Protein Kinase Inhibitors: all 15,278 studies that test it

Page 72 of 153. Open to participants first (2,556), then studies with results posted, then the rest; newest registration first within each.

• Imatinib Mesylate and Interferon Alfa in Treating Patients With Chronic Myelogenous LeukemiaTerminatedNCT00015847Phase 2Results posted
• Islet Transplantation for Type 1 DiabetesCompletedNCT00014911Phase 2Results posted
• Sirolimus and Thymoglobulin to Prevent Kidney Transplant RejectionCompletedNCT00006178Phase 2Results posted
• Benmelstobart Plus Anlotinib Versus Sunitinib as First-Line Treatment for Advanced Non-Clear Cell Renal Cell CarcinomaActive, not recruitingNCT07881900Phase 3
• A Phase III, Randomized, Double-blind, Multi-center Trial Comparing Efficacy and Safety of Trilaciclib Versus Placebo in Participants With Limited-stage Small Cell Lung CancerActive, not recruitingNCT07881705Phase 3
• Effect of Ursodeoxycholic Acid on Indirect Hyperbilirubinemia in Neonates Treated With PhototherapyCompletedNCT07867366Not applicable
• An Open-label DDI Study to Investigate the Effect of Rilzabrutinib on P-gp, BCRP, OATP1B1 and OATP1B3 InhibitionActive, not recruitingNCT07855250Phase 1
• Baricitinib for Central Centrifugal Cicatricial Alopecia in Adults of African DescentCompletedNCT07843732Phase 2
• A Clinical Trial to Evaluate [14C]-MK-4208/[14C]-TERN-701 in Healthy Adult Male Participants (MK-4208-002/TERN701-1016)CompletedNCT07839000Phase 1
• A Clinical Trial to Evaluate MK-4208/Embibatinib in Healthy Adult Participants (MK-4208-001/Embibatinib-1014)CompletedNCT07838987Phase 1
• Tofacitinib in the Treatment of IgG4 Related DiseasesCompletedNCT07827469Not applicable
• Lucitanib (AL3810) in Patients With Advanced Thymic Carcinoma After ChemotherapyCompletedNCT07824505Phase 2
• Sirolimus Treatment in Pediatric Patients With Ataxia-TelangiectasiaCompletedNCT07820579Phase 2
• Topical Delgocitinib for Facial VitiligoActive, not recruitingNCT07820098Phase 2
• Effect of a Known P-glycoprotein (P-gp) Inhibitor, Itraconazole, on the Pharmacokinetics (PK) of EngasertibActive, not recruitingNCT07800429Phase 1
• Efficacy of Asciminib in Chronic Phase CML Patients With T315I MutationsActive, not recruitingNCT07789574Phase 2
• An Interventional Study of Upadacitinib Extended-Release Tablets in Patients With Refractory UveitisActive, not recruitingNCT07773623Phase 4
• Phase 1 Study in Healthy Adults to See How Sevabertinib Changes Metformin Levels in the BodyCompletedNCT07753252Phase 1
• A 24-Week Real-World Study of Upadacitinib in Moderate-to-Severe Hidradenitis SuppurativaActive, not recruitingNCT07727889Phase 2
• QT Interval/Corrected QT Interval （QT/QTc） Clinical Study to Evaluate the Cardiac Safety of TQ05105 Tablets in Healthy ParticipantsActive, not recruitingNCT07708272Phase 1
• Second-Line Sacituzumab Tirumotecan Plus Anlotinib for Advanced Driver Gene-Negative Non-Squamous NSCLCActive, not recruitingNCT07703228Phase 2
• The Study on Effects of CYP3A and P-glycoprotein Inhibitor Itraconazole and CYP Enzyme Inducer Rifampin of HMPL-453 Tartrate TabletsCompletedNCT07697157Phase 1
• A Study of Food Effect on Tersolisib (LY4064809) in Healthy ParticipantsCompletedNCT07662798Phase 1
• A Study to Evaluate How Multiple Doses of Itraconazole Interacts With Nacresertib in Healthy Adult ParticipantsActive, not recruitingNCT07649954Phase 1
• A Study in Healthy Men to Test How Bosentan Influences the Amount of Zongertinib in the BloodCompletedNCT07649941Phase 1
