Onychomycosis clinical trials
The registry lists 158 studies for Onychomycosis across more than 10 countries. 16 are recruiting or about to start. 153 of them are mainly about Onychomycosis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Who runs them
Pfizer (11) · Moberg Pharma AB (7) · Erchonia Corporation (6) · Oystershell NV (5) · Mahidol University (4) · Stiefel, a GSK Company (4) · Galderma R&D (4) · Dow Pharmaceutical Sciences (3)
What is being tested here
Drugs under test in Onychomycosis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4
- Dec 2026URGO MICKAEL Filmogel, Topical Treatment of Onychomycosis · CEN Biotech
- Apr 2027In Vitro Susceptibility of Dermatophytes to Terbinafine and Itraconazole: MIC Distributions and Elevated-MIC Isolates in Faisalabad, Pakistan · Dr. Amara Safdar
- Jun 2027Photodynamic Therapy For Onychomycosis · The University of Texas Health Science Center, Houston
- Oct 2027Systemic Antifungal Plus Q-Switched Nd:YAG Laser for Onychomycosis · Assiut University
Who these studies take
Of the 9 Onychomycosis studies recruiting now, 3 (33%) set no upper age limit and 5 (56%) stop at 75 or younger. 1 (11%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (22%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (11%) | 1 (11%) |
| 18 | 9 (100%) | 9 (100%) |
| 30 | 9 (100%) | 9 (100%) |
| 40 | 9 (100%) | 9 (100%) |
| 50 | 9 (100%) | 9 (100%) |
| 65 | 8 (89%) | 8 (89%) |
| 75 | 4 (44%) | 4 (44%) |
| 85 | 4 (44%) | 4 (44%) |
Across all 158 studies, recruiting or not: 58% stop at 75 or younger and 25% at 65; 11% take children; 2% are for women only and 0% for men only; 19% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Onychomycosis studies take
Of 16 phase 2 interventional studies under Onychomycosis, half reached primary completion within 20 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 20 mo14–22 · 16 studies | — | — |
| Interventional, no phase | 13 mo7–18 · 21 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered2
Studies
Recruiting first, then most recently updated. Showing 50 of 158. Browse all 158 → or search them.
- Safety and Efficacy Study of SKX-16 in Participants With Mild to Moderate Distal Subungual OnychomycosisNot yet recruitingNCT07929844Phase 21 country
- In Vitro Susceptibility of Dermatophytes to Terbinafine and Itraconazole: MIC Distributions and Elevated-MIC Isolates in Faisalabad, PakistanRecruitingNCT078984751 country
- Systemic Antifungal Plus Q-Switched Nd:YAG Laser for OnychomycosisNot yet recruitingNCT07869706Not applicable
- URGO MICKAEL Filmogel, Topical Treatment of OnychomycosisRecruitingNCT07828184Not applicable1 country
- Isotretinoin Versus Excimer Light an Adjuvant in Treating OnychomycosisRecruitingNCT06485505Phase 11 country
- A Phase 2 Study to Assess the Effectiveness of Topical Terbinafine in Participants With Mild to Moderate Onychomycosis of the ToenailsNot yet recruitingNCT07382427Phase 2
- CLINICAL INVESTIGATION FOR THE EVALUATION OF EFFICACY AND SAFETY OF TWO PRODUCTS FOR THE TREATMENT OF ONYCHOMYCOSISRecruitingNCT06689852Not applicable1 country
- Fractional CO₂ Laser or 40% Urea With Topical Fluconazole Microemulsion in OnychomycosisNot yet recruitingNCT07033962Not applicable
- Study in Patients With Onychomycosis Treated With Mycoclear® and CiclopiroxNot yet recruitingNCT069713411 country
- A Study of ATB1651 in Adults With Mild to Moderate OnchomycosisRecruitingNCT06327295Phase 21 country
- Clinical Investigation for the Evaluation of Efficacy and Safety of Two Medical Devices for Onychomycosis TreatmentNot yet recruitingNCT06254027Not applicable
- Evaluation of the Effectiveness of Nail Genesis DLSO Product for OnychomycosisRecruitingNCT06074315Not applicable1 country
- Infrared Bioeffect System for the Treatment of OnychomycosisRecruitingNCT06036654Not applicable1 country
- Combined Fractional CO2 Laser With Topical Tioconazole Versus Q-switched Nd:YAG Laser in the Treatment of Onychomycosis; a Randomized Controlled TrialRecruitingNCT05999474Phase 41 country
- Diode Laser and Photodynamic Therapy Vs. Ciclopirox.Not yet recruitingNCT05809297Phase 4
- Safety and Efficacy of Next Science Gel on Toenail FungusRecruitingNCT04042857Not applicable1 country
