Drug
Tiotropium clinical trials
Also written Spiriva and Spiriva Respimat.
Includes 3 studies of Tiotropium-olodaterol.
- studies test it
- 169
- open now
- 2
- in phase 3
- 48
- first study started
- 1998
Keep track of what changes. Save the tiotropium studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
169 studies that test it; most in 2006 (16)
| Year | Studies |
|---|---|
| 1998 | 2 |
| 1999 | 1 |
| 2000 | 4 |
| 2001 | 3 |
| 2002 | 14 |
| 2003 | 6 |
| 2004 | 1 |
| 2005 | 3 |
| 2006 | 16 |
| 2007 | 10 |
| 2008 | 15 |
| 2009 | 4 |
| 2010 | 9 |
| 2011 | 11 |
| 2012 | 10 |
| 2013 | 8 |
| 2014 | 10 |
| 2015 | 2 |
| 2016 | 8 |
| 2017 | 14 |
| 2018 | 2 |
| 2019 | 4 |
| 2020 | 2 |
| 2021 | 3 |
| 2022 | 3 |
| 2023 | 1 |
| 2024 | 1 |
| 2025 | 1 |
| 2026 | 1 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 2
- Phase 1
- 21
- Phase 2
- 25
- Phase 3
- 48
- Phase 4
- 66
- No phase
- 7
What it is tested for
Each study’s main condition, where its own words name it.
- Asthma
- 19
Who runs them
Industry 119 · Other 50
Boehringer Ingelheim (84) · GlaxoSmithKline (8) · Novartis Pharmaceuticals (7) · Solventum US LLC (4) · University of Saskatchewan (4) · Orion Corporation, Orion Pharma (3) · University of Dundee (3) · James J. Peters Veterans Affairs Medical Center (2)
Often tested with
Tested in the same studies.
Olodaterol (25) · Salmeterol Xinafoate (16) · Formoterol (9) · Indacaterol (7) · Glycopyrrolate (6) · Fluticasone (5) · BEA 2180 (3) · Vilanterol (3)
Studies
Open first, then newest update. How each study uses tiotropium is read from its arms, and is right about nine times in ten.
Testing it · 169
- PREterm Infants With Bronchial Obstruction - Prospective Study of Efficacy and Safety of Inhaled TiotropiumNot yet recruitingPhase 4General University Hospital, PragueNCT07827859Written as tiotropium bromide (Spiriva Respimat)
- Evaluating the Impact of Single Dose Tiotropium on Allergen-induced Early Asthmatic ResponseNot yet recruitingPhase 4University of SaskatchewanNCT06679465Written as Tiotropium (Spiriva®)
- Effect of Tiotropium on Airway Remodeling in Patients With Early Stage COPD Accessed by Optical Coherence TomographyCompletedNot applicableGuangzhou Institute of Respiratory DiseaseNCT03842839Written as Tiotropium Inhalation Powder [Spiriva] 0.018mg
- Comparative Efficacy of Once-daily LAMA/LABA Combinations Versus Tiotropium on Constant-work-rate Cycle Endurance in COPDSuspendedNot applicableMedical University of BialystokNCT07541378Written as Tiotropium
- Tiotropium/Salmeterol Inhalation Powder in COPDTerminatedPhase 3Boehringer IngelheimNCT00668772Written as Tiotropium/Salmeterol
- Effects of Tiotropium/Olodaterol on Cardio-pulmonary Exercise Capacity in Patients With Hyperinflated Chronic Obstructive Pulmonary Disease [ACHIEVE]CompletedNot applicableYonsei UniversityNCT04994574Written as tiotropium/olodaterol
- Tiotropium vs. Inhaled Corticosteroids in Children With Nonatopic Asthma Pilot Study (TioNAAP)TerminatedPhase 2Nemours Children's ClinicNCT04990167Written as Tiotropium Bromide
- Two-period 21 Day Cross-over Study to Compare the Pharmacokinetics of Tiotropium From Two InhalersCompletedPhase 1Kindeva Drug DeliveryNCT03246581Written as Tiotropium
- Pharmacodynamic and Pharmacokinetic Dose Ranging Study of Tiotropium Bromide Administered Via Respimat Device in Patients With Chronic Obstructive Pulmonary Disease (COPD)CompletedPhase 2Boehringer IngelheimNCT02175342Written as Tiotropium 0.625 mcg/puff