• Does Cediranib Prevent Bowel Perforation in Platinum-resistant Ovarian CancerCompletedNCT07648745Phase 2
• Assessment of Interleukin-15 and Interferon Gamma in Alopecia Areata Before and After Baricitinib.CompletedNCT07645430Not applicable
• Study on [14C]HMPL-453（FGFR Inhibitor） in Healthy Chinese Adult Male SubjectsCompletedNCT07644442Phase 1
• A Study on the Effect of Food and Proton Pump Inhibitor on the Pharmacokinetics of HMPL-760 CapsulesCompletedNCT07643272Phase 1
• Anlotinib+Cadonilimab+PULSAR in Advanced Biliary Tract CancerActive, not recruitingNCT07635290Phase 2
• Ivarmacitinib for Refractory Behcet's SyndromeWithdrawnNCT07634848Phase 2
• Study to Evaluate the Effect of Rabeprazole Sodium Enteric-coated Tablets on the Pharmacokinetics of TQ05105 TabletsActive, not recruitingNCT07608666Phase 1
• A Study to Assess Adverse Events, Tolerability and How a Single Oral Dose of Nacresertib Moves Through the Body In Healthy Adult Japanese ParticipantsCompletedNCT07600762Phase 1
• Study To Investigate The Potential DDI Between HEC585 And Pirfenidone/Nintedanib In Healthy SubjectsCompletedNCT07588646Phase 1
• A Study to Evaluate Dermal Open-Flow Microperfusion and Plasma Pharmacokinetic Study of Multiple Doses of Oral Povorcitinib or Topical Ruxolitinib Cream in Healthy Adult ParticipantsCompletedNCT07588139Phase 1
• A Study to Understand What the Body Does to the Study Medicine Called PF-07799544 When Taken by Healthy AdultsCompletedNCT07578636Phase 1
• A Study to Assess Adverse Events, Tolerability and How Single and Ascending Oral Doses of Nacresertib Move Through the Body In Healthy Adult ParticipantsCompletedNCT07566130Phase 1
• Relative Bioavailability and Impact of Rabeprazole for PF-07799933, Food-Effect for PF-07799933 and PF-07799544CompletedNCT07563894Phase 1
• Evaluate the Effect of Vimseltinib on Pharmacokinetics of Combined Oral Contraceptive (Ethinyl Estradiol/Levonorgestrel)CompletedNCT07539090Phase 1
• Efficacy and Safety Comparison Between PD-1 Inhibitor Combined With Lenvatinib or With Regorafenib For UHCC After Failure of First-line TreatmentCompletedNCT07537985Not applicable
• A Study of [14C]-LY4064809 in Healthy ParticipantsCompletedNCT07519525Phase 1
• TP-3654 Food Effect StudyCompletedNCT07492355Phase 1
• Clinical and Pharmacoeconomic Assessment of CDK4/6 Inhibitors for Treatment of Breast Cancer in EgyptCompletedNCT07487129Phase 4
• Treatment of Orelabrutinib+Hi-CVP Regimen for Previously Untreated MZLActive, not recruitingNCT07480863Phase 2
• Efficacy of Tofacitinib on Skin Thickening in Diffuse Cutaneous Systemic Sclerosis: A Comparative Study With MethotrexateCompletedNCT07472166Phase 4
• A Mass Balance Study of DZD8586 in Healthy Male Participants (TAI-SHAN15)CompletedNCT07454863Phase 1
• COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DMEActive, not recruitingNCT07449936Phase 3
• CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DMEActive, not recruitingNCT07449923Phase 3
• A Study to Assess a Medicine Called Tovorafenib in Japanese Children and Young Adults With Brain TumoursActive, not recruitingNCT07441707Phase 1
• A Phase 1 Study of the Safety and How the Body Processes ABBV-722 and Upadacitinib After Multiple Oral Doses in Healthy Adult ParticipantsCompletedNCT07425899Phase 1
• A Study of Elenestinib in Healthy Adult Female ParticipantsCompletedNCT07388511Phase 1
• Pacritinib With Aza for Upfront Myelodysplastic SyndromeWithdrawnNCT07387354Phase 1/2
• An Investigational Study to Evaluate the Cardiac Safety Assessment (TQTc Study) of ESK-001CompletedNCT07378579Phase 1
