Hepatorenal Syndrome clinical trials
The registry lists 50 studies for Hepatorenal Syndrome across more than 10 countries. 7 are recruiting or about to start. 32 of them are mainly about Hepatorenal Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13.
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Who runs them
Hospital Clinic of Barcelona (4) · Mallinckrodt (3) · University of Turin, Italy (2) · The University of Hong Kong (2) · Institute of Liver and Biliary Sciences, India (2) · National Hepatology & Tropical Medicine Research Institute (2) · River 2 Renal Corp. (1) · Lahore General Hospital (1)
What is being tested here
Drugs under test in Hepatorenal Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 2
- Mar 2027Initial Resuscitation for Acute Kidney Injury in Cirrhosis · Massachusetts General Hospital
- May 2027A Retrospective Analysis of Outcomes in Patients With Hepatorenal Syndrome at Methodist Dallas Medical Center · Methodist Health System
Who these studies take
Of the 6 Hepatorenal Syndrome studies recruiting now, 2 (33%) set no upper age limit and 1 (17%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 6 (100%) | 6 (100%) |
| 30 | 6 (100%) | 6 (100%) |
| 40 | 6 (100%) | 6 (100%) |
| 50 | 6 (100%) | 6 (100%) |
| 65 | 6 (100%) | 6 (100%) |
| 75 | 6 (100%) | 6 (100%) |
| 85 | 4 (67%) | 4 (67%) |
Across all 50 studies, recruiting or not: 34% stop at 75 or younger and 8% at 65; 0% take children; 0% are for women only and 0% for men only; 0% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 50. search them.
- A Retrospective Analysis of Outcomes in Patients With Hepatorenal Syndrome at Methodist Dallas Medical CenterRecruitingNCT060954401 country
- Initial Resuscitation for Acute Kidney Injury in CirrhosisRecruitingNCT06525623Not applicable1 country
- Renal Histopathology and Transcriptomic Analysis in Hepatorenal Syndrome During Liver TransplantationNot yet recruitingNCT07300709Not applicable1 country
- Faecal Microbiota Transplantation for Liver CirrhosisRecruitingNCT04932577Phase 2/31 country
- Use of Novel Plasma and Urinary Biomarkers to Predict the Development of Hepatorenal Syndrome in Cirrhotic PatientsRecruitingNCT024344451 country
- HRS-AKI Treatment With TIPS in Patients With CirrhosisRecruitingNCT05346393Not applicable1 country
- Study to Evaluate R2R01 Plus Terlipressin Versus Terlipressin Alone in Patients With Hepatorenal SyndromeRecruitingNCT05875948Phase 21 country
- Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Hepatorenal Syndrome-Acute Kidney InjuryCompletedNCT054342861 country
- The Selective Cytopheretic Device (SCD) for Acute Kidney Injury (AKI) and Hepatorenal Syndrome (HRS) Type ISuspendedNCT04898010Not applicable1 country
- NEPH-ROSIS (NEPHrology in CirRhOSIS) Pilot Trial: A Trial to Treat Acute Kidney Injury Among Hospitalized Cirrhosis PatientsTerminatedNCT06000748Phase 2/31 country
- Statin Impact on Hepatic DecompensationCompletedNCT05563389Phase 2/31 country
- Endothelin Receptor Antagonism With Ambrisentan to Treat Hepatorenal SyndromeActive, not recruitingNCT06256432Phase 21 country
- Comparison of Terlipressin Versus Octreotide in Patients With Hepatorenal SyndromeCompletedNCT07460908Not applicable1 country
- Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With PrednisoloneCompletedNCT02281929Phase 31 country
- Interest of the Echocardiography in the Management of Cirrhotic Patients With Acute Kidney InjuryCompletedNCT02097784Not applicable1 country
- Terlipressin in Combined Hepatorenal Syndrome in Patients With Signs of Chronic Renal DiseaseCompletedNCT061617661 country
- Terlipressin for HRS-AKI in Liver Transplant Candidates (INFUSE)CompletedNCT04460560Phase 31 country
- Angiotensin 2 for Hepatorenal SyndromeWithdrawnNCT04048707Phase 2
- International Registry of Acute Kidney Injury in Cirrhosis: The GLOBAL AKI ProjectCompletedNCT0538781121 countries
