Medically Unexplained Symptoms clinical trials
The registry lists 71 studies for Medically Unexplained Symptoms across more than 10 countries. 22 are recruiting or about to start. 42 of them are mainly about Medically Unexplained Symptoms (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
Get an email when these change. Save the Medically Unexplained Symptoms studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
University of Aarhus (7) · Daniel Maroti (5) · Karolinska Institutet (5) · National Taiwan University Hospital (4) · Philipps University Marburg (3) · RenJi Hospital (2) · Wayne State University (2) · Region Stockholm (2)
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7
- Dec 2026Alexithymia and Attachment Style in Patients With Somatic Symptoms · Meyer Children's Hospital IRCCS
- Dec 2026Stress and Musculoskeletal Health in Employees · University of Thessaly
- Dec 2026Use Repetitive Transcranial Magnetic Stimulation to Treat Somatic Symptom Disorder · National Taiwan University Hospital
- Feb 2027Effectiveness of a Cognitive and Behavioral Treatment Program in People With Idiopathic Environmental Intolerance (IEI) · Institut National de la Santé Et de la Recherche Médicale, France
- Mar 2027Stress Management and Meditative Movements for Asian Americans With Depression and Physical Symptoms · Massachusetts General Hospital
- Aug 2027Grow With Grit: A School Nurse-Led SBIRT Pilot for Early Anxiety Detection · McLaughlin Research Institute for Biomedical Sciences, Inc.
- Nov 2027Patient Education and Duloxetine, Alone and in Combination, for Patients With Multisystem Functional Somatic Disorder · Aarhus University Hospital
Who these studies take
Of the 20 Medically Unexplained Symptoms studies recruiting now, 6 (30%) set no upper age limit and 12 (60%) stop at 75 or younger. 6 (30%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 9 (45%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (5%) | 1 (5%) |
| 18 | 15 (75%) | 15 (75%) |
| 30 | 15 (75%) | 15 (75%) |
| 40 | 15 (75%) | 15 (75%) |
| 50 | 14 (70%) | 14 (70%) |
| 65 | 12 (60%) | 12 (60%) |
| 75 | 8 (40%) | 8 (40%) |
| 85 | 7 (35%) | 7 (35%) |
Across all 71 studies, recruiting or not: 51% stop at 75 or younger and 41% at 65; 20% take children; 1% are for women only and 0% for men only; 27% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Medically Unexplained Symptoms studies take
Of 33 interventional studies with no phase under Medically Unexplained Symptoms, half reached primary completion within 29 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 29 mo10–43 · 33 studies | — | 29 mo10–43 · 33 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 71. Browse all 71 → or search them.
- Stress Management and Meditative Movements for Asian Americans With Depression and Physical SymptomsRecruitingNCT07610928Not applicable1 country
- Grow With Grit: A School Nurse-Led SBIRT Pilot for Early Anxiety DetectionRecruitingNCT07766785Not applicable1 country
- Exposure Therapy for Reactivity to SymptomsNot yet recruitingNCT07757854Not applicable1 country
- Mapping the Healthcare Pathway to Multidisciplinary Assessment of 12-25 Year Olds With Somatic Symptom DisorderRecruitingNCT065821731 country
- An Ecological Momentary Intervention for the Reduction of Impairment in Somatic Symptom DisorderRecruitingNCT07646509Not applicable1 country
- Use Repetitive Transcranial Magnetic Stimulation to Treat Somatic Symptom DisorderRecruitingNCT05161819Not applicable1 country
- Developing an Integrated Psychotherapy With Cognitive-behavioral Therapy and Biofeedback Therapy for Somatic Symptom DisorderRecruitingNCT05792930Not applicable1 country
- Alexithymia and Attachment Style in Patients With Somatic SymptomsRecruitingNCT056669211 country
- Effect of Venlafaxine Versus Dosulepin in Pain Predominant Somatic Symptom DisorderRecruitingNCT06803485Phase 41 country
- Effectiveness of a Cognitive and Behavioral Treatment Program in People With Idiopathic Environmental Intolerance (IEI)RecruitingNCT05973214Not applicable1 country
- Predicting Treatment Outcomes in Refractory Constipation Through Brain Connectivity EvaluationRecruitingNCT062217221 country
- Trauma-Focused Cognitive Behavioral Therapy in Unaccompanied Refugee Minors With PTSD in Greece: An RCTRecruitingNCT06975280Not applicable1 country
- Non-Medication Methods to Relieve Adolescents with Somatoform DisordersRecruitingNCT068658331 country
- Online Therapy Youth, Equivalent to Treatment As Usual?RecruitingNCT06617663Not applicable1 country
