Tissue Plasminogen Activator: all 119 studies that test it
Page 1 of 2. Open to participants first (10), then studies with results posted, then the rest; newest registration first within each.
- INtra-arterial AltEplase folloWing successfuL reperfusIoN After mEchanical ThrombectomyRecruitingNCT07727395Phase 3
- Intra-arterial Thrombolysis For Acute Ischemic Stroke With Medium Vessel OcclusionRecruitingNCT07668323Phase 3
- CleaRRAflow: Isotonic Solution vs. TPA for IVH ClearanceEnrolling by invitationNCT07643493Phase 4
- Thrombolysis in Factor Xa-inhibitors TrialRecruitingNCT06878066Phase 3
- the Predictors of Hemorrhagic Transformation Subtypes in Acute Embolic Stroke PatientsRecruitingNCT06653946Phase 4
- The RAPID - PE Study: RESCUE Advanced Protocol for the Treatment of Pulmonary EmbolismRecruitingNCT06433011Not applicable
- Alteplase Through an Indwelling Pleural Catheter for the Management of Symptomatic Septated Malignant Pleural EffusionRecruitingNCT06184321Early Phase 1
- Application of tPA in Suprachoroidal and Subretinal HemorrhageRecruitingNCT05736757Not applicable
- Viscoelastic Testing Guided Tissue Plasminogen Activator Treatment in Acute Respiratory FailureRecruitingNCT05540834Phase 2
- Vitrectomy, Subretinal Tissue Plasminogen Activator (TPA) and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative (Wet) Age-related Macular Degeneration (TIGER).RecruitingNCT04663750Phase 3
- Intrapleural Fibrinolytic Therapy to Enhance Chemical Pleurodesis Enhance Chemical PleurodesisCompletedNCT04806373Phase 4Results posted
- Massive Pulmonary Embolism: Trial of Non-immunogenic Recombinant Staphylokinase VS Alteplase FORPECompletedNCT04688320Phase 3Results posted
- A Study in Healthy Men to Compare 2 Different Formulations of AlteplaseCompletedNCT04419493Phase 1Results posted
- Fibrinolytic Therapy to Treat ARDS in the Setting of COVID-19 InfectionCompletedNCT04357730Phase 2Results posted
- Nebulised Rt-PA for ARDS Due to COVID-19CompletedNCT04356833Phase 2Results posted
- tPA by Endovascular Administration for the Treatment of Submassive PE Using CDT for the Reduction of Thrombus BurdenCompletedNCT04248868Phase 3Results posted
- First - In - Man Study to Assess the Safety and Feasibility of The Bashir™ Endovascular Catheter for the Treatment of Acute Pulmonary EmbolismCompletedNCT03927508Phase 1Results posted
- t-PA Prophylaxis to Prevent Catheter-associated Thrombosis and InfectionCompletedNCT03672006Phase 2Results posted
- Fibrinolysis Compared to Thoracoscopy for Pleural InfectionCompletedNCT03468933Phase 4Results posted
- Fibrinolytic Therapy Versus Medical ThoracoscopyCompletedNCT03213834Phase 4Results posted
- Safety and Efficacy of Alteplase When Administered in Chinese Patients With Acute Ischemic Hemispheric Stroke Where Thrombolysis is Initiated Between 3 and 4.5 Hours After Stroke OnsetCompletedNCT02930837Phase 3Results posted
- Optimum Duration of Acoustic Pulse Thrombolysis Procedure in Acute Pulmonary EmbolismCompletedNCT02396758Phase 4Results posted
- rtPA in in the Prevention of CVAD-Associated Thrombosis and Infection in Pediatric Patients With Short Bowel SyndromeCompletedNCT02355743Phase 4Results posted
- Inhaled Tissue Plasminogen Activator for Acute Plastic BronchitisCompletedNCT02315898Phase 2Results posted
- Treatment of Chronic Deep Vein Thrombosis (DVT) and Post-Thrombotic Syndrome (PTS) With the EkoSonic® Endovascular SystemCompletedNCT02159521Phase 4Results posted
- A Study of the Efficacy and Safety of Alteplase in Participants With Mild StrokeTerminatedNCT02072226Phase 3Results posted
- Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase IIICompletedNCT01827046Phase 3Results posted
- Safety of Intravenous Thrombolytics in Stroke on AwakeningCompletedNCT01643902Phase 2Results posted
- Thrombolysis in Pediatric Stroke (TIPS)TerminatedNCT01591096Phase 1Results posted
- Submassive and Massive Pulmonary Embolism Treatment With Ultrasound Accelerated Thrombolysis TherapyCompletedNCT01513759Phase 3Results posted
- A Study of Intravenous Thrombolysis With Alteplase in MRI-Selected PatientsCompletedNCT01282242Phase 2Results posted
