Protease Inhibitors: all 1,856 studies that test it
Page 12 of 19. Open to participants first (69), then studies with results posted, then the rest; newest registration first within each.
- First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BCX7353 in Healthy Western and Japanese VolunteersCompletedNCT02448264Phase 1
- Pharmacokinetics and Safety of ABT-493 and ABT-530 in Subjects With Normal and Impaired Renal FunctionCompletedNCT02442258Phase 1
- Latency and Early Neonatal Provision of Antiretroviral Drugs Clinical TrialCompletedNCT02431975Phase 4
- Ixazomib Citrate With Gemcitabine Hydrochloride and Doxorubicin Hydrochloride in Treating Patients With Urothelial Cancer That is Metastatic or Cannot Be Removed by SurgeryActive, not recruitingNCT02420847Phase 1/2
- Pharmacokinetics and Safety of Rifabutin 150 mg Once Daily Versus Rifabutin 300 mg Thrice WeeklyCompletedNCT02415985Phase 2
- Ixazomib in Combination With Thalidomide - Dexamethasone in Patients With Relapsed and/or Refractory Multiple MyelomaCompletedNCT02410694Phase 2
- Trial Studying Maintenance Treatment With Lenalidomide and Dexamethasone Versus Lenalidomide, Dexamethasone and MLN9708 After Autologous Hematopoietic Stem Cell Transplantation in Patients With Newly-diagnosed Symptomatic Multiple MyelomaCompletedNCT02406144Phase 3
- Open Label, Pilot Study of Darunavir Boosted by Cobicistat in Combination With Rilpivirine to Treat HIV+ Naïve SubjectsStatus unknownNCT02404233Phase 4
- An Efficacy, Safety, Tolerability and Pharmacokinetics Study of 12 Weeks Treatment With Simeprevir and Daclatasvir in Participants With Chronic Hepatitis C Virus Genotype 1b or 4 Infection and Either Severe Renal Impairment or End-stage Renal Disease on Hemodialysis.WithdrawnNCT02397395Phase 2
- A Crossover Study to Evaluate Relative Bioavailability of Simeprevir Age-appropriate Oral Formulation Candidates Compared With 150-milligram (mg) Oral Capsule in Healthy Adult ParticipantsCompletedNCT02385071Phase 1
- Evaluation of a Dose Reduction of Darunavir (400 mg/d) in Virologically Suppressed HIV-1 PatientsCompletedNCT02384967Phase 2
- Phase I Study of the Combination of MLN9708 and FulvestrantTerminatedNCT02384746Phase 1
- A Study of the Efficacy and Safety of PPI-668 (NS5A Inhibitor) Plus Sofosbuvir, With or Without Ribavirin, in Patients With Chronic Hepatitis C Genotype-4Status unknownNCT02371408Phase 2/3
- Early Infant HIV Treatment in BotswanaActive, not recruitingNCT02369406Phase 2/3
- A Study of Nelfinavir Added to Cisplatin Chemotherapy Concurrent With Pelvic Radiation for Locally Advanced Cervical Cancer (II-IVA)CompletedNCT02363829Phase 1
- Pharmacokinetics of Lopinavir/Ritonavir Superboosting in Infants and Young Children Co-infected With HIV and TBCompletedNCT02348177Phase 4
- Randomized Evaluation of Anagliptin Versus Sitagliptin On Low-density lipoproteiN Cholesterol in Diabetes TrialCompletedNCT02330406Phase 4
- An Efficacy and Safety Study of Beloranib in Obese Subjects With Type 2 Diabetes MellitusTerminatedNCT02324491Phase 2
- A Bioequivalence Study of Daclatasvir Tablets and Bioavailability Studies of Daclatasvir and AsunaprevirCompletedNCT02323594Phase 1
- A Study to Investigate the Safety, Tolerability and Pharmacokinetics of RO6889678 and the Combination of RO6889678 With Ritonavir in Healthy ParticipantsTerminatedNCT02321384Phase 1
- Taste Properties of Atazanavir and CobicistatCompletedNCT02307656Phase 1
- Pharmacokinetics and Safety of ABT-493 and/or ABT-530 in Subjects With Normal and Impaired Hepatic FunctionCompletedNCT02296905Phase 1
- Impact of HCV Treatment on Neurocognitive Functions and Brain MetabolismWithdrawnNCT02292966Phase 4
- A Single Dose Pharmacokinetic (PK) and Safety Study of GSK2838232 With and Without Ritonavir (RTV) Conducted in Healthy SubjectsTerminatedNCT02289482Phase 1