- A Randomised, Double- Blind, Placebo Controlled, Cross-over Efficacy and Safety Comparison of Tiotropium 5 µg Once Daily and Tiotropium 2.5 µg Twice Daily for Four Weeks in Patients With Moderate Persistent AsthmaCompletedPhase 2Boehringer IngelheimNCT01152450Written as Tiotropium 2.5 µg b.i.d
- Comparison of the Pharmacokinetics of Tiotropium Delivered From Test Inhaler Products With ReferenceCompletedPhase 1Solventum US LLCNCT03302065Written as Tiotropium
- Comparison of the Pharmacokinetics of Tiotropium Delivered From Test Inhaler Products With A Reference ProductCompletedEarly Phase 1Solventum US LLCNCT03155204Written as tiotropium pMDI
- Comparison of the Pharmacokinetics of Tiotropium Delivered From Test Inhaler Products With Two Reference ProductsCompletedPhase 1Solventum US LLCNCT02627625Written as Tiotropium
- Cross-over Study in Volunteers to Compare the Pharmacokinetics of Tiotropium Delivered From Test and Reference ProductsCompletedPhase 1Solventum US LLCNCT02676297Written as tiotropium
- Anti-inflammatory Effects of Tiotropium in Patients with Stable COPDCompletedPhase 4University Medical Center GroningenNCT04061161Written as Tiotropium Bromide
- Efficacy of Intermittent Tiotropium in Early Childhood WheezingTerminatedPhase 4Helsinki University Central HospitalNCT03199976Written as Tiotropium Bromide
- Open Label Study to Assess the Effect of Patient Use and Robustness of Tiotropium 18ug Inhalation Powder, Hard Capsule,Zephir Inhaler DeviceCompletedPhase 1Xiromed LLCNCT06254664Written as Tiotropium 18 µg inhalation powder, hard capsule
- 12 Week Efficacy of Tiotropium Versus Placebo in Patients With Mild COPD According to Swedish Guidelines (SPIRIMILD)CompletedPhase 4Boehringer IngelheimNCT00144196Written as tiotropium (Spiriva)
- Trial Comparing Treatment With Tiotropium Inhalation Capsules to Combivent® Inhalation Aerosol in COPD Patients.CompletedPhase 4Boehringer IngelheimNCT00388882Written as tiotropium
- A Multiple Dose Comparison of Tiotropium Inhalation Capsules and Salmeterol Inhalation Aerosol.CompletedPhase 3Boehringer IngelheimNCT00274560Written as Tiotropium
See all 169 studies that test tiotropium →
Given in every arm · 18 — tiotropium is usual care beside what is tested
- Salvational Intervention for Reducing AECOPD Under Severe Air PollutionCompletedNot applicablePeking University First HospitalNCT03083067Written as tiotropium bromide
- Pharmacokinetic Study Comparing Tiotropium Easyhaler® and Spiriva® HandiHaler®CompletedPhase 1Orion Corporation, Orion PharmaNCT04850144Written as Tiotropium Bromide Monohydrate
- A Randomized Study, Comparing Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC /VI) Single Inhaler Triple Therapy, Versus Multiple Inhaler Therapy (Budesonide/Formoterol Plus Tiotropium) in Subjects With Chronic Obstructive Pulmonary Disease (COPD)CompletedPhase 4GlaxoSmithKlineNCT03478696Written as tiotropium
- A Randomized Study, Comparing Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Single Inhaler Triple Therapy, Versus Multiple Inhaler Therapy (Budesonide/Formoterol Plus Tiotropium) in Subjects With Chronic Obstructive Pulmonary Disease (COPD)CompletedPhase 4GlaxoSmithKlineNCT03478683Written as tiotropium
- Bronchodilator Effect of RPL554 Administered in Addition to Tiotropium/Olodaterol in Patients With COPDCompletedPhase 2Verona Pharma plcNCT03673670Written as Tiotropium/olodaterol (Respimat)
- Effect of Tiotropium + Olodaterol on Breathlessness in COPD PatientsCompletedPhase 4Boehringer IngelheimNCT02853123Written as Tiotropium
- Comparing the Efficacy of Tiotropium + Olodaterol Fixed Dose Combination (FDC) Over Tiotropium in Improvement of Lung Hyperinflation, Exercise Capacity and Physical Activity in Japanese COPD PatientsCompletedPhase 3Boehringer IngelheimNCT02629965Written as tiotropium
