Protease Inhibitors: all 1,856 studies that test it
Page 15 of 19. Open to participants first (69), then studies with results posted, then the rest; newest registration first within each.
- Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid TumorsCompletedNCT01131234Phase 1
- A Multicenter, Open Label, Single Dose Study to Evaluate the Effect of Renal Insufficiency on the Pharmacokinetics of SK 0403CompletedNCT01131091Phase 1
- TMC435-TiDP16-C125 - Study in Healthy Volunteers to Evaluate the Potential of TMC435 to Increase the Sensitivity of the Skin Towards Exposure to Sun LightCompletedNCT01124799Phase 1
- RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant GliomaCompletedNCT01119599Phase 1
- The First Failure StudyTerminatedNCT01118871Phase 4
- MK0752 and Gemcitabine Hydrochloride in Treating Patients With Stage III and IV Pancreatic Cancer That Cannot Be Removed by SurgeryCompletedNCT01098344Phase 1
- Gamma-Secretase Inhibitor RO4929097 in Treating Patients With Metastatic or Unresectable Solid MalignanciesCompletedNCT01096355Phase 1
- Study in Healthy Adults to Evaluate the Bioavailability of Two Test Tablet Formulations of ABT-450CompletedNCT01091649Phase 1
- TMC435-TiDP16-C112 - Interaction Trial With AntidepressantsCompletedNCT01090700Phase 1
- Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell LeukemiaTerminatedNCT01088763Phase 1
- Clinical Study of an Aluvia-based HAART Regimen for Prevention of Mother-to-child HIV Transmission in AfricaCompletedNCT01088516Phase 4
- Evaluation of Nelfinavir and Chemoradiation for Pancreatic CancerTerminatedNCT01086332Phase 1
- A Safety and Efficacy Study of the Combination of VX-222 and Telaprevir in Treatment-Naïve Subjects With Genotype 1 Chronic Hepatitis C Virus InfectionTerminatedNCT01080222Phase 2
- Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of BMS-708163CompletedNCT01079819Phase 1
- Study of Nelfinavir and Temsirolimus in Patients With Advanced CancersCompletedNCT01079286Phase 1
- Efficacy and Safety Study of GS-9256 and GS-9190 Alone and in Combination With Ribavirin for 28 Days in Patients With Chronic Hepatitis C Virus InfectionCompletedNCT01072695Phase 2
- RO4929097 and Vismodegib in Treating Patients With Breast Cancer That is Metastatic or Cannot Be Removed By SurgeryTerminatedNCT01071564Phase 1
- An Exploratory Study of RO4929097 in Patients With Recurrent or Refractory Non-Small Cell Lung CancerCompletedNCT01070927Phase 2
- Stereotactic Radiation, Nelfinavir Mesylate & Neoadjuvant Chemotherapy in Locally Advanced Pancreatic CancerCompletedNCT01068327Phase 1
- Drug Interaction Oral Contraceptive Pill (OCP)CompletedNCT01063023Phase 1
- Hemostatic Effects of Ulinastatin and Tranexamic Acid in Cardiac SurgeryCompletedNCT01060189Not applicable
- Multiple Dose Japanese Bridging StudyCompletedNCT01057030Phase 1
- An Anti-viral Combination Study With Japanese Hepatitis C Infection (HCV) SubjectCompletedNCT01051414Phase 2
- Study of VX-765 in Subjects With Treatment-resistant Partial EpilepsyCompletedNCT01048255Phase 2
- Pharmacokinetics (PK) Study of Once Daily Darunavir/Ritonavir and Twice and Once Daily Raltegravir in HIV-infected SubjectsCompletedNCT01047995Phase 1
- TMC435-TiDP16-C113: A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics of TMC435CompletedNCT01046058Phase 1
- A Pilot Study of Kaletra and Intelence Tablets in Naive SubjectsCompletedNCT01045369Phase 4
