Naltrexone: all 267 studies that test it

Page 2 of 3. Open to participants first (21), then studies with results posted, then the rest; newest registration first within each.

• The Effect of Naltrexone and Varenicline on Alcohol-Mediated Smoking LapseCompletedNCT00773422Phase 2Results posted
• Effects of Low-dose Naltrexone in Combination With a Range of Smoked MarijuanaCompletedNCT00743145Phase 2Results posted
• The Efficacy of Low Dose Naltrexone Therapy in Children With Crohn's DiseaseCompletedNCT00715117Phase 2Results posted
• A Study Using Functional Magnetic Resonance Imaging (fMRI) to Assess the Effects of Naltrexone SR/ Bupropion SR Therapy in Overweight or Obese SubjectsCompletedNCT00711477Phase 2Results posted
• An Exploratory Study of Naltrexone Plus Aripiprazole for Alcohol DependenceCompletedNCT00667875Phase 2Results posted
• The Effects of Naltrexone on Active Crohn's DiseaseCompletedNCT00663117Phase 2Results posted
• Medication Development in Alcoholism: Acamprosate Versus NaltrexoneCompletedNCT00656630Phase 2Results posted
• Behavioral Naltrexone Therapy for Promoting Adherence to Oral Naltrexone vs Extended Release Injectable Depot NaltrexoneCompletedNCT00577408Phase 3Results posted
• Naltrexone for Heavy Drinking in Young AdultsCompletedNCT00568958Phase 4Results posted
• A Safety and Efficacy Study of Naltrexone SR/Bupropion SR in Overweight and Obese SubjectsCompletedNCT00567255Phase 3Results posted
• A Study of the Safety and Efficacy of Two Doses of Naltrexone SR/Bupropion SR and Placebo in Overweight and Obese SubjectsCompletedNCT00532779Phase 3Results posted
• Naltrexone and Varenicline: Weight Gain and Tolerability in Cigarette SmokersCompletedNCT00502216Phase 1/2Results posted
• A Safety and Efficacy Study Comparing Naltrexone SR/Bupropion SR and Placebo in Obese Subjects With Type 2 DiabetesCompletedNCT00474630Phase 3Results posted
• Double-Blind Naltrexone in Compulsive Sexual BehaviorCompletedNCT00467558Phase 2Results posted
• A Safety and Efficacy Study of Naltrexone SR/Bupropion SR and Placebo in Overweight and Obese Subjects Participating in an Intensive Behavior Modification ProgramCompletedNCT00456521Phase 3Results posted
• Effects of a Range of Naltrexone Doses in Combination With Smoked MarijuanaCompletedNCT00403117Phase 2Results posted
• Phase II of Naltrexone in Hormone-Refractory Metastatic Breast CancerTerminatedNCT00379197Phase 2Results posted
• Effectiveness of Naltrexone Versus Placebo to Reduce Craving for Alcohol With Evaluation of Genetic Variability.CompletedNCT00366626Phase 4Results posted
• Naltrexone & SSRI in Alcoholics With Depression/PTSDCompletedNCT00338962Phase 3Results posted
• N-Acetyl Cysteine Plus Naltrexone in Methamphetamine DependenceCompletedNCT00332605Phase 2Results posted
• Double-Blind Naltrexone in KleptomaniaCompletedNCT00332579Phase 2Results posted
• Optimizing Pharmacotherapy for Bipolar AlcoholicsCompletedNCT00302133Phase 1/2Results posted
• Efficacy of Naltrexone in Women's Smoking CessationCompletedNCT00271024Phase 2Results posted
• Effects of Naltrexone on Nicotine ReinforcementCompletedNCT00270231Phase 2Results posted
• Endophenotype for Alcohol Misuse in Healthy Minority PopulationsCompletedNCT00256451Phase 4Results posted
• Addiction Treatment in Russia: Oral vs. Naltrexone ImplantCompletedNCT00218426Phase 2/3Results posted
• Medications for Stopping Cocaine Dependence and Preventing RelapseCompletedNCT00218023Phase 2Results posted
• Effectiveness of Gabapentin When Used With Naltrexone to Treat Alcohol Dependence Compared to Placebo and Naltrexone AloneCompletedNCT00183196Phase 3Results posted
• Modafinil and Naltrexone to Reduce Cocaine and Alcohol DependenceCompletedNCT00142818Phase 2Results posted
• Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight GainCompletedNCT00129246Phase 1/2Results posted
• Managing Alcoholism in People Who Do Not Respond to NaltrexoneCompletedNCT00115037Phase 4Results posted
• Targeted Interventions for Weight-Concerned SmokersCompletedNCT00105482Phase 2Results posted