- Beta Blocker Therapy in Moderate to Severe COPDCompletedPhase 4University of DundeeNCT01656005Written as Tiotropium
- Effect of Yong Chong Cao Capsule on Outcomes in Patients With Mild to Severe COPDStatus unknownPhase 3Henan University of Traditional Chinese MedicineNCT03745261Written as Tiotropium Bromide (Spiriva®)
- Comparing the Efficacy of Tiotropium + Olodaterol (5/5 µg) Fixed Dose Combination (FDC) Over Tiotropium 5µg in Reducing Moderate to Severe Exacerbations in Patients With Severe to Very Severe Chronic Obstructive Pulmonary Disease.CompletedPhase 3Boehringer IngelheimNCT02296138Written as tiotropium
- Tiotropium Respimat Versus HandiHaler on SaO2 and Sleep in COPD PatientsCompletedNot applicableUniversity of CreteNCT02331940Written as tiotropium
- Efficacy and Tolerability of Symbicort as an add-on Treatment to Spiriva Compare With Spiriva Alone in Patients With Severe Chronic Obstructive Pulmonary Disease (COPD)CompletedPhase 4AstraZenecaNCT01397890Written as Tiotropium (SpirivaTM)
- Co-administration of Olodaterol Respimat® and Tiotropium Handihaler®CompletedPhase 3Boehringer IngelheimNCT01696058Written as Tiotropium
- Co-administration of Olodaterol Respimat® and Tiotropium Handihaler®CompletedPhase 3Boehringer IngelheimNCT01694771Written as Tiotropium
- To Compare the Pharmacokinetics of Tiotropium in Subjects With Chronic Obstructive Pulmonary Disease (COPD)CompletedPhase 1/2Teva Branded Pharmaceutical Products R&D, Inc.NCT01785433Written as Spiriva® Respimat® 5 mcg/day
- Efficacy and Safety Comparison of Steroid or Placebo in Combination With Salmeterol and Tiotropium in COPDCompletedPhase 2Boehringer IngelheimNCT00535366Written as Tiotropium
- Efficacy and Safety of Indacaterol Plus Tiotropium Versus Tiotropium Alone in Patients With Chronic Obstructive Pulmonary DiseaseCompletedPhase 3Novartis PharmaceuticalsNCT00877383Written as Tiotropium 18 μg
- Efficacy and Safety of Indacaterol Plus Tiotropium Versus Tiotropium Alone in Patients With Chronic Obstructive Pulmonary DiseaseCompletedPhase 3Novartis PharmaceuticalsNCT00846586Written as Tiotropium 18 μg
As the comparator · 72 — what is tested is compared with tiotropium
- ANTES B+ Clinical TrialTerminatedPhase 4Fundacio Privada Mon Clinic BarcelonaNCT06282861Written as Spiolto Respimat
- Efficacy and Safety of Indacaterol vs Tiotropium in Women With COPD Secondary to Biomass ExposureCompletedPhase 4National Institute of Respiratory Diseases, MexicoNCT05506865Written as Tiotropium
- Phase 4 COPD and Suboptimal Inspiratory Flow RateCompletedPhase 4Theravance BiopharmaNCT05165485Written as Tiotropium
- A Trial to Assess the Bioequivalence of Generic Tiotropium Bromide Inhalation Powder and Reference Product in Healthy Adult Participants Under Fasting Conditions (Pilot)Active, not recruitingPhase 1Chia Tai Tianqing Pharmaceutical Group Co., Ltd.NCT06326671Written as Spiriva HandiHaler
- Bioequivalence Study of Tiotropium 18 μg Inhalation Powder, Hard Capsule With Spiriva®Handihaler® 18 μg Inhalation Powder, Hard Capsule in Patients With Chronic Obstructive Pulmonary Disease (COPD)CompletedPhase 3Xiromed LLCNCT05986591Written as Spiriva Handihaler (Tiotropium Bromide) 18 mcg
- Tiotropium/Salmeterol Inhalation Powder (Spiriva Handihaler and Salmeterol Polyethylene (PE) Capsule) in Chronic Obstructive Pulmonary Disease (COPD)TerminatedPhase 3Boehringer IngelheimNCT00662740Written as Tiotropium (Spiriva®)
