Beta-Lactamase Inhibitors: all 294 studies that test it

Page 2 of 3. Open to participants first (48), then studies with results posted, then the rest; newest registration first within each.

• Ceftazidime-Avibactam for the Treatment of Infections Due to Ceftazidime Resistant PathogensCompletedNCT01644643Phase 3Results posted
• Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections)CompletedNCT01599806Phase 3Results posted
• Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections)CompletedNCT01595438Phase 3Results posted
• Efficacy of Short-Course Antimicrobial Treatment for Children With Acute Otitis Media and Impact on ResistanceTerminatedNCT01511107Phase 2Results posted
• Study of the Safety, Tolerability, and Efficacy of Relebactam (MK-7655) + Imipenem/Cilastatin Versus Imipenem/Cilastatin Alone to Treat Complicated Intra-Abdominal Infection [cIAI] (MK-7655-004)CompletedNCT01506271Phase 2Results posted
• Safety, Tolerability, and Efficacy of MK-7655 (Relebactam) + Imipenem/Cilastatin Versus Imipenem/Cilastatin Alone for Treating Complicated Urinary Tract Infection (cUTI) (MK-7655-003)CompletedNCT01505634Phase 2Results posted
• Effects of S. Boulardii and Amoxicillin/Clavulanate on Gut MicrobiotaCompletedNCT01473368Not applicableResults posted
• Study Comparing the Safety and Efficacy of Intravenous CXA-201 and Intravenous Meropenem in Complicated Intraabdominal InfectionsCompletedNCT01445678Phase 3Results posted
• Study Comparing the Safety and Efficacy of Intravenous CXA-201 and Intravenous Levofloxacin in Complicated Urinary Tract Infection, Including PyelonephritisCompletedNCT01345929Phase 3Results posted
• The Study of Unasyn-S 12g/Day for Community Acquired Pneumonia (CAP)CompletedNCT01189487Phase 3Results posted
• Short (5 Days) Versus Long (14 Days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in ChildrenCompletedNCT01166945Not applicableResults posted
• Safety and Efficacy Study to Compare IV CXA 101/Tazobactam and Metronidazole With Meropenem in Complicated Intraabdominal InfectionsCompletedNCT01147640Phase 2Results posted
• Pharmacokinetics and Safety of Piperacillin-tazobactam in NeonatesCompletedNCT00873327Phase 1Results posted
• Amoxicillin-Clavulanic Acid 400 Mg-57 mg Chewable Tablets Under Non-Fasting ConditionsCompletedNCT00836901Phase 1Results posted
• Amoxicillin-Clavulanic Acid 400 Mg-57 mg Chewable Tablets Under Fasting ConditionsCompletedNCT00835705Phase 1Results posted
• Benefit of a Single Preoperative Dose of Antibiotics for the Prevention of Surgical Site InfectionsCompletedNCT00801099Not applicableResults posted
• Prospective Multicenter Doubleblind Randomized Study of NXL104/Ceftazidime + Metronidazole vs. Meropenem in Treatment of Complicated Intra-abdominal InfectionsCompletedNCT00752219Phase 2Results posted
• Comparative Study of NXL104/Ceftazidime Versus Comparator in Adults With Complicated Urinary Tract InfectionsCompletedNCT00690378Phase 2Results posted
• Effectiveness of Antibiotic Therapy for Exacerbations of Chronic Obstructive Pulmonary DiseaseCompletedNCT00495586Phase 4Results posted
• Acute Otitis Media (AOM) Therapy Trial in Young ChildrenCompletedNCT00377260Phase 4Results posted
• The Efficacy of Prophylactic Antibiotic Administration During Breast Cancer Surgery in Overweight Patients.CompletedNCT00356148Phase 4Results posted
• Antibiotic Therapy in Impacted Mandibular Third Molar SurgeryCompletedNCT07817940Phase 4