- Enhancing Donated After Cardiac Death (DCD) Utilization With Thrombolytic TherapyCompletedNCT01197573Not applicableResults posted
- Safety of Intravenous Thrombolysis for Wake-up StrokeCompletedNCT01183533Phase 2Results posted
- Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed ThrombolysisCompletedNCT00790335Phase 3Results posted
- Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase IIICompletedNCT00784134Phase 3Results posted
- Clinical Trial on Treatment of Intraventricular HemorrhageCompletedNCT00650858Phase 2Results posted
- Efficacy and Safety of Activase (Ateplase) vs Placebo in Complicated Pleural Effusions (CPE)/EmpyemasCompletedNCT00468104Not applicableResults posted
- Post-marketing Clinical Study of Alteplase for Acute Ischemic Stroke （Japan Alteplase Clinical Trial Ⅱ：J-ACT Ⅱ）CompletedNCT00412867Phase 4Results posted
- Alteplase for Percutaneous Treatment of Loculated Abdominopelvic AbscessesCompletedNCT00284739Phase 2Results posted
- Study of Tenecteplase (TNK) in Acute Ischemic Stroke (TNK-S2B)TerminatedNCT00252239Phase 2Results posted
- Minimally Invasive Surgery and rtPA for Intracerebral Hemorrhage EvacuationCompletedNCT00224770Phase 2Results posted
- Japan Alteplase Clinical Trial (J-ACT): Efficacy and Safety Study of Tissue Plasminogen Activator (Alteplase) for Ischemic StrokeCompletedNCT00147316Phase 3Results posted
- Low-Dose Alteplase to Treat Blood Clots in Deep Leg VeinsCompletedNCT00082355Phase 2Results posted
- To Compare the Efficacy & Safety of Ultra-Slow (24 hr) Low Dose (25 mg) Infusion of Alteplase Over Slow (24hr) Infusion of Streptokinase in Mechanical Prosthetic Valve ThrombosisCompletedNCT07360717Not applicable
- Safe Delivery of Thrombolytic Treatment for Pulmonary Embolism Using ClotPro® Viscoelastic TestsCompletedNCT06667882Not applicable
- Predictors of Post-alteplase Hemorrhagic Transformation of Brain InfarctionCompletedNCT06337175Phase 4
- Predictors of AIS Unfavorable OutcomesCompletedNCT06058884Phase 4
- Intra-arterial Alteplase for Acute Ischemic Stroke After Mechanical ThrombectomyCompletedNCT05856851Phase 3
- Trial of Reduced Alteplase Dose for Parapneumonic Effusion (TRAPPE)CompletedNCT05766124Phase 2/3
- Direct Endovascular Treatment Versus Bridging Treatment In Basilar Artery Occlusive StrokeCompletedNCT05631847Not applicable
- Use of Tissue Plasminogen Activator in the Clearance of Chronic Subdural HematomasCompletedNCT05491356Phase 4
- EXtending the Time Window for Thrombolysis in Posterior Circulation Stroke Without Early CT SignsCompletedNCT05429476Phase 3
- TPA in Acute Stroke With COVID Verus Non-COVID-19 PatientsCompletedNCT05258565Phase 1
- Direct Mechanical Thrombectomy Versus Bridging TherapyCompletedNCT05155540Phase 4
- In Situ Thrombolysis With tPA and Inflow Perfusion Analysis in Patient With Severe Covid-19 InfectionCompletedNCT04926428Not applicable
- 24 Hours Treatment with Alteplase in Patients with Ischemic StrokeCompletedNCT04879615Phase 3
- Tenecteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-ⅡCompletedNCT04797013Phase 3
- Impact of Tissue Plasminogen Activator (tPA) Treatment for an Atypical Acute Respiratory Distress Syndrome (COVID-19)WithdrawnNCT04453371Phase 3
- Pulmonary Embolism International THrOmbolysis Study-3Active, not recruitingNCT04430569Phase 3
- Low Dose Thrombolysis, Ultrasound Assisted Thrombolysis or Heparin for Intermediate High Risk Pulmonary EmbolismActive, not recruitingNCT04088292Phase 3
- Tenecteplase Versus Alteplase for Stroke Thrombolysis Evaluation Trial in the AmbulanceCompletedNCT04071613Phase 2
- A PhaseⅡ of Injection for Recombinant Human Tissue Plasminogen Kinase Derivative in Treatment of Acute Ischemic Stroke.Status unknownNCT04028518Phase 2
- Thrombolysis Endovascular Treatment of Pulmonary EmbolismCompletedNCT03966079Phase 3
- Alteplase Compared to Tenecteplase in Patients With Acute Ischemic StrokeCompletedNCT03889249Phase 3
- The Norwegian Tenecteplase Stroke Trial 2TerminatedNCT03854500Phase 3
- Low Dose Catheter Directed Thrombolysis for Acute Pulmonary EmbolismStatus unknownNCT03854266Phase 2
- The Safety and Efficacy of Fibrinolysis in Patients With an Indwelling Pleural Catheter for Multi-loculated Malignant Pleural Effusion.WithdrawnNCT03678090Phase 2
