Children's Oncology Group: Precursor Cell Lymphoblastic Leukemia-Lymphoma trials

The registry lists 79 Precursor Cell Lymphoblastic Leukemia-Lymphoma studies with Children's Oncology Group as lead sponsor. 2 are open to participants now and 21 have results posted.

Phase 1 7Phase 2 12Phase 3 24No phase 39(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Backtracking Leukemia-Typical Somatic Mutations in Cord BloodRecruitingNCT05014165
• Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer TreatmentRecruitingNCT01790152
• Palbociclib in Combination With Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LL)CompletedNCT03792256Phase 1Results posted
• Chlorhexidine Gluconate Cleansing in Preventing Central Line Associated Bloodstream Infection and Acquisition of Multi-drug Resistant Organisms in Younger Patients With Cancer or Undergoing Donor Stem Cell TransplantCompletedNCT01817075Phase 3Results posted
• Levofloxacin in Preventing Infection in Young Patients With Acute Leukemia Receiving Chemotherapy or Undergoing Stem Cell TransplantationCompletedNCT01371656Phase 3Results posted
• Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell TransplantCompletedNCT01305200Phase 3Results posted
• Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic LymphomaCompletedNCT01190930Phase 3Results posted
• Alisertib in Treating Young Patients With Recurrent or Refractory Solid Tumors or LeukemiaCompletedNCT01154816Phase 2Results posted
• Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia (Closed to Accrual 4-22-2011)CompletedNCT00866307Phase 1Results posted
• Calaspargase Pegol or Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic LeukemiaCompletedNCT00671034Phase 3Results posted
• Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic LeukemiaCompletedNCT00557193Phase 3Results posted
• Erwinia Asparaginase After Allergy to PEG-Asparaginase in Treating Young Patients With Acute Lymphoblastic LeukemiaCompletedNCT00537030Not applicableResults posted
• Donor Bone Marrow Transplant With or Without G-CSF in Treating Young Patients With Hematologic Cancer or Other DiseasesCompletedNCT00450450Phase 3Results posted
• Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete RemissionCompletedNCT00382109Phase 3Results posted
• Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic LeukemiaCompletedNCT00381680Phase 3Results posted
• Clofarabine and Cytarabine in Treating Young Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Lymphoblastic LeukemiaCompletedNCT00372619Phase 1/2Results posted
• Etanercept in Treating Young Patients With Idiopathic Pneumonia Syndrome After Undergoing a Donor Stem Cell TransplantCompletedNCT00309907Phase 2Results posted
• Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic LeukemiaCompletedNCT00103285Phase 3Results posted
• Chemoimmunotherapy With Epratuzumab in Relapsed Acute Lymphoblastic Leukemia (ALL)CompletedNCT00098839Phase 1/2Results posted
• Combination Chemotherapy and Radiation Therapy in Treating Patients With Acute Lymphoblastic Leukemia That Has Relapsed in the CNS or TestesCompletedNCT00096135Not applicableResults posted
• Dexamethasone Compared With Prednisone During Induction Therapy and Methotrexate With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic LeukemiaCompletedNCT00075725Phase 3Results posted
• Rituximab, Rasburicase, and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Advanced B-Cell Leukemia or LymphomaCompletedNCT00057811Phase 2Results posted
• Combination Chemotx in Treating Children or Adolescents With Newly Diagnosed Stg III or Stg IV Lymphoblastic LymphomaCompletedNCT00004228Phase 3Results posted
• A Study to Find the Highest Dose of SNDX-5613 (Revumenib) as a Treatment Option After Hematopoietic Stem Cell Transplant in Children With Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, and Mixed Phenotype Acute LeukemiaWithdrawnNCT07498465Phase 1
• A Study of Different Programs to Help ALL Patients With Taking Maintenance Medicine at HomeSuspendedNCT06639958Not applicable
• A Study of Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory LeukemiaActive, not recruitingNCT05761171Phase 2
• Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or LymphomaActive, not recruitingNCT05602194Phase 3
• Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic SyndromeActive, not recruitingNCT05457556Phase 3
• A Study of the Drug IMGN632 in Children With Leukemia That Has Come Back After Treatment or is Difficult to TreatWithdrawnNCT05320380Phase 1/2
• Financial Distress During Treatment for Pediatric Acute Lymphoblastic Leukemia in the United StatesActive, not recruitingNCT04928599
• Cancer Care Delivery in Adolescent and Young Adult Patients With Acute Lymphoblastic LeukemiaCompletedNCT03204916
• Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic LeukemiaActive, not recruitingNCT03007147Phase 3
• Identifying, Understanding, and Overcoming Barriers to the Use of Clinical Practice Guidelines in Pediatric OncologyCompletedNCT02847130
• Studying RNA in Samples From Younger Patients With T-Cell Acute Lymphoblastic LeukemiaCompletedNCT01626183
• Studying Genes in Samples From Younger Patients With Relapsed Acute Lymphoblastic LeukemiaCompletedNCT01625143
• Studying Genes Associated With Non-Hodgkin Lymphoma in Young PatientsCompletedNCT01623856
• Studying Samples From Patients With T-Cell Acute Lymphoblastic LeukemiaCompletedNCT01581528