• A Clinical Study of Connective Tissue Graft and Enamel Matrix Derivative in the Treatment of Intrabony Periodontal DefectsCompletedNCT07233733Not applicable
• Effects of Different Antibiotic Regimens in Preterm Premature Rupture of MembranesCompletedNCT07148622Not applicable
• A Study to Investigate Safety and Pharmacokinetics of Intravenous Cefiderocol/Xeruborbactam in Participants With Renal ImpairmentCompletedNCT07104162Phase 1
• Comparison Between Carbapenems and Noncarbapenem Beta-lactam Antibiotics in Septic Burn PatientsActive, not recruitingNCT07096310Phase 1/2
• Mass Balance Study of [14C]Xeruborbactam (QPX7728) in Healthy Adult Male ParticipantsCompletedNCT07083817Phase 1
• Effects of Saccharomyces Boulardii CNCM I-745 on Antibiotic-Associated Perturbation in Children Treated for Acute Respiratory Infections (RESTORE Study)CompletedNCT07015736Phase 4
• Evaluation of the Concentration of ANT3310 and Meropenem in the Lung in Healthy Adult ParticipantsCompletedNCT06916156Phase 1
• A Study to Characterize Single and Repeat Dose Pharmacokinetics of Tebipenem-Pivoxil-Hydrobromide (TBP-PI-HBr) and Its Major Metabolite (SPR1349) in Healthy ParticipantsCompletedNCT06727136Phase 1
• A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Meropenem-Vaborbactam in Children With Complicated Urinary Tract Infection, Including Acute PyelonephritisActive, not recruitingNCT06672978Phase 2
• A DDI Study to Investigate PK and Safety of Cefiderocol in Combination With Xeruborbactam in Healthy Adult ParticipantsCompletedNCT06547554Phase 1
• Assessment of the Pharmacokinetics and Safety of ANT3310 Combined With Meropenem in Renally Impaired SubjectsCompletedNCT06527677Phase 1
• Piperacillin/Tazobactam Versus ceftriAxone and Metronidazole for Children With Perforated Appendicitis (ALPACA)CompletedNCT05943223Phase 2
• FiH Study to Assess Safety and PK of SAD and MAD of ANT3310 Alone and in Combination With Meropenem in Healthy SubjectsCompletedNCT05905913Phase 1
• Efficacy of Oral vs IV Antibiotics in the Treatment of Orofacial OsteomyelitisStatus unknownNCT05867654Phase 4
• A Study to Compare Two Bioanalytical Assays for TebipenemCompletedNCT05856747Phase 1
• Evaluate Bioequivalence of Burotam (1/1 g/Vial)Status unknownNCT05654090Phase 4
• Imipenem/Cilastatin/Relebactam Pharmacokinetics, Safety, and Outcomes in Adults and Adolescents With Cystic FibrosisTerminatedNCT05561764Phase 4
• Food Effect on Ceftibuten/VNRX-7145 in Healthy ParticipantsCompletedNCT05527834Phase 1
• Ceftibuten/VNRX-7145 in Participants With Varying Degrees of Renal FunctionCompletedNCT05488678Phase 1
• PipEracillin/Tazobactam Versus mERoPENem for Treatment of AmpC Producing Blood Stream InfectionsWithdrawnNCT05355350Phase 4
• Ceftazidime-Avibactam Use in Critically Ill Patients With Carbapenem-Resistant Enterobacteriaceae InfectionsTerminatedNCT05258851Phase 3
• Impact of Obesity on the Pharmacokinetics of Imipenem-Relebactam in ICU PatientsWithdrawnNCT05146154Phase 4
• Tebipenem Trial in Children With ShigellosisCompletedNCT05121974Phase 2
• Collaborative Urological Prosthetics Investigation Directive Research GroupActive, not recruitingNCT05100654Early Phase 1
• Drug-Drug Interaction Study of IV QPX2014 Combined With QPX7728 in Healthy Adult SubjectsCompletedNCT05072444Phase 1
• CEFtolozane-Tazobactam for the Empiric Anti-bacterial Treatment of Neutropenic Fever in Hematology PatientsWithdrawnNCT05061654Phase 4