- Effect of ASV and DCV Therapy on the Quality of Immune Status in Chronic HCV PatientsCompletedNCT02282709Phase 3
- An Efficacy and Safety Study of a 8 or 12-Week Treatment Regimen of Simeprevir in Combination With Sofosbuvir in Treatment-Naive and Experienced Participants With Chronic Genotype 4 Hepatitis C Virus InfectionCompletedNCT02278419Phase 2
- A Phase 1 Antiretroviral Drug-Drug Interaction Study in Healthy Volunteers (DDI)CompletedNCT02277600Phase 1
- Pharmacokinetics (PK) of Tipranavir/Ritonavir, Ribavirin, Pegylated Interferon (Peg INF) in Hepatitis C (HCV) Subjects With Mild Hepatic Impairment and in HCV, Hepatitis B (HBV), Hepatitis D Infected Subjects or Alcoholic Cirrhosis With Moderate Hepatic ImpairmentCompletedNCT02259855Phase 1
- Effect of Ulinastatin on Postoperative Renal Function in Patients Undergoing Robot-assisted Laparoscopic Partial NephrectomyCompletedNCT02258906Not applicable
- Phase 1 Study of Relative Bioavailability of PPI-668 New Tablet Versus Capsule FormulationsCompletedNCT02258321Phase 1
- Pharmacokinetic Interaction Between Tipranavir and BILR 355 BS Plus Ritonavir in Healthy Male VolunteersCompletedNCT02257021Phase 1
- Study of Pharmacokinetic Interaction Between Kaletra® (LPV/r) and BILR 355 BS Plus Ritonavir in Healthy SubjectsCompletedNCT02256826Phase 1
- Study of Pharmacokinetic Interaction Between Combivir® (ZDV+3TC) and BILR 355 BS Plus Ritonavir in Healthy SubjectsCompletedNCT02256774Phase 1
- Pharmacokinetics of Single Doses of BILR 355 BS Given With Ritonavir in Healthy Male VolunteersCompletedNCT02253953Phase 1
- Dose Escalation Study of Pharmacokinetics, Safety and Tolerability After Single Dose Administration of BILR 355 (SDS) Plus Low-dose Ritonavir in Healthy VolunteersCompletedNCT02253927Phase 1
- Dose Escalation Study of the Safety, Tolerability and Pharmacokinetics of BILR 355 BS Plus Low Dose Ritonavir in HIV-uninfected Male VolunteersCompletedNCT02253914Phase 1
- Pharmacokinetic Interaction Between TRUVADA™ and BILR 355 BS Plus Ritonavir in Healthy VolunteersCompletedNCT02253901Phase 1
- Study to Determine the Effects of Multiple-dose Omeprazole on the Single-dose Pharmacokinetics of Tipranavir (TPV) Coadministered With Ritonavir (RTV) in Healthy Adult VolunteersCompletedNCT02253875Phase 1
- Pharmacokinetic of Tadalafil Co-administered With Tipranavir/Ritonavir to Healthy Male VolunteersCompletedNCT02253862Phase 1
- Pharmacokinetic Study in Healthy Adult Volunteers to Assess the Interactions Between Steady-State Tipranavir and Atazanavir in the Presence of RitonavirCompletedNCT02253836Phase 1
- Pharmacokinetics of Tipranavir/Ritonavir and Its Metabolites in Healthy Male SubjectsCompletedNCT02253797Phase 1
- Simeprevir in Combination With Sofosbuvir in Treatment-Naïve or -Experienced Adults With Chronic Genotype 4 Hepatitis C Virus InfectionCompletedNCT02253550Phase 2
- Effects of Steady State Tipranavir/Ritonavir or Darunavir/Ritonavir or Ritonavir on Platelet Function, Coagulation and Fibrinolysis Biomarkers in Healthy SubjectsCompletedNCT02251795Phase 1
- Effects of Single-dose and Steady-state TPV/r on the Steady-state Pharmacokinetics of Clarithromycin and a Preliminary Assessment of the Effects of a Standard High-fat Test Meal on the Steady-state Pharmacokinetics of TipranavirCompletedNCT02251769Phase 1
- Bioavailability of Tipranavir/Ritonavir Paediatric Solution Compared to Tipranavir/Ritonavir Capsules in Healthy Female and Male SubjectsCompletedNCT02251158Phase 1
- The Pharmacodynamic/Pharmacokinetic Interaction of Tipranavir and Ritonavir With Loperamide in Healthy VolunteersCompletedNCT02251119Phase 1
- Study to Determine the Pharmacokinetics on TPV/r in Subjects With Mild and Moderate Hepatic InsufficiencyCompletedNCT02249442Phase 1
