Calcineurin Inhibitors: all 993 studies that test it

Page 2 of 10. Open to participants first (83), then studies with results posted, then the rest; newest registration first within each.

• Envarsus Neurotoxicity Burden in Liver Transplant PatientsCompletedNCT03823768Phase 4Results posted
• Tacrolimus, Nivolumab, and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic CancersActive, not recruitingNCT03816332Phase 1Results posted
• Dosing Strategies for de Novo Once-daily Extended Release Tacrolimus (LCPT) in Kidney Transplant RecipientsCompletedNCT03713645Phase 4Results posted
• 2-Step Approach to Stem Cell Transplant in Treating Participants With Hematological MalignanciesCompletedNCT03712878Phase 2Results posted
• Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or DysregulationActive, not recruitingNCT03663933Phase 2Results posted
• Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Single Lung Transplant (BOSTON-1)CompletedNCT03657342Phase 3Results posted
• Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Double Lung Transplant (BOSTON-2)CompletedNCT03656926Phase 3Results posted
• Envarsus on the Effect of Total Tacrolimus Dose/Trough Level Ratio on Renal Function (eGFR) in Kidney TransplantationCompletedNCT03511560Phase 4Results posted
• Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' ExpressionCompletedNCT03480360Phase 3Results posted
• Effect of Tacrolimus Formulation on Neurological Side Effects in Older Kidney Transplant RecipientsCompletedNCT03461445Phase 4Results posted
• Comparison of the Cognitive and Motor Effects of Treatment Between an Immediate- and Extended-release Tacrolimus (Envarsus® XR) Based Immunosuppression Regimen in Kidney Transplant RecipientsCompletedNCT03437577Phase 1/2Results posted
• Extended Release Tacrolimus vs. Twice-Daily TacrolimusCompletedNCT03289650Phase 3Results posted
• CNS Study of Patients Switching From Tacrolimus to EnvarsusCompletedNCT03270462Phase 4Results posted
• Trial to Evaluate Safety and Tolerability of Tacrolimus Extended-Release (Astagraf XL) in Human Leukocyte Antigen (HLA) Sensitized Kidney Transplant RecipientsCompletedNCT03194321Phase 4Results posted
• Efficacy and Safety of a 0.1% Tacrolimus Nasal Ointment as a Treatment for Epistaxis in Hemorrhagic Hereditary Telangiectasia (HHT)CompletedNCT03152019Phase 2Results posted
• Umbilical Cord Blood Transplant With Added Sugar and Chemotherapy and Radiation Therapy in Treating Patients With Leukemia or LymphomaCompletedNCT03096782Phase 2Results posted
• Study of Pharmacogenomic-Guided Tacrolimus Dosing and Monitoring in Kidney Transplant RecipientsCompletedNCT03020589Phase 4Results posted
• Eltrombopag Combined With Cyclosporine as First Line Therapy in Patients With Severe Acquired Aplastic AnemiaCompletedNCT02998645Phase 2Results posted
• Envarsus XR in African American Renal Transplant RecipientsTerminatedNCT02956005Not applicableResults posted
• Vedolizumab Monotherapy Vs Combination Therapy With Tacrolimus in UCTerminatedNCT02954159Phase 3Results posted
• Dosing Requirements of Astagraf XL® in African American Kidney Transplant RecipientsCompletedNCT02953873Phase 4Results posted
• Optimizing Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502)CompletedNCT02918292Phase 2Results posted
• Haploidentical (Half-matched) Related Donor Stem Cell Transplantation Using Killer Immunoglobulin-like Receptors in Addition to Normal Selection Factors to Determine the Best DonorCompletedNCT02880293Not applicableResults posted
• Tacrolimus, Bortezomib, & Thymoglobulin in Preventing Low Toxicity GVHD in Donor Blood Stem Cell Transplant PatientsTerminatedNCT02877082Phase 2Results posted
• Prospective Study Comparing Brand and Generic Immunosuppression on Transplant Outcomes, Adherence, & Immune Response in Kidney Transplant RecipientsCompletedNCT02866682Phase 4Results posted
