Malaria: all 1,315 studies

Page 2 of 14. Open to participants first (86), then studies with results posted, then the rest; newest registration first within each.

• Pyronaridine in Healthy Adult Participants Infected With Blood Stage MalariaCompletedNCT05287893Phase 1Results posted
• MMV533 Plasmodium Falciparum Volunteer Infection StudyCompletedNCT05205941Phase 1Results posted
• Study of the Transmission-Blocking Vaccine Pfs230D1-EPA/Matrix-M Against Malaria in Adults in MaliCompletedNCT05135273Phase 1Results posted
• Blood-Stage Plasmodium Vivax Cell BankCompletedNCT05095272Phase 1Results posted
• Trial to Evaluate L9LS in Healthy AdultsCompletedNCT05019729Phase 1Results posted
• Malaria as a Protection Factor Against Severe COVID-19 (Known as SARS-COV-2) in the Democratic Republic of Congo (Palu-COVID)TerminatedNCT05012280Results posted
• PfSPZ Vaccine Trial in Malian ChildrenCompletedNCT04940130Phase 2Results posted
• Safety and Efficacy of R0.6C VaccineCompletedNCT04862416Phase 1Results posted
• Efficacy of SJ733 in Adults With Uncomplicated Plasmodium Falciparum or Vivax MalariaCompletedNCT04709692Phase 2Results posted
• To Evaluate Efficacy, Safety, Tolerability and PK of Intravenous Cipargamin in Participants With Severe Plasmodium Falciparum MalariaCompletedNCT04675931Phase 2Results posted
• Clinical Investigation Study to Evaluate the Consistency and Reproducibility of Two Consecutive Mosquito Feeding AssaysCompletedNCT04666350Results posted
• Study of Malaria Vaccine RTS,S/AS01E in Plasmodium Falciparum-infected and Uninfected Adults Pre-treated With Anti-malarial TherapyCompletedNCT04661579Phase 2Results posted
• LLIN Evaluation in Uganda ProjectCompletedNCT04566510Not applicableResults posted
• Assess Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Profile of Ruxolitinib With Artemether-lumefantrineCompletedNCT04456634Phase 1Results posted
• Malaria Diagnostic Testing and Conditional Subsidies to Target ACTs in the Retail Sector: TESTsmART Aim 2 - NigeriaCompletedNCT04428385Not applicableResults posted
• Malaria Diagnostic Testing and Conditional Subsidies to Target ACTs in the Retail Sector: TESTsmART Aim 2 - KenyaCompletedNCT04428307Not applicableResults posted
• Safety and Efficacy of Pyronaridine Artesunate Vs Chloroquine in Children and Adult Patients With Acute Vivax MalariaTerminatedNCT04368910Phase 3Results posted
• Optimal Chemopreventive Regimens to Prevent Malaria and Improve Birth Outcomes in UgandaCompletedNCT04336189Phase 3Results posted
• Safety and Efficacy of CIS43LS Anti-malaria mAb in MaliCompletedNCT04329104Phase 2Results posted
• A Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetic Profile of a Single Doses of MMV533.CompletedNCT04323306Phase 1Results posted
• Study to Assess Safety, Tolerability and Phamacokinetics of KAE609 Administered Intravenously in Healthy SubjectsCompletedNCT04321252Phase 1Results posted
• Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ) Extension StudyCompletedNCT04319380Phase 3Results posted
• Gut and Azithromycin Mechanisms in Infants and Children IICompletedNCT04315272Phase 4Results posted
• Study in Blood Stage Malaria Infection After DVI of Cryopreserved P. Falciparum (NF54 Strain) SporozoitesCompletedNCT04310085Phase 1Results posted
• Pharmacokinetics, Safety, Tolerability and Efficacy of a New Artemether-lumefantrine Dispersible Tablet in Infants and Neonates <5 kg Body Weight With Acute Uncomplicated Plasmodium Falciparum MalariaTerminatedNCT04300309Phase 2/3Results posted
• Safety, Tolerability, and Pharmacokinetics and Pharmacodynamics of TB31FCompletedNCT04238689Phase 1Results posted
• TES of Artemether-lumefantrine for Pf and Chloroquine for Pv in the Philippines From 2013-2014CompletedNCT04222088Results posted
