studies

Page 1 of 3. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• An Extension Study to Assess Long-Term Safety and Efficacy of Afimkibart in Participants With Rheumatoid ArthritisRecruitingNCT07620392Phase 2
• A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)RecruitingNCT07137598Phase 2
• A Study of RO7123520 to Evaluate the Safety and Efficacy in Participants With Moderately To Severely Active Rheumatoid Arthritis (RA) Who Are Inadequately Responding to Anti-Tumor Necrosis Factor (TNF)-Alpha TherapyTerminatedNCT03001219Phase 2Results posted
• A Study to Evaluate the Long-Term Safety and Efficacy of GDC-0853 in Participants With Moderate to Severe Rheumatoid Arthritis Enrolled in Study GA29350CompletedNCT02983227Phase 2Results posted
• Safety and Efficacy Study of GDC-0853 Compared With Placebo and Adalimumab in Participants With Rheumatoid Arthritis (RA)CompletedNCT02833350Phase 2Results posted
• Use of Tocilizumab for Rheumatoid Arthritis (RA) in Daily RoutineCompletedNCT02809833Results posted
• Study to Examine Efficacy and Safety of Rituximab in Participants With Rheumatoid ArthritisCompletedNCT02699892Results posted
• Tocilizumab Real-Life Human Factors (RLHFs) Validation StudyCompletedNCT02682823Phase 4Results posted
• An Observational Study to Describe in Routine Clinical Practice the Treatment Patterns of Usage of Biological DMARDs in RA Patients.CompletedNCT02590562Results posted
• Study to Compare the Efficacy of Tocilizumab With or Without Glucocorticoid Discontinuation in Rheumatoid Arthritis ParticipantsCompletedNCT02573012Phase 4Results posted
• An Observational Quality of Life Study in Participants With Rheumatoid Arthritis Treated With RituximabCompletedNCT02507752Results posted
• Study for Validation of Standardized Questionnaires on Depression and Investigation of the Frequency of Depression in Rheumatoid Arthritis (RA) ParticipantsCompletedNCT02485483Results posted
• A Study of the Efficacy and Safety of Re-treatments With Rituximab in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-tnfa TherapiesCompletedNCT02097745Phase 3Results posted
• Extension Study to Assess the Efficacy and Safety of Repeat Treatment With Rituximab (MabThera) in Participants With Active Rheumatoid Arthritis (RA)CompletedNCT02093026Phase 2Results posted
• A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to a Single Anti-TNF InhibitorCompletedNCT02079532Phase 3Results posted
• A Study of Subcutaneous (SC) Tocilizumab (RoActemra/Actemra) in Participants With Active Rheumatoid Arthritis (RA) and Inadequate Response to Disease-Modifying Anti-Rheumatic Drugs (DMARDs)CompletedNCT02046616Phase 3Results posted
• A Study of Tocilizumab (RoActemra/Actemra) in Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Participants With Active Rheumatoid Arthritis and an Inadequate Response to Current Non-Biologic DMARD Therapy or the First Anti-TNF Biologic AgentCompletedNCT02046603Phase 3Results posted
• TOSCARA Study: A Study of Subcutaneous Tocilizumab (RoActemra/Actemra) in Participants With Active Rheumatoid Arthritis Naïve to RoActemra/Actemra TreatmentCompletedNCT02031471Phase 3Results posted
• A Study of RoActemra/Actemra (Tocilizumab) in Adult Patients With Rheumatoid Arthritis (SVOBODA Programme)CompletedNCT02010216Phase 4Results posted
• A Study of MabThera/Rituxan (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis and Inadequate Response to DMARD TherapyCompletedNCT02006706Phase 3Results posted
• A Study of Tocilizumab (RoActemra) in Tocilizumab-Naive Participants With Rheumatoid Arthritis and Inadequate Response to Non-Biologic Disease-Modifying Antirheumatic Drugs (DMARDs) and/or Biologic TherapyCompletedNCT02001987Phase 3Results posted
• A Study of Subcutaneous RoActemra/Actemra (Tocilizumab) as Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Patients With Active Rheumatoid ArthritisCompletedNCT01995201Phase 3Results posted
• A Study of the Efficacy and Safety of Tocilizumab in Adults With Rheumatoid Arthritis.CompletedNCT01988012Phase 3Results posted
• A Study on Safety and Efficacy of Tocilizumab (RoActemra/Actemra) Alone or in Combination With Non-Biologic Antirheumatics in Participants With Rheumatoid ArthritisCompletedNCT01987479Phase 3Results posted
• An Open-Label Study of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Active Rheumatoid ArthritisCompletedNCT01951170Phase 3Results posted
