An observational study in Recurrent Adult Acute Lymphoblastic Leukemia, Recurrent Adult Non-Hodgkin Lymphoma and Recurrent Childhood Acute Lymphoblastic Leukemia, sponsored by Children's Oncology Group. Completed at 183 sites in 5 countries. Open to participants aged Up to 30 Years. Per ClinicalTrials.gov, last updated 2020-01-18.
Sponsored by Children's Oncology Group · Observational
This research study is collecting and storing samples of bone marrow and blood from patients with relapsed acute lymphoblastic leukemia or relapsed non-Hodgkin lymphoma. Collecting and storing samples of bone marrow and blood from patients with cancer to study in the laboratory may help doctors learn more about cancer and help predict the recurrence of cancer.
OBJECTIVES:
I. Establish a mechanism to bank specimens of tumor cells and host germline DNA from patients with acute lymphoblastic leukemia (ALL) at first and subsequent relapse.
II. Make these specimens available to qualified researchers to study the biology of ALL.
OUTLINE: This is a multicenter study.
Patients undergo collection of bone marrow and peripheral blood at diagnosis of relapse and/or at the end of the first month of treatment.
Patients are followed periodically for up to 10 years.
5,578 studies on the registry are indexed under Lymphoma; 825 are open to participants now.
This study's enrollment of 811 is above the median of 136 across 625 observational studies indexed under Lymphoma.
Browse Lymphoma studies →Children's Oncology Group is the lead sponsor of 436 studies on the registry; 34 are open to participants now.
Of its 12 completed or terminated interventional studies of FDA-regulated products, 11 (92%) have results posted.
Counted across the registry records on this site, refreshed daily.
Patient has ALL (or a prior history of Non Hodgkin lymphoma) at first or subsequent marrow relapse with greater than or equal to 25% blasts in the bone marrow and/or peripheral blood.
Inclusion Criteria:
No concurrent systemic antileukemic treatment administered for current relapse
Patients undergo collection of bone marrow and peripheral blood at diagnosis of relapse and/or at the end of the first month of treatment.
Other: Cytology Specimen Collection Procedure · Other: Laboratory Biomarker Analysis
Correlative studies
Also known as: Cytologic Sampling
Correlative studies
Banking of tumor cells and germline DNA
Time frame: Not Provided
Showing the first 100 of 183 sites across 5 countries.
This study is completed, as verified in Jan 2020. You cannot join it, but the record below documents what was studied.
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Children's Oncology Group