Osteoradionecrosis clinical trials
The registry lists 24 studies for Osteoradionecrosis across more than 10 countries. 8 are recruiting or about to start. 10 of them are mainly about Osteoradionecrosis (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-07.
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Who runs them
Wake Forest University Health Sciences (3) · M.D. Anderson Cancer Center (2) · Gustave Roussy, Cancer Campus, Grand Paris (1) · Chang Gung Memorial Hospital (1) · National Baromedical Services (1) · University of Manitoba (1) · University of Santiago de Compostela (1) · Radboud University Medical Center (1)
What is being tested here
Drugs under test in Osteoradionecrosis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Sodium Fluoride | 0 | 0 | 1 |
| Pentoxifylline | 0 | 0 | 1 |
| Tocopherols | 0 | 0 | 1 |
| Hyperbaric Oxygen | 0 | 1 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 2
- May 2027Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Diagnosing Osteoradionecrosis in Patients With Head and Neck Cancer That Is Primary, Has Come Back, or Has Spread to Other Places in the Body · M.D. Anderson Cancer Center
- Jul 2027L-PRF in Prevention of ORN and MRONJ Following Tooth Extractions;v3.0 · Swansea Bay University Health Board
Who these studies take
Of the 5 Osteoradionecrosis studies recruiting now, 5 (100%) set no upper age limit and 0 (0%) stop at 75 or younger. 2 (40%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (40%) | 2 (40%) |
| 18 | 5 (100%) | 5 (100%) |
| 30 | 5 (100%) | 5 (100%) |
| 40 | 5 (100%) | 5 (100%) |
| 50 | 5 (100%) | 5 (100%) |
| 65 | 5 (100%) | 5 (100%) |
| 75 | 5 (100%) | 5 (100%) |
| 85 | 5 (100%) | 5 (100%) |
Across all 24 studies, recruiting or not: 4% stop at 75 or younger and 0% at 65; 17% take children; 0% are for women only and 0% for men only; 4% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 24 of 24. search them.
- Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Diagnosing Osteoradionecrosis in Patients With Head and Neck Cancer That Is Primary, Has Come Back, or Has Spread to Other Places in the BodyRecruitingNCT03145077Not applicable1 country
- Platelet-Rich Fibrin for Preventing Osteoradionecrosis After Dental ExtractionsNot yet recruitingNCT07856875Not applicable1 country
- Risk Factors of Jaw Osteoradionecrosis in Oral Cavity Cancer Patients Post-RadiotherapyNot yet recruitingNCT07836829
- Serial Magnetic Resonance Imaging for the Prediction of Radiation-Induced Changes in Normal Tissue of Patients With Oral Cavity or Skull Base TumorsRecruitingNCT04265430Phase 41 country
- L-PRF in Prevention of ORN and MRONJ Following Tooth Extractions;v3.0Not yet recruitingNCT07585123Not applicable1 country
- Combination Therapy: Hyperbaric Oxygen and PENTOCLO for Treatment of Osteoradionecrosis of the MandibleRecruitingNCT06055257Phase 31 country
- Radiation Field, Dose and Fractionation Related to Mandibular ComplicationsRecruitingNCT054128491 country
- Prospective Registry of Prosthodontic Rehabilitation in Oncology Patients Undergoing Jaw ReconstructionRecruitingNCT026611391 country
- Observational Study of Dental Outcomes in Head and Neck Cancer PatientsCompletedNCT020575101 country
- Clinical Registry of Long-Term Dental Outcomes in Head and Neck Cancer PatientsCompletedNCT053259701 country
- Intensive Preventative Dental Program Pilot StudyCompletedNCT07218068Early Phase 11 country
- Efficacy of Hyperbaric Oxygen Therapy in the Treatment of OsteoradionecrosisTerminatedNCT00989820Phase 2/31 country
- Risk for Subsequent Osteoradionecrosis in A Transferred Fibula Flap in Head and Neck Cancer Patients Undergoing Segmental Mandibulectomy: a Cohort StudyCompletedNCT064289941 country
- Photobiomodulation in Oral Lesions Resulting From Anti-neoplastic PreventionCompletedNCT04717765Not applicable1 country
- Osteoradionecrosis Rate in Patients Undergoing Radiotherapy for Head and Neck Cancer Treatment.Status unknownNCT040091611 country
- The Effect of Hyperbaric Oxygen Treatment in Patients With Osteoradionecrosis.Status unknownNCT04934644Not applicable1 country
- USE OF 18FDG PET-CT TO PREDICT THE RESPONSE OF MANDIBULAR OSTEORADIONECROSIS TO THE PENTOCLO PROTOCOL WITH DOCUMENTED ANTIBIOTHERAPYStatus unknownNCT048264451 country
- Osteoradionecrosis and PENTOCLO Protocol: Retrospective StudyCompletedNCT040978471 country
- ORN Study: Curative Treatment of Osteoradionecrosis (ORN) With Hybrid Bone SubstitutionCompletedNCT01147315Not applicable1 country
- Management of Mandibular ORN: PENTO as Medical TreatmentCompletedNCT02368457Phase 41 country
- Saliva, Hyperbaric Oxygen Therapy, & Gland Function: A Prospective StudyWithdrawnNCT015324791 country
- Study to Determine if Hyperbaric Oxygen Therapy is Helpful for Treating Radiation Tissue InjuriesTerminatedNCT00134628Phase 35 countries
- Bisphosphonate-Associated Jaw Osteonecrosis and PET ImagingCompletedNCT005929821 country
- Hyperbaric Oxygen Treatment of Mandibular Osteoradionecrosis. A Randomized Clinical StudyStatus unknownNCT00760682Phase 23 countries