- Drug-Drug Interaction Study With Aricept® (Donepezil)CompletedNCT01042314Phase 1
- The Effect of Lansoprazole in Combination With Ecabet Sodium for Gastroesophageal Reflux DiseaseCompletedNCT01039558Not applicable
- Drug-Drug Interaction to Study the Effect of BMS-708163 on Pharmacokinetics (PK) of Galantamine Extended Release (ER)CompletedNCT01039194Phase 1
- AZD9668 Relative BioavailabilityCompletedNCT01035411Phase 1
- AZD9668 Relative BioavailabilityCompletedNCT01034982Phase 1
- Optimisation of Primary HIV1 Infection Treatment(ANRS 147 OPTIPRIM)CompletedNCT01033760Phase 3
- Analysis of Changes in Adipose Tissue of Patients With Lipoatrophy HIV Infection Treated With Nucleoside Thymidine, After Switching to Monotherapy With Lopinavir / RitonavirTerminatedNCT01031849Phase 4
- Study of BMS-650032 With Peginterferon Alfa-2a Plus RibavirinCompletedNCT01030432Phase 2
- Safety, Tolerability and Pharmacokinetics of Multiple Doses of ZGN-433 in Obese Female VolunteersCompletedNCT01028261Phase 1
- TMC435-TiDP16-C121: A Study Comparing 2 Tablet Formulations of TMC435 to an Established Capsule Formulation and Evaluating the Effect of Food on Blood Levels of TMC435CompletedNCT01022125Phase 1
- A Trial of the Protease Inhibitor Nelfinavir and Concurrent Radiation and Temozolomide in Patients With WHO Grade IV GliomaCompletedNCT01020292Phase 1
- Hepatic Impaired Subjects Compared to Healthy Subjects Receiving Multi-dose BMS-650032CompletedNCT01019070Phase 1
- Maraviroc (Celsentri) With Raltegravir and Darunavir/Ritonavir for the Treatment of Triple Class Failure in Adult HIV-1 Infected PatientsStatus unknownNCT01013987Phase 4
- Study to Determine the Effectiveness of Antiviral Combination Therapy to Treat Hepatitis C Virus (HCV) Infected Patients Who Have Previously Failed Standard of CareCompletedNCT01012895Phase 2
- Ritonavir and Its Effects on Biomarkers in Women Undergoing Surgery for Newly Diagnosed Breast CancerCompletedNCT01009437Phase 1
- Ritonavir-boosted Lopinavir MonotherapyCompletedNCT01002898Phase 3
- Drug-Drug Interaction Study With RifampinCompletedNCT01002079Phase 1
- Clinical Study to Evaluate the Efficacy and Safety of Lopinavir/Ritonavir Monotherapy Versus Darunavir/Ritonavir Monotherapies as Simplification Switching Strategies of PI/NNRTI-Triple Therapy Based-RegimensCompletedNCT00994344Phase 4
- A Relative Bioavailability Study of Moexipril HCl 15 mg Tablets Under Fasting ConditionsCompletedNCT00992862Phase 1
- Europe-Africa Research Network for Evaluation of Second-line TherapyCompletedNCT00988039Phase 3
- Pilot Assessment of Lopinavir/Ritonavir and MaravirocTerminatedNCT00981318Phase 4
- Effect on the Electrocardiographic QT Interval Corrected for Heart Rate (QTc) in Healthy SubjectsCompletedNCT00979316Phase 1
- Clinical Trial to Assess the Effect of the Change of Efavirenz (EFV) for Lopinavir/Ritonavir (LPV/r) in Lipoatrophy in HIV-infected PatientsCompletedNCT00978237Phase 4
- Interaction Between Fosamprenavir/Ritonavir and a Single-dose Olanzapine (FORZA)CompletedNCT00977301Phase 1
- CD4 Cell Recovery in HIV-1 Patients Comparing 2 Treatment RegimesCompletedNCT00966160Phase 3
- TMC114-C201: A Study to Determine the Antiviral Activity of TMC114 in Patients With Multiple Protease Inhibitor (PI) Resistant Human Immunodeficiency Virus (HIV) StrainsCompletedNCT00964327Phase 2
