Paraproteinemias clinical trials
The registry lists 69 studies for Paraproteinemias across more than 10 countries. 22 are recruiting or about to start. 14 of them are mainly about Paraproteinemias (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-29. Counting its 6 narrower conditions too, such as Multiple Myeloma: 4,362 studies, 906 open.
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Breast cancer · Recruiting: 2 came in, 3 changed
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A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
Hellenic Society of Hematology (5) · Alexion Pharmaceuticals, Inc. (2) · Zhujiang Hospital (2) · Ohio State University Comprehensive Cancer Center (2) · Seagen Inc. (2) · Pfizer (2) · University Hospital, Brest (2) · Baylor College of Medicine (2)
What is being tested here
Drugs under test in Paraproteinemias studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 8
- Dec 2026This Study Aims to Investigate the Efficacy of Photobiomodulation in the Treatment of Anti-MAG-induced Peripheral Neuropathy (LASER-MAG) · Centre Hospitalier de Cornouaille
- Dec 2026A Study to Evaluate the Safety, PK/PD of (OriCAR-017) in Subjects With RR/MM - RIGEL Study · OriCell Therapeutics Co., Ltd.
- Jan 2027Pilot Trial of Homebound Stem Cell Transplantation · Memorial Sloan Kettering Cancer Center
- Mar 2027A Study to Evaluate a Novel Gene Therapy in Patients With Relapsed and Refractory Multiple Myeloma · Kelonia Therapeutics, Inc.
- Apr 2027Pre-malignant States to Hematologic Malignancies in Firefighters · Wake Forest University Health Sciences
- May 2027Investigating the Pathogenic Role of N-glycosylation in AL Amyloidosis: Molecular Bases, Diagnosis, and Treatment · Fondazione IRCCS Policlinico San Matteo di Pavia
- Jun 2027The Effect of Daratumumab in Patients With Monoclonal Gammopathy of Renal Significance (MGRS) in Finland · Helsinki University Central Hospital
- Sep 2027A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001) · ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)
Who these studies take
Of the 13 Paraproteinemias studies recruiting now, 7 (54%) set no upper age limit and 3 (23%) stop at 75 or younger. 1 (8%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (23%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (8%) | 1 (8%) |
| 18 | 11 (85%) | 11 (85%) |
| 30 | 12 (92%) | 12 (92%) |
| 40 | 13 (100%) | 13 (100%) |
| 50 | 12 (92%) | 12 (92%) |
| 65 | 12 (92%) | 12 (92%) |
| 75 | 12 (92%) | 12 (92%) |
| 85 | 10 (77%) | 10 (77%) |
Across all 69 studies, recruiting or not: 14% stop at 75 or younger and 1% at 65; 12% take children; 0% are for women only and 0% for men only; 7% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 69. Browse all 69 → or search them.
- The Indiana Myeloma RegistryRecruitingNCT036164831 country
- The Effect of Daratumumab in Patients With Monoclonal Gammopathy of Renal Significance (MGRS) in FinlandRecruitingNCT06889948Phase 21 country
- A Study to Evaluate a Novel Gene Therapy in Patients With Relapsed and Refractory Multiple MyelomaRecruitingNCT07075185Phase 12 countries
- Pre-malignant States to Hematologic Malignancies in FirefightersRecruitingNCT068707601 country
- Integrated Cancer Repository for Cancer ResearchRecruitingNCT020126991 country
- This Study Aims to Investigate the Efficacy of Photobiomodulation in the Treatment of Anti-MAG-induced Peripheral Neuropathy (LASER-MAG)Enrolling by invitationNCT076616671 country
- Early Detection of Amyloidosis in Monoclonal Gammopathy Using Nuclear Medicine ImagingNot yet recruitingNCT07624760Not applicable1 country
- Ohio State University Multiple Myeloma and Amyloidosis Data Registry and Sample ResourceRecruitingNCT014082251 country
- Investigating the Pathogenic Role of N-glycosylation in AL Amyloidosis: Molecular Bases, Diagnosis, and TreatmentRecruitingNCT074487791 country
- GammaGA: Prevalence of Acid Sphingomyelinase Deficiency Disease (ASMD) and Gaucher Disease in Patients With Monoclonal Gammopathies and/or Multiple MyelomaRecruitingNCT059925321 country
- Safety and Efficacy of GPRC5D CAR-T Cell Therapy in Relapsed/Refractory Plasma Cell DisordersNot yet recruitingNCT07365059Early Phase 1
- Multi-center Screening for Serum M ProteinNot yet recruitingNCT06750965
- Screening and Therapeutic Monitoring of Multiple Myeloma by MALDI-TOF MS AnalysisRecruitingNCT056864471 country
- Dara-BCD for Rare MGRSNot yet recruitingNCT06771180Phase 2
- BCMA-GPRC5D CAR-T Therapy in Relapsed or Refractory Multiple MyelomaRecruitingNCT06644443Phase 1/21 country
- A Study to Evaluate the Safety, PK/PD of (OriCAR-017) in Subjects With RR/MM - RIGEL StudyRecruitingNCT06271252Phase 11 country
- Screening for Monoclonal Gammopathy in Individuals Undergoing Physical Examinations Using iMS-LC Assay Technology.Not yet recruitingNCT064896131 country
- Autologous Stem Cell Transplantation for Patients With AL AmyloidosisEnrolling by invitationNCT042107911 country