• Fluorizoparib Plus Apatinib Versus Chemotherapy in HRD-positive, HER2-negative Advanced Breast CancerActive, not recruitingNCT07371910Phase 3
• Comparative Effectiveness of Ruxolitinib Monotherapy Versus Its Combination With Tacrolimus and Corticosteroids in the Management of Vitiligo: A Randomized Controlled TrialCompletedNCT07368673Phase 4
• A Pilot Study on Reverse Aging (The REVERSE Study)Active, not recruitingNCT07354620Early Phase 1
• Study of Food Effect on Pharmacokinetics of HMPL-523 Acetate TabletsCompletedNCT07348133Phase 1
• Study of Pelabresib add-on to Ruxolitinib in Japanese Adult Patients With MyelofibrosisActive, not recruitingNCT07340138Phase 1
• A Study of LY4064809 in Healthy Adult ParticipantsCompletedNCT07339735Phase 1
• Pharmacokinetics and Bioequivalence Study of HMPL-523 Acetate Tablets in HumansCompletedNCT07331194Phase 1
• A Study to Evaluate the Efficacy and Safety of Inavolisib When Administered in Combination With Bevacizumab and FOLFOX or FOLFIRI as First Line Therapy in Participants With Colorectal CancerWithdrawnNCT07323576Phase 2
• A Clinical Trial of Mass Balance of [14C] TQ05105 in Healthy Chinese SubjectsCompletedNCT07293390Phase 1
• To Assess the Enzyme Inducing Effects of Carbamazepine on the PK of Mirdametinib in Healthy ParticipantsCompletedNCT07279233Phase 1
• Neoadjuvant Sunvozertinib in Stage II-IIIB Non-small Cell Lung Cancer Harboring EGFR Exon 20 Insertion Mutation.Active, not recruitingNCT07274761Phase 2
• A Study of LY4064809 in Healthy Adult Chinese ParticipantsCompletedNCT07247357Phase 1
• A Study to Investigate the Effect of Capivasertib on the Pharmacokinetics of Oral Dextromethorphan (CYP2D6 Substrate) in Healthy ParticipantsCompletedNCT07241065Phase 1
• A Study of the Effect of Diltiazem on the Plasma Levels of Nemtabrutinib (MK-1026-022)CompletedNCT07232589Phase 1
• A 16-Week Study to Learn About the Study Medicine Called Ritlecitinib in Adults With Long Lasting Painful Red Skin Lumps, Known by the Medical Term, Hidradenitis Suppurativa, or HS.Active, not recruitingNCT07228390Phase 2
• Study to Evaluate the Effect of Repotrectinib on the Drug Levels of Transporter and CYP P450 Probe Substrates in Healthy Adult ParticipantsCompletedNCT07223671Phase 1
• A Trial of Regorafenib Plus Lorigerlimab in Patients With Locally Recurrent or Regrowing pMMR/MSS Localized Rectal CancerWithdrawnNCT07223567Phase 2
• Study Assessing the Mass Balance, Pharmacokinetics, and Metabolite Profiles of a Single Oral Dose of [14C]-INCB123667 in Healthy Male ParticipantsCompletedNCT07218744Phase 1
• RP2 and Tivozanib for the Treatment of Metastatic Renal Cell Cancer After Progression on ImmunotherapyWithdrawnNCT07218692Phase 2
• Rilzabrutinib for the Adult Participants With Chronic ITP Who Have Completed Phase 3 Study in JapanActive, not recruitingNCT07216079Phase 3
• Study About Whether Atirmociclib/PF-07220060 Proportionally Increases Exposure as Dose Increases in Healthy ParticipantsCompletedNCT07215078Phase 1
• A Study to Evaluate the Relative Bioavailability of Pimicotinib Capsules Containing Free Base in Different Proportions in Healthy SubjectsCompletedNCT07210996Phase 1
• A Study to Investigate the Pharmacokinetics of Tirabrutinib in Participants With Mild, Moderate, and Severe Hepatic Impairment Compared to Healthy ParticipantsCompletedNCT07198087Phase 1
• A Study of SHR-A2009 Combined With Aumolertinib Versus Aumolertinib for First-line Treatment in EGFR-mutated, Advanced or Metastatic NSCLCActive, not recruitingNCT07183189Phase 3