- Photodynamic Therapy For OnychomycosisActive, not recruitingNCT07756671Phase 11 country
- Safety and Tolerability Study of SKX-16 in Subjects With Moderate to Severe Distal Subungual OnychomycosisCompletedNCT05110638Phase 11 country
- Evaluation of a Combination of Two Medical Devices and One Device Use in the Treatment of Toenail OnychomycosisCompletedNCT06175013Not applicable1 country
- Comparison of Efficacy and Safety Between Methylene Blue-mediated Photodynamic Therapy and 5% Amorolfine Nail Lacquer for Toenail Onychomycosis TreatmentCompletedNCT03098342Not applicable1 country
- Exploring Different Dose-frequency Home Photodynamic Therapy Protocols Using a Novel Home-targeted LED Device for OnychomycosisActive, not recruitingNCT07012343Not applicable1 country
- Light Therapy for Onychomycosis StudyCompletedNCT05139888Not applicable1 country
- An Open-label Study Evaluating the Effectiveness of CGB-400 Topical Gel for Fungal InfectionCompletedNCT052023661 country
- Safety, Tolerability and Efficacy of Trichostatin A in Patients With Mild to Severe OnychomycosisActive, not recruitingNCT07065773Phase 21 country
- Effect of the Erchonia® LunulaLaser™ for the Treatment of Toenail OnychomycosisTerminatedNCT06006455Not applicable1 country
- Pilot Study of Swift Microwave Device for OnychomycosisCompletedNCT05674747Phase 1/21 country
- Spread of Dermatophytes Among FamiliesCompletedNCT002334931 country
- A Vehicle-controlled Study of Topical MOB015B in the Treatment of Distal Subungual Onychomycosis (DSO)Active, not recruitingNCT05279846Phase 32 countries
- Human Factors Testing for OTC Use of the Erchonia® LunulaLaserCompletedNCT05626270Not applicable1 country
- Mycosis Culture Collection From Dermatological IsolatedActive, not recruitingNCT054827631 country
- Efficacy and Safety Study of ME1111 in Patients With OnychomycosisCompletedNCT02022215Phase 21 country
- Efficacy and Safety of a Medical Device for the Treatment of Toenail OnychomycosisCompletedNCT03382717Not applicable1 country
- Clinical Evaluation to Assess the Safety and Efficacy of GentleMax Pro PlusCompletedNCT04993066Not applicable1 country
- A Study of ATB1651 in Adults With Mild to Moderate OnychomycosisCompletedNCT05089409Phase 11 country
- Effectiveness and Safety of Nailner Brush 2in1 in OnychomycosisCompletedNCT05560841Not applicable1 country
- A Trial to Evaluate the Safety and Efficacy of DBI-001 Gel, DBI-002 Gel, and Aqueous Gel in Subjects With OnychomycosisSuspendedNCT05491603Phase 21 country
- A Study to See if Low Level Laser Light Can Help to Treat Toenail FungusWithdrawnNCT03066336Not applicable1 country
- To Evaluate Hallux Terbinafine Subungual Gel (HSG) in the Treatment of OnychomycosisActive, not recruitingNCT05135910Phase 21 country
- A Trial Involving Treatment of BB2603 in Subjects With Distal Subungual Onychomycosis of the ToenailCompletedNCT04188574Phase 23 countries
- Antifungal Activity of Loceryl Nail Lacquer in Combination With a Cosmetic VarnishCompletedNCT02321098Phase 41 country
- 1320 nm Nd:YAG Laser for Improving the Appearance of OnychomycosisCompletedNCT01498393Phase 11 country
- Comparative Study Between Pulse Therapy With Oral Itraconazole Versus Continuous Oral Terbinafine Therapy for Treatment of OnychomycosisCompletedNCT05578950Phase 11 country
- Lasers in OnychomycosisStatus unknownNCT05415852Not applicable
- Radiofrequency in OnychomycosisStatus unknownNCT05390190Not applicable
- Laser Treatment of Toenail Onychomycosis With a 1064 nm Nd:YAG-laserCompletedNCT05260450Not applicable1 country
- Blue Light Photodynamic Therapy Treatment for Distal and Lateral Subungual Toenail OnychomycosisCompletedNCT03022903Not applicable1 country
- Efficacy of Intralesional PRP in Treatment of OnychomycosisStatus unknownNCT05128916Phase 31 country
- Efficacy, Safety, and Tolerability of HTS-519 Insert in Patients With Toenail Fungus of the Big ToenailCompletedNCT02798380Phase 21 country
- Safety and Pharmacokinetics of Efinaconazole Topical Solution in Subjects With Mild to Severe OnychomycosisCompletedNCT02812771Phase 42 countries
- Comparison Between Long-pulsed Nd:YAG, Amorolfine and Combination Treatment in Treating Non-dermatophyte OnychomycosisCompletedNCT02812043Phase 41 country