Meningeal Carcinomatosis: all 146 studies
Page 1 of 2. Open to participants first (48), then studies with results posted, then the rest; newest registration first within each.
- Combined Intrathecal and Systemic Therapy With Trastuzumab Rezetecan for Leptomeningeal MetastasesNot yet recruitingNCT07833657Phase 2
- BRain-AVOidant Proton Craniospinal Irradiation for Leptomeningeal Metastases From Solid Tumor MalignanciesRecruitingNCT07789912Not applicable
- Thiotepa Administration Via Ommaya Reservoir for Leptomeningeal Metastases in Non-Small Cell Lung Cancer Resistant to EGFR-TKI.Not yet recruitingNCT07778940Phase 2
- Wearable-Triggered Digital Safety Net for Real-Time Monitoring & Intervention in Leptomeningeal MetastasisNot yet recruitingNCT07704034Not applicable
- Safety and Efficacy of Intrathecal Sacituzumab Tirumotecan for Leptomeningeal Metastasis in EGFR-TKI-Resistant Non-Small Cell Lung CancerNot yet recruitingNCT07702305Phase 1
- Phase 1 Study of WBRT or PCSI With REYOBIQ for Leptomeningeal MetastasesNot yet recruitingNCT07674693Phase 1
- QH101 Cell Injection in Patients With Brain, Brain (Spinal) Meninges, and Spinal Cord Metastatic Malignant Solid TumorsNot yet recruitingNCT07656103Early Phase 1
- Zorifertinib Plus Intra-Ommaya CSF Chemotherapy for Leptomeningeal Progression in NSCLC After Third-Generation EGFR-TKINot yet recruitingNCT07551414Phase 2
- Double-Dose Third-Generation EGFR-TKI Plus Bevacizumab and Intrathecal Chemotherapy for Refractory Leptomeningeal Metastatic NSCLC: A Phase II StudyRecruitingNCT07398599Not applicable
- Zorifertinib With Osimertinib for NSCLC With Meningeal ProgressionRecruitingNCT07361705Phase 1
- Pulsatile High-dose Furmonertinib in EGFR-mutant NSCLC With Leptomeningeal MetastasisRecruitingNCT07348965Not applicable
- Furmonertinib Combined With Intrathecal Chemotherapy and Stereotactic Radiotherapy (SRT) for EGFR-Mutated NSCLC Patients With Brain Parenchymal and Leptomeningeal MetastasesRecruitingNCT07304739Phase 2
- Evaluate the Safety, Tolerability, Biodistribution Characteristics and Preliminary Efficacy of BioTTT001RecruitingNCT07264569Phase 1/2
- Stupp Treatment With Intrathecal Injection of Thiotepa for Glioblastoma With Advanced SpreadRecruitingNCT07193654Phase 2
- A Two-cohort Study of SHR-A1811 in the Treatment of HER2-positive Breast Cancer With Brain MetastasesNot yet recruitingNCT07177950Phase 1/2
- Multiple Dose Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal MetastasesRecruitingNCT07098806Phase 1/2
- Firmonertinib Combined With Intrathecal Injection for the Treatment of EGFR Mutant NSCLC With Leptomeningeal MetastasesRecruitingNCT07092202Phase 4
- AI-Based Ultrasound Prediction Model for Intracranial Pressure and Prognosis in Lung Cancer Patients With Leptomeningeal Metastasis: A Dual-Center StudyNot yet recruitingNCT07005791
- High-Dose Firmonertinib Combined With Bevacizumab and Intrathecal Pemetrexed in the Treatment of EGFR-Mutated Non-Small Cell Lung Cancer With Leptomeningeal MetastasisNot yet recruitingNCT06971406Phase 2
- Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung CancerRecruitingNCT06910761Phase 2
- A Study of the Safety and Efficacy of Pemetrexed Combined with Nivolumab Via Intraventricular Injection for the Treatment of Refractory Non-squamous Non-small Cell Lung Cancer with Leptomeningeal MetastasesRecruitingNCT06901817Phase 2
