Adapalene clinical trials
Counted the way a researcher would: Adapalene with its salts, dosage forms, brands and biosimilars. Looking for a trial to join? Including related medicines shows more you could take part in.
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How each study uses Adapalene is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
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A study of drug A after surgery for early breast cancer
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Approvals
The first approval found in each region, with its record
- United States
- 31 May 1996 · DIFFERIN · NDA 020338 (FDA, Drugs@FDA)
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
40 studies that test it; most in 2010 (5)
| Year | Studies |
|---|---|
| 2004 | 2 |
| 2006 | 3 |
| 2007 | 2 |
| 2008 | 4 |
| 2009 | 2 |
| 2010 | 5 |
| 2011 | 4 |
| 2013 | 1 |
| 2014 | 1 |
| 2015 | 2 |
| 2016 | 2 |
| 2017 | 1 |
| 2018 | 1 |
| 2019 | 1 |
| 2020 | 2 |
| 2022 | 2 |
| 2024 | 3 |
| 2025 | 1 |
| 2026 | 1 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 31 · Other 9
Galderma R&D (14) · Taro Pharmaceuticals USA (2) · Stiefel, a GSK Company (2) · Allergan (2) · Bausch Health Americas, Inc. (2) · Actavis Mid-Atlantic LLC (2) · Wake Forest University Health Sciences (1) · Treatment and Diagnostic Center of Private Enterprise "Asklepiy" (1)
Often tested with
Tested in the same studies.
Benzoyl Peroxide (9) · Tretinoin (5) · Clindamycin (3) · Clindamycin phosphate (1) · Lactobacillus rhamnosus (1) · Chiro-inositol, (+)- (1) · Inulin (1) · Salicylic Acid (1)
Related medicines
As reviewed, each with the page that says it.
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Reaching primary completion within a year · 1
Studies that test Adapalene.
- Nov 2026Adapalene Gel for Acute Radiation-Induced Skin InjuryEarly Phase 1 · Yunnan Cancer Hospital
Studies
Open first, then newest update. How each study uses Adapalene is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 40
- Adapalene Gel for Acute Radiation-Induced Skin InjuryRecruitingEarly Phase 1Yunnan Cancer HospitalNCT07886320Written as Adapalene gel 0.1%
- Comparison of Efficacy of Topical Adaplene Gel Versus Crythotherapy in Recurrent Plantar WartsRecruitingPhase 4Khyber Teaching HospitalNCT07016360Written as Topical Adapalene Gel 0.1%
- Auricular Acupressure Combined With Adapalene for the Treatment of Acne VulgarisCompletedNot applicableUniversity of Medicine and Pharmacy at Ho Chi Minh CityNCT07348978Written as Adapalene 0.1% Gel
- Experience With Topical Acne TreatmentActive, not recruitingEarly Phase 1Wake Forest University Health SciencesNCT05582434Written as adapalene 0.3%/BPO 2.5% gel and compounded clindamycin phosphate 1.2% gel
- Efficacy, Safety Profile, and Post-Acne Sequelae of 0.025% Retinoic Acid Cream vs. 0.1% Adapalene Cream in Mild Acne Vulgaris in Fitzpatrick Skin Types III-VCompletedPhase 1/2Indonesia UniversityNCT07015931Written as adapalene cream 0.1%
- Study to Demonstrate the Efficacy and Safety of Adapalene/Benzoyl Peroxide Topical Gel in Subjects With Acne VulgarisCompletedPhase 3Galderma R&DNCT00422240Written as Adapalene/Benzoyl Peroxide
- A Clinical Trial to Evaluate the Efficacy of Two Acne TreatmentsCompletedPhase 4Galderma R&DNCT02755545Written as Product A