• Trial to Evaluate CIS43LS in Healthy AdultsCompletedNCT04206332Phase 1Results posted
• Safety, Immunogenicity and Efficacy of the Blood-stage Plasmodium Vivax Malaria Vaccine Candidate PvDBPII in Matrix M1CompletedNCT04201431Phase 1/2Results posted
• Absolute BA and OZ439 PK Effect of Different OZ439 Dose Volumes and Cobicistat Co-administration StudyCompletedNCT04069221Phase 1Results posted
• VAC071: A Study to Assess Efficacy of the ChAd63/MVA PvDBP VaccinesCompletedNCT04009096Phase 2Results posted
• Safety, Immunogenicity, and Protective Efficacy of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites (PfSPZ Vaccine) During Malaria Transmission Season in Healthy African Adult Women of Childbearing Potential in MaliCompletedNCT03989102Phase 2Results posted
• Repeat Ivermectin Mass Drug Administrations for MALaria Control IICompletedNCT03967054Phase 3Results posted
• Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine Chemoprophylaxis Vaccination (PfSPZ-CVac Approach): A Randomized Double Blind Placebo Controlled Phase I/II Trial to Determine Safety and Protective Efficacy Against Natural Plasmodium Falcipa...CompletedNCT03952650Phase 1/2Results posted
• Pfs230D1M-EPA/AS01 Vaccine, a Transmission Blocking Vaccine Against Plasmodium Falciparum, in an Age De-Escalation Trial of Children and a Family Compound Trial in MaliCompletedNCT03917654Phase 2Results posted
• Evaluate the Infectivity Equivalence of Current and New Lots of Plasmodium Falciparum Strain NF54CompletedNCT03882528Phase 1Results posted
• A Study to Evaluate the Efficacy, Immunogenicity and Safety in a Sporozoite Challenge Model of a Fractional Booster Dose of GSK Biologicals' Candidate Malaria Vaccine Administered to Previously Vaccinated Healthy Malaria-naïve AdultsCompletedNCT03824236Phase 2Results posted
• Safety and Efficacy of NF135 CPS ImmunizationTerminatedNCT03813108Not applicableResults posted
• Malaria Diagnostic Testing and Conditional Subsidies to Target ACTs in the Retail Sector: the TESTsmART Trial AIM 1CompletedNCT03810014Not applicableResults posted
• VAC069: A Study of Blood-stage Controlled Human P. Vivax InfectionCompletedNCT03797989Early Phase 1Results posted
• Safety, Tolerability and Chemoprotective Activity of P218 in PfSPZ Challenge ModelCompletedNCT03707041Phase 1Results posted
• Study to Investigate the Clinical and Parasiticidal Activity and Pharmacokinetics of Different Doses of Artefenomel and Ferroquine in Patients With Uncomplicated Plasmodium Falciparum MalariaCompletedNCT03660839Phase 2Results posted
• Efficacy of 3 Regimens of Chloroquine and Primaquine for Treatment of P. Vivax Malaria, Cruzeiro do Sul, Acre, BrazilCompletedNCT03610399Not applicableResults posted
• Safety, Tolerability and Antimalarial Activity of Single Doses of OZ439 and PQPCompletedNCT03542149Phase 1Results posted
• Safety, Immunogenicity, and Protective Efficacy of Two Regimens of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites (PfSPZ Vaccine) During Natural Transmission Season in Healthy African Adults in MaliCompletedNCT03510481Phase 1Results posted
• Safety, Tolerability, Immunogenicity and Protective Efficacy of PfSPZ Vaccine and PfSPZ-CVac in Indonesian Adults Against Naturally-Transmitted MalariaCompletedNCT03503058Phase 2Results posted
• Controlled Human Malaria Infection Model for Evaluation of Transmission-blocking Interventions - Study 2CompletedNCT03454048Not applicableResults posted
• Extended Duration Artemether-lumefantrine Treatment for Malaria in ChildrenCompletedNCT03453840Phase 4Results posted
• A Novel Regimen to Prevent Malaria and STI in Pregnant Women With HIVCompletedNCT03431168Phase 2Results posted
• Aggressive Antipyretics for Fever Reduction in CNS MalariaCompletedNCT03399318Phase 2Results posted
