Neoplasm Recurrence, Local clinical trials
The registry lists 43 studies for Neoplasm Recurrence, Local across more than 10 countries. 15 are recruiting or about to start. 3 of them are mainly about Neoplasm Recurrence, Local (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-27.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
Radboud University Medical Center (3) · Shandong Cancer Hospital and Institute (2) · Bioniche Life Sciences Inc. (2) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (2) · Wuerzburg University Hospital (1) · Danish Breast Cancer Cooperative Group (1) · Fujian Medical University Union Hospital (1) · St George Hospital, Australia (1)
What is being tested here
Drugs under test in Neoplasm Recurrence, Local studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Cadonilimab | 1 | 0 | 1 |
| Zanzalintinib | 1 | 0 | 1 |
| Cisplatin | 0 | 2 | 2 |
| Fluorouracil | 0 | 2 | 2 |
| Tamoxifen | 0 | 1 | 1 |
| Talaporfin | 0 | 1 | 1 |
| Docetaxel | 0 | 1 | 1 |
| Bevacizumab | 0 | 0 | 1 |
| Erlotinib | 0 | 0 | 1 |
| Oxaliplatin | 0 | 1 | 1 |
Drug classes tested here Antimetabolites 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5, phase 3 first
- Jul 2027Study of TLX101-Tx Plus Standard of Care (SoC) Versus SoC Alone for the Treatment of Patients With Recurrent Glioblastoma · Phase 3 · Telix Pharmaceuticals (Innovations) Pty Limited
- Jun 2027Methylation Profile Test (Methylscape) in Body Fluids for Multi-Cancer Detection and Monitoring in Colombia · Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo
- Jun 2027Dose Finding Study of Zanzalintinib With Pembrolizumab and Cetuximab in Head and Neck SCC · University of Chicago
- Aug 2027Single and Combined Modality Trans-Oral Robotic Surgery in Early Oropharyngeal Cancer · Royal Marsden NHS Foundation Trust
- Oct 2027Search for Circulating Tumour Cells in the Blood and/or Cerebrospinal Fluid in Patients With Recurrent Aggressive Meningiomas: Proof-of-concept Study · University Hospital, Montpellier
Who these studies take
Of the 14 Neoplasm Recurrence, Local studies recruiting now, 11 (79%) set no upper age limit and 2 (14%) stop at 75 or younger. 0 (0%) take children under 18. 4 (29%) are for women only and 1 (7%) for men only; 1 (7%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 11 (79%) | 9 (64%) |
| 30 | 12 (86%) | 10 (71%) |
| 40 | 12 (86%) | 10 (71%) |
| 50 | 12 (86%) | 10 (71%) |
| 65 | 13 (93%) | 10 (71%) |
| 75 | 13 (93%) | 10 (71%) |
| 85 | 10 (71%) | 9 (64%) |
Across all 43 studies, recruiting or not: 21% stop at 75 or younger and 2% at 65; 2% take children; 28% are for women only and 7% for men only; 2% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 43 of 43. search them.
- TMV Vaccine Alone or With Toripalimab-tpzi for Recurrent Head and Neck Squamous Cell CarcinomaRecruitingNCT07898124Phase 11 country
- Six Versus Twelve Month Index Follow-up After Large Colon Polyp ResectionEnrolling by invitationNCT07198945Not applicable3 countries
- Irreversible Electroporation (IRE) for Treating Recurrent Pelvic Tumors (PELFIRE Study)RecruitingNCT077821641 country
- Study of TLX101-Tx Plus Standard of Care (SoC) Versus SoC Alone for the Treatment of Patients With Recurrent GlioblastomaRecruitingNCT07100730Phase 34 countries
- Methylation Profile Test (Methylscape) in Body Fluids for Multi-Cancer Detection and Monitoring in ColombiaRecruitingNCT077414351 country
- Search for Circulating Tumour Cells in the Blood and/or Cerebrospinal Fluid in Patients With Recurrent Aggressive Meningiomas: Proof-of-concept StudyRecruitingNCT07398170Not applicable1 country
- Non-inferiority Study Comparing Salvage Pelvic Radiotherapy in 25 Fractions (62.5 Gy/25) Versus 20 Fractions (52.5 Gy/20) for Recurrent Prostate Cancer After Surgery.RecruitingNCT07483658Not applicable1 country
- Cadonilimab With Chemoradiation for Recurrent and Oligometastatic Endometrial CarcinomaRecruitingNCT06532539Phase 21 country
- Dose Finding Study of Zanzalintinib With Pembrolizumab and Cetuximab in Head and Neck SCCRecruitingNCT06912087Phase 11 country
- Iparomlimab and Tuvonralimab With Chemoradiation for the Treatment of Locally Recurrent and Oligometastatic Cervical CancerRecruitingNCT06942416Phase 21 country
- Single and Combined Modality Trans-Oral Robotic Surgery in Early Oropharyngeal CancerRecruitingNCT059338891 country