- Long-term Study of Efficacy/Safety of Adapalene/Benzoyl Peroxide Topical Gel in Acne Vulgaris SubjectsCompletedPhase 3Galderma R&DNCT00446043Written as Adapalene/Benzoyl Peroxide
- "A Comparative Clinical Evaluation of the Efficacy of Topical Adapalene, Benzoyl Peroxide Gel, Oral Lactobacillus Rhamnosus, D-chiro-inositol, Inulin Capsule, and Their Fixed Combination in Mild to Moderate Acne Vulgaris Patients."Active, not recruitingNot applicableTreatment and Diagnostic Center of Private Enterprise "Asklepiy"NCT05855629Written as Topical Adapalene, Benzoyl Peroxide Gel
- Plantar Wart Treatment Using Adapalene GelWithdrawnEarly Phase 1University of LouisvilleNCT04823845Written as Topical Adapalene Gel 0.1%
- A Treatment for Severe Inflammatory Acne SubjectsCompletedPhase 4Galderma R&DNCT02899000Written as Adapalene 0.3% / benzoyl peroxide 2.5% emulsion gel
- Tolerability Comparison Between Differin® Cream 0.1% Versus Differin® Lotion 0.1% in Subjects With Healthy SkinCompletedPhase 1Galderma R&DNCT01046565Written as adapalene cream 0.1%
- Tolerability Comparison of Differin® Cream 0.1% Versus Differin® Lotion 0.1% in Subjects With Healthy SkinCompletedPhase 1Galderma R&DNCT01046396Written as adapalene cream 0.1% and adapalene lotion 0.1%
- Assessment of Subjects' Efficacy and Experiences Using Adapalene BPO Gel in the Treatment of Acne VulgarisCompletedPhase 4Galderma R&DNCT01209949Written as Adapalene 0.1% and Benzoyl Peroxide 2.5% gel
- Adapalene Gel 0.3% Versus Tretinoin 0.05% Emollient Cream for Treatment of PhotodamageCompletedPhase 3Galderma R&DNCT00647556Written as adapalene gel, 0.3%
- Comparative Safety and Bioequivalence of Two Treatments in the Treatment of Acne VulgarisCompletedPhase 3Padagis LLCNCT02525549Written as Adapalene and Benzoyl Peroxide Gel
- A Study Comparing Adapalene Gel 0.1% and to Differin Gel in the Treatment of Acne VulgarisCompletedEarly Phase 1Taro Pharmaceuticals USANCT04797793Written as Adapalene Gel 0.1%
- Subject Reported Outcomes With Use of Adapalene 0.3% - Benzoyl Peroxide (BPO) 2.5% in Dark Skin AcneCompletedPhase 3Galderma R&DNCT02932267Written as Adapalene 0.3% / BPO 2.5% gel
- Epiduo Pediatric Acne StudyCompletedPhase 4Galderma R&DNCT01138735Written as adapalene/benzoyl peroxide
- Adapalene-Benzoy Peroxide (BPO) Gel in the Treatment of Acne Vulgaris as a 6-month MaintenanceCompletedPhase 3Galderma R&DNCT00687908Written as Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel
See all 40 studies that test Adapalene →
Given beside what is tested · 5 — Adapalene is usual care or a partner of the new treatment
- Clascoterone Versus Clindamycin Added to Adapalene/Benzoyl Peroxide for Moderate Facial AcneNot yet recruitingPhase 4Allied Hospital FaisalabadNCT07881315Written as Adapalene 0.1%/benzoyl peroxide 2.5% gel
- Vitamin D Supplementation in AcneCompletedNot applicableHITEC-Institute of Medical SciencesNCT06141330Written as Adapalene
- Analysis of Adherence in Subjects Undergoing Differin Gel, 0.1% Treatment of Moderate to Severe Acne VulgarisCompletedPhase 4Wake Forest UniversityNCT00696449Written as Adapalene
- Efficacy and Tolerability of Nicotinamide Plus Cream for Moderate Acne Vulgaris in IndonesiaCompletedPhase 4Rumah Sakit Pusat Angkatan Darat Gatot SoebrotoNCT03626298Written as Adapalene