• Study to Compare the Triple ACT AL+AQ With the ACT AL in Cambodia and VietnamCompletedNCT03355664Phase 3Results posted
• Safety of KAE609 in Adults With Uncomplicated Plasmodium Falciparum Malaria.CompletedNCT03334747Phase 2Results posted
• Treating Brain Swelling in Pediatric Cerebral MalariaCompletedNCT03300648Phase 3Results posted
• Study to Assess the Vaccine Efficacy Against Malaria Infection, in Children Immunized With the Primary and Yearly Booster of the RTS,S/AS01E Vaccine, as Part of Their Participation in the Malaria-094 (204889/NCT03276962) Study.CompletedNCT03281291Results posted
• Efficacy, Safety and Immunogenicity Study of GSK Biologicals' Candidate Malaria Vaccine (SB257049) Evaluating Schedules With or Without Fractional Doses, Early Dose 4 and Yearly Doses, in Children 5-17 Months of AgeCompletedNCT03276962Phase 2Results posted
• Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE)CompletedNCT03178643Phase 4Results posted
• Efficacy and Safety of KAF156 in Combination With LUM-SDF in Adults and Children With Uncomplicated Plasmodium Falciparum MalariaCompletedNCT03167242Phase 2Results posted
• Efficacy, Immunogenicity and Safety Study of GSK Biologicals' Candidate Malaria Vaccine Evaluating Different Dose Schedules in a Sporozoite Challenge Model in Healthy Malaria-naïve AdultsCompletedNCT03162614Phase 2Results posted
• Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ)CompletedNCT03143218Phase 3Results posted
• Safety and Protective Efficacy of Pb(PfCS@UIS4)CompletedNCT03138096Phase 1/2Results posted
• Dose Escalation PfSPZ-CVacCompletedNCT03083847Phase 1Results posted
• Malaria Vaccine Safety and Immunogenicity Study in Healthy AdultsCompletedNCT02992119Phase 2Results posted
• Safety and Immunogenicity of Pfs25M-EPA/AS01 and Pfs230D1M-EPA/AS01 Vaccines, Transmission Blocking Vaccines Against Plasmodium Falciparum, at Full and Fractional Dosing in Adults in MaliCompletedNCT02942277Phase 1Results posted
• A Challenge Study to Assess the Safety, Immunogenicity and Efficacy of a Malaria Vaccine CandidateCompletedNCT02927145Phase 1/2Results posted
• A Study to Assess the Safety and Immunogenicity of the Malaria Vaccine, R21, With Matrix-M1 AdjuvantCompletedNCT02925403Phase 1/2Results posted
• A FIH Study to Investigate the Safety, Tolerability and PK of P218CompletedNCT02885506Phase 1Results posted
• MMV390048 POC in Patients With P. Vivax and P. Falciparum MalariaTerminatedNCT02880241Phase 2Results posted
• SJ733 Induced Blood Stage Malaria Challenge StudyCompletedNCT02867059Phase 1Results posted
• Methylene Blue Against Falciparum Malaria in Burkina FasoCompletedNCT02851108Phase 2Results posted
• Efficacy and Safety Study of Tafenoquine (TQ) Co-administered With Dihydroartemisinin-piperaquine (DHA-PQP) for the Radical Cure of Plasmodium Vivax (P. Vivax) MalariaCompletedNCT02802501Phase 3Results posted
• Prevention of Malaria in HIV-uninfected Pregnant Women and InfantsCompletedNCT02793622Phase 3Results posted
• Safety, Tolerability and Pharmacokinetic Profile of Ascending Oral Doses of MMV390048, Part ACompletedNCT02783820Phase 1Results posted
• Immunogenicity and Safety Study of GSK Biologicals' Candidate Malaria Vaccine Given at 6, 7.5 and 9 Months of Age in Co-administration With Measles, Rubella and Yellow Fever (YF) Vaccines Followed by a Booster of the Malaria Vaccine.CompletedNCT02699099Phase 3Results posted
• Artemether-lumefantrine for Treatment of P. Falciparum Malaria in BrazilCompletedNCT02600767Not applicableResults posted
• A Study to Characterise the Antimalarial and Transmission Blocking Activity of a Single Dose of DSM265 or OZ439 in Healthy Subjects With Induced Blood Stage Plasmodium Falciparum or Plasmodium Vivax InfectionTerminatedNCT02573857Phase 1/2Results posted