- Peripheral Systemic Thrombolysis Versus Catheter Directed Thrombolysis for Submassive PEActive, not recruitingNCT03581877Phase 4
- Regisry of the Stroke Patients in Assiut University HospitalStatus unknownNCT03392792Not applicable
- Study of Sodium Bicarbonate in Restoring Blocked CathetersWithdrawnNCT03348826Phase 2
- Adjunctive, Low-dose tPA in Primary PCI for STEMICompletedNCT03335839Phase 3
- A Phase III Randomized, Blind, Double Dummy, Multicenter Study Assessing the Efficacy and Safety of IV THrombolysis (Alteplase) in Patients With acutE Central retInal Artery OcclusionCompletedNCT03197194Phase 3
- Optimal Coronary Flow After PCI for Myocardial Infarction - a Pilot StudyStatus unknownNCT02894138Phase 3
- Pediatric High-Risk Deep Venous Thrombosis Lytic Outcomes TrialWithdrawnNCT02767232Phase 3
- Efficacy and Safety of Half Dose Alteplase Added to Heparine, in Patients With Moderate Pulmonary EmbolismWithdrawnNCT02604238Phase 3
- TOP-TRIAL Safety of Not Flushing Non-used PORT-A-CATH® in Cancer PatientsTerminatedNCT02492477Phase 1
- Intensive Versus Standard Hemodialysis CVC Dysfunction ProtocolCompletedNCT02474810Not applicable
- Dose-effect Relationship of Rt-PA on ICH EvacuationStatus unknownNCT02472574Phase 2
- Helping Stroke Patients With ThermoSuit CoolingTerminatedNCT02453373Not applicable
- A Trial of Low-dose Adjunctive alTeplase During prIMary PCICompletedNCT02257294Phase 2
- Trial to Compare 1.0 Versus 2.0 mg Alteplase (tPA) Dosing in Restoring Hemodialysis Catheter FunctionStatus unknownNCT02225782Not applicable
- Combination Tissue Plasminogen Activator (Tpa) and Dornase Alfa (Dnase) Administration Through Intrapleural Catheters for the Treatment of Loculated or Non-Draining Malignant Pleural EffusionsStatus unknownNCT02135588Phase 1
- Comparison of Thrombgolytic and Anticoagulation Therapy in Submassive Pulmonary EmbolismCompletedNCT02132689Phase 4
- THrombolysis for Acute Wake-up and Unclear-onset Strokes With Alteplase at 0.6 mg/kg Trial (THAWS)Status unknownNCT02002325Phase 3
- Comparison of Low-Molecular-Weight Heparin (LMWH) and Unfractionated Heparin (UFH) in Combination With Thrombolytic Treatment of Acute Massive Pulmonary ThromboembolismStatus unknownNCT01956955Phase 4
- Study of Tenecteplase Versus Alteplase for Thrombolysis (Clot Dissolving) in Acute Ischemic StrokeCompletedNCT01949948Phase 3
- EARLY Routine Catheterization After Alteplase Fibrinolysis vs. PPCI in ST-Segment-Elevation MYOcardial InfarctionCompletedNCT01930682Phase 4
- Effect of Intraventricular tPA Following Aneurysmal Subarachnoid HemorrhageWithdrawnNCT01878136Phase 1/2
- Intravitreal tPA and C3F8 for the Treatment of Submacular Haemorrhage as a Complication of Neovascular AMDCompletedNCT01835067Phase 2/3
- Safety and Efficacy Study of PD-616 Plus Cytarabine to Treat Acute Myelogenous Leukemia or Myelodysplastic SyndromeTerminatedNCT01795924Phase 1/2
- Prolonged Hemodialysis Catheter Survival With Copolymer Coating and Rt-PAStatus unknownNCT01670474Phase 4
- Intra-arterial Thrombolysis for Severe Recent Central Retinal Vein OcclusionCompletedNCT01581411Phase 1
- EXTEND (International): Extending the Time for Thrombolysis in Emergency Neurological Deficits (International)CompletedNCT01580839Phase 3
- Safety and Efficacy of the Use of Tissue Plasminogen Activator (tPA) in Intra-Abdominal Collections in Children - A Prospective StudyTerminatedNCT01576679Phase 3
- Low Dose Rt-PA for Acute Normotensive Pulmonary Embolism With RVDStatus unknownNCT01531829Phase 4
- Efficacy and Safety of MRI-based Thrombolysis in Wake-up StrokeCompletedNCT01525290Phase 3
- The Safety and Tolerability of Intra-abdominal t-PA and DNase on Peritonitis in Peritoneal Dialysis PatientsTerminatedNCT01478698Phase 1
- Wake up Symptomatic Stroke - Benefit of Intravenous Clot Busters or Endovascular InterventionStatus unknownNCT01455935Phase 2
- Comparison of Different TRansesophageal Echocardiography Guided thrOmbolytic Regimens for prosthetIc vAlve ThrombosisCompletedNCT01451320Not applicable
- Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED)CompletedNCT01422616Phase 3