Histiocytosis clinical trials

The registry lists 25 studies for Histiocytosis across more than 10 countries. 8 are recruiting or about to start. 12 of them are mainly about Histiocytosis (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-13. Counting its 7 narrower conditions too, such as Lymphohistiocytosis, Hemophagocytic: 329 studies, 105 open.

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Status

Active, not recruiting: 6
Completed: 6
Recruiting: 4
Not yet recruiting: 3
Terminated: 3
Status unknown: 2

Phase

Phase 2: 11
Phase 1: 4
Phase 3: 1

Where

United States: 14
France: 5
Poland: 3
China: 2
Russian Federation: 1
Japan: 1

Who runs them

Assistance Publique - Hôpitaux de Paris (4) · Anna Raciborska (3) · Diane George (2) · Fairview University Medical Center (2) · Federal Research Institute of Pediatric Hematology, Oncology and Immunology (1) · Memorial Sloan Kettering Cancer Center (1) · Tampere University Hospital (1) · St. Jude Children's Research Hospital (1)

What is being tested here

Drugs under test in Histiocytosis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Phase 3	All
Vemurafenib	0	2
Busulfan	0	2
Fludarabine	0	2
Trametinib	0	1
Fluorodeoxyglucose F18	1	1
Melphalan	0	1
Dabrafenib mesylate	0	1
Dabrafenib	0	1
Etanercept	0	1
Thiotepa	0	1

Drug classes tested here Antimetabolites 3

Coming up

1phase 3 study under way

5studies finish main data collection within a year1 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 5, phase 3 first

Jun 2027Determination of Molecular Status, the Efficacy and Safety of Fluorodeoxyglucose in PET-CT Imaging · Phase 3 · Anna Raciborska
Apr 2027A Study of Memory, Thinking, and Brain Imaging in Adults With Histiocytosis · Memorial Sloan Kettering Cancer Center
Jun 2027Optimization of the Time and Dosage of Trametinib in BRAF Negative Juvenile Patients · Anna Raciborska
Jun 2027Optimization of the Time and Dosage of Vemurafenib in BRAF Positive Juvenile Patients With Refractory Histiocytosis · Anna Raciborska
Jul 2027Histiocytic Disorder Follow-up Study · University of Alabama at Birmingham

Who these studies take

Of the 4 Histiocytosis studies recruiting now, 3 (75%) set no upper age limit and 0 (0%) stop at 75 or younger. 2 (50%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.

Recruiting studies that take each age, of 4
Age	Women	Men
10	2 (50%)	2 (50%)
18	4 (100%)	4 (100%)
30	4 (100%)	4 (100%)
40	4 (100%)	4 (100%)
50	4 (100%)	4 (100%)
65	4 (100%)	4 (100%)
75	4 (100%)	4 (100%)
85	4 (100%)	4 (100%)

Across all 25 studies, recruiting or not: 56% stop at 75 or younger and 48% at 65; 60% take children; 4% are for women only and 0% for men only; 4% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

Studies

Recruiting first, then most recently updated. Showing 25 of 25. search them.