• A Study to Assess the Safety and Immunogenicity of the Malaria Vaccine, R21, Administered With and Without Matrix-M1CompletedNCT02572388Phase 1Results posted
• A Pharmacokinetics, Safety and Efficacy Study of Tafenoquine (TQ) in Pediatric Subjects With Plasmodium Vivax (P. Vivax) MalariaCompletedNCT02563496Phase 2Results posted
• A Study to Evaluate the Pharmacokinetics of Oral Formulations of MMV390048 Administered Fasted to Healthy VolunteersCompletedNCT02554799Phase 1Results posted
• Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy StudyCompletedNCT02509481Phase 2/3Results posted
• To Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of a Single Dose Regimen of Ferroquine and Artefenomel in Adults and Children With Uncomplicated Plasmodium Falciparum MalariaTerminatedNCT02497612Phase 2Results posted
• Innovative Public-private Partnership to Target Subsidized Antimalarials in the Retail Sector (Aim 2)CompletedNCT02461628Not applicableResults posted
• Evaluate the Safety and Efficacy of Plasmodium Falciparum Malaria Protein 010 (FMP010) Administered With Adjuvant AS01BCompletedNCT02458092Phase 1Results posted
• Effectiveness of OZ439 Against Early Plasmodium Falciparum Blood Stage Infection in Healthy VolunteersCompletedNCT02453581Phase 1Results posted
• DSM265 Chemoprophylaxis of Plasmodium Falciparum MalariaCompletedNCT02450578Phase 1Results posted
• Effectiveness of OZ439 as a Gametocytocidal and Transmission Blocking AgentCompletedNCT02431650Phase 1/2Results posted
• Experimental Falciparum Transmission to AnophelesCompletedNCT02431637Phase 1Results posted
• A Study to Assess Safety of Current Standard Malaria Treatment and an Assessment of G6PD Status in South-east BangladeshCompletedNCT02389374Phase 4Results posted
• Bioavailability Study of Oral OZ439 Prototype Granule Formulations Administered With Piperaquine Phosphate (PQP) TabletsCompletedNCT02387580Phase 1Results posted
• A Surveillance Study of Diseases Specified as Adverse Events of Special Interest, of Other Adverse Events Leading to Hospitalisation or Death, and of Meningitis in Children in Africa Prior to Implementation of the RTS,S/AS01E Candidate VaccineCompletedNCT02374450Results posted
• Validation of RealAmp Method for the Diagnosis of Malaria in Endemic Areas of BrazilCompletedNCT02371395Results posted
• Reducing the Burden of Malaria in HIV-Infected Pregnant Women and Their HIV-Exposed Children (PROMOTE-BC2)CompletedNCT02282293Phase 3Results posted
• MMV390048 Against Early Plasmodium Falciparum Blood Stage Infection in Healthy ParticipantsTerminatedNCT02281344Phase 1Results posted
• Epidemiology Study of Malaria Transmission Intensity in Sub-Saharan AfricaCompletedNCT02251704Phase 4Results posted
• Phase I Study of Ascending Doses of MMV390048 in Healthy Adult VolunteersCompletedNCT02230579Phase 1Results posted
• Effect of ACT-451840 Against Early Plasmodium Falciparum Blood Stage Infection in Healthy SubjectsCompletedNCT02223871Phase 1Results posted
• Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax MalariaCompletedNCT02216123Phase 3Results posted
• An Extension to Study MALARIA-055 PRI (NCT00866619) to Evaluate the Long-term Efficacy, Safety and Immunogenicity of GSK Biologicals' Candidate Malaria Vaccine in Infants and Children in AfricaCompletedNCT02207816Phase 3Results posted
• Reducing the Burden of Malaria in HIV-uninfected Pregnant Women and InfantsCompletedNCT02163447Phase 3Results posted
• Clinical and Biological Efficacy of Mirasol-treated Fresh Whole Blood for the Prevention of Transfusion-transmitted MalariaCompletedNCT02118428Not applicableResults posted
• Bioavailability Study of Oral OZ439 Prototype Formulations Administered With Piperaquine Phosphate (PQP)CompletedNCT02083406Phase 1Results posted

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