• NMA Haplo or MUD BMT for Newly Diagnosed Severe Aplastic AnemiaCompletedNCT02833805Phase 2Results posted
• Bone Marrow Transplantation vs Standard of Care in Patients With Severe Sickle Cell Disease (BMT CTN 1503)CompletedNCT02766465Phase 2Results posted
• Early Allogeneic Hematopoietic Cell Transplantation in Treating Patients With Relapsed or Refractory High-Grade Myeloid NeoplasmsCompletedNCT02756572Phase 2Results posted
• To Compare the Effects of Immediate-release Tacrolimus and Astagraf XL on Donor-Specific Antibody (DSA) Formation and the Development of Immune Activation (IA) in de Novo Kidney Transplant RecipientsCompletedNCT02723591Phase 4Results posted
• Phase 3 Study of OTX-101 in the Treatment of Keratoconjunctivitis SiccaCompletedNCT02688556Phase 3Results posted
• TCR-α/β and CD19 Depleted Stem Cell Grafts From Haplo Donors for HSCT in Relapsed LymphomaCompletedNCT02652468Not applicableResults posted
• Safety, Tolerability and Pharmacokinetics of Oral CellCept (Mycophenolate Mofetil) in Pediatric Liver Transplant Recipients on Concomitant Treatment With Cyclosporine and CorticosteroidsTerminatedNCT02630563Phase 2Results posted
• CyclASol for the Treatment of Moderate to Severe Dry-eye Disease (DED)CompletedNCT02617667Phase 2Results posted
• Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating Patients With Hematologic MalignanciesCompletedNCT02566304Phase 2Results posted
• Shorter Course Tacro After NMA, Related Donor PBSCT With High-dose Posttransplant Cy for Hard-to-Engraft MalignanciesCompletedNCT02556931Phase 2Results posted
• Evaluation of Maintaining Visual Performance in Participants Who Engage in Electronic Visual Tasking While Using Restasis®CompletedNCT02554981Phase 4Results posted
• A Pharmacokinetic Analysis of Tacrolimus ER Dosing in Obese Kidney Transplant RecipientsCompletedNCT02444143Phase 4Results posted
• Eltrombopag in Combination With Rabbit Anti-thymocyte Globulin/Cyclosporine A in Naive Aplastic Anemia (AA) SubjectsCompletedNCT02404025Phase 2Results posted
• Pharmacokinetic Comparison Of All FK-506 FormulationsCompletedNCT02339246Phase 3Results posted
• Peginterferon Alfa-2a to Enhance Anti-leukemic Responses After Allogeneic Transplantation in Acute Myeloid LeukemiaCompletedNCT02328755Phase 1/2Results posted
• JAK Inhibitor Before Donor Stem Cell Transplant in Treating Patients With Primary or Secondary MyelofibrosisCompletedNCT02251821Phase 2Results posted
• Transplantation of Partially Mismatched Related or Matched Unrelated Bone Marrow for Patients With Refractory Severe Aplastic AnemiaCompletedNCT02224872Phase 2Results posted
• CCFZ533X2201 - PoC Study in de Novo Renal TransplantationCompletedNCT02217410Phase 1/2Results posted
• Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203)CompletedNCT02208037Phase 2Results posted
• A Study of Tacrolimus/Methotrexate and Tocilizumab to Prevent Acute Graft-Versus-Host Disease (AGVD) After Allogeneic Hematopoietic Stem Cell TransplantCompletedNCT02206035Phase 2Results posted
• The Effects of Cyclosporin A in a Low Humidity Environment, on the Ocular SurfaceTerminatedNCT02199964Not applicableResults posted
• Combined T Cell Depleted Haploidentical Peripheral Blood Stem Cell and Unrelated Umbilical Cord Blood Transplantation in Patients With Hematologic Malignancies Using a Total Lymphoid Irradiation Based Preparative RegimenTerminatedNCT02199041Phase 2Results posted
• Combined Bone Marrow and Renal Transplantation for Hematologic Disorders With End Stage Renal DiseaseCompletedNCT02158052Not applicableResults posted
• Investigation of Maintaining Visual Performance Achieved With Cyclosporine TherapyCompletedNCT02121847Phase 4Results posted