• A Study to Evaluate Efficacy of Tocilizumab Administered as Monotherapy or in Combination With Methotrexate and/or Other Disease Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis (RA) ParticipantsCompletedNCT01941940Phase 3Results posted
• A Study of Subcutaneous Tocilizumab as Monotherapy and/or in Combination With Non-Biologic Disease Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Rheumatoid ArthritisCompletedNCT01941095Phase 3Results posted
• A Retrospective, Observational Chart Review of Biologics in Monotherapy Versus the Combination Biologic Plus Methotrexate in Patients With Rheumatoid ArthritisCompletedNCT01866150Results posted
• A Study of the Impact of Methotrexate (MTX) Discontinuation on the Efficacy of Subcutaneous (SC) Tocilizumab (TCZ) With MTXCompletedNCT01855789Phase 3Results posted
• ARMONIA: An Observational Study of Biologic Drugs in Monotherapy or Combination With DMARDs in Italian Clinical Practice and the Efficacy and Safety of RoActemra/Actemra (Tocilizumab) Monotherapy in Patients With Rheumatoid ArthritisCompletedNCT01791205Results posted
• A Long-Term Extension Study of WA22763 and NA25220 of Subcutaneous RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Rheumatoid ArthritisCompletedNCT01772316Phase 3Results posted
• An Observational Study of Tocilizumab (Actemra) in Participants With Moderate to Severe Rheumatoid ArthritisCompletedNCT01741688Results posted
• A Long-Term Extension Study of WA22762 to Evaluate Safety and Efficacy of Subcutaneous Tocilizumab in Participants With Moderate to Severe Rheumatoid Arthritis (RA).CompletedNCT01734993Phase 3Results posted
• A Long-term Safety Extension Study of Tocilizumab in Brazilian Participants With Rheumatoid Arthritis (RA) Who Completed the Studies ML21530 and MA21488CompletedNCT01715831Phase 4Results posted
• A Non-Interventional Study of Rheumatoid Arthritis Patients Treated With RoActemra/Actemra (Tocilizumab) in MonotherapyCompletedNCT01705730Results posted
• Observational Study of Tocilizumab in Participants With Rheumatoid Arthritis in AustraliaCompletedNCT01683604Results posted
• A Non-Interventional Study of RoActemra/Actemra in Patients With Moderate to Severe Rheumatoid ArthritisCompletedNCT01672970Results posted
• A Non-Interventional Study Evaluating Rheumatoid Arthritis Participants Treated With Tocilizumab (RoActemra/Actemra)CompletedNCT01671059Results posted
• A Non-Interventional Study of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Rheumatoid ArthritisCompletedNCT01670045Results posted
• An Observational Study of RoActemra/Actemra (Tocilizumab) in Monotherapy in Patients With Rheumatoid ArthritisCompletedNCT01669902Results posted
• A Long Term Extension Study of WA19926 (NCT01007435) of Tocilizumab (RoActemra/Actemra) in Participants With Early, Moderate to Severe Rheumatoid Arthritis (RA)CompletedNCT01668966Phase 3Results posted
• A Long-Term Extension Study to WA19926 (NCT01007435) of Tocilizumab in Participants With Early, Moderate to Severe Rheumatoid ArthritisTerminatedNCT01665430Phase 3Results posted
• An Extension Study of WA19926 of the Long-Term Safety of Tocilizumab (RoActemra/Actemra) in Patients With Early Moderate to Severe Rheumatoid ArthritisCompletedNCT01664598Phase 3Results posted
• An Observational Study in Clinical Practice Management of Patients With Biological Drugs in MonotherapyCompletedNCT01664117Results posted
• A Study to Evaluate Tocilizumab Treatment in a Real-Life SettingCompletedNCT01664104Results posted
• A Non-Interventional Study in Patients With Moderate to Severe Rheumatoid Arthritis Treated With RoActemra/Actemra (Tocilizumab)CompletedNCT01663506Results posted
• A Long-Term Extension Study of WA22762 and NA25220 of Subcutaneous (SC) Tocilizumab (TCZ) in Moderate to Severe Rheumatoid Arthritis (RA)CompletedNCT01662063Phase 3Results posted
• A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Severe Active Rheumatoid Arthritis, Comparing Tapering Versus Maintaining the Methotrexate DosageTerminatedNCT01661140Phase 4Results posted
• A Long-Term Extension Study of WA19926 on the Safety of Tocilizumab (RoActemra/Actemra) in Participants With Early Moderate to Severe Rheumatoid ArthritisCompletedNCT01655381Phase 3Results posted
• A Long-Term Safety Extension Study of WA19926 in Participants With Rheumatoid ArthritisCompletedNCT01649804Phase 3Results posted
