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CompletedNCT03309384PARACALUpdated Oct 20, 2026

Intraoperative Monitoring to Predict Postoperative Complications After Thyroidectomy

An observational study in Endocrine Procedural Complications, Thyroid and Parathyroid; Deficiency, sponsored by Central Hospital, Nancy, France. Completed at 1 site in France. Per ClinicalTrials.gov, last updated 2026-10-20.

Sponsored by Central Hospital, Nancy, France · Observational

Updated Oct 20, 2026Now CompletedPrimary completion moved+1 moreGo to Updates ↓
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
1,000
Sex
All
01

Study summary

The goal of this study is to evaluate the role of intraoperative continous and intermittent neuromonitoring and intraoperative parathormone (PTH) to predict postoperative nerve morbidity and hypocalcemia.

Read the detailed description

Intraoperative PTH values and intraoperative continuous neuromonitoring will be collected prospectively in consecutive patients who undergo total thyroidectomy.

Postoperative parathyroid morbidity and recurrent laryngeal nerve morbidity will be evaluated within 1 week after total thyroidectomy and at 1 year postoperatively.

Other postoperative morbidity will be evaluated at 1 year postoperatively using validated classification.

02

Conditions studied

  • Endocrine Procedural Complications
  • Thyroid
  • Parathyroid; Deficiency
  • Laryngeal Injury
03

In context

Thyroid Diseases

365 studies on the registry are indexed under Thyroid Diseases; 80 are open to participants now.

This study's planned enrollment of 1,000 is above the median of 198 across 158 observational studies indexed under Thyroid Diseases.

Browse Thyroid Diseases studies →

Lead sponsor

Central Hospital, Nancy, France is the lead sponsor of 798 studies on the registry; 186 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

All patients scheduled for total thyroidectomy in university of Nancy (University Hospital)

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • patients scheduled for total thyroidectomy in university of Nancy (University Hospital)

Exclusion criteria

Exclusion Criteria:

  • refusal to participate
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
1,000 participants (estimated)
Target follow-up
1 Year
Patient registry
Yes
06

What researchers measure

Primary outcomes

  1. intraoperative parathormone values

    parathormone in pg/mL

    Time frame: intraoperative

Secondary outcomes

  1. postoperative hypocalcemia

    calcium in mg/L

    Time frame: within 1 week after thyroidectomy

  2. postoperative hypoparathyroidism

    parathormone in pg/mL

    Time frame: within 1 week after thyroidectomy

  3. permanent postoperative hypocalcemia

    calcium in mg/L

    Time frame: at one year after thyroidectomy

  4. permanent postoperative hypoparathyroidism

    parathormone in pg/mL

    Time frame: at one year after thyroidectomy

  5. laryngeal nerve palsy

    continuous intraoperative neuromonitoring (\> 50% baseline values yes/no)

    Time frame: during thyroidectomy

  6. laryngeal nerve palsy

    laryngoscopy (normal / palsy)

    Time frame: within 1 week after thyroidectomy

  7. laryngeal nerve palsy

    laryngoscopy (normal / palsy)

    Time frame: at one year after thyroidectomy

  8. Postoperative complications other than outcomes from 1 to 8

    Postoperative morbidity classification (using a Clavien-Dindo classification) postoperatively

    Time frame: at one year after thyroidectomy

07

Study locations

1 site
  • CHU Nancy
    Vandœuvre-lès-Nancy, 54511, France
08

Timeline

1 registry update since Sep 25, 2026
Not marked actual or estimatedDates not marked actual or estimatedDate before it movedWhere the date was before it moved

The record gives a start of Mar 2016, a primary completion of Oct 2026 and a completion of Oct 2026. It does not say whether these dates are actual or estimated.

Since we started tracking on Sep 25, 2026, the dates moved once, on Oct 20, 2026: primary completion Mar 2026 → Oct 2026 and completion Mar 2026 → Oct 2026.

Earlier changes are on the record history on ClinicalTrials.gov ↗

How these figures are worked out, and which studies are left out of them.

Registered
Sep 6, 2017
First posted
Oct 13, 2017
Start
Mar 20, 2016
Primary completionActual
Oct 19, 2026was Mar 2026
CompletionActual
Oct 19, 2026was Mar 2026
Last update
Oct 20, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Status
Recruiting→Completed
changed Oct 20, 2026
Primary completion
Mar 20, 2026→Oct 19, 2026 (actual)
Oct 20, 2026
Study completion
Mar 20, 2026→Oct 19, 2026 (actual)
Oct 20, 2026
Show all 1 update
  1. Oct 20, 2026
    Recruiting→Completed
    Primary completion Mar 20, 2026→Oct 19, 2026 (now actual)
    Study completion Mar 20, 2026→Oct 19, 2026 (now actual)
    + 4 other changes: verification date, contact details, site details and index terms

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

09

Registry details

Key details

Study ID
NCT03309384
Responsible party
Laurent BRUNAUD (Professor of Surgery, MD, PhD, Central Hospital, Nancy, France) — Principal investigator
First posted
Oct 13, 2017
Start date
Mar 20, 2016
Primary completion
Oct 19, 2026
Completion
Oct 19, 2026
Last update
Oct 20, 2026

Study contacts

Brunaud
principal investigator · Central Hospital, Nancy, France

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

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