Severe Combined Immunodeficiency: all 65 studies
Page 1 of 1. Open to participants first (16), then studies with results posted, then the rest; newest registration first within each.
- 25BT056: Basket Study of Viral Cytotoxic T LymphocytesNot yet recruitingNCT07873970Early Phase 1
- Follow-up of the Cohort of Newborns Screened at Birth Using TREC AnalysisNot yet recruitingNCT07704281
- Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)RecruitingNCT07284641Phase 2
- Expanded Access to CD34+ Selection Utilizing Miltenyi CliniMACS Prodigy® for Patients Receiving Peripheral Blood Stem Cell Transplantations and Stem Cell BoostsAvailableNCT06731036
- The Experience of Screening for SCIDRecruitingNCT05651113
- Safety and Efficacy Study of Transplantation of Autologous CD34+ Cells Transduced With the G2ARTE Lentiviral Vector Expressing the DCLRE1C cDNA in Artemis (DCLRE1C) Deficient Severe Combined Immunodeficiency Patients (ARTEGENE)RecruitingNCT05071222Phase 1/2
- Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RICRecruitingNCT04528355
- Gene Therapy for X Linked Severe Combined ImmunodeficiencyRecruitingNCT04286815Not applicable
- An Observational LTFU Study for Patients Previously Treated With Autologous ex Vivo Gene Therapy for ADA-SCIDEnrolling by invitationNCT04049084
- Lentiviral Gene Therapy for X-linked Severe Combined ImmunodeficiencyRecruitingNCT03601286Phase 1
- Autologous Gene Therapy for Artemis-Deficient SCIDRecruitingNCT03538899Phase 1/2
- Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCTRecruitingNCT01962415Phase 2
- Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency DiseasesEnrolling by invitationNCT01852370Phase 1/2
- Natural History Study of SCID DisordersEnrolling by invitationNCT01186913
- Establishing Fibroblast-Derived Cell Lines From Skin Biopsies of Patients With Immunodeficiency or Immunodysregulation DisordersEnrolling by invitationNCT00895271
- Genetic Basis of ImmunodeficiencyRecruitingNCT00055172
- Registry Study of Revcovi Treatment in Patients With ADA-SCIDCompletedNCT03878069Results posted
- Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell TransplantationCompletedNCT03513328Phase 1/2Results posted
- SCID Bu/Flu/ATG Study With T Cell DepletionTerminatedNCT02127892Phase 1/2Results posted
- Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic MalignanciesCompletedNCT01529827Phase 2Results posted
- EZN-2279 in Patients With ADA-SCIDCompletedNCT01420627Phase 3Results posted
- Lentiviral (LV) Gene Therapy for Adenosine Deaminase (ADA) DeficiencyCompletedNCT01380990Phase 1/2Results posted
- Hematopoietic Stem Cell Transplantation (HSCT) for Children With SCID Utilizing Alemtuzumab, Plerixafor & FilgrastimTerminatedNCT01182675Phase 2Results posted
- Gene Transfer for Severe Combined Immunodeficiency, X-linked (SCID-X1) Using a Self-inactivating (SIN) Gammaretroviral VectorCompletedNCT01129544Phase 1/2Results posted
- MND-ADA Transduction of CD34+ Cells From Children With ADA-SCIDCompletedNCT00794508Phase 2Results posted
- Allogeneic SCT Of Pts With SCID And Other Primary Immunodeficiency DisordersTerminatedNCT00579137Phase 1/2Results posted
- Treatment for Growth Failure in Patients With X-Linked Severe Combined Immunodeficiency: Phase 2 Study of Insulin-Like Growth Factor-1TerminatedNCT00490100Phase 1/2Results posted
- Study of Populations at Risk of Developing Chronic Hepatitis Linked to Chronic Enteric Virus Infection in Patients With Primary Immunodeficiency and Secondary Humoral DeficiencyCompletedNCT06659588
- Baby Detect : Genomic Newborn ScreeningCompletedNCT05687474
- Feasibility Study to Assess an Adapted Physical Activity Program in Children, Adolescents and Young Adults Requiring Hematopoietic Stem Cell TransplantationCompletedNCT05298930Not applicable
- Methodology Study of Retroviral Insertion Site Analysis in Strimvelis Gene TherapyActive, not recruitingNCT04959890