• An Observational Study of MabThera/Rituxan (Rituximab) in Patients With Rheumatoid Arthritis and an Inadequate Response or Intolerance to One Anti-Tumor Necrosis Factor (Anti-TNF) AgentCompletedNCT01641952Results posted
• A Retrospective Chart Review on the Use of Biologics in Monotherapy for the Treatment of Patients With Rheumatoid ArthritisCompletedNCT01640548Results posted
• A Study of Tocilizumab in Participants With Active Rheumatoid Arthritis (RA) and an Inadequate Response to Non-Biological Disease-modifying Anti-rheumatic Drugs (DMARDs)CompletedNCT01617005Results posted
• A Non-Interventional Study in Rheumatoid Arthritis Patients Treated With Tocilizumab (RoActemra/Actemra)CompletedNCT01613378Results posted
• An Observational Study of MabThera in Participants With Severe Active Rheumatoid ArthritisCompletedNCT01613027Results posted
• A Study of RoActemra/Actemra (Tocilizumab) in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to DMARDs (REMISSION)CompletedNCT01610791Phase 3Results posted
• An Observational Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis And Inadequate Response Or Intolerance to a First Anti-TNF Alpha TherapyCompletedNCT01592292Results posted
• A Study of RoActemra/Actemra (Tocilizumab) With or Without Methotrexate in Patients With Mild to Moderate Rheumatoid Arthritis With an Inadequate Response to MethotrexateCompletedNCT01587989Phase 3Results posted
• Observational Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid ArthritisCompletedNCT01579006Results posted
• A Non-interventional Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid ArthritisCompletedNCT01562327Results posted
• An Observational Study of MabThera/Rituxan (Rituximab) and Alternative TNF-Inhibitors in Patients With Rheumatoid Arthritis and an Inadequate Response to a Single Previous TNF-InhibitorCompletedNCT01557348Results posted
• An Global Comparative Observational Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid ArthritisCompletedNCT01543503Results posted
• An Observational Study of RoActemra/Actemra (Tocilizumab) As Monotherapy in Rheumatoid Arthritis Patients in Routine Clinical PracticeCompletedNCT01474291Results posted
• A Study in Patients With Moderate to Severe Active Rheumatoid Arthritis Comparing Different Infusion Durations of RoActemra/Actemra (Tocilizumab) TreatmentCompletedNCT01468077Phase 2Results posted
• A Prospective Observational Study of Tocilizumab (RoActemra/Actemra) in Participants With Rheumatoid ArthritisCompletedNCT01462162Results posted
• A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate Versus RoActemra/Actemra Monotherapy in Patients With Rheumatoid Arthritis and an Inadequate Response to MethotrexateCompletedNCT01399697Phase 4Results posted
• An Observational Study on RoActemra/Actemra (Tocilizumab) in Clinical Practice in Patients With Rheumatoid Arthritis (TRUST)CompletedNCT01394276Results posted
• A Study on The Safety of Administering Rituximab at A More Rapid Rate in Patients With Rheumatoid ArthritisCompletedNCT01382940Phase 4Results posted
• Study to Evaluate the Safety, Tolerability and Efficacy of Tocilizumab in Participants With Rheumatoid Arthritis (RA) Who Have an Inadequate Response to Non-Biologic Disease Modifying Anti-rheumatic Drugs (DMARDs) and/or Anti-tumor Necrosis Factor (Anti-TNF) TherapyCompletedNCT01362062Results posted
• A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Non-biologic DMARDsCompletedNCT01353859Phase 3Results posted
• A Study of RoActemra/Actemra and, if Initially Inadequately Responded to RoActemra/Actemra, Followed by MabThera/Rituxan in Patients With Rheumatoid ArthritisCompletedNCT01332994Phase 3Results posted
• A Study of Tocilizumab in Comparison to Etanercept in Participants With Rheumatoid Arthritis and Cardiovascular Disease Risk FactorsCompletedNCT01331837Phase 4Results posted
• A Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid Arthritis Who Have an Inadequate Response to DMARDs or Anti-TNFCompletedNCT01326962Phase 3Results posted
• An Observational Study of MabThera/Rituxan (Rituximab) in Patients With Sero-Positive Rheumatoid Arthritis Who Are Non-Responders or Intolerant to a Single TNF-Inhibitor (PORTSMAB)CompletedNCT01309282Results posted
• A Study of RoActemra/Actemra (Tocilizumab) Versus Adalimumab in Combination With Methotrexate (MTX) in Patients With Moderate to Severe Active Rheumatoid Arthritis And an Inadequate Response to Treatment With Only One Tumor Necrosis Factor (TNF)-InhibitorTerminatedNCT01283971Phase 4Results posted
