Prostatic Neoplasms, Castration-Resistant clinical trials
The registry lists 85 studies for Prostatic Neoplasms, Castration-Resistant across more than 10 countries. 28 are recruiting or about to start. 73 of them are mainly about Prostatic Neoplasms, Castration-Resistant (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
Get an email when these change. Save the Prostatic Neoplasms, Castration-Resistant studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
Janssen Research & Development, LLC (8) · Bayer (7) · Novartis Pharmaceuticals (6) · MacroGenics (4) · Nuvation Bio Inc. (3) · Michael Graham PhD, MD (3) · Hoffmann-La Roche (2) · Radboud University Medical Center (2)
What is being tested here
Drugs under test in Prostatic Neoplasms, Castration-Resistant studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Drug classes tested here Antiandrogens 2 open · Immune checkpoint inhibitors 7 · Antimitotic agents 5
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2027A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer · Phase 3 · Janssen Research & Development, LLC
- Jan 2027Study of 225Ac-PSMA-617 in Men With PSMA-positive Prostate Cancer · Endocyte
- Jan 2027Pluvicto Real-world Investigation in Survival in Metastatic CRPC · Novartis Pharmaceuticals
- Apr 2027Local Ablative Radiotherapy for OLIgoprogressive Castration Resistant Prostate Cancer · Technische Universität Dresden
- May 2027A Study of Real-World Characteristics, Treatment Patterns, and Clinical Outcomes in Patients With Metastatic Castration-Resistant Prostate Cancer · Novartis Pharmaceuticals
- May 2027A Study of Real-World Characteristics, Treatment Patterns, and Outcomes Among mCRPC Patients Previously Treated With an Androgen Receptor Pathway Inhibitor, Taxane-Based Chemotherapy, and Lutetium-177 Vipivotide Tetraxetan · Novartis Pharmaceuticals
- Jul 2027Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01) · Janux Therapeutics
- Jul 2027A Study of JSB462 (Luxdegalutamide) Plus Lutetium (177Lu) Vipivotide Tetraxetan in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC) · Novartis Pharmaceuticals
- Sep 2027Safety, Pharmacokinetics, and Preliminary Efficacy of VIR-5500 (AMX-500) in Prostate Cancer · Astellas Pharma Global Development, Inc.
- Nov 202718F-Fluciclovine PET/CT Impact on Predicting Clinical Outcome of 177Lu-PSMA-617 Therapy in Patients With Prostate Cancer · VA Greater Los Angeles Healthcare System
Who these studies take
Of the 25 Prostatic Neoplasms, Castration-Resistant studies recruiting now, 22 (88%) set no upper age limit and 0 (0%) stop at 75 or younger. 1 (4%) take children under 18. 0 (0%) are for women only and 20 (80%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 1 (4%) |
| 18 | 5 (20%) | 25 (100%) |
| 30 | 5 (20%) | 25 (100%) |
| 40 | 5 (20%) | 25 (100%) |
| 50 | 5 (20%) | 25 (100%) |
| 65 | 5 (20%) | 25 (100%) |
| 75 | 5 (20%) | 25 (100%) |
| 85 | 5 (20%) | 25 (100%) |
Across all 85 studies, recruiting or not: 0% stop at 75 or younger and 0% at 65; 6% take children; 0% are for women only and 82% for men only; 0% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- Pluvicto Real-world Investigation in Survival in Metastatic CRPCOct 30, 2026NCT07697989
Studies
Recruiting first, then most recently updated. Showing 50 of 85. Browse all 85 → or search them.
- A Rollover Study for Continued Study Treatment and Ongoing Safety MonitoringEnrolling by invitationNCT06788509Phase 115 countries
- A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate CancerRecruitingNCT07225946Phase 317 countries
- A Study of Pasritamig With or Without JNJ-87189401 Versus Placebo for Late Line Metastatic Castration-resistant Prostate Cancer (mCRPC)RecruitingNCT07164443Phase 317 countries
- Pluvicto Real-world Investigation in Survival in Metastatic CRPCRecruitingNCT076979891 country
- Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)RecruitingNCT05519449Phase 13 countries
- A Study of MGC026 in Participants With Advanced Solid TumorsRecruitingNCT06242470Phase 13 countries
- Safety, Pharmacokinetics, and Preliminary Efficacy of VIR-5500 (AMX-500) in Prostate CancerRecruitingNCT05997615Phase 14 countries
- A Study of Real-World Characteristics, Treatment Patterns, and Clinical Outcomes in Patients With Metastatic Castration-Resistant Prostate CancerRecruitingNCT076772541 country
- A Study of Real-World Characteristics, Treatment Patterns, and Outcomes Among mCRPC Patients Previously Treated With an Androgen Receptor Pathway Inhibitor, Taxane-Based Chemotherapy, and Lutetium-177 Vipivotide TetraxetanRecruitingNCT076772671 country
- Predictive Factors for Response to Lutetium-177 PSMA Radioligand Therapy in Patients With Metastatic Castration-Resistant Prostate CancerRecruitingNCT078639861 country
- A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)RecruitingNCT06863272Phase 1/219 countries
- HTL0039732 in Participants With Advanced Solid TumoursRecruitingNCT05944237Phase 1/21 country
- A Study in Patients With Metastatic Castration-Resistant Prostate CancerRecruitingNCT07719361Phase 11 country
- A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and LymphomasRecruitingNCT04104776Phase 1/27 countries
- A Study to Assess BMS-986460 in Participants With Metastatic Castration-resistant Prostate CancerRecruitingNCT06067841Phase 13 countries