- A Study of RO5190591 (Danoprevir) in Combination With Pegasys and Copegus in Treatment-Naive Patients With Chronic Hepatitis C Genotype 1 Virus InfectionCompletedNCT00963885Phase 2
- Study Evaluating The Coadministration of Begacestat And DonepezilCompletedNCT00959881Phase 1
- Drug-Drug Interaction Study of VCH-222 and Telaprevir in Healthy SubjectsCompletedNCT00958152Phase 1
- Evaluation of a Lopinavir/Ritonavir Monotherapy vs a Triple Therapy as Maintenance Regimens in HIV-1 Infected PatientsCompletedNCT00946595Phase 2/3
- Effects of Ulinastatin on Myocardial Protection and Blood Loss in Patients Undergoing Aortic Valve ReplacementCompletedNCT00944385Phase 4
- Pharmacokinetic and Safety Study of Raltegravir and Atazanavir in a Once Daily Dose Regimen in HIV-1 Infected PatientsCompletedNCT00943540Phase 2
- VX-950-TiDP24-C133 - A Phase I Study Investigating the Interaction Between Telaprevir and EscitalopramCompletedNCT00933894Phase 1
- A Study to Investigate the Potential Interaction Between Telaprevir and Methadone, at Steady-StateCompletedNCT00933283Phase 1
- Study in Healthy Adults to Evaluate Pharmacokinetics, Safety and Tolerability of ABT-450 With RitonavirCompletedNCT00931281Phase 1
- Drug Interaction Study of Darunavir/Ritonavir and Lopinavir/Ritonavir on GSK2248761 PK and CYP450 Probe DrugsCompletedNCT00920088Phase 1
- The Effects of Atazanavir-induced Hyperbilirubinemia During Human EndotoxemiaCompletedNCT00916448Not applicable
- Nelfinavir Mesylate, Radiation Therapy, and Temozolomide in Treating Patients With Glioblastoma MultiformeTerminatedNCT00915694Phase 1
- A Study to Investigate the Potential Pharmacokinetic Interaction Between TMC435 and MethadoneCompletedNCT00915564Phase 1
- Study in Healthy Adults to Evaluate Effect of Food on Pharmacokinetics, Safety and Tolerability of ABT-450 With RitonavirCompletedNCT00909311Phase 1
- PEPI-TiDP23-C104 is a First in Human Study With a Single Dose Escalation Part and a Multiple Dosing Part for Compounds TMC589337 and TMC589354.WithdrawnNCT00908414Phase 1
- Drug-Drug Interaction Study in Healthy SubjectsCompletedNCT00904059Phase 1
- VX-950-TiDP24-C132: A Study to Investigate the Effect of Renal Impairment on the Pharmacokinetics of Telaprevir.CompletedNCT00903773Phase 1
- Relative Bioavailability Study of Four Experimental Formulations for Alzheimer's DiseaseCompletedNCT00901498Phase 1
- Study to Evaluate Different Regimens of Vaniprevir (MK7009) for the Treatment of Chronic Genotype 1 Hepatitis C Virus Infection in Treatment-naive Patients (MK-7009-019)(WITHDRAWN)WithdrawnNCT00895882Phase 2
- A Multicenter, Double Blind, Placebo-Controlled, Safety and Tolerability Study of BMS-708163 in Patients With Prodromal Alzheimer's DiseaseTerminatedNCT00890890Phase 2
- GSK1349572 Drug Interaction Study With Atazanavir/Ritonavir and AtazanavirCompletedNCT00883935Phase 1
- Disulfiram Interactions With HIV Medications: Clinical ImplicationsCompletedNCT00878306Phase 1
- Interaction of Buprenorphine With HIV Medications and Tuberculosis MedicationsCompletedNCT00877591Phase 1
- Raltegravir and Atazanavir Dosing Strategy StudyCompletedNCT00874523Phase 3
- GSK1349572 Drug Interaction With Etravirine and Either Darunavir/Ritonavir or Lopinavir/RitonavirCompletedNCT00867152Phase 1
