Hypoparathyroidism clinical trials
The registry lists 128 studies for Hypoparathyroidism across more than 10 countries. 30 are recruiting or about to start. 94 of them are mainly about Hypoparathyroidism (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06. Counting its narrower condition DiGeorge Syndrome too: 170 studies, 41 open.
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Who runs them
Shire (12) · University of Aarhus (5) · Aristotle University Of Thessaloniki (4) · Ascendis Pharma A/S (4) · Sumitomo Pharma Switzerland GmbH (3) · Entera Bio Ltd. (3) · Ascendis Pharma Bone Diseases A/S (3) · MBX Biosciences (3)
What is being tested here
Drugs under test in Hypoparathyroidism studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jun 2027A Phase 3 Randomized Clinical Trial to Investigate the Safety and Efficacy of Palopegteriparatide at Doses Greater Than 30 μg/Day in Adult Participants With Hypoparathyroidism · Phase 3 · Ascendis Pharma Bone Diseases A/S
- Aug 2027A Study to Test the Effects and Safety of Palopegteriparatide in Adolescents With Long-term Hypoparathyroidism · Phase 3 · Ascendis Pharma A/S
- Dec 2026Hypoparathyroidism Natural History Study · Columbia University
- Dec 2026Postoperative Hypocalcemia After Thyroidectomy · Minia University
- Dec 2026Evaluating the Safety and Efficacy of AMOR-1 as a Treatment for Hypocalcemia Associated With Hypoparathyroidism in Adults · Amorphical Ltd.
- Jan 2027Surgery for Thyroid Cancer With or Without Autofluorescence to Prevent Hypoparathyroidism · Aarhus University Hospital
- May 2027A Phase 2 Trial Investigating the Safety, Tolerability and Efficacy of EXT608 in Adults With Hypoparathyroidism · Extend Biosciences Inc.
- May 2027Psychological Problems in Post Thyroidectomy Patients · Assiut University
- Jul 2027Effects of Total Thyroid Removal on Parathyroid Function and Quality of Life · Aarhus University Hospital
- Aug 2027A Study to Assess the Amount of Palopegteriparatide in Breast Milk of Lactating Females Requiring YORVIPATH® (Palopegteriparatide) · Ascendis Pharma A/S
Who these studies take
Of the 26 Hypoparathyroidism studies recruiting now, 19 (73%) set no upper age limit and 5 (19%) stop at 75 or younger. 5 (19%) take children under 18. 2 (8%) are for women only and 0 (0%) for men only; 3 (12%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (8%) | 2 (8%) |
| 18 | 25 (96%) | 23 (88%) |
| 30 | 25 (96%) | 23 (88%) |
| 40 | 25 (96%) | 23 (88%) |
| 50 | 25 (96%) | 23 (88%) |
| 65 | 23 (88%) | 23 (88%) |
| 75 | 22 (85%) | 22 (85%) |
| 85 | 21 (81%) | 21 (81%) |
Across all 128 studies, recruiting or not: 22% stop at 75 or younger and 13% at 65; 19% take children; 4% are for women only and 1% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hypoparathyroidism studies take
Of 15 phase 3 interventional studies under Hypoparathyroidism, half reached primary completion within 17 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 3 | 17 mo10–86 · 15 studies | — | — |
| Observational | 23 mo7–122 · 25 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- NIRAF-Guided Parathyroid Identification During ThyroidectomyNov 6, 2026NCT07617584
Studies
Recruiting first, then most recently updated. Showing 50 of 128. Browse all 128 → or search them.
- NIRAF-Guided Parathyroid Identification During ThyroidectomyRecruitingNCT07617584Not applicable1 country
- A Phase 3 Randomized Clinical Trial to Investigate the Safety and Efficacy of Palopegteriparatide at Doses Greater Than 30 μg/Day in Adult Participants With HypoparathyroidismRecruitingNCT07081997Phase 31 country
- Efficacy, Safety, and Tolerability of Encaleret in Participants With Chronic HypoparathyroidismRecruitingNCT07805356Phase 32 countries
- A Study to Investigate Canvuparatide Compared With Placebo in Adult Patients With HypoparathyroidismRecruitingNCT07699471Phase 32 countries
- German Hypoparathyroidism RegistryRecruitingNCT078574601 country
- Postoperative Hypocalcemia After ThyroidectomyRecruitingNCT074280571 country
- A Study to Assess the Amount of Palopegteriparatide in Breast Milk of Lactating Females Requiring YORVIPATH® (Palopegteriparatide)RecruitingNCT072646341 country
- A Study to Test the Effects and Safety of Palopegteriparatide in Adolescents With Long-term HypoparathyroidismRecruitingNCT07706764Phase 32 countries
- Risk Factors for Hypoparathyroidism Following ThyroidectomyRecruitingNCT075825621 country
- Calcium Replacement Therapy in Postoperative HypoparathyroidismRecruitingNCT07577570Not applicable1 country
- Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)RecruitingNCT070835571 country
- PRESS -PAR: Early Detection and PREvention of Symptomatic postSurgical hypoPARathyroidism After Thyroid Surgery"RecruitingNCT07491601Not applicable1 country