- Fractionated Stereotactic Radiotherapy Plus Second-generation Antiandrogen for Oligometastatic Castration-resistant Prostate Cancer Patients.RecruitingNCT07717268Phase 21 country
- A Clinical Trial Evaluating the Safety of TD001 In Patients With PSMA-Expressing Metastatic Prostate CancerRecruitingNCT07258407Phase 1/25 countries
- Impact of Body Composition on Dosimetry of 177Lu-PSMA Radioligand TherapyNot yet recruitingNCT07587814Not applicable1 country
- 64Cu-SAR-bisPSMA and 67Cu-SAR-bisPSMA for Identification and Treatment of PSMA-expressing Metastatic Castrate Resistant Prostate Cancer (SECuRE)RecruitingNCT04868604Phase 1/21 country
- Fatty Acid Synthase Inhibition in Castration Refractory Prostate CancerRecruitingNCT04337580Phase 21 country
- Gedatolisib in Combination With Darolutamide in Metastatic Castration-Resistant Prostate CancerRecruitingNCT06190899Phase 1/24 countries
- Development and Prospective Validation of a Pathology-Based Artificial Intelligence Model for Predicting the Time to Castration Resistance of Prostate CancerNot yet recruitingNCT073760571 country
- Treatment With Darolutamide +/- Radiation Therapy for Patients With a Castration Resistant Cancer and Metastases Detected by Functional ImagingRecruitingNCT06276465Phase 31 country
- The Bispecific PSMAxCD3 Antibody CC-1 in Patients with Castration Resistant Prostate CarcinomaRecruitingNCT04104607Phase 11 country
- 18F-Fluciclovine PET/CT Impact on Predicting Clinical Outcome of 177Lu-PSMA-617 Therapy in Patients With Prostate CancerRecruitingNCT06706921Phase 41 country
- Phase II Randomised Controlled Trial of Patient-specific Adaptive vs. Continuous Abiraterone or eNZalutamide in mCRPCRecruitingNCT05393791Phase 22 countries
- Actium-225-Prostate Specific Membrane Antigen Imaging & TherapyRecruitingNCT05902247Phase 11 country
- Prospective REgistry of Targeted RadionucLide TherapY in Patients With mCRPC (REALITY Study)RecruitingNCT048335171 country
- Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)Active, not recruitingNCT06353386Phase 1/220 countries
- A Study to Evaluate the Effect of Multiple Doses of JNJ-56021927 on the Pharmacokinetics of Multiple Cytochrome P450 and Transporter Substrates in Participants With Castration-Resistant Prostate CancerActive, not recruitingNCT02592317Phase 12 countries
- A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate CancerActive, not recruitingNCT03748641Phase 329 countries
- Study of TVB-2640 in Men With Metastatic Castration-Resistant Prostate CancerActive, not recruitingNCT05743621Phase 11 country
- A Study of JSB462 (Luxdegalutamide) Plus Lutetium (177Lu) Vipivotide Tetraxetan in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC)Active, not recruitingNCT07047118Phase 215 countries
- An External Control Arm Study Comparing Survival Among Metastatic Castration-Resistant Prostate Cancer (mCRPC) Patients Treated With 177Lu-PSMA-617 vs Androgen Receptor Pathway Inhibitor (ARPI) Switch in Routine CareCompletedNCT078437581 country
- A Study of Niraparib Combination Therapies for the Treatment of Metastatic Castration-Resistant Prostate CancerActive, not recruitingNCT03431350Phase 27 countries
- Survival Outcomes in Metastatic Prostate Cancer in the Brazilian Population - Analysis of Individual Characteristics and Treatment Modalities in Different National Health Institutions.CompletedNCT049629191 country
- Local Ablative Radiotherapy for OLIgoprogressive Castration Resistant Prostate CancerActive, not recruitingNCT04141709Not applicable1 country
- A Study of Lorigerlimab With Docetaxel or Docetaxel Alone in Participants With Metastatic Castration-Resistant Prostate CancerCompletedNCT05848011Phase 210 countries
- Study of 225Ac-PSMA-617 in Men With PSMA-positive Prostate CancerActive, not recruitingNCT04597411Phase 12 countries
- A Study to Learn About the Study Medicines Called Enzalutamide and Abiraterone in People With Metastatic Castration-resistant Prostate CancerCompletedNCT059685991 country
- Cognitive Effects of Androgen Receptor Directed Therapies for Advanced Prostate CancerActive, not recruitingNCT03016741Phase 41 country
- A Study of Vobramitamab Duocarmazine in Participants With Metastatic Castration Resistant Prostate Cancer and Other Solid TumorsTerminatedNCT05551117Phase 29 countries
- Ipilimumab With Nivolumab for Molecular-selected Patients With Castration-resistant Prostate CancerCompletedNCT04717154Phase 21 country
- Study to Evaluate the Safety and Tolerability of CC-94676 in Participants With Metastatic Castration-Resistant Prostate CancerCompletedNCT04428788Phase 11 country
- NUV-868 as Monotherapy and in Combination With Olaparib or Enzalutamide in Adult Patients With Advanced Solid TumorsTerminatedNCT05252390Phase 12 countries
- A Study of MGC018 in Combination With MGD019 in Participants With Advanced Solid TumorsCompletedNCT05293496Phase 11 country
- A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid TumoursActive, not recruitingNCT05057013Phase 1/21 country
- Adenosine Receptor Antagonist Combination Therapy for Metastatic Castrate Resistant Prostate CancerCompletedNCT04381832Phase 1/22 countries
- BI836845 Plus Enzalutamide in Castrate Resistant Prostate Cancer (CRPC)CompletedNCT02204072Phase 18 countries
- Drug Use Investigation of Xofigo, Castration Resistant Prostate Cancer With Bone MetastasesCompletedNCT028034371 country