An observational study in Rectal Cancer, Treatment and Postoperative Complications, sponsored by Beijing Chao Yang Hospital. Status unknown at 7 sites in China. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2013-11-28.
Sponsored by Beijing Chao Yang Hospital · Observational
The purpose of this study is to determine whether cylindrical abdominoperineal resection is effective in the treatment of advanced very low rectal cancer
Abdominoperineal resection (APR) is still a common operation in patients with tumours less than 6 cm from the anal verge. The perineal phase of APR is a difficult part of the operation, often done with the patient in the supine position.The risk of inadvertent bowel perforation is high, the resulting specimen frequently has a waist at the lower border of the mesorectum, and the circumferential resection margin (CRM) is often close to the rectal muscle tube. The cylindrical APR may be performed via an extended posterior perineal approach, that aims to create a more cylindrical specimen without a waist. The potential benefit of this technique is a reduction in the risk of bowel perforation and tumour involvement of the CRM, and thus in the risk of local recurrence.
Perineal wounds in patients following APR are at considerable risk for infection, dehiscence and delayed healing when closed primarily. This can be further increased in patients who have received neoadjuvant chemoradiation therapy. The adoption of extended resection, such as the cylindrical APR, may cause additional risks. The use of acellular biomaterials, including human acellular dermal matrix (HADM) has drawn great interest for the complex abdominal wall reconstruction.
The purpose of this study is to determine whether cylindrical abdominoperineal resection is effective in the treatment of advanced very low rectal cancer, and to determine the initial results of pelvic reconstruction using human acellular dermal matrix after cylindrical abdominoperineal resection.
1,762 studies on the registry are indexed under Rectal Neoplasms; 518 are open to participants now.
This study's planned enrollment of 300 is above the median of 160 across 413 observational studies indexed under Rectal Neoplasms.
Browse Rectal Neoplasms studies →Beijing Chao Yang Hospital is the lead sponsor of 135 studies on the registry; 49 are open to participants now.
Counted across the registry records on this site, refreshed daily.
hospitalized patients with rectal cancer
Exclusion Criteria:
patients underwent cylindrical abdominoperineal resection for advanced very low rectal cancer
Procedure: cylindrical abdominoperineal resection
patients underwent conventional abdominoperineal resection for advanced very low rectal cancer
Extended abdominoperineal resection with human acellular dermal matrix reconstruction of the pelvic floor for rectal cancer
Also known as: Ruinuo
postoperative complications
Time frame: 08/01/2011
3-years overall survival
Time frame: 08/01/2013
This study is status unknown, as verified in Nov 2013. You cannot join it, but the record below documents what was studied.
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Beijing Chao Yang Hospital