An observational study in Severe Combined Immunodeficiency, sponsored by Association Pour l'Aide a la Recherche en Immunologie Pediatrique. Completed at 1 site in France. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-07-22.
Sponsored by Association Pour l'Aide a la Recherche en Immunologie Pediatrique · Observational
To investigate the presence of seconday of lymphoid organs in patients who underwent allogenic hematopoietic stem cell transplantation 15 to 45 years ago.
The goal aims to assess the development of seconday lymphoid organs given the fact that the absence of myeloablation these patients present a split chimerism between T lymphocytes and the other leucocytes. Thus, they may not be able to generate seconday lymphoid organs. Practically, whole body MRI is being used to visualise and quantify both mediastinal and intraabdominal lymph nodes. Delta will be compared with those obtained in healthy age-matched individuals. It is scheduled to include 15 patients and 15 controls.
64 studies on the registry are indexed under Severe Combined Immunodeficiency; 15 are open to participants now.
This study's enrollment of 18 is below the median of 70 across 21 observational studies indexed under Severe Combined Immunodeficiency.
Browse Severe Combined Immunodeficiency studies →This is the only study on the registry with Association Pour l'Aide a la Recherche en Immunologie Pediatrique as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Patients with SCID transplanted 15-45 years ago and healthy conrtrols
Exclusion Criteria:
15 adult patients who underwent allogenic hematopoietic stem cell transplantation (HSCT) for severe combined immunodeficieny 15 to 45 years ago
15 age-matched healthy individuals
Size of mediastinal and intraabdominal lymph nodes
analysis by MRI
Time frame: 1 year
This study is completed, as verified in Jul 2021. You cannot join it, but the record below documents what was studied.
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Severe Combined Immunodeficiency→