- Cerebrospinal Fluid Cytology-guided Intrathecal Chemo-holiday Therapy for EGFR-positive NSCLC Leptomeningeal MetastasesNot yet recruitingNCT06861218Phase 2
- Intrathecal PD-1/VEGF Bispecific Antibody Plus Pemetrexed for Leptomeningeal MetastasisRecruitingNCT06809517Phase 1/2
- Ivonescimab Combined With Chemotherapy for the Treatment of Leptomeningeal Metastases Failed to EGFR-TKIsNot yet recruitingNCT06766591Not applicable
- Intrathecal Combination of Programmed Death-1 (PD-1)/Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) Bispecific Antibody and Pemetrexed for Leptomeningeal MetastasisRecruitingNCT06762080Phase 1/2
- A Real-world Study on the Treatment of Non-small Cell Lung Cancer With Leptomeningeal Metastasis in ChinaRecruitingNCT06718972
- Retrospective Study on Leptomeningeal Metastasis of Solid TumorsEnrolling by invitationNCT06705049
- Intrathecal Injection Pemetrexed And Bevacizumab in Patients With Leptomeningeal Metastases in NSCLCRecruitingNCT06663306Phase 1
- Evaluating High-dose Furmonertinib with Bevacizumab and Pemetrexed for EGFRm NSCLC with Leptomeningeal MetastasisRecruitingNCT06643000Not applicable
- Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung CancerRecruitingNCT06518057Phase 2
- Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM TrialRecruitingNCT06500481Phase 3
- Sacituzumab Govitecan and Intrathecal Chemotherapy for Treating Leptomeningeal Metastases From Her2-negative Breast CancerRecruitingNCT06462092Phase 1/2
- Double Dose of Third-generation EGFR-TKI Plus Intrathecal Pemetrexed Versus Double Dose of Third-generation EGFR-TKI in Patients With LM Progression Following the Treatment of Routine Dose of Third-generation EGFR-TKINot yet recruitingNCT06441045Phase 2
- Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung CancerRecruitingNCT06431685Phase 1
- Standardized Clinical Assessment of Patients With Leptomeningeal MetastasisRecruitingNCT06417710
- Efficacy and Safety of Intraventricule Pemetrexed Disodium Administered Via Ommaya ReservoirRecruitingNCT06399926
- Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung CancerRecruitingNCT06304441Not applicable
- Intrathecal Pemetrexed for Leptomeningeal Metastasis From Lung Adenocarcinoma That Progressed After Osimertinib.RecruitingNCT06296745Phase 2
- Intrathecal Chemotherapy Through Ommaya Reservoir Upon Her-2 Negative Breast Cancer With Leptomeningeal MetastasisRecruitingNCT06230055Phase 4
- Trastuzumab Deruxtecan (T-DXd) for People With Brain CancerRecruitingNCT06058988Phase 2
- Furmonertinib in Patients With Leptomeningeal Metastases Associated With EGFR Mutated NSCLCEnrolling by invitationNCT05813522Phase 2
- Intrathecal Pemetrexed for Leptomeningeal Metastasis in EGFR-Mutant NSCLCRecruitingNCT05805631Phase 2
- Capecitabine, Tucatinib, and Intrathecal Trastuzumab for Breast Cancer Patients With Leptomeningeal DiseaseRecruitingNCT05800275Phase 2
- Proton Cranio-spinal Irradiation for Leptomeningeal MetastasisRecruitingNCT05746754Not applicable
- Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung CancerRecruitingNCT05746325Not applicable
- Dual-targeting VEGFR1 and PD-L1 CAR-T for Pleural, Peritoneal, or Leptomeningeal MetastasesRecruitingNCT05477927Phase 1
- CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal DiseaseRecruitingNCT05257967Not applicable
- A Study of Deferoxamine (DFO) in People With Leptomeningeal MetastasisRecruitingNCT05184816Phase 1