• Treatment for Alcoholism and Post-Traumatic Stress Disorder (Naltrexone)CompletedNCT00006489Phase 4Results posted
• Combination Gerotherapeutic Interventions for Healthspan ImprovementActive, not recruitingNCT07475546Phase 3
• Targeted Naltrexone to Support Individuals Participating in Dry JanuaryCompletedNCT07132177Phase 2
• A Randomized, Double-Blind, Single-Center Clinical Study on the Efficacy of Naltrexone Implant in Antagonizing Opioid Agonist HydromorphoneCompletedNCT07014644Phase 2
• Study of Injectable Naltrexone and Oral Bupropion Among Cigarette Smokers With SchizophreniaTerminatedNCT06374290Phase 1
• An Acute Migraine Factorial StudyCompletedNCT06245902Phase 2
• The Use of Naltrexone Hydrochloride to Promote Healing in Patients With Resistant Non-infectious Corneal UlcerCompletedNCT05924893Not applicable
• Single-Site Study of Naltrexone/Acetaminophen for the Acute Treatment of Migraine: A Phase 2 Randomized TrialWithdrawnNCT05685225Phase 2
• Naltrexone Neuroimaging in Teens With Eating DisordersActive, not recruitingNCT05509257Early Phase 1
• Safety, Tolerability, and Pharmacokinetics of Naltrexone Implant (DLP-160)CompletedNCT05304364Phase 1
• Extended-Release Naltrexone and Monthly Extended-Release Buprenorphine for Cocaine Use Disorder (CURB-2)CompletedNCT05262270Phase 2
• In Hospital IM Naltrexone: A Pilot StudyWithdrawnNCT05087771Phase 4
• Effects of Naltrexone on Nocturnal Breathing Patterns at AltitudeCompletedNCT05037032Phase 4
• Understanding How Opioids Affect the Experiential and Neural Signatures of Social ExperiencesCompletedNCT05007561Early Phase 1
• Phase III Trial Assessing the Efficacy and Safety of PXT3003 in CMT1A PatientsActive, not recruitingNCT04762758Phase 3
• An Investigation of the Effects of Opioid Receptor Blockade on Changes in Self-esteem and Social AttentionCompletedNCT04757506Not applicable
• RCT for Gambling and Naltrexone, Using Use Eye-tracking Analysis to Predict Treatment ResponseStatus unknownNCT04738773Phase 2
• Pilot Study Into LDN and NAD+ for Treatment of Patients With Post-COVID-19 SyndromeCompletedNCT04604704Phase 2
• Pilot Study Into the Use of Metformin and LDN for Patients With COVID-19WithdrawnNCT04604678Phase 2
• Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (RDD)Active, not recruitingNCT04464980Phase 2
• Naltrexone/Bupropion (Mysimba) to Optimize Weight Outcomes After Obesity SurgeryWithdrawnNCT04399395Phase 4
• Effect of Naltrexone in Achieving and Maintaining Abstinence From Alcohol in Patients With Cirrhosis.CompletedNCT04391764Not applicable
• Treatment of Chronic Itch in Atopic Dermatitis With Opioid Antagonist NaltrexoneWithdrawnNCT04325802Phase 2
• Rapid Antidepressant Improvement Secondary to Excitatory Brain ResponsesCompletedNCT04276259Phase 4
• Fibromyalgia and Naltrexone: The FINAL StudyCompletedNCT04270877Phase 2
• Efficacy of Low Dose Naltrexone in PsoriasisCompletedNCT04250792Phase 1
• Long-acting Buprenorphine vs. Naltrexone Opioid Treatments in CJS-involved AdultsCompletedNCT04219540Phase 4
• Treatment of Chronic Itch in Atopic Dermatitis With Topical NaltrexoneWithdrawnNCT04154033Phase 2
• Low Dose Naltrexone for Chronic Pain in Osteoarthritis and Inflammatory ArthritisWithdrawnNCT04115020Phase 2
• The Evaluation of Safety and Tolerance of Commercially Available Naltrexone Administered Daily - Assessment for CBRN OperationsCompletedNCT03879460Phase 1
• Study of the Opioid Modulation of the Effect of Alcohol on the Dopaminergic Reward SystemTerminatedNCT03854942Phase 1
• Evaluation of Intranasal Naltrexone and NaloxoneCompletedNCT03851731Phase 1
• Medication Maintenance Therapy in Community Pharmacy SettingsCompletedNCT03766893Early Phase 1
• Naltrexone Plus Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use DisorderCompletedNCT03658330Phase 2
• Effects of Mediterranean Diet and Naltrexone/Bupropion Treatment in Obese Breast Cancer PatientsCompletedNCT03581630Not applicable
• Defining the Clinical Role of Topiramate in the Treatment of Alcohol Dependence in AustraliaStatus unknownNCT03479086Phase 3