- TMC435-TiDP16-C107: This Study Measures the (Possible) Influence of TMC435 on the Activity of a Selected Set of Drug-degrading Proteins by Measuring the Blood Levels of Drugs That Have Been Taken Together With TMC435 and That Are Known to be Specifically Degraded by These Drug-degrading Proteins.CompletedNCT00866853Phase 1
- Treatment of HIV/HCV Coinfection With Peg-IFN and Ribavirin in Patients Receiving ART Monotherapy With Lopinavir/rCompletedNCT00866021Phase 4
- Prevention of Lipoatrophy in Patients Treated With Lopinavir/Ritonavir in Monotherapy Versus ZDV + 3TC + ABCCompletedNCT00865475Phase 4
- A Single-Dose Study of the Safety, Tolerability, and Pharmacokinetics of Odanacatib (MK0822) in Healthy VolunteersCompletedNCT00863590Phase 1
- A Study to Assess the Effects of a Light Breakfast on the Safety, Tolerability, and Pharmacokinetics of Odanacatib (MK0822)CompletedNCT00863525Phase 1
- Drug-Drug Interaction (DDI) w/Ketoconazole or FluconazoleCompletedNCT00860275Phase 1
- Study in Healthy Males to Measure Darunavir and Etravirine in Blood, Seminal Fluid, and Rectal TissueCompletedNCT00855088Phase 1
- Innovation-TiFP4-C101: A Study to Evaluate the Pharmacokinetics of TMC114 and TMC41629 After a Single Oral Dose of 2 Controlled-release Coformulations as Compared to an Immediate-release Coformulation of TMC114/TMC41629CompletedNCT00854204Phase 1
- Safety, Tolerability and PK Study of Single Doses of ABT-450 With and Without Ritonavir to Treat Hepatitis C Virus (HCV) Genotype 1CompletedNCT00850044Phase 1
- Study of Protease Inhibitor Regimen Switch in HIV-1 Infected Patients With Undetectable Viral Load to Prove the Non-inferiority of Once Daily Dose Regimen Versus the Current Twice Daily Regimen to Maintain the Viral Load Under the Limit of Detection.CompletedNCT00849160Phase 3
- A Pilot Study Of the Effects of Highly Active Antiretroviral Therapy on Kaposi's Sarcoma in ZimbabweCompletedNCT00834457Phase 2/3
- Drug Interaction Study Between Eltrombopag and Lopinavir/Ritonavir in Healthy Adult Subjects.CompletedNCT00833378Phase 1
- Safety Study of Multiple-dose of Gamma-secretase Inhibitor in Healthy Male Japanese and Healthy Elderly JapaneseCompletedNCT00828646Phase 1
- Open-Label Study to Assess the Safety/Tolerability in Patients With Solid TumorsCompletedNCT00820560Phase 1
- Early and Intermittent Antiretroviral Therapy in Naive HIV Infected AdultsCompletedNCT00820118Phase 2
- Pharmacokinetic Study of Posaconazole Boosted FosamprenavirCompletedNCT00817765Phase 1
- A Phase II, Multicenter, Double Blind, Placebo-Controlled Safety, Tolerability Study of BMS-708163 in Patients With Mild to Moderate Alzheimer's DiseaseCompletedNCT00810147Phase 2
- A Clinical Study to Determine Biomarkers of Response to a Gamma Secretase InhibitorCompletedNCT00803894Phase 1
- TDM of Generic Lopinavir/Ritonavir 200/50 mgCompletedNCT00802334Phase 2
- A Study of Combination Treatment With an HCV Polymerase Inhibitor (RO5024048) and an HCV Protease Inhibitor (RO5190591/Danoprevir) in Genotype 1 Chronic Hepatitis C PatientsCompletedNCT00801255Phase 1
- A Pharmacokinetics/Pharmacodynamics Study of SCH 900518 in Previously Untreated Subjects With Genotype 1 Chronic Hepatitis C (Protocol No. P05104AM2)(COMPLETED)CompletedNCT00797745Phase 2
- A Study To Evaluate The Safety, Tolerability And Pharmacokinetics Of Single Oral Doses Of PF-03716539 In Healthy Adult SubjectsCompletedNCT00783484Phase 1