- Tipranavir Dose-response Study Using a Prototype Self-emulsifying Drug Delivery System (SEDDS) Formulation in Treatment-naive HIV-1 Infected Patients Report on the Post-study Option, a Treatment of Triple Therapy With Delavirdine, ZDV and 3TC Without TipranavirCompletedNCT02249130Phase 2
- Management of Participants With Low-level Persistent Viremia (ANRS 161 L-VIR)TerminatedNCT02247687Phase 3
- Study of Tipranavir and Ritonavir on the Pharmacokinetic Characteristics of Methadone Administered in Healthy VolunteersCompletedNCT02245451Phase 1
- Pharmacokinetics of Atorvastatin With Tipranavir/Ritonavir and the Effect of Antacid on the Pharmacokinetics of Single-Dose Tipranavir/Ritonavir in Healthy VolunteersCompletedNCT02245269Phase 1
- Bioequivalence of Two Different Oral Solutions Tipranavir Administered in Combination With Ritonavir to Healthy VolunteersCompletedNCT02244190Phase 1
- Effects of Tipranavir (With Ritonavir) Capsule and Liquid Formulation on Cytochrome P450 and P-glycoprotein Activity in Healthy VolunteersCompletedNCT02243553Phase 1
- Effect of Steady State TPV/r on Intracellular Concentrations of Zidovudine and Carbovir for Patients With HIVTerminatedNCT02229760Phase 1/2
- Phase I Study of MLN 9708 in Addition to Chemotherapy for the Treatment of Acute Lymphoblastic Leukemia in Older AdultsCompletedNCT02228772Phase 1
- Effects of Steady-state Efavirenz 600 mg QD (Sustiva®) on Tipranavir Concentration at Steady-state in Healthy Adult VolunteersCompletedNCT02226991Phase 1
- Pharmacokinetic Interaction Study of Steady-state Tipranavir/Ritonavir (TPV/r) With Single-dose Valaciclovir (VAL) in Healthy VolunteersCompletedNCT02226978Phase 1
- Antiviral Efficacy, Pharmacokinetics and Safety of BILN 2061 ZW in Patients With Cirrhosis and Chronic Hepatitis CCompletedNCT02226939Phase 2
- Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ABT-957 in Subjects With Mild-to-Moderate Alzheimer's Disease on Stable Doses of Acetylcholinesterase InhibitorsTerminatedNCT02220738Phase 1
- A Study of the Safety and Effectiveness of Simeprevir and Sofosbuvir for Patients With HIV and Hepatitis CWithdrawnNCT02206932Phase 4
- Grazoprevir (MK-5172)/Elbasvir (MK-8742) Versus Boceprevir/Pegylated Interferon/Ribavarin for Chronic Hepatitis C Infection (MK-5172-066)WithdrawnNCT02204475Phase 3
- Clinical Trial of Deferasirox Combination Treatment With Deferiprone In Thalassaemia PatientsCompletedNCT02198508Not applicable
- Effects of Single-dose and Steady-state TPV/RTV on the Steady-state Pharmacokinetics of Fluconazole in Healthy Adult VolunteersCompletedNCT02195466Phase 1
- Single Dose Administration of Alpha-1 Anti-Trypsin for the Amelioration of Organ Injury in Patients Undergoing Cardiac SurgeryStatus unknownNCT02191839Phase 1/2
- Nelfinavir as Bortezomib-sensitizing Drug in Patients With Proteasome Inhibitor-nonresponsive MyelomaCompletedNCT02188537Phase 2
- A Study to Assess the Long-term Safety and Tolerability of TMC114/Rtv in HIV-1 Infected Participants After Rolling-over From Other TMC114 TrialsCompletedNCT02187107Phase 2
- Investigation of the Potential Pharmacokinetic Interaction Between Nevirapine, Abacavir and Amprenavir in HIV-1 Infected Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Naive AdultsTerminatedNCT02182765Phase 1
- Multiple Doses of BI 207127 NA, BI 201335 NA Followed by the Combination of BI 207127 NA and BI 201335 NA in Healthy Male VolunteersTerminatedNCT02182401Phase 1
- Safety, Tolerability and Pharmacokinetics of Multiple Rising Doses of BI 201335 NA in Healthy Male SubjectsCompletedNCT02182362Phase 1
- Metabolism and Pharmacokinetics of Oral Solution of [14C]-BI 201335 in Healthy Male VolunteersCompletedNCT02182349Phase 1
- Effects of BI 201335 NA on Cytochrome P450 and P-glycoprotein Activity Using a Probe Drug Cocktail in Healthy VolunteersCompletedNCT02182336Phase 1
