Psilocybin: all 235 studies that test it

Page 2 of 3. Open to participants first (116), then studies with results posted, then the rest; newest registration first within each.

• Evaluation of Psilocybin-Assisted Psychotherapy in Treating Severe Depression in Patients With PTSDNot yet recruitingNCT06141876Phase 2
• Psilocybin rTMS for Treatment Resistant DepressionRecruitingNCT06132178Phase 2
• Outpatient Buprenorphine Induction With Psilocybin for Opioid Use DisorderRecruitingNCT06067737Phase 2
• Psilocybin in Cancer Pain StudyRecruitingNCT06001749Phase 2
• Psilocybin-Assisted Psychotherapy for Alcohol Use DisorderRecruitingNCT05995769Phase 2
• Evaluation of Psilocybin-assisted Psychotherapy (PaP) for the Treatment of Post-traumatic Stress Disorder (PTSD) in Military VeteransNot yet recruitingNCT05876481Phase 2
• Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid MedicationRecruitingNCT05585229Phase 2
• The Role of Personal Experience for the Therapeutic Attitude in the Context of Substance-assisted Therapy TrainingEnrolling by invitationNCT05570708Not applicable
• 5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use DisorderRecruitingNCT05452772Phase 2
• Pragmatic Trial of Psilocybin Therapy in Palliative CareRecruitingNCT05403086Phase 2
• Psilocybin Versus Ketamine in Treatment-Resistant DepressionRecruitingNCT05383313Phase 2
• Effects of Psilocybin on Electrophysiology and the Dynamic Content of ThoughtRecruitingNCT05301608Phase 1/2
• Investigating the Mechanisms of the Effects of Psilocybin on Visual Perception and Visual Representations in the BrainRecruitingNCT05265546Phase 1
• Psilocybin-facilitated Treatment for Chronic PainRecruitingNCT05068791Early Phase 1
• Northwest Therapies Trauma Psilocybin Study Compassionate Use StudyNot yet recruitingNCT05042466Phase 1
• Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's DiseaseRecruitingNCT04123314Early Phase 1
• Psilocybin-Assisted Therapy for the Treatment of Cancer-Related Anxiety in Patients With Metastatic CancerCompletedNCT05847686Phase 1/2Results posted
• The Safety and Tolerability of COMP360 in Participants With Post-traumatic Stress DisorderCompletedNCT05312151Phase 2Results posted
• Psilocybin-assisted CBT for DepressionCompletedNCT05227612Phase 1Results posted
• Frontline Clinician Psilocybin StudyCompletedNCT05163496Phase 3Results posted
• Open-label Study to Assess the Safety and Efficacy of Psilocybin With Psychotherapy in Adult Participants With FibromyalgiaCompletedNCT05128162Phase 2Results posted
• Pilot Study of Psilocybin-Assisted Therapy for Demoralization in Patients Receiving Hospice CareCompletedNCT04950608Phase 2Results posted
• Psilocybin Therapy for Depression and Anxiety in Parkinson's DiseaseCompletedNCT04932434Phase 2Results posted
• The Safety and Efficacy Of Psilocybin as an Adjunctive Therapy in Participants With Treatment Resistant DepressionCompletedNCT04739865Phase 2Results posted
• Safety and Efficacy of Psilocybin for Body Dysmorphic DisorderCompletedNCT04656301Phase 2Results posted
• Visual Surround Suppression and Perceptual Expectation Under PsilocybinTerminatedNCT04424225Phase 1Results posted
• A Study of Psilocybin for Major Depressive Disorder (MDD)CompletedNCT03866174Phase 2Results posted
• The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant DepressionCompletedNCT03775200Phase 2Results posted
• Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study.CompletedNCT03356483Phase 1Results posted
• Effects of Psilocybin in Major Depressive DisorderCompletedNCT03181529Phase 2Results posted
• Persisting Effects of PsilocybinCompletedNCT02971605Phase 1/2Results posted
• Psilocybin-assisted Group Therapy for Demoralization in Long-term AIDS SurvivorsCompletedNCT02950467Phase 1Results posted
• A Double-Blind Trial of Psilocybin-Assisted Treatment of Alcohol DependenceCompletedNCT02061293Phase 2Results posted