- Evaluation of Recurrence Risk Factors in Locally Advanced Breast Cancer Patients Underwent Neoadjuvant Chemotherapy.RecruitingNCT064412401 country
- Multicenter Clinical Trial on the Effectiveness and Safety of Instillation of BCG and Alternative BCG Protocols for Intermediate and High-risk Non-muscle Invasive Bladder CancerRecruitingNCT06441110Phase 31 country
- Rhenium Re 188 P2045 in Patients With Lung Cancer Who Have Received or Refused to Receive Prior ChemotherapyRecruitingNCT00100256Phase 1/21 country
- Partial Breast Versus no Irradiation for Women With Early Breast CancerRecruitingNCT03646955Not applicable4 countries
- Accelerated Partial Breast Irradiation With IMRT in Early Breast CancerActive, not recruitingNCT03583580Not applicable1 country
- Randomized Trial of Accelerated Partial Breast IrradiationCompletedNCT03583619Not applicable1 country
- Prospective Phase II Study of Intraoperative Radiotherapy (IORT) in Elderly Patients with Small Breast CancerCompletedNCT01299987Not applicable1 country
- PSMA-PET and MRI for Detection of Recurrent Prostate Cancer After Radical TreatmentCompletedNCT042981121 country
- Recurrences After Standard EMR vs Plus Thermal Ablation EMRStatus unknownNCT05121805Not applicable1 country
- SLNB After Neoadjuvant Treatment in Node Positive PatientsCompletedNCT03833960
- Incidence, Risk Factor, Treatment and Overall Survival of Locally Recurrent Rectal CancerCompletedNCT05475301
- Trial of Low Dose Tamoxifen in Women With Breast Intraepithelial Neoplasia - Long Term Follow-upActive, not recruitingNCT01357772Phase 31 country
- Intra-Operative Electron Boost and Hypofractionated Whole-Breast Irradiation During Breast-conserving Treatment (BCT)CompletedNCT01343459Not applicable1 country
- Follow-up Protocol of Colorectal Endoscopic Mucosal Resection ScarsCompletedNCT04239365Not applicable1 country
- Incidence, Risk Factor, Treatment and Overall Survival of Locoregionally Recurrent Colon CancerCompletedNCT05475288
- Epidural Anesthesia-analgesia and Long-term Survival After Lung Cancer SurgeryCompletedNCT02801409Not applicable1 country
- Fractionated Radiosurgery for Painful Spinal MetastasesCompletedNCT01594892Not applicable4 countries
- Perioperative FOLFIRI VS Adjuvant FOLFIRI in Resectable Advanced CRC Failed to OxaliplatinStatus unknownNCT02087475Phase 31 country
- Efficacy and Safety Evaluation of EN3348 (Mycobacterial Cell Wall-DNA Complex [MCC]) as Compared With Mitomycin C in the Intravesical Treatment of Subjects With BCG Recurrent/Refractory Non-muscle Invasive Bladder CancerTerminatedNCT01200992Phase 36 countries
- PET-MRI After Radiofrequency Ablation (RFA) or Microwave Ablation (MWA)CompletedNCT018956731 country
- Mycobacterial Cell Wall-DNA Complex in Treatment of BCG-refractory Patients With Non-muscle Invasive Bladder CancerCompletedNCT00406068Phase 2/32 countries
- Screening MRI for Cancer Recurrence in Patients Treated With Breast Conserving TherapyCompletedNCT012571521 country
- Phase 3 Trial of Litx™ Plus Chemotherapy vs. Chemotherapy Only Treating Colorectal Cancer Patients With Recurrent Liver MetastasesCompletedNCT00440310Phase 313 countries
- Safety and Efficacy Study of Cylindrical Abdominoperineal Resection to Treat Rectal CancerStatus unknownNCT009492731 country
- Gene Therapy for Prostate Cancer That Returns After Radiation TherapyWithdrawnNCT00110526Phase 1
- Chemotherapy or Not, Following Complete Treatment of Hepatic Cancer in Cirrhotic PatientsTerminatedNCT00470340Phase 31 country
- Taxotere (Docetaxel) in 1st Line Treatment of Recurrent/Metastatic Head and Neck Squamous Cell CarcinomaCompletedNCT00401323Phase 2/320 countries
- Introduction and Influence of Total Mesorectal Excision (TME) in the Treatment of Rectal CancerCompletedNCT009101431 country
- A Study to Evaluate Bevacizumab and Chemotherapy or Tarceva in Treating Recurrent or Refractory NSCLC (Non-Small Cell Lung Cancer)CompletedNCT00095225Phase 21 country
- Study of Neurologic Progression With Motexafin Gadolinium and Radiation Therapy (SMART)CompletedNCT00054795Phase 38 countries
- Boost Use in Breast Conservation RadiotherapyStatus unknownNCT00138814Phase 31 country
- Study of NS-9 in Patients With Liver MetastasesCompletedNCT00094003Phase 11 country