- A Study to Investigate the Safety and Clinical Activity of Belantamab Mafodotin in Combination With Daratumumab, Lenalidomide and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Transplant IneligibleRecruitingNCT05280275Phase 1/21 country
- A Study to Investigate Safety and Clinical Activity of Belantamab Mafodotin in Combination With Lenalidomide, Dexamethasone and Nirogacestat in Patients With Transplant Ineligible Newly Diagnosed Multiple MyelomaRecruitingNCT05573802Phase 1/21 country
- A Study to Investigate the Safety and Clinical Activity of Belantamab Mafodotin in Combination With Daratumumab, Pomalidomide and Dexamethasone in Patients With Relapsed/ Refractory Multiple Myeloma Previously Treated With One Line Therapy Who Are Lenalidomide RefractoryNot yet recruitingNCT05581875Phase 1/2
- A Phase 2 Study of Isatuximab in Combination With Pomalidomide and Dexamethasone in MM Patients Who Received One Prior Line of Therapy Containing Lenalidomide and a Proteasome InhibitorNot yet recruitingNCT05298683Phase 21 country
- A Study of Elranatamab (PF-06863135) in Chinese Participants With Refractory Multiple Myeloma.CompletedNCT05228470Phase 21 country
- Isatuximab in Patients With Monoclonal Gammopathy of Renal SignificanceActive, not recruitingNCT04614558Phase 21 country
- Pilot Trial of Homebound Stem Cell TransplantationActive, not recruitingNCT02671448Not applicable1 country
- A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosis (CARES)Active, not recruitingNCT04504825Phase 319 countries
- A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIa AL Amyloidosis (CARES)Active, not recruitingNCT04512235Phase 319 countries
- A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)Active, not recruitingNCT03162536Phase 1/21 country
- Rifaximin in Patients With Monoclonal GammopathyCompletedNCT03820817Phase 11 country
- Phase II Study of the CD38 Antibody Daratumumab in Patients With High-Risk MGUS and Low-Risk Smoldering Multiple MyelomaActive, not recruitingNCT03236428Phase 21 country
- Study of Iopofosine I-131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) With Expansion in WaldenstromActive, not recruitingNCT02952508Phase 211 countries
- Lenalidomide, Bortezomib and Dexamethasone Induction Therapy With Either Intravenous or Subcutaneous Isatuximab in Patients With Newly Diagnosed Multiple MyelomaCompletedNCT05804032Phase 32 countries
- Plerixafor Harvesting And No Chemotherapy for Transplantation of Autologous STem Cells In Cancer (PHANTASTIC)CompletedNCT01186224Not applicable1 country
- Study of the Efficacy and Safety of RPH-104 in Adult Subjects With Schnitzler SyndromeWithdrawnNCT04213274Phase 21 country
- Monoclonal Gammopathy With Clinical Significance in Patients With and Without Haematological Malignancies in Finistère Between 2012 and 2017 (GammaClinik)CompletedNCT065595791 country
- Effect of AT7519M Alone and AT7519M Plus Bortezomib in Patients With Previously Treated Multiple MyelomaCompletedNCT01183949Phase 1/21 country
- A Study of KW-2478 in Combination With Bortezomib in Subjects With Relapsed and/or Refractory Multiple MyelomaCompletedNCT01063907Phase 1/23 countries
- MGRS: Clinical-histological Features of a Multicenter Case SeriesCompletedNCT051193091 country
- Dendritic Cell DKK1 Vaccine for Monoclonal Gammopathy and Stable or Smoldering MyelomaWithdrawnNCT03591614Early Phase 11 country
- Natural Killer Cell (CYNK-001) Infusions in Adults With Multiple MyelomaStatus unknownNCT04309084Phase 11 country
- Companion for CAR-T Web App During Chimeric Antigen Receptor T-cell TherapyWithdrawnNCT05362331Not applicable
- Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple MyelomaCompletedNCT01345019Phase 329 countries
- Shorter Course Tacro After NMA, Related Donor PBSCT With High-dose Posttransplant Cy for Hard-to-Engraft MalignanciesCompletedNCT02556931Phase 21 country
- A Phase 2 Study of Isatuximab in Combination With Bortezomib, Cyclophosphamide and Dexamethasone Followed by Isatuximab and Lenalidomide Maintenance in Newly Diagnosed Patients With Multiple Myeloma and Severe Renal ImpairmentStatus unknownNCT05147493Phase 21 country
- Study of Epratuzumab (hLL2) in Patients With Waldenstrom's MacroglobulinemiaTerminatedNCT00113802Phase 21 country
- Study of Vorinostat (MK-0683) or Placebo, in Combination With Bortezomib in Participants With Multiple Myeloma (MK-0683-088 AMN)CompletedNCT00773747Phase 3
- A Study of ARRY-520 in Patients With Relapsed or Refractory Multiple MyelomaCompletedNCT00821249Phase 1/21 country
- A Study of ARRY-520 and Bortezomib Plus Dexamethasone in Patients With Relapsed/Refractory Multiple MyelomaCompletedNCT01248923Phase 11 country
- Antigen-Lipid-Driven Monoclonal Gammopathies Targeting Epicardial FatWithdrawnNCT02920190Phase 4
- Frequency and Characteristics of Pruritus in Patients With Monoclonal GammopathyCompletedNCT038321401 country