• Psilocybin-facilitated Treatment for Cocaine UseCompletedNCT02037126Phase 2Results posted
• Effects and Therapeutic Potential of Psilocybin in Alcohol DependenceCompletedNCT01534494Phase 2Results posted
• Psilocybin Cancer Anxiety StudyCompletedNCT00957359Early Phase 1Results posted
• Psychopharmacology of Psilocybin in Cancer PatientsCompletedNCT00465595Phase 2Results posted
• Group Retreat Psilocybin Therapy for the Treatment of Anxiety and Depression in Patients With Metastatic Solid Tumors or Incurable Hematologic MalignanciesActive, not recruitingNCT07336238Phase 2
• A Study Assessing Brain Activity, Safety, Tolerability, and Pharmacokinetics Following Multiple Doses of MLS101 (Psilocybin) in Healthy VolunteersCompletedNCT07050368Phase 1
• Acute Effects of MDMA Co-administration on the Response to Psilocybin in Healthy SubjectsCompletedNCT06884514Phase 1
• PsiloStudy: Psilocybin With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring PTSD & Alcohol Use Disorder (AUD)Active, not recruitingNCT06853912Phase 2
• Effect of Psilocybin Only and Psilocybin Assisted Cognitive Behavioral Therapy in the Management of Major Depressive Disorder and Associated Metabolic, Immune, Inflammatory, Neuroplasticity and Electrical Activity MarkersCompletedNCT06746441Phase 2
• Psilocybin for Treatment-Resistant Depression in AutismActive, not recruitingNCT06731621Phase 1
• Effect of Psilocybin on the Positive Valence System in Treatment-resistant DepressionCompletedNCT06650800Not applicable
• Evaluation of the Effect of a Single Dose of Psilocybin on Neural Correlates of Cognitive Control in Patients With Psychogenic Nonepileptic SeizuresCompletedNCT06647056Not applicable
• A Second Psilocybin Group Therapy for the Treatment of Cancer-Related Anxiety in Partial Responders With Metastatic CancerCompletedNCT06644170Phase 1
• A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Multiple Doses of MLS101 in Healthy ParticipantsCompletedNCT06643637Phase 1
• Neurobiological Effects of Psilocybin in Treatment Resistant Bipolar DepressionActive, not recruitingNCT06506019Phase 1
• Safety for Home Administration of Microdose Psilocybin UseCompletedNCT06450210Phase 1
• Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced CancerActive, not recruitingNCT06416085Phase 2
• Psilocybin-Assisted Cognitive Processing Therapy for Chronic PTSDActive, not recruitingNCT06386003Phase 2
• Low-Income Group Psilocybin Assisted Therapy for DepressionCompletedNCT06372197Not applicable
• A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of MLS101 in Healthy ParticipantsCompletedNCT06326606Phase 1
• Psilocybin for Major Depressive Disorder (MDD)Active, not recruitingNCT06308653Phase 3
• Psilocybin-Assisted Therapy in Treatment-Resistant DepressionActive, not recruitingNCT06303739Phase 3
• Feasibility, Clinical Effects, and Safety of Psilocybin-assisted Psychotherapy for Treatment-resistant OCDCompletedNCT06299319Phase 1
• PsilOCD: A Pharmacological-Challenge Feasibility StudyCompletedNCT06258031Phase 1
• Psilocybin in Alcohol Use Disorder With Comorbid DepressionCompletedNCT06235411Not applicable
• Psilocybin for Treatment-Resistant DepressionCompletedNCT06230757Phase 2
• Safety Profile of Psilocybin for Cocaine Use DisorderSuspendedNCT06102434Early Phase 1
• Does Serotonin System Stimulation Increase Pro-social Behavior? - A Comparative Pharmacological Neuroscientific Study in Healthy HumansCompletedNCT06081179Phase 1
• Does Psilocybin Change Synaptic Density in Amnestic Mild Cognitive ImpairmentCompletedNCT06041152Phase 2
• Inpatient Buprenorphine Induction With Psilocybin for Opioid Use DisorderWithdrawnNCT06005662Phase 2
• Two Doses of Psilocybin for the Treatment of MDD in Adults With CancerActive, not recruitingNCT05947383Phase 2
• An Investigation of Psilocybin on Behavioural and Cognitive Symptoms of Adults With Fragile X SyndromeSuspendedNCT05832255Phase 2