- Stress and Musculoskeletal Health in EmployeesRecruitingNCT06488547Not applicable1 country
- Feasibility of Virtual Tai Chi Easy for Registered NursesRecruitingNCT06423638Not applicable1 country
- Assessment of Somatic Symptom BurdenRecruitingNCT033214091 country
- VivAer: A Correlation Between Symptom Scores and Objective FindingsRecruitingNCT05573919Not applicable1 country
- Patient Education and Duloxetine, Alone and in Combination, for Patients With Multisystem Functional Somatic DisorderRecruitingNCT06232473Phase 41 country
- MR-spectroscopy in Post-covid Condition Prior to and Following a Yoga Breathing InterventionRecruitingNCT05946512Not applicable1 country
- Development of Online EMDR Therapy System and Its Comparative Testing With Face-to-Face EMDR Therapy for Treatment of Anxiety and Depressive Disorders in PakistanNot yet recruitingNCT05785312Not applicable1 country
- Sense of Coherence and Empowerment at Patients With MUPSRecruitingNCT05121922Not applicable1 country
- Exposure-Based Treatment for Undifferentiated Somatic Symptom DisorderCompletedNCT04511286Not applicable1 country
- Impact of Humor Prescription on the Emotional Well-being of Patients With Medically Unexplained Symptoms: A Quasi-experimental StudyCompletedNCT07007013Not applicable1 country
- Somatic Symptoms in Autism Spectrum Disorder: Data IntegrationActive, not recruitingNCT058863611 country
- Internet Based Emotional Awareness and Expression Therapy for Functional Somatic Disorder With and Without Therapist SupportCompletedNCT06301360Not applicable1 country
- ISTDP for Patients With Treatment Resistance PPSCompletedNCT06682104Not applicable1 country
- Telehealth Group-based Emotional Awareness and Expression Therapy for Patients With Persistent Physical Symptoms: A Pilot StudyWithdrawnNCT06631963Not applicable1 country
- Does the First Interview Matter: A Comparing Life Stress Interview Versus a Standard Psychiatric Intake Interview for Patients With Functional Somatic DisorderCompletedNCT06149182Not applicable1 country
- Emotional Awareness and Expression Therapy for Patients With Persistent Physical Symptoms in Routine Psychiatric Care: A Pilot StudyTerminatedNCT06631911Not applicable1 country
- Interoceptive Awareness and Dream ThemesActive, not recruitingNCT077165141 country
- Exposure Therapy vs. Standardized Education for Distress Related to Somatic SymptomsCompletedNCT04942028Not applicable1 country
- App-Based Self-Management for Somatic Symptom Disorder and MUS: A Pilot StudyCompletedNCT07296406Not applicable1 country
- Hybrid Trial of Brief Cognitive-Behavioral Therapy for Health Anxiety in Primary CareCompletedNCT03789084Not applicable1 country
- CBT Enriched With Emotion Regulation Training for Multiple Somatoform Symptoms (ENCERT) - A 3-year Follow-upCompletedNCT03982524Not applicable1 country
- Efficacy and Safety of Toluedesvenlafaxine Hydrochloride Extended-release Tablets in Somatic Symptoms of DepressionCompletedNCT05849272Phase 41 country
- A Training Program for Developing Social- and Personal ResourcesCompletedNCT041654731 country
- Build a Research Clinic for Somatoform PatientsCompletedNCT04835103Not applicable1 country
- A Multicenter Cross-sectional Study on Mental Health of Patients With Multiple MyelomaCompletedNCT056204201 country
- Acceptance and Commitment Therapy Based Group Psychoeducation for Nursing StudentsCompletedNCT06553703Not applicable1 country
- Mindfulness Meditation: Alleviating Symptoms and Inflammation in NursesActive, not recruitingNCT06635278Not applicable1 country
- Effects of Biofeedback on Somatic SymptomsCompletedNCT051206481 country
- Halifax Somatic Symptoms Disorder TrialCompletedNCT02076867Not applicable1 country
- Feasibility Evaluation of a Self-guided Exposure-based Digital Intervention for Health AnxietyCompletedNCT05446766Not applicable1 country
- Parent Training for Youth With Chronic SymptomsCompletedNCT04277715Not applicable1 country
- Effects of COVID-19 Forced Isolation Context on Adolescents With and Without Somatic Symptom DisorderCompletedNCT057958031 country
- Welfare Benefits in Functional Somatic DisordersCompletedNCT05611606
- Psychological Risk Factors for Functional Somatic DisordersCompletedNCT05631860
- National Investigation in College and High School Among Adolescents on Health and Substances at the FSEFCompletedNCT052254411 country
- Reappraisal Of Medical Assurance (ROMA): An Experimental Study in Patients With Functional Somatic SymptomsCompletedNCT04044469Not applicable1 country