- A Study of OCE-205 in Participants With Cirrhosis With Ascites Who Developed Hepatorenal Syndrome-Acute Kidney InjuryCompletedNCT05309200Phase 22 countries
- Efficacy of Early Terlipressin Plus Albumin Therapy in Comparison to Standard Treatment for HRS-AKI in Acute-on-chronic Liver Failure.CompletedNCT04416282Not applicable1 country
- Study To Confirm Efficacy and Safety of Terlipressin in Hepatorenal Syndrome (HRS) Type 1CompletedNCT02770716Phase 32 countries
- A Placebo-Controlled, Double-Blind Study to Confirm the Reversal of Hepatorenal Syndrome Type 1 With TerlipressinCompletedNCT01143246Phase 32 countries
- Fractional Excretion of Urea for the Differential Diagnosis of Acute Kidney Injury in CirrhosisStatus unknownNCT049861371 country
- MRI to Assess the Effect of Terlipressin in Patients With Acute Hepatorenal Syndrome (HRS-AKI)CompletedNCT034832721 country
- Norepinephrine Infusion Versus Midodrine & Octreotide in Patients With Hepatorenal Syndrome Type 1.CompletedNCT03455322Phase 41 country
- Nor-epinephrine Versus Midodrine/Octreotide in Patients With Hepatorenal SyndromeCompletedNCT04522297Not applicable1 country
- RAI & HRS: Relationship Between Relative Adrenal Insufficiency and Failure of Treatment in Hepatorenal SyndromeCompletedNCT042737501 country
- Treatment of Type I Hepatorenal Syndrome (HRS) With PentoxyfyllineTerminatedNCT02123576Not applicable1 country
- Midodrine, Octreotide and Albumin: Impact on Renal Function of Patients With Liver Cirrhosis and Renal FailureWithdrawnNCT01587222Phase 21 country
- Korean Cohort Study of AKI & HRS in CirrhosisStatus unknownNCT035307611 country
- Outcomes of Renal Function in Hepatorenal Syndrome (HRS) Determined By Comparison of Target Mean Arterial Pressure (MAP) of 65 - 70 Mmhg Versus ≥ 85 MmhgCompletedNCT02789150Early Phase 11 country
- Study of Terlipressin Versus Placebo to Treat Hepatorenal Syndrome Type 1CompletedNCT00089570Phase 31 country
- Safety and Pharmacokinetics of Ifetroban in Hepatorenal Syndrome PatientsCompletedNCT01436500Phase 22 countries
- Study of Accuracy of NGAL, a Renal Injury Biomarker, in Patients With CirrhosisStatus unknownNCT020491251 country
- To Compare the Efficacy of Nor Adrenaline and Terlipressin vs Step up Terlipressin Therapy in Hepatorenal SyndromeWithdrawnNCT01649037Not applicable1 country
- Midodrine and Albumin for Cirrhotic Patients With Functional Renal ImpairmentCompletedNCT01133795Phase 21 country
- A Phase 1 Study of LJPC-501 in Patients With Hepatorenal SyndromeTerminatedNCT01906307Phase 11 country
- The Effect of Terlipressin in the Prevention of Type 2 Hepatorenal Syndrome by Improving Mean Arterial PressureStatus unknownNCT02489864Phase 41 country
- Plasma and Hemodynamic Markers During HepatectomyCompletedNCT017002311 country
- Single Pass Albumin Dialysis in Patients With CirrhosisCompletedNCT00764049Phase 1/21 country
- Terlipressin + Albumin Versus Midodrine + Octreotide in the Treatment of Hepatorenal SyndromeTerminatedNCT00742339Phase 2/31 country
- Treatment of Type-1 Hepatorenal Syndrome Associated With SepsisCompletedNCT01932151Not applicable1 country
- A Study of Terlipressin in Patients With Hepatorenal Syndrome Type 1CompletedNCT01373606Phase 1/21 country
- Role Of Angiogenic Factors In The Development Of Hepatorenal SyndromeTerminatedNCT00734136Not applicable1 country
- Adrenal Insufficiency in Cirrhotics With Ascites. Effects of Hydrocortisone on Renal and Haemodynamic FunctionStatus unknownNCT00657306Phase 21 country
- Noradrenalin vs Terlipressin in Hepatorenal SyndromeCompletedNCT00370253Phase 31 country
- The Use of Drugs to Improve Kidney Function in Patients With Liver and Kidney DysfunctionCompletedNCT00240045Phase 2/31 country
- Treatment of Hepatorenal Syndrome With Terlipressin Plus Albumin vs AlbuminSuspendedNCT00287664Phase 41 country
- Norfloxacin In The Primary Prophylaxis Of Spontaneous Bacterial PeritonitisCompletedNCT00359853Phase 41 country