GlaxoSmithKline: Hepatitis B, Chronic trials

The registry lists 30 Hepatitis B, Chronic studies with GlaxoSmithKline as lead sponsor. 1 are open to participants now and 18 have results posted.

Phase 1 4Phase 2 7Phase 3 8Phase 4 10No phase 3(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• B-Ensure: Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study ParticipantsNot yet recruitingNCT07908459Phase 4
• Study of GSK3965193 in Healthy Participants and Participants Living With Chronic Hepatitis B InfectionTerminatedNCT05330455Phase 1/2Results posted
• Study of Sequential GSK3228836 and Peginterferon Treatment in Participants With Chronic Hepatitis B (CHB)CompletedNCT04676724Phase 2Results posted
• A Study of GSK3228836 in Participants With Chronic Hepatitis B (CHB)CompletedNCT04449029Phase 2Results posted
• Safety, Efficacy, Immunogenicity Study of GSK Biologicals' HBV Viral Vector and Adjuvanted Proteins Vaccine (GSK3528869A) in Adult Patients With Chronic Hepatitis B InfectionTerminatedNCT03866187Phase 1/2Results posted
• A Study of Switching From Entecavir to Tenofovir Disoproxil Fumarate in Subjects With Chronic Hepatitis BCompletedNCT03258710Phase 4Results posted
• A Study to Assess the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of GSK3389404 in Chronic Hepatitis B (CHB) SubjectsCompletedNCT03020745Phase 2Results posted
• Efficacy and Safety Study of Tenofovir Disoproxil Fumarate (TDF) in Chinese Chronic Hepatitis B (CHB) Subjects With Advanced Fibrosis & Compensated CirrhosisCompletedNCT02224456Phase 4Results posted
• Tenofovir Disoproxil Fumarate (TDF) 300mg 3 Years RD Therapy Chinese Chronic Hepatitis B (CHN) CHB Multiple Nucleos(t)Ide Analogues (NAs) Failure Points Pts PH4 PMS StudyCompletedNCT02195518Phase 4Results posted
• Phase 3 Study of GSK548470 in Patients With Compensated Chronic Hepatitis B Untreated With Nucleic Acid AnalogueCompletedNCT01480284Phase 3Results posted
• Phase 3 Study of GSK548470 in Patients With Compensated Chronic Hepatitis B With Poor Response to Other DrugsCompletedNCT01475851Phase 3Results posted
• Efficacy and Safety of Tenofovir Disoproxil Fumarate (TDF) 300mg in Chinese Subjects With Chronic Hepatitis B (CHB)CompletedNCT01300234Phase 3Results posted
• An Open Label, Multi Centre Phase IV Study of Adefovir Dipivoxil in Korean Patients With Chronic Hepatitis B (CHB)CompletedNCT01205165Phase 4Results posted
• A Study in Adult Subjects With Chronic Hepatitis B Infection to Support the Development of Immunological AssaysCompletedNCT01098006Not applicableResults posted
• Adefovir Dipivoxil For The Treatment Of Chinese Compensated Chronic Hepatitis B(CHB)PatientsCompletedNCT00441974Phase 4Results posted
• Study of Adefovir Dipivoxil for Korean Patients With Chronic Hepatitis B(CHB) Who Have Completed ADF 103814CompletedNCT00403585Phase 4Results posted
• Adefovir Dipivoxil For The Treatment Of Patients With Chronic Hepatitis B Related Advanced Fibrosis Or CirrhosisCompletedNCT00347009Phase 4Results posted
• Adefovir Dipivoxil Tablets (10mg) In Chinese Subjects With HBe Antigen Negative Chronic Hepatitis BCompletedNCT00324961Phase 4Results posted
• Adefovir Dipivoxil In Compensated Chronic Hepatitis B PatientsCompletedNCT00316719Phase 3Results posted
• A Study of Sequential Therapy With Daplusiran/Tomligisiran (DAP/TOM) Followed by Bepirovirsen in Participants Living With Chronic Hepatitis B (CHB)Active, not recruitingNCT06537414Phase 2
• Study of Bepirovirsen in Nucleos(t)Ide Analogue-treated Participants With Chronic Hepatitis B (B-Well 2)CompletedNCT05630820Phase 3
• Study of Bepirovirsen in Nucleos(t)Ide Analogue-treated Participants With Chronic Hepatitis B (B-Well 1)CompletedNCT05630807Phase 3
• A Study on the Safety, Efficacy and Immune Response Following Sequential Treatment With an Anti-sense Oligonucleotide Against Chronic Hepatitis B (CHB) and Chronic Hepatitis B Targeted Immunotherapy (CHB-TI) in CHB Patients Receiving Nucleos(t)Ide Analogue (NA) TherapyCompletedNCT05276297Phase 2
• Pharmacokinetic (PK) Profiles of Tenofovir Disoproxil Fumarate (TDF) 300 mg in Healthy Chinese SubjectsCompletedNCT01480622Phase 1
• Special Drug Use Investigation for ZEFIX (Lamivudine) Tablet (HBV Cirrhosis)CompletedNCT01376154
• Lamivudine and Adefovir Dipivoxil Fixed Dose CombinationCompletedNCT01353742Phase 1
• Lamivudine(LAM) Good Responder StudyCompletedNCT01128686
• A Efficacy and Safety Study of Adefovir Dipivoxil to Treat Chinese Patients With HBeAg+ve Chronic Hepatitis BCompletedNCT00857675Phase 3
• A Trial To Study The Effect Of Lamivudine In Adult Patients Who Suffer From Chronic Hepatitis B AloneCompletedNCT00354653Phase 4
• Lamivudine Plus Interferon Versus Lamivudine For The Treatment Of HBeAg Positive Chronic Hepatitis B Virus (HBV)CompletedNCT00140725Phase 3