• Evaluation of the Safety, Tolerability and Pharmacokinetics of Intravenous FL058 Administered in Healthy Subjects(SAD)CompletedNCT05058118Phase 1
• Safety, Tolerability, Pharmacokinetics of Intravenous FL058 and Meropenem in Healthy Subjects(SAD/MAD)CompletedNCT05058105Phase 1
• Evaluation of the Safety, Tolerability and Pharmacokinetics of Intravenous FL058 Administered in Healthy Subjects(SAD/MAD)CompletedNCT05055687Phase 1
• Clindamycin Versus Amoxicillin With Clavulanic Acid in Prevention of Early Dental Implants FailureStatus unknownNCT04980170Early Phase 1
• Early Versus Late Stopping of Antibiotics in Children With Cancer and High-risk Febrile NeutropeniaCompletedNCT04948463Phase 4
• Tebipenem (SPR994) Tissue Penetration in Diabetic Patients With Wound Infections and Healthy Volunteers Via In Vivo MicrodialysisCompletedNCT04919954Phase 1
• VNRX-7145 Drug-Drug Interaction in Healthy Adult VolunteersCompletedNCT04877379Phase 1
• Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of Oral WCK 2349CompletedNCT04874324Phase 1
• Antibiotics Continuous Infusion at HomeStatus unknownNCT04816968Phase 1
• Imipenem/Cilastatin/Relebactam (IMI/REL) in Treatment of CRE InfectionsWithdrawnNCT04785924Phase 4
• Study to Assess the Intrapulmonary Pharmacokinetics of SPR859 by Comparing the Plasma, Epithelial Lining Fluid (ELF), and Alveolar Macrophages (AM) Concentrations Following the Oral Administration of Five Doses of SPR994 in Healthy, Nonsmoking VolunteersCompletedNCT04710407Phase 1
• Evaluating the EBA of Meropenem With Amoxicillin/Clavulanate and Pyrazinamide or Bedaquiline in Adults With PTBCompletedNCT04629378Phase 2
• Study of the Absorption, Metabolism, and Excretion of [14C]-Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) Following a Single Oral Dose in Healthy Male SubjectsCompletedNCT04625855Phase 1
• Bioequivalence Study Comparing Two Tablet Formulations of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Healthy Adult SubjectsCompletedNCT04421885Phase 1
• Ultra Low Doses of Therapy With Radiation Applicated to COVID-19SuspendedNCT04394182Not applicable
• P1 Single and Multiple Ascending Dose (SAD/MAD) Study of IV QPX7728 Alone and Combined With QPX2014 in NHVCompletedNCT04380207Phase 1
• Effect of Tebipenem on Normal Human Intestinal MicrobiotaCompletedNCT04376554Phase 1
• Azithromycin+Amoxicillin/Clavulanate vs Amoxicillin/Clavulanate in COVID19 Patients With Pneumonia in Non-intensive UnitStatus unknownNCT04363060Phase 3
• Pharmacokinetics and Pleural Fluid Penetration of Amoxicillin and Clavulanic Acid in Patients With Pleural InfectionsCompletedNCT04350502Not applicable
• Efficacy of Piperacillin-tazobactam as Empirical Antimicrobial Therapy for VAP Among ESBL-E Carriers.CompletedNCT04276480Not applicable
• 2-day Prophylactic Antibiotic is Effective in Transoral Endoscopic ThyroidectomyCompletedNCT04268407Not applicable
• VNRX-7145 SAD/MAD Safety and PK in Healthy Adult VolunteersCompletedNCT04243863Phase 1
• Ceftolozane-tazobactam Versus Meropenem for ESBL and AmpC-producing Enterobacterales Bloodstream InfectionWithdrawnNCT04238390Phase 3
• A Single-Dose, Randomized, Placebo- and Active-Control, Four-Way, Cross-Over Study for the Evaluation of the Effect of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) on the QT/QTc Intervals in Adult Healthy SubjectsCompletedNCT04238195Phase 1
• Efficacy of Extended Infusion of β-lactam Antibiotics for the Treatment of Febrile Neutropenia in Hematologic PatientsStatus unknownNCT04233996Phase 4