- Matched Related and Unrelated Donor Stem Cell Transplantation for Severe Combined Immune Deficiency (SCID): Busulfan-based Conditioning With h-ATG, Radiation, and SirolimusWithdrawnNCT04370795Phase 1/2
- A Study to Assess a Physical Activity Program in Children, Adolescents and Young Adults Requiring Hematopoietic Stem Cell AllograftsWithdrawnNCT04331483Not applicable
- Study Through Imaging of Visceral Lymphoid Organs in Patients With SCID Who Have Recieved Bone Marrow AllograftCompletedNCT04246840
- Multi-center Clinical Study of Cord Blood Stem Cell Transplantation for SCIDStatus unknownNCT04172181
- A Clinical Study to Enable Process Validation of Commercial Grade OTL-101WithdrawnNCT04140539Phase 2/3
- Efficacy and Safety of the Cryopreserved Formulation of OTL-101 in Subjects With ADA-SCIDCompletedNCT03765632Phase 1/2
- Haplocompatible Transplant Using TCRα/β Depletion Followed by CD45RA-Depleted Donor Lymphocyte Infusions for Severe Combined Immunodeficiency (SCID)Active, not recruitingNCT03597594Phase 1/2
- Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age With X-Linked Severe Combined ImmunodeficiencyStatus unknownNCT03315078Phase 1/2
- Evaluating the Effectiveness of STRIMVELIS Risk Minimization Measures (RMMs)CompletedNCT03232203
- Safety and Early Efficacy Study of TBX-1400 in Patients With Severe Combined ImmunodeficiencyStatus unknownNCT02860559Phase 1
- Neonatal Screening of Severe Combined ImmunodeficienciesCompletedNCT02590328
- Generalized Neonatal Screening of Severe Combined ImmunodeficienciesCompletedNCT02244450Not applicable
- Clinical Characteristics and Genetic Profiles of Severe Combined Immunodeficiency in ChinaStatus unknownNCT02231983
- Sirolimus Prophylaxis for aGVHD in TME SCIDWithdrawnNCT02177760Phase 2
- Immune Disorder HSCT ProtocolActive, not recruitingNCT01821781Phase 2
- Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune DeficienciesActive, not recruitingNCT01652092Not applicable
- Patients Treated for SCID (1968-Present)Status unknownNCT01346150
- Gene Therapy ADA DeficiencyCompletedNCT01279720Phase 1/2
- Quality of Life and Neuropsychiatric Sequelae in Patients Treated With Gene Therapy for ADA-SCID and in Their ParentsWithdrawnNCT01182857
- Gene Therapy for X-linked Severe Combined Immunodeficiency (SCID-X1)Status unknownNCT01175239Not applicable
- Risk-Adapted Allogeneic Stem Cell Transplantation For Mixed Donor Chimerism In Patients With Non-Malignant DiseasesCompletedNCT01019876Phase 2/3
- Newborn Screening for Severe Combined Immunodeficiency (SCID) in a High-Risk PopulationCompletedNCT00845416
- Long Term Follow Up Of Patients Who Have Received Gene Therapy Or Gene Marked ProductsCompletedNCT00695279
- Gene Therapy for ADA-SCIDCompletedNCT00599781Phase 1/2
- IMM 0212: Busulfan With Fludarabine and Antithymocyte Globulin as Preparative Therapy for Hematopoietic Stem Cell Transplant for the Treatment of Severe Congenital T-Cell ImmunodeficiencyCompletedNCT00228852Phase 1/2
- Rapid Infusion of Immune Globulin Intravenous (Human) In Primary Immunodeficiency PatientsCompletedNCT00220766Phase 3
- Transplantation of Hematopoietic Cells in Children With Severe Combined Immunodeficiency SyndromeCompletedNCT00152100Phase 1
- Stem Cell Gene Therapy to Treat X-Linked Severe Combined Immunodeficiency (XSCID)CompletedNCT00028236Phase 1
- Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) DeficiencyCompletedNCT00018018Phase 1
- Total-Body Irradiation Followed By Cyclosporine and Mycophenolate Mofetil in Treating Patients With Severe Combined Immunodeficiency Undergoing Donor Bone Marrow TransplantCompletedNCT00008450Phase 1
- Influences on Female Adolescents' Decisions Regarding Testing for Carrier Status of XSCIDCompletedNCT00006335
- Allogeneic Bone Marrow Transplantation in Patients With Primary ImmunodeficienciesTerminatedNCT00006054Not applicable
- Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) Deficiency: A Natural History StudyCompletedNCT00001255
- Cord Blood Stem Cell Transplantation Study (COBLT)CompletedNCT00000603Phase 2