• Low-Dose Naltrexone and Acetaminophen Combination and Its Components in the Acute Treatment of MigraineCompletedNCT03061734Phase 2
• Immune Effects of Low-dose Naltrexone in ME/CFSWithdrawnNCT02965768Not applicable
• Double-Blind Trial of Ketamine Therapy Plus or Minus Naltrexone in Treatment Resistant Depression (TRD)CompletedNCT02911597Phase 1
• The Impact of the Opiate Antagonist Naltrexone on the Emotional Valence of DreamsCompletedNCT02792140Phase 4
• Study to Evaluate the Effect of Naltrexone and Bupropion Combination on the Pharmacokinetics of Metformin in Healthy ParticipantsCompletedNCT02745912Phase 1
• Study to Evaluate the Effect of Naltrexone and Bupropion Extended-Release Combination on Cardiac Repolarization in Healthy ParticipantsCompletedNCT02735603Phase 1
• Evaluation of Naltrexone as a Treatment for Self-injurious BehaviorWithdrawnNCT02726035Phase 4
• Validation of a Test System for Development of Medications for AlcoholismCompletedNCT02652585Phase 3
• Efficacy of Naltrexone HCl/Bupropion HCl Extended Release Versus Placebo for Treatment of Weight Regain in Participants Post Bariatric SurgeryWithdrawnNCT02616315Phase 4
• Medication-Assisted Treatment for Youth With Substance Use DisordersCompletedNCT02593474Phase 1
• Dopamine and Opioid Receptor Antagonists Reduce Cue-induced Reward Responding and Reward ImpulsivityCompletedNCT02557984Not applicable
• The Effect of Regular Naltrexone Dosing on Disordered GamblersCompletedNCT02537197Phase 1
• Assessment of the Effect of Naltrexone on Lofexidine Single Dose Pharmacokinetics in Healthy SubjectsCompletedNCT02446002Phase 1
• A Study to Evaluate Withdrawal Effects Following Dosing of Oxycodone/Naltrexone in Methadone-Maintained SubjectsCompletedNCT02391571Phase 3
• The Comparison of Stress Response to Rapid Opioid Detoxification Applying Different Methods of Opioid AntagonismCompletedNCT02362256Not applicable
• Biomarkers of Injectable Extended Release Naltrexone TreatmentCompletedNCT02324725Phase 4
• Treatment of Chronic Itch in Atopic Dermatitis (Eczema): Nerve FunctionCompletedNCT02268448Phase 1
• Opioid Relapse & HIV Risk: 48 Versus 24 Weeks of Injectable Extended Release NaltrexoneCompletedNCT01882361Phase 2/3
• A Study to Characterize the Abuse Liability of Intravenous Oxycodone Alone or in Combination With Intravenous Naltrexone in Healthy, Non-Dependent, Recreational Opioid UsersCompletedNCT01825447Phase 1
• To Evaluate the Influence of the A118G Polymorphism in the mu Opioid Receptor Gene (OPRM1) on Effects of GSK1521498 and Naltrexone on Physiological and Behavioural Markers of Brain Function in Healthy Social DrinkersCompletedNCT01738867Phase 1
• Naltrexone vs Buprenorphine-Naloxone for Opioid Dependence in NorwayCompletedNCT01717963Phase 3
• Pharmacotherapy for Alcohol Dependence in Convicted Drinking DriversTerminatedNCT01638377Phase 4
• The Effects of Treatment With Naltrexone in Alcohol and Cannabis-dependent PatientsStatus unknownNCT01560013Not applicable
• Depot Naltrexone Mechanism of Action in Heroin Dependent Patients Using fMRI and SPECTCompletedNCT01471145Phase 4
• Extended-Release Naltrexone to Treat Methamphetamine Dependence in Men Who Have Sex With Men (MSM)CompletedNCT01449565Phase 2
• Naltrexone and Behavioral Drug and HIV Risk Reduction Counseling in RussiaCompletedNCT01389167Phase 3
• Improved Strategies for Outpatient Opioid DetoxificationCompletedNCT01377610Phase 1
• Naltrexone for Medication Compliance Among HIV-infected Men With Alcohol Use DisorderCompletedNCT01377168Phase 4
• Role of the Endogenous Opioid System Underlying Modulation of Experimental PainWithdrawnNCT01327326Not applicable
• Stress, Hormones, and EatingCompletedNCT01175512Early Phase 1
• Effectiveness Study Low-Dose Naltrexone Versus ARV's for HIV+CompletedNCT01174914Phase 2
• Naltrexone in the Treatment of Dissociative Symptoms in Patients With Borderline Personality DisorderCompletedNCT01133301Phase 2

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