• Studying Dexamethasone and Prednisone Sensitivity in Samples From Younger Patients With High-Risk B-Cell Precursor Acute Lymphoblastic LeukemiaCompletedNCT01553162
• Studying Biomarkers as a Diagnostic Tool in Samples From Younger Patients With B-Cell Acute Lymphoblastic LeukemiaCompletedNCT01540578
• Genetic Test To Identify Previously Undetectable Minimal Residual Disease in Cell Samples From Younger Patients With Acute Lymphoblastic LeukemiaCompletedNCT01533168
• Gene Expression in Samples From Patients With T-Cell Acute Lymphoblastic LeukemiaCompletedNCT01520246
• Assessing Compliance With Mercaptopurine Treatment in Younger Patients With Acute Lymphoblastic Leukemia in First RemissionCompletedNCT01503632Phase 3
• Biomarker Study in Bone Marrow Samples From Patients With T-Cell Acute Lymphoblastic LeukemiaCompletedNCT01295476
• Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia or Advanced Lymphoblastic Non-Hodgkin's LymphomaCompletedNCT01230983Phase 3
• Biomarkers to Classify Young Patients With Acute Lymphoblastic Leukemia (ALL) and Remission Induction Therapy in Young Patients With B-Precursor ALLCompletedNCT01225874Not applicable
• Lestaurtinib With or Without Chemotherapy Agents in Samples From Young Patients With LeukemiaCompletedNCT01150669
• Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic LeukemiaCompletedNCT01142427
• Biomarkers in DNA Samples From Patients With High-Risk Acute Lymphoblastic LeukemiaCompletedNCT01119586
• Studying DNA in Blood and Bone Marrow Samples From Young Patients With Acute Lymphoblastic LeukemiaCompletedNCT01016379
• Study of Biomarkers in DNA Samples From Patients With Acute Lymphoblastic Leukemia or Acute Myeloid LeukemiaCompletedNCT01005277
• Studying Body Mass Index in Younger Patients Who Are Receiving Treatment for High-Risk Acute Lymphoblastic LeukemiaWithdrawnNCT00900445
• Resistance to Methotrexate in Patients With Acute Lymphoblastic Leukemia in Relapse or RemissionCompletedNCT00899899
• DNA Analysis of Bone Marrow and Blood Samples From Young Patients With Acute Myeloid Leukemia or Acute Lymphoblastic LeukemiaCompletedNCT00899652
• Collecting and Storing Tissue From Young Patients With CancerCompletedNCT00898755
• Response or Resistance to Chemotherapy in Young Patients With Acute Lymphoblastic Leukemia Treated With MethotrexateCompletedNCT00898404
• Collecting and Storing Malignant, Borderline Malignant Neoplasms, and Related Samples From Young Patients With CancerCompletedNCT00898079
• DNA Analysis of Tumor Tissue Samples From Young Patients With Acute Lymphoblastic LeukemiaCompletedNCT00897507
• Collecting and Storing Samples of Bone Marrow and Blood From Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin LymphomaCompletedNCT00897325
• Laboratory Study of Lymphoblasts in Young Patients With High-Risk Acute Lymphoblastic LeukemiaCompletedNCT00896766
• Evaluating Dactinomycin and Vincristine in Young Patients With CancerCompletedNCT00674193
• Risk-Group Classification of Patients With Newly Diagnosed Acute Lymphoblastic LeukemiaCompletedNCT00482352
• Brain Function in Young Patients Receiving Methotrexate for Acute Lymphoblastic LeukemiaCompletedNCT00437060
• Study to Assess Compliance With Long-Term Mercaptopurine Treatment in Young Patients With Acute Lymphoblastic Leukemia in RemissionCompletedNCT00268528
• Neurobehavioral Complications in Children Who Were Previously Treated With Steroids and Intrathecal Therapy for Acute Lymphoblastic LeukemiaCompletedNCT00085176
• Study of the Physical and Emotional Needs of Parents Caring for Children Receiving Chemotherapy for Acute Lymphoblastic LeukemiaCompletedNCT00056069Not applicable
• Combination Chemotherapy With or Without Donor Bone Marrow Transplantation in Treating Infants With Previously Untreated Acute Lymphoblastic LeukemiaCompletedNCT00022126Phase 2
• Gemcitabine in Treating Children With Relapsed or Refractory Acute Lymphoblastic Leukemia or Acute Myelogenous LeukemiaCompletedNCT00006462Phase 2
• Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic LeukemiaCompletedNCT00005945Phase 3
• Combination Chemotherapy in Treating Children With Acute Lymphoblastic LeukemiaCompletedNCT00005603Phase 3
• Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic LeukemiaCompletedNCT00005596Phase 3
• Combination Chemotherapy in Treating Children With Acute Lymphoblastic LeukemiaCompletedNCT00005585Phase 3
• Diagnostic Study of Gene Alterations in Children Who Have Been Treated for Relapsed Acute Lymphocytic LeukemiaCompletedNCT00003933Not applicable
• Combination Chemotherapy in Treating Children With Very High Risk Acute Lymphocytic LeukemiaCompletedNCT00003783Phase 2
• Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphocytic LeukemiaCompletedNCT00003671Phase 2
• Combination Chemotherapy in Treating Children With Stage III or Stage IV Non-Hodgkin's Lymphoma or Acute Lymphoblastic LeukemiaCompletedNCT00003217Phase 1
• Combination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic LeukemiaCompletedNCT00002816Phase 3
• Combination Chemotherapy in Treating Children With Acute Lymphocytic LeukemiaCompletedNCT00002812Phase 3
• Combination Chemotherapy, Bone Marrow Transplantation, and Radiation Therapy in Treating Infants With Acute Lymphoblastic LeukemiaCompletedNCT00002785Phase 2
• Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic LeukemiaCompletedNCT00002744Phase 3