• A Study Evaluating Efficacy and Safety of CRO-SBT in the Treatment of GonorrheaCompletedNCT04202068Phase 4
• Phase 1 Study of PK and Safety of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Subjects With Various Degrees Of Renal FunctionCompletedNCT04178577Phase 1
• Antibiotic-Associated Diarrhea and the Role of Microorganisms in the GutCompletedNCT04156555Phase 4
• Antibiotic Therapy in Erupted Tooth ExtractionsCompletedNCT04082598Phase 4
• PHase IV Clinical Trial of Ceftriaxone Sodium and Sulbactam Sodium for Injection (CRO-SBT)CompletedNCT04066621Phase 4
• A Study to Compare Different Antibiotics and Different Modes of Fluid Treatment for Children With Severe PneumoniaCompletedNCT04041791Phase 3
• Study to Determine the Excretion and Metabolism of 14C-ETX2514 Administered Intravenously in Healthy Male SubjectsCompletedNCT04018950Phase 1
• Open Label Pharmaco- Magnetic Resonance Spectrography (MRS) Study of Clavulanic AcidCompletedNCT03986762Phase 1
• Acute Appendicitis: Active Observation With and Without AntibioticsCompletedNCT03985514Phase 4
• Study Evaluating the Effect of ETX2514 on Cardiac Repolarization in Healthy Male or Female VolunteersCompletedNCT03985410Phase 1
• Fecal Transplant +/- Gut Decontamination in Preventing Acute Graft Versus Host Disease in Patients Given Broad-Spectrum AntibioticsWithdrawnNCT03862079Phase 2
• Comparison of 9 Doses vs 3 Doses of Post Operative Antibiotics in Live Liver DonorsCompletedNCT03765645Not applicable
• An fMRI Study of the Effects of Clavulanic Acid on Drug AddictionActive, not recruitingNCT03713424Phase 2
• Does Antibiotics Use During Surgery Help to Decrease Wound Infection and Increase Success After Ear Surgery in ChildrenCompletedNCT03700814Phase 4
• Investigation of AAI101 Safety, Tolerability & PK in Healthy VolunteersCompletedNCT03685084Phase 1
• Lung Pharmacokinetics (PK) in Epithelial Lining Fluid (ELF)CompletedNCT03680378Phase 1
• Pharmacokinetics of Cefepime and AAI101 in Subjects With Renal Insufficiency and Healthy SubjectsCompletedNCT03680352Phase 1
• Study the Efficacy of Topical Antibiotherapy in the Prophylaxis of Incisional Surgical Infection in Colorectal SurgeryCompletedNCT03574090Phase 4
• Evaluate Effects of Meropenem-Vaborbactam on QT/QTc in Healthy VolunteersCompletedNCT03564158Phase 1
• Noninferiority Comparison of Prophylactic Open Fracture Antimicrobial RegimensTerminatedNCT03560232Phase 4
• Role of Antibiotics Post TonsillectomyStatus unknownNCT03491085Phase 1/2
• A Crossover Study to Assess the Effect of Intravenous Infusion of Piperacillin/Tazobactam on the Pharmacokinetics of Orally Administered Lumicitabine (JNJ-64041575) in Healthy Adult ParticipantsCompletedNCT03441529Phase 1
• Comparative Study of Levonadifloxacin (IV and Oral) With Linezolid (IV and Oral) in Acute Bacterial Skin and Skin Structure Infections (ABSSSI)CompletedNCT03405064Phase 3
• Phase 1 Study of Safety, Tolerability and Pharmacokinetics of SPR994CompletedNCT03395249Phase 1
• Study to Determine and Compare Plasma and Intrapulmonary Concentrations of ETX2514 and Sulbactam in Healthy SubjectsCompletedNCT03303924Phase 1
• Comparing Efficacy of Postoperative Oral Antibiotic Use in Trans-Oral ThyroidectomyStatus unknownNCT03295955Not applicable
• Reduction of Intravenous Antibiotics In NeonatesCompletedNCT03247920Phase 4

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