- Testing the Addition of an Anti-cancer Drug, Adavosertib, to Radiation Therapy for Patients With Incurable Esophageal and Gastroesophageal Junction CancersActive, not recruitingNCT04460937Phase 1Results posted
- DS-8201a for trEatment of aBc, BRain Mets, And Her2[+] DiseaseCompletedNCT04420598Phase 2Results posted
- 131I-omburtamab Radioimmunotherapy for Neuroblastoma Central Nervous System/Leptomeningeal MetastasesTerminatedNCT03275402Phase 2/3Results posted
- Microfluidic Device to Diagnose Leptomeningeal Metastasis in Breast CancerCompletedNCT02948751Results posted
- Ipilimumab and Nivolumab in Leptomeningeal MetastasesCompletedNCT02939300Phase 2Results posted
- Phase 2 Study of Study of Tesevatinib in Subjects With NSCLC and Brain or Leptomeningeal MetastasesCompletedNCT02616393Phase 2Results posted
- Intrathecal Rituximab in Lymphoid Malignancies Involving Central Nervous SystemTerminatedNCT01596127Phase 1/2Results posted
- Liposomal Cytarabine and High-Dose Methotrexate in Treating Patients With Central Nervous System Metastases From Breast CancerCompletedNCT00992602Phase 2Results posted
- Depocyt® With Sorafenib in Neoplastic MeningitisTerminatedNCT00964743Not applicableResults posted
- A Pilot Study of Bevacizumab for Neoplastic MeningitisCompletedNCT00924820Phase 1/2Results posted
- High-dose Sequential Chemoimmunotherapy for B-cell Lymphomas With Central Nervous System InvolvementCompletedNCT00801216Phase 2Results posted
- DepoCyt for Active Lymphomatous or Leukemic MeningitisTerminatedNCT00523939Phase 2Results posted
- Epothilone B in Treating Patients With CNS Metastases From Breast CancerCompletedNCT00450866Phase 2Results posted
- Firmonertinib in the Treatment of EGFR(+) NSCLC Patients With Central Nervous System MetastasisCompletedNCT07239102
- Allogeneic, Antigen-Presenting, GM-CSF-secreting, SV-BR-1-GM Whole Cell-Therapeutic Vaccine and ImmunotherapyWithdrawnNCT07199413Phase 1
- Study of Craniospinal Irradiation With Linac Based Volumetric Modulated Arc Therapy (VMAT) for Patients With Leptomeningeal MetastasisActive, not recruitingNCT06984523Not applicable
- High-dose Furmonertinib Combined With Bevacizumab and Intrathecal Pemetrexed Chemotherapy in Patients With EGFR-mutated Non-small Cell Lung Cancer and Meningeal MetastasisCompletedNCT06812871Phase 2
- Intrathecal Dual Checkpoint Inhibitor (PD-1 and CTLA-4) in Combination With Pemetrexed for Leptomeningeal MetastasisActive, not recruitingNCT06809530Phase 1/2
- Evaluation of the Efficacy and Safety of Befotertinib Combined With Bevacizumab as First-Line Treatment for EGFR-Positive Non-Small Cell Lung Cancer With Brain Metastases: A Single-Arm, Open-Label, Prospective Phase II Clinical StudyActive, not recruitingNCT06728865Phase 2
- Concurrent Azeliragon With Craniospinal IrradiationActive, not recruitingNCT06724926Phase 1
- Clinical Study of QH104 Cell Injection for the Treatment of Meningeal Metastases of B7H3+ Solid TumorsCompletedNCT06592092Not applicable
- Immune Checkpoint Inhibitor Combined With Pemetrexed Intrathecal Injection for Leptomeningeal Metastasis From Solid TumorsActive, not recruitingNCT06462222Phase 1/2
- A Retrospective Study of the Efficacy and Safety of Lolatinib in ALK+ NSCLC Patients With Brain or Meningeal MetastasisActive, not recruitingNCT06410040
- Lorlatinib in Patients With ALK-Positive NSCLC With Brain or Leptomeningeal MetastasesActive, not recruitingNCT06282874Phase 4
- Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal MetastasisWithdrawnNCT06137651Phase 1