• A Phase II, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of COMP360 in Participants With Recurrent Major Depressive DisorderActive, not recruitingNCT05733546Phase 2
• Psilocybin in Functional Neurological DisorderCompletedNCT05723276Not applicable
• Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRDActive, not recruitingNCT05711940Phase 3
• Does Psilocybin Require Psychedelic Effects to Treat Depression?CompletedNCT05710237Phase 2
• Neural and Physiological Correlates of Psychedelic Sub-statesActive, not recruitingNCT05698511Phase 1
• Psilocybin for Major Depressive DisorderWithdrawnNCT05675800Phase 2
• Psilocybin in Adults With and Without Autism Spectrum DisorderCompletedNCT05651126Not applicable
• Psilocybin-Assisted Psychotherapy in Adults With Alcohol Use Disorder (AUD)Active, not recruitingNCT05646303Phase 2
• Efficacy, Safety, and Tolerability of COMP360 in Participants With TRDCompletedNCT05624268Phase 3
• PET Synaptogenesis After Psilocybin In DEpression RecoveryWithdrawnNCT05601648Phase 2
• Effect of SSRIs on Response to Psilocybin TherapyWithdrawnNCT05594667Phase 2
• Safety and Tolerability of Psilocybin in Post-Traumatic Stress DisorderWithdrawnNCT05562973Phase 1
• PAPR: PAP + MBSR for Front-line Healthcare Provider COVID-19 Related BurnoutCompletedNCT05557643Phase 1
• Psilocybin for the Treatment of Veterans With Post-Traumatic Stress DisorderCompletedNCT05554094Phase 2
• Effects of Psilocybin in Obsessive Compulsive DisorderActive, not recruitingNCT05546658Early Phase 1
• Psilocybin Combined With Multidisciplinary Palliative Care in Demoralized Cancer Survivors With Chronic PainCompletedNCT05506982Phase 1
• Efficacy and Safety of COMP360 Psilocybin Therapy in Anorexia Nervosa: a Proof-of-concept StudyCompletedNCT05481736Phase 2
• An Evaluation of Psilocybin's Effect on Cardiac Repolarization and the Effect of Food on Psilocybin's PharmacokineticsCompletedNCT05478278Phase 1
• Bioavailability Study of Psilocybin in Normal AdultsWithdrawnNCT05467761Phase 1
• Psilocybin-Assisted vs Ketamine-Assisted Psychotherapy for Alcohol Use DisorderActive, not recruitingNCT05421065Phase 2
• Psilocybin-assisted Therapy for Treatment of Alcohol Use DisorderCompletedNCT05416229Phase 2
• Psilocybin in Co-occuring Major Depressive Disorder and Borderline Personality DisorderCompletedNCT05399498Phase 2
• The Effects of Psilocybin on Self-Focus and Self-Related Processing in Treatment Resistant MDDWithdrawnNCT05381974Phase 2
• Effects of Repeated Psilocybin Dosing in OCDActive, not recruitingNCT05370911Phase 1
• Study of the Safety and Feasibility of Psilocybin in Adults With Methamphetamine Use DisorderTerminatedNCT05322954Phase 1
• Comparing the Effects of Psilocin and Psilocybin in Healthy AdultsActive, not recruitingNCT05317689Phase 1
• Effects of Psilocybin in Post-Treatment Lyme DiseaseCompletedNCT05305105Phase 1
• Mood and Cognitive Effects of Psilocybin in Healthy ParticipantsWithdrawnNCT05252598Early Phase 1
• Investigating the Therapeutic Effects of Psilocybin in Treatment-Resistant Post-Traumatic Stress DisorderActive, not recruitingNCT05243329Phase 2
• Psilocybin for Opioid Use Disorder in Patients on Methadone Maintenance With Ongoing Opioid UseWithdrawnNCT05242029Phase 2
• Exploratory Study of Low Dose PsilocybinWithdrawnNCT05227742Early Phase 1
• Psilocybin-assisted Therapy for Phantom Limb PainActive, not recruitingNCT05224336Phase 1
• The Safety and Efficacy of Psilocybin in Patients With Treatment-resistant Depression and Chronic Suicidal IdeationCompletedNCT05220410Phase 2
• Palliadelic Treatment to Reduce Psychological Distress in Persons With Advanced Gastrointestinal CancersCompletedNCT05220046Phase 1
• Naturalistic Study of Microdosing With PsilocybinCompletedNCT05160220Not applicable

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