- Contribution of ICG Angiography in the Detection of Parathyroids and the Prevention of Hypoparathyroidism Post Total ThyroidectomyRecruitingNCT04785443Phase 31 country
- A Global Pregnancy Registry to Assess Maternal, Fetal, and Infant Outcomes Following Exposure to YORVIPATH® (Palopegteriparatide) During Pregnancy and BreastfeedingRecruitingNCT073454941 country
- Parathyroid Allotransplant for Treatment of HypoparathyroidismRecruitingNCT06961071Phase 1/21 country
- Comparing PTeye-assisted Versus Conventional Total ThyroidectomyRecruitingNCT07416149Not applicable1 country
- Effects of Total Thyroid Removal on Parathyroid Function and Quality of LifeEnrolling by invitationNCT07381998Not applicable1 country
- Hypoparathyroidism Natural History StudyRecruitingNCT057938531 country
- Surgery for Thyroid Cancer With or Without Autofluorescence to Prevent HypoparathyroidismRecruitingNCT06222606Not applicable1 country
- Translation and Validation of the Hypoparathyroidism Patient Experience Scales (HPES) Questionnaire in GreekNot yet recruitingNCT07160348
- Treatment With Indapamide in Patients With Post-Surgical HypoparathyroidismRecruitingNCT07034677Phase 41 country
- A Phase 2 Trial Investigating the Safety, Tolerability and Efficacy of EXT608 in Adults With HypoparathyroidismRecruitingNCT06988670Phase 21 country
- Psychological Problems in Post Thyroidectomy PatientsNot yet recruitingNCT06929104
- Tunisian Clinical Registry on Hypoparathyroidism and Pseudo-hypoparathyroidismNot yet recruitingNCT064450361 country
- Establishment of a Registry of Patients with Parathyroid DiseaseRecruitingNCT067979341 country
- Institution of an Italian Multicenter Database of Patients Affected by Hypoparathyroidism or PseudohypoparathyroidismRecruitingNCT066458991 country
- Survey on Epidemiology of Hypoparathyroidism in FranceRecruitingNCT028389271 country
- Quality of Life Related to Different Treatment Protocols for Post-thyroidectomy HypoparathyroidismRecruitingNCT03249012Not applicable1 country
- Parathyroid Allotransplant for Severe Refractory HypoparathyroidismRecruitingNCT06499246Not applicable1 country
- The Use of Dexamethasone in Total Thyroidectomy to Improve Voice Outcome and HypocalcaemiaRecruitingNCT05732883Phase 21 country
- Intraoperative Monitoring to Predict Postoperative Complications After ThyroidectomyCompletedNCT033093841 country
- Efficacy and Safety of XH02 for the Treatment of HypoparathyroidismSuspendedNCT07197450Early Phase 11 country
- Extension Study to Evaluate the Long-Term Safety and Tolerability of MBX 2109 in Patients With HypoparathyroidismActive, not recruitingNCT06531941Phase 23 countries
- A Cohort Study on the Safety and Efficacy of XH-02 in Treating HypoparathyroidismSuspendedNCT07540286Phase 21 country
- Efficacy and Safety of Subcutaneous Injection of XH-02 in the Treatment of Adult HypoparathyroidismSuspendedNCT07530705Phase 1/21 country
- Parathyroid Allotransplantation in Medically Refractory HypoparathyroidismWithdrawnNCT05114980Not applicable1 country
- Evaluating the Safety and Efficacy of AMOR-1 as a Treatment for Hypocalcemia Associated With Hypoparathyroidism in AdultsActive, not recruitingNCT06547151Phase 21 country
- Efficacy and Safety of Encaleret Compared to Standard of Care in Participants With ADH1Active, not recruitingNCT05680818Phase 310 countries
- Ionized Calcium Changes for Predicting Postoperative Hypocalcemia After Total ThyroidectomyCompletedNCT077018241 country
- A Registry for Participants With Chronic HypoparathyroidismCompletedNCT0192244011 countries
- A Trial Investigating the Safety, Tolerability and Efficacy of TransCon PTH Administered Daily in Adults With HypoparathyroidismCompletedNCT04701203Phase 37 countries
- Postoperative Dose of Parathyroid Hormone as a Marker for the Occurrence of Hypoparathyroidism After Total ThyroidectomyCompletedNCT029245321 country
- A Trial Investigating the Safety, Tolerability and Efficacy of TransCon PTH in Adults With HypoparathyroidismCompletedNCT04009291Phase 26 countries
- ADH1 and ADH2 Disease Monitoring Study (DMS)Active, not recruitingNCT0522728713 countries
- Safety, Pharmacokinetics and Efficacy of MBX 2109 in Patients With HypoparathyroidismCompletedNCT06465108Phase 23 countries
- PTH-independent Effects of EncaleretCompletedNCT05735015Phase 21 country
- Comparing Pump With Subcutaneous Injection Delivery of PTH 1-34 in the Management of Chronic HypoparathyroidismCompletedNCT00743782Phase 21 country
- Assess Safety and Compare PK of New Oral hPTH(1-34) Tablet Formulations vs. EBP05 Tablets and Subcutaneous ForteoCompletedNCT05965167Phase 11 country
- Intraoperative Methylene Blue Spray for the Identification and Preservation of Vital Structures in ThyroidectomyCompletedNCT07395388Not applicable1 country
- Palopegteriparatide in Chronic HypoparathyroidismCompletedNCT072998381 country