- Bioequivalence Study of Tiotropium Bromide Inhalation PowderCompletedPhase 3Phargentis SANCT05161156Written as 18 mcg of Spiriva (Reference Product)
- A 52-Week Parallel Group Safety Study of TD-4208 in Chronic Obstructive Pulmonary Disease (COPD)CompletedPhase 3Mylan Inc.NCT02518139Written as Tiotropium
- Revefenacin Peak Inspiratory Flow Rate (PIFR) Study in COPDCompletedPhase 3Mylan Inc.NCT03095456Written as Spiriva Handihaler®
- A Study of 3 Doses of Tiotropium Hydrofluoralkane (HFA) Breath Actuated Inhaler (BAI), in Patients With Chronic Obstructive Pulmonary DiseaseWithdrawnPhase 2Teva Branded Pharmaceutical Products R&D, Inc.NCT02203474Written as Tiotropium 18 mcg Capsule
- Safety and Efficacy Study of Glyco pMDI After Single and Repeated AdministrationCompletedPhase 1/2Chiesi Farmaceutici S.p.A.NCT01176903Written as Tiotropium
- Efficacy of Fixed Combination of Beclometasone + Formoterol + Glycopyrrolate in Chronic Obstructive Pulmonary DiseaseCompletedPhase 3Chiesi Farmaceutici S.p.A.NCT01911364Written as Tiotropium
- Study to Compare QVM149 and Free Triple Combination of Salmeterol/Fluticasone + TiotropiumCompletedPhase 3Novartis PharmaceuticalsNCT03158311Written as Salmeterol/fluticasone plus tiotropium
- PET Study to Determine Muscarinic Receptor Occupancy in Lungs After Inhalation of AZD2115 and TiotropiumCompletedPhase 1AstraZenecaNCT03097380Written as SPIRIVA
- A 6-week Dose Ranging Study of CHF 5259 pMDI in Subjects With Chronic Obstructive Pulmonary DiseaseCompletedPhase 2Chiesi Farmaceutici S.p.A.NCT03084796Written as Tiotropium Bromide 18 µg Inhalation Capsule
- Clinical Endpoint Bioequivalence Study of Test and Reference Inhalation Products in Patients With COPD With Device RobustnessCompletedPhase 3Lupin, Inc.NCT03137992Written as Reference Product (Spiriva®)
- Safety and Tolerability QAT370 Compared to Tiotropium in Patients With Chronic Obstructive Pulmonary DiseaseCompletedPhase 1NovartisNCT00532350Written as Tiotropium
- Safety and Efficacy of Multiple Doses of QAX028 in Chronic Obstructive Pulmonary Disease (COPD) PatientsCompletedPhase 2Novartis PharmaceuticalsNCT01068613Written as Tiotropium
- Efficacy and Safety of PT001 to Placebo and Open-label Spiriva® Respimat® in Subjects With Persistant AsthmaCompletedPhase 2/3Pearl Therapeutics, Inc.NCT03358147Written as Spiriva Respimat 2.5 μg
- Tiotropium/Salmeterol/Fluticasone Fixed Dose Combination Tratment Via Discair vs Tiotropium Via Handihaler + Salmeterol/Fluticasone Via Diskus Free Combination TreatmentCompletedPhase 4Neutec Ar-Ge San ve Tic A.ŞNCT03395002Written as Tiotropium 18 mcg Inhalation Powder
Showing 20 of 72.
Codes
What other systems call tiotropium · ClinicalTrials.gg INT006581
- MeSH (NLM) D000069447Tiotropium BromideConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 0EB439235FTIOTROPIUMConfirmed FDA, NLM, Wikidata
- RxNorm 69120Confirmed FDA, Wikidata
- Wikidata Q424316tiotropiumConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C76004TiotropiumOne source FDA
- DrugBank DB01409One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D000069447 | Tiotropium Bromide | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 0EB439235F | TIOTROPIUM | Confirmed FDA, NLM, Wikidata |
| RxNorm | 69120 | — | Confirmed FDA, Wikidata |
| Wikidata | Q424316 | tiotropium | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C76004 | Tiotropium | One source FDA |
| DrugBank | DB01409 | — | One source Wikidata |
Also registered as tiotropium bromide anhydrous (UNII XX112XZP0J · RxNorm 393575) and tiotropium bromide monohydrate (UNII L64SXO195N · RxNorm 1298831).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.