• A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Failed on One Prior Anti-TNF Therapy (RESET)CompletedNCT01272908Phase 3Results posted
• An Open-label Study With Tocilizumab in Patients With Rheumatoid Arthritis in a Local EnvironmentCompletedNCT01254331Phase 3Results posted
• A Study of RoActemra/Actemra (Tocilizumab) in Combination With DMARDs Versus Current Best Practice DMARD Therapy in Patients With Rheumatoid ArthritisTerminatedNCT01251120Phase 4Results posted
• A Study of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Rheumatoid ArthritisCompletedNCT01245439Phase 3Results posted
• A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARDs) (ALABASTER)CompletedNCT01235507Phase 3Results posted
• A Study of RoActemra/Actemra (Tocilizumab) Given Subcutaneously in Combination With Traditional DMARDs in Patients With Moderate to Severe Active Rheumatoid ArthritisCompletedNCT01232569Phase 3Results posted
• A Study of Glucocorticoid Use to Evaluate Systematic Methylprednisolone Reduction in Patients With Rheumatoid Arthritis on Background RoActemra/Actemra (Tocilizumab) (ACT-ALONE)CompletedNCT01219933Phase 4Results posted
• A Study of the Effects of RoActemra/Actemra (Tocilizumab) on Neutrophils in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Biologic and/or Non-biologic DMARDs.CompletedNCT01195272Phase 4Results posted
• A Study to Compare Subcutaneous Versus Intravenous Administration of RoActemra/Actemra (Tocilizumab) in Participants With Moderate to Severe Active Rheumatoid ArthritisCompletedNCT01194414Phase 3Results posted
• An Observational Study of the Impact of RoActemra/Actemra on Fatigue in Patients With Rheumatoid Arthritis (PEPS)CompletedNCT01185522Results posted
• A Study of the Effects of RoActemra/Actemra on Vaccination in Patients With Rheumatoid Arthritis on Background Methotrexate (VISARA)CompletedNCT01163747Phase 4Results posted
• A Study of RoActemra/Actemra (Tocilizumab) in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Current Non-Biologic and/or Biologic DMARDSCompletedNCT01149057Phase 4Results posted
• SMART Study: A Study of Re-treatment With MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Failed on Anti-TNF Alfa TherapyCompletedNCT01126541Phase 3Results posted
• A Study of Tocilizumab (RoActemra/Actemra) Versus Adalimumab in Patients With Rheumatoid ArthritisCompletedNCT01119859Phase 4Results posted
• A Study of Tocilizumab as Monotherapy or in Combination With DMARDs in Patients With Moderate to Severe Active Rheumatoid ArthritisCompletedNCT01089023Phase 4Results posted
• An Observational Study on the Safety and Effectiveness of Rituximab in Patients With Severe Active Rheumatoid ArthritisCompletedNCT01071798Results posted
• A Study With Tocilizumab [RoActemra/Actemra] Monotherapy or in Combination With Methotrexate in Patients With Rheumatoid Arthritis (PICTURE)CompletedNCT01063062Phase 3Results posted
• A Study of Tocilizumab in Combination With an Oral Contraceptive in Patients With Rheumatoid ArthritisCompletedNCT01044498Phase 3Results posted
• A Study of Tocilizumab Plus Non-biological DMARD in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Non-biological DMARDsCompletedNCT01034397Phase 4Results posted
• A Study of Tocilizumab and Methotrexate in Combination or as Monotherapy in Treatment-Naïve Patients With Early Rheumatoid ArthritisCompletedNCT01034137Phase 3Results posted
• A Study of Tocilizumab With or Without Methotrexate in Patients With Rheumatoid Arthritis.CompletedNCT01010503Phase 4Results posted
• A Study of Tocilizumab as Monotherapy and in Combination With Methotrexate Versus Methotrexate in Patients With Early Moderate to Severe Rheumatoid ArthritisCompletedNCT01007435Phase 3Results posted
• A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis and an Inadequate Response to MethotrexateCompletedNCT01000610Phase 4Results posted
• A Study of Tocilizumab in Combination With Disease-Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Moderate to Severe Active Rheumatoid Arthritis With an Inadequate Response to DMARDsCompletedNCT00996606Phase 3Results posted
• A Study of Tocilizumab Added to DMARDs in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to DMARDs.CompletedNCT00996203Phase 4Results posted