- Aumolertinib Combined Intrathecal Chemotherapy for Leptomeningeal Metastasis From EGFR-Mutated NSCLC and Prognostic Value of Dynamic Changes in cfDNA ProfilesCompletedNCT05810350Phase 2
- Intrathecal Double Checkpoint InhibitionActive, not recruitingNCT05598853Phase 1
- A Therapy Treatment Response Trial in Patients With Leptomeningeal Metastases ((LM) Using CNSideTerminatedNCT05414123
- Clinical Observation of ICI Combined With Recombinant Human Endostatin on Leptomeningeal Metastasis of Lung CancerStatus unknownNCT05385185Phase 2
- Intra-pemetrexed Alone or Combined With Concurrent Radiotherapy for Leptomeningeal MetastasisStatus unknownNCT05305885Not applicable
- Intrathecal Pemetrexed for Leptomeningeal MetastasisCompletedNCT05289908Phase 1/2
- Feasibility of Exosome Analysis in Cerebrospinal Fluid During the Diagnostic Workup of Metastatic MeningitisCompletedNCT05286684Not applicable
- Study of TY-9591 in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR MutationCompletedNCT05146219Phase 2
- Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal MetastasesCompletedNCT05034497Phase 1
- Almonertinib With Bevacizumab for EGFR-Mutant NSCLC Patients With Leptomeningeal MetastasisStatus unknownNCT04944069Not applicable
- Clinical Efficacy and Safety of EGFR-TKI Combined With Nimotuzumab in the Treatment of Leptomeningeal Metastases From Lung CancerStatus unknownNCT04833205Phase 2
- A Dose Exploration Study of Almonertinib for EGFRm NSCLC Patients With Brain/Leptomeningeal Metastasis (ARTISTRY)Status unknownNCT04778800Not applicable
- Pembrolizumab And Lenvatinib In Leptomeningeal MetastasesTerminatedNCT04729348Phase 2
- Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or MedulloblastomaActive, not recruitingNCT04661384Phase 1
- Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal DiseaseActive, not recruitingNCT04588545Phase 1/2
- Osimertinib With Bevacizumab for Leptomeningeal Metastasis From EGFR-mutation Non-Small Cell Lung CancerStatus unknownNCT04425681Phase 2
- Efficacy and Safety of Durvalumab in Non-Small Cell Lung Cancer With Leptomeningeal MetastasisStatus unknownNCT04356222Phase 4
- Efficacy and Safety of Recombinant Human Endostatin in Non-Small Cell Lung Cancer With Leptomeningeal MetastasisStatus unknownNCT04356118Phase 4
- Proton Craniospinal Radiation Therapy vs. Partial Photon Radiation Therapy for Leptomeningeal Metastasis From Solid TumorsCompletedNCT04343573Phase 2
- 177Lu-DTPA-Omburtamab Radioimmunotherapy for Leptomeningeal Metastasis From Solid Tumors (Breast, NSCLC, Malignant Melanoma)WithdrawnNCT04315246Phase 1/2
- Study of Osimertinib in Patients with a Lung Cancer with Brain or Leptomeningeal Metastases with EGFR MutationCompletedNCT04233021Phase 2
- GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal MetastasesActive, not recruitingNCT04192981Phase 1
- Tomotherapy for Leptomeningeal MetastasesCompletedNCT04178343Not applicable
- Osimertinib With or Without Bevacizumab for EGFR- Mutant Non-small Cell Lung Cancer With Leptomeningeal MetastasisStatus unknownNCT04148898Phase 2
- Analyses of Exosomes in the Cerebrospinal Fluid for Breast Cancer Patients With Suspicion of Leptomeningeal Metastasis.WithdrawnNCT03974204Not applicable
- Avelumab With Radiotherapy in Patients With Leptomeningeal DiseaseCompletedNCT03719768Phase 1
- HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal MetastasesActive, not recruitingNCT03696030Phase 1