• Study to Ascertain if Prolonged Release Tacrolimus (FK506E - MR4) is Safe and Effective When Used in the Long Term and in Combination With Other Immunosuppressive Drugs in Patients Who Have Received a TransplantCompletedNCT02118896Phase 3Results posted
• REnal Function in Liver Transplantation: Everolimus With Calcineurin Inhibitor (CNI)-Sparing sTrategyCompletedNCT02115113Phase 3Results posted
• A Study of CellCept (Mycophenolate Mofetil) in Combination Therapy in Heart Transplant Patients.CompletedNCT02091414Phase 3Results posted
• Nonmyeloablative Conditioning and Transplantation for Patients With Refractory Systemic Lupus Erythematosus (SLE)TerminatedNCT02080195Phase 1/2Results posted
• Investigation of Potential Drug-drug Interactions Between Faldaprevir and the Immunosuppressant Drugs Cyclosporine or TacrolimusCompletedNCT02016625Phase 1Results posted
• Conversion From Brand to Generic Tacrolimus in High Risk Transplant RecipientsCompletedNCT02014103Phase 4Results posted
• OPERA Study: A Study of Two Dosing Regimens of CellCept (Mycophenolate Mofetil) in Kidney Transplant Patients.CompletedNCT02005562Phase 3Results posted
• Cyclosporine in Interstitial Cystitis: Efficacy, Safety and Mechanism of ActionCompletedNCT01990898Phase 2Results posted
• Safety and Efficacy of Topical Tacrolimus 0.05% in the Treatment of Ocular Graft-Versus-Host DiseaseCompletedNCT01977781Phase 1Results posted
• A Study of Baricitinib and Ciclosporin in Healthy ParticipantsCompletedNCT01968057Phase 1Results posted
• Crossover Study to Compare PK of Once Daily LCP-Tacro Tablets to Generic Tacrolimus Capsules Twice Daily.CompletedNCT01962922Phase 3Results posted
• In Vivo Treg Expansion and Graft-Versus-Host Disease ProphylaxisCompletedNCT01927120Phase 2Results posted
• Role of Everolimus in Highly Sensitized PatientsCompletedNCT01911546Phase 2Results posted
• Natural Killer Cells Before and After Donor Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous LeukemiaCompletedNCT01904136Phase 1/2Results posted
• Evaluation of Preimplantation Portal Vein and Hepatic Artery Flushing With TacrolimusCompletedNCT01887171Not applicableResults posted
• Immunosuppression in Amyotrophic Lateral Sclerosis (ALS)CompletedNCT01884571Phase 2Results posted
• Haploidentical Donor Hematopoietic Stem Cell Transplant in Treating Patients With Hematologic MalignanciesTerminatedNCT01871441Phase 2Results posted
• Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts in Preventing GVHD in ChildrenCompletedNCT01858740Phase 2Results posted
• Open-Label Phase 2 Trial of a Steroid-Free, CNI-Free, Belatacept-Based Immunosuppressive RegimenTerminatedNCT01856257Phase 2Results posted
• 12 Month Athena Study: Everolimus vs. Standard Regimen in de Novo Kidney Transplant PatientsCompletedNCT01843348Phase 3Results posted
• Lotemax® Gel 0.5% and Restasis 0.05% in Participants With Mild or Moderate Keratoconjunctivitis Sicca (Dry Eye Disease)CompletedNCT01817582Phase 2Results posted
• Targeting the IPA and Matching for the Non-Inherited Maternal Antigen for Haplo-Cord TransplantationCompletedNCT01810588Phase 2Results posted
• Vorinostat Plus Tacrolimus & Methotrexate to Prevent Graft vs Host Disease Following Unrelated Stem Cell TransplantCompletedNCT01790568Phase 2Results posted
• Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological MalignanciesCompletedNCT01789255Phase 2Results posted
• Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in With High-Risk Hematologic MalignanciesCompletedNCT01760655Phase 2Results posted
• 1% Topical Pimecrolimus Cream for the Treatment of the Rash Associated With ERBITUXTerminatedNCT01692626Phase 2Results posted
• Multicenter, Prospective, Rand, PK Study of LCP-Tacro™ Compared to Prograf® Capsules in De Novo Adult Kidney TransplantCompletedNCT01666951Phase 2Results posted