- Low Glycemic Index and Load Diet for the Treatment of AcneCompletedNot applicableCentro Dermatológico Dr. Ladislao de la PascuaNCT03585140Written as Adapalene 0.1% Gel
As the comparator · 12 — what is tested is compared with Adapalene
- Comparison of Topical Clascoterone 1% Cream Versus Adapalene 0.1% Cream in the Treatment of Mild-to-Moderate Acne VulgarisRecruitingNot applicablePak Emirates Military HospitalNCT07883538Written as Adapalene 0.1% cream
- Radiofrequency Treatment Versus Topical Therapy for Facial Acne VulgarisRecruitingNot applicableJeisys Medical IncNCT07805655Written as Adapalene 0.1% and Benzoyl Peroxide 2.5% gel
- Topical 5% Spironolactone Gel Versus 0.1% Adapalene Gel for Acne Vulgaris: A Randomized Split-Face StudyNot yet recruitingPhase 2Assiut UniversityNCT07473895Written as Adapalene 0.1% Topical Gel
- MC RCT - BPO vs AdapaleneWithdrawnPhase 3University of OklahomaNCT05536882Written as Adapalene Gel
- A Study to Evaluate the Efficacy and Safety of Adapalene-Clindamycin Combination Gel in the Treatment of Acne VulgarisCompletedPhase 3Lee's Pharmaceutical LimitedNCT03615768Written as Adapalene Gel
- Efficacy and Safety Study of GK530G Versus CD0271 0.1% Gel and CD1579 2.5% Gel in the Treatment of Acne Vulgaris.CompletedPhase 3Galderma R&DNCT02073448Written as CD0271
- Tazarotene Plus Clindamycin vs. Adapalene Plus Clindamycin in the Treatment of Facial Acne VulgarisCompletedPhase 4All India Institute of Medical Sciences, BhubaneswarNCT02721173Written as Adapalene 0.1% gel plus clindamycin 1% gel
- A Comparative Study of the Tolerability of Two Combination Therapies for the Treatment of AcneCompletedPhase 4Stiefel, a GSK CompanyNCT00887484Written as BENZOYL PEROXIDE/ ADAPALENE
- A Study to Evaluate Tolerability of Two Topical Drug Products in the Treatment of Facial AcneCompletedPhase 4Stiefel, a GSK CompanyNCT00964223Written as benzoyl peroxide and adapalene gel (EPIDUO™ Gel)
- Study for Long-term Treatment of Acne Vulgaris With Skinoren Versus DifferinCompletedPhase 4University of MagdeburgNCT01387048Written as differin
- Pharmacokinetics Study of Dapsone-Adapalene Fixed Combination Gel in AcneWithdrawnPhase 1AllerganNCT01425320Written as adapalene 0.3% gel
- Evaluation of Quality of Life, Efficacy, and Tolerance of Duac® Gel Compared to Differin® Gel in the Treatment of AcneCompletedPhase 4Stiefel, a GSK CompanyNCT00807014Written as Differin gel
What changed recently
From the registry's own updates since Oct 15, 2026.
Newly registered1
- Adapalene Gel for Acute Radiation-Induced Skin InjuryOct 21, 2026NCT07886320
Codes
What other systems call Adapalene · ClinicalTrials.gg INT006544
- MeSH (NLM) D000068816AdapaleneConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 1L4806J2QFADAPALENEConfirmed FDA, NLM, Wikidata
- RxNorm 60223Confirmed FDA, Wikidata
- Wikidata Q352348adapaleneConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C28989AdapaleneOne source FDA
- DrugBank DB00210One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D000068816 | Adapalene | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 1L4806J2QF | ADAPALENE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 60223 | — | Confirmed FDA, Wikidata |
| Wikidata | Q352348 | adapalene | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C28989 | Adapalene | One source FDA |
| DrugBank | DB00210 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.