• Efficacy and Safety of Seralutinib in Adult Subjects With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)SuspendedNCT07181382Phase 3
• A Ph2 Study to Evaluate the Safety, Efficacy and Tolerability of HT-6184 and Semaglutide in Obese Participants With T2DMWithdrawnNCT07172867Phase 2
• A Study to Evaluate the Efficacy and Safety of Zanubrutinib in Chinese Adults With Treatment-Naive Waldenström MacroglobulinemiaActive, not recruitingNCT07169331Phase 4
• Phase II Study to Assess the Efficacy of ASLAN001 Plus Capecitabine in CNS Metastases for HER2+ Breast CancerTerminatedNCT07166367Phase 2
• Long-Term Safety of Pirtobrutinib in Participants With Previously Treated Types of Blood CancersActive, not recruitingNCT07162181Phase 2
• A Study to Learn About How the Study Medicines Called Itraconazole and Probenecid Change How the Body Processes PF-07220060CompletedNCT07160738Phase 1
• Evaluate the Effect of Vimseltinib on Organic Cation Transporter 2 (OCT2)CompletedNCT07158411Phase 1
• Evaluate the Effect of Vimseltinib on the Pharmacokinetics of a BCRP and OATP1B1 SubstrateCompletedNCT07158398Phase 1
• Improving Physical Ability and Cellular Senescence Elimination in HIVCompletedNCT07144293Phase 2
• A Study to Evaluate the Effect of Moderate or Severe Hepatic Impairment on the Pharmacokinetics (PK) of InavolisibCompletedNCT07144111Phase 1
• A Bioavailability Study of Nilotinib in Healthy, Adult, Human Subjects Under Fasted Conditions.CompletedNCT07138378Phase 1
• A Trial of Regorafenib Plus Lorigerlimab as Neoadjuvant Therapy for Patients With pMMR/MSS, Resectable, Lung-limited Metastatic Colorectal CancerWithdrawnNCT07137390Phase 1/2
• A Phase 2 Trial of Fruquintinib and Tislelizumab in ctDNA-defined Minimal Residual Disease in Colorectal Cancer After Completion of Adjuvant ChemotherapyActive, not recruitingNCT07136077Phase 2
• A Study to Compare Two Tablet Formulations of Study Medicine Atirmociclib in Healthy ParticipantsCompletedNCT07130097Phase 1
• A Study to Understand How the Body Processes [14C]PF-07104091 in Healthy ParticipantsCompletedNCT07127770Phase 1
• A Study to Evaluate the the Bioequivalence of Two Different Pimicotinib Capsules in Healthy SubjectsCompletedNCT07126249Phase 1
• Tovorafenib (DAY101) or in Combination With Pimasertib for Participants With Melanoma and Other Solid TumorsTerminatedNCT07121829Phase 1
• A Multiple Ascending Dose Study With AGMB-129 in Healthy ParticipantsCompletedNCT07118878Phase 1
• A Study of SYS6010 in Combination With SYH2051 in Patients With Advanced Colorectal Cancer and Other Gastrointestinal TumorsActive, not recruitingNCT07104877Not applicable
• Remedial Mechanism of Simvastatin and Ursodeoxycholic Acid in Liver Cirrhosis: Crosstalk of Bile Secretion, Gut Microbiome, and Host Immune ResponseTerminatedNCT07102979Not applicable
• A Study Evaluating How Moderate Liver Impairment Affects the Absorption, Distribution, Metabolism, and Elimination of Sevabertinib After a Single Oral DoseCompletedNCT07102095Phase 1
• A Randomized, Double-blind, Placebo-controlled Phase I Clinical Trial to Evaluate the Safety and Pharmacokinetic Profile of Single and Multiple Dose Escalation Topical Dermal Administration of SHR0302 Alkali Gel in Healthy SubjectsCompletedNCT07098117Phase 1
• Surgical or Radiotherapeutic Intervention Concerning Large Singular Stable to Progressive Metastases in Patients With BRAFV600-mutated Melanoma Receiving Treatment With Encorafenib + BinimetinibWithdrawnNCT07092410Phase 4

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