• Pharmacogenetic Trial of Tacrolimus After Pediatric TransplantationCompletedNCT01655563Phase 2Results posted
• Study in Recipients of Renal Transplant Allograft to Evaluate the Impact of Two Immunosuppressive RegimensCompletedNCT01653847Not applicableResults posted
• Aerosol Liposomal Cyclosporine for Chronic Rejection in Lung Transplant RecipientsCompletedNCT01650545Phase 1/2Results posted
• Comparison of a Tacrolimus Hexal® Based Regimen Versus a Prograf® Based Regimen in de Novo Renal Transplant RecipientsCompletedNCT01649427Phase 4Results posted
• Reduced-Intensity Hematopoietic Stem Cell Transplant for High Risk Lysosomal and Peroxisomal DisordersCompletedNCT01626092Not applicableResults posted
• T-Cell Replete Haploidentical Donor Hematopoietic Stem Cell Plus Natural Killer (NK) Cell Transplantation in Patients With Hematologic Malignancies Relapsed or Refractory Despite Previous Allogeneic TransplantTerminatedNCT01621477Phase 2Results posted
• Open Label Comparative Study Of De Novo Renal Allograft Recipients Receiving CSA + MMF + Corticosteroids Versus CSA + Rapamune + CorticosteroidsCompletedNCT01601821Phase 4Results posted
• Pharmacodynamics, Efficacy and Safety of Basiliximab 40 or 80 mg in Combination With Ciclosporine Microemulsion or Everolimus, in Adult Low Risk de Novo Renal Transplant Recipients (IDEALE Study)CompletedNCT01596062Phase 2Results posted
• Crohn's Allogeneic Transplant StudyTerminatedNCT01570348Phase 2Results posted
• Donor Atorvastatin Treatment in Preventing Severe Acute GVHD After Nonmyeloablative Peripheral Blood Stem Cell Transplant in Patients With Hematological MalignanciesCompletedNCT01527045Phase 2Results posted
• Switching Study of Kidney Transplant Patients With Tremor to LCP-Tacro (STRATO)CompletedNCT01438710Phase 3Results posted
• A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological MalignanciesCompletedNCT01384513Phase 2Results posted
• Bone Marrow Transplantation of Patients in Remission Using Partially Matched Relative DonorCompletedNCT01350245Phase 2Results posted
• Cyclosporine, Pravastatin Sodium, Etoposide, and Mitoxantrone Hydrochloride in Treating Patients With Relapsed or Refractory Acute Myeloid LeukemiaTerminatedNCT01342887Phase 1/2Results posted
• Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic MalignanciesCompletedNCT01341301Phase 2Results posted
• Pilot Study of Leuprolide to Improve Immune Function After Allogeneic Bone Marrow TransplantationCompletedNCT01338987Phase 2Results posted
• Study of Two Formulations of Cyclosporine Ophthalmic Emulsion in Healthy Volunteers and in Patients With Dry EyeCompletedNCT01319773Phase 1Results posted
• Research Study of ATG and Rituximab in Renal TransplantationTerminatedNCT01318915Early Phase 1Results posted
• A Reduced Toxicity Allogeneic Unrelated Donor Stem Cell Transplantation (SCT) for Severe Sickle Cell DiseaseTerminatedNCT01279616Phase 2Results posted
• Everolimus in Combination With Cyclosporine Microemulsion in de Novo Renal Transplant RecipientsCompletedNCT01276457Phase 3Results posted
• A Pilot Study Comparing the Use of Low-target Versus Conventional Target AdvagrafCompletedNCT01265537Not applicableResults posted
• Pharmacokinetics of Generic to Brand Tacrolimus in Stable Renal Transplant PatientsCompletedNCT01256294Phase 4Results posted
• Sirolimus, Cyclosporine, and Mycophenolate Mofetil in Preventing Graft-versus-Host Disease in Treating Patients With Blood Cancer Undergoing Donor Peripheral Blood Stem Cell TransplantCompletedNCT01251575Phase 2Results posted
• Tacrolimus and Thymoglobulin, as GvHD Prophylaxis in Patients Undergoing Related Donor HCTCompletedNCT01246206Phase 2Results posted

← Calcineurin Inhibitors overview