An observational study in Endocrine Procedural Complications, Thyroid and Parathyroid; Deficiency, sponsored by Central Hospital, Nancy, France. Recruiting at 1 site in France. Per ClinicalTrials.gov, last updated 2025-02-12.
Sponsored by Central Hospital, Nancy, France · Observational
The goal of this study is to evaluate the role of intraoperative continous and intermittent neuromonitoring and intraoperative parathormone (PTH) to predict postoperative nerve morbidity and hypocalcemia.
Intraoperative PTH values and intraoperative continuous neuromonitoring will be collected prospectively in consecutive patients who undergo total thyroidectomy.
Postoperative parathyroid morbidity and recurrent laryngeal nerve morbidity will be evaluated within 1 week after total thyroidectomy and at 1 year postoperatively.
Other postoperative morbidity will be evaluated at 1 year postoperatively using validated classification.
All patients scheduled for total thyroidectomy in university of Nancy (University Hospital)
Exclusion Criteria:
intraoperative parathormone values
parathormone in pg/mL
Time frame: intraoperative
postoperative hypocalcemia
calcium in mg/L
Time frame: within 1 week after thyroidectomy
postoperative hypoparathyroidism
parathormone in pg/mL
Time frame: within 1 week after thyroidectomy
permanent postoperative hypocalcemia
calcium in mg/L
Time frame: at one year after thyroidectomy
permanent postoperative hypoparathyroidism
parathormone in pg/mL
Time frame: at one year after thyroidectomy
laryngeal nerve palsy
continuous intraoperative neuromonitoring (\> 50% baseline values yes/no)
Time frame: during thyroidectomy
laryngeal nerve palsy
laryngoscopy (normal / palsy)
Time frame: within 1 week after thyroidectomy
laryngeal nerve palsy
laryngoscopy (normal / palsy)
Time frame: at one year after thyroidectomy
Postoperative complications other than outcomes from 1 to 8
Postoperative morbidity classification (using a Clavien-Dindo classification) postoperatively
Time frame: at one year after thyroidectomy
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Central Hospital, Nancy, France