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Osteogenesis Imperfecta clinical trials

The registry lists 84 studies for Osteogenesis Imperfecta across more than 10 countries. 20 are recruiting or about to start. 78 of them are mainly about Osteogenesis Imperfecta (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-04.

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Status

Completed
43
Recruiting
14
Active, not recruiting
11
Terminated
6
Not yet recruiting
5
Status unknown
3

Phase

Phase 2
15
Phase 1
11
Phase 3
11
Phase 4
6

Where

United States
38
France
16
Canada
15
Italy
14
United Kingdom
10
Germany
9

Who runs them

Ultragenyx Pharmaceutical Inc (7) · Baylor College of Medicine (6) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (5) · Istituto Ortopedico Rizzoli (5) · Amgen (5) · Assiut University (4) · St. Jude Children's Research Hospital (3) · IRCCS Eugenio Medea (2)

What is being tested here

Drugs under test in Osteogenesis Imperfecta studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Humanized bispecific antibody neutralizing both sclerostin AND DICKKOPF-1 (AGA-2115)203
Risedronic Acid113
Setrusumab037
Zoledronic Acid015
Teriparatide003
Pamidronate013
Denosumab023
Romosozumab012
Alendronate002
Fresolimumab001

Coming up

5phase 3 studies under way
10studies finish main data collection within a year2 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 10, phase 3 first

Who these studies take

Of the 14 Osteogenesis Imperfecta studies recruiting now, 4 (29%) set no upper age limit and 8 (57%) stop at 75 or younger. 12 (86%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (14%) take healthy volunteers.

Recruiting studies that take each age, of 14
AgeWomenMen
1010 (71%)10 (71%)
1813 (93%)13 (93%)
309 (64%)9 (64%)
409 (64%)9 (64%)
509 (64%)9 (64%)
659 (64%)9 (64%)
758 (57%)8 (57%)
855 (36%)5 (36%)

Across all 84 studies, recruiting or not: 65% stop at 75 or younger and 58% at 65; 81% take children; 1% are for women only and 1% for men only; 14% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Osteogenesis Imperfecta studies take

Of 17 interventional studies with no phase under Osteogenesis Imperfecta, half reached primary completion within 22 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Interventional, no phase22 mo15–35 · 17 studies——

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

Studies

Recruiting first, then most recently updated. Showing 50 of 84. Browse all 84 → or search them.