- Safety, Tolerance, and Pharmacokinetics of Single Oral Doses of BI 201335 NA and Bioavailability in Healthy Male SubjectsCompletedNCT02182323Phase 1
- Assessment of the Effect of BI 201335 on the QT Interval in Healthy Female and Male SubjectsCompletedNCT02182310Phase 1
- Safety, Tolerability, and Pharmacokinetics of BI 201335 NA in Healthy Male SubjectsCompletedNCT02182297Phase 1
- Single Rising Dose Study of BI 201335 ZW in Healthy Male SubjectsTerminatedNCT02182271Phase 1
- Double-Blind, Placebo Controlled, Phase 3 Trial of ZGN-440 (Beloranib) in Obese Subjects With Prader-Willi SyndromeTerminatedNCT02179151Phase 3
- An Efficacy and Safety Study of Simeprevir and Sofosbuvir With and Without Ribavirin in Participants With Recurrent Genotype 1 Hepatitis C Post-Orthotopic Liver TransplantCompletedNCT02165189Phase 2
- Drug-drug Interaction (DDI) RifabutinCompletedNCT02138084Phase 1
- Comparative Effectiveness and Tolerability of Boceprevir vs TelaprevirCompletedNCT02113631Not applicable
- Study to Evaluate the PK, Relative Bioavailability and Safety of TG-2349 With Single Oral Dose Under Fed Condition in Healthy VolunteersCompletedNCT02108418Phase 1
- Therapy With Asunaprevir, Daclatasvir, Ribavirin and Pegylated Interferon Alpha-2a in HCV Genotype 4-infected Patients Who Have Failed to a Previous Therapy With Peg-Interferon/Ribavirin (ANRS HC32 QUATTRO)CompletedNCT02107365Phase 2
- Drug Interaction Between Daclatasvir/Asunaprevir/BMS-791325 and RosuvastatinCompletedNCT02104843Phase 1
- ATAGLU: Study of Glucose Metabolism in HIV Positive Patients That Switch From Another Protease Inhibitor to AtazanavirStatus unknownNCT02102048Not applicable
- Rapid Hepatitis C Elimination Trial- A Pilot Study of Daclatasvir/Asunaprevir/BMS-791325 With or Without Ribavirin To Treat Hepatitis C VirusCompletedNCT02098616Not applicable
- Food Effect of a Fixed Dose Combination of Daclatasvir, Asunaprevir and BMS-791325CompletedNCT02095860Phase 1
- Pilot Study of alpha1-antitrypsin to Treat Neuromyelitis Optica RelapsesWithdrawnNCT02087813Phase 1
- Telaprevir in Genotype 3 HCVCompletedNCT02087111Phase 4
- Role of Vitamin C to Augment Iron Chelation With DFP or DFXStatus unknownNCT02083575Phase 2/3
- Study to Evaluate the Drug Interaction Between Dolutegravir (DTG) and Daclatasvir (DCV) in Healthy Adult SubjectsCompletedNCT02082808Phase 1
- Nelfinavir for the Treatment of Gammaherpesvirus-Related TumorsTerminatedNCT02080416Early Phase 1
- A Study to Examine the Pharmacokinetics, Safety and Tolerability of Multiple Oral Doses of TMC435 in Healthy Chinese ParticipantsCompletedNCT02071355Phase 1
- Ixazomib, Mitoxantrone Hydrochloride, Etoposide, and Intermediate-Dose Cytarabine in Relapsed or Refractory Acute Myeloid LeukemiaCompletedNCT02070458Phase 1
- A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of TMC647055 in Combination With Ritonavir (Part 1) and the Co-administration of TMC435, TMC647055 and Ritonavir (Part 2) in Healthy Japanese ParticipantsCompletedNCT02064842Phase 1
- DDI Study of BMS-663068 With Etravirine (ETR) and/or Darunavir (DVR) + Ritonavir (RTV)CompletedNCT02063360Phase 1
- An Efficacy, Safety, and Pharmacokinetics Study of Beloranib in Obese Subjects With Hypothalamic InjuryCompletedNCT02063295Phase 2
- Bioavailability of ABT-450 and ABT-267 With RitonavirCompletedNCT02052362Phase 1
- Drug Interaction & Methadone & BuprenorphineCompletedNCT02045693Phase 1
- MLN9708 and Vorinostat in Patients With Advanced p53 Mutant MalignanciesCompletedNCT02042989Phase 1
- Microboosting of Atazanavir 300 mg With 50 mg Versus 100mg Ritonavir Daily in HIV-infected Patients: a Pharmacokinetic StudyCompletedNCT02034838Phase 1
- Systemic Therapy and Chemoradiation in Advanced Localised Pancreatic Cancer - 2CompletedNCT02024009Phase 1/2