Granulomatous Disease, Chronic clinical trials
The registry lists 79 studies for Granulomatous Disease, Chronic across more than 10 countries. 17 are recruiting or about to start. 54 of them are mainly about Granulomatous Disease, Chronic (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
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A study of drug A after surgery for early breast cancer
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· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
National Institute of Allergy and Infectious Diseases (NIAID) (31) · Paul Szabolcs (4) · University of Colorado, Denver (2) · Ensoma (2) · Federal Research Institute of Pediatric Hematology, Oncology and Immunology (2) · Genethon (2) · Emory University (2) · Children's Hospital of Fudan University (2)
What is being tested here
Drugs under test in Granulomatous Disease, Chronic studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Busulfan | 2 | 0 | 7 |
| Alemtuzumab | 2 | 0 | 5 |
| Sirolimus | 2 | 0 | 2 |
| Fludarabine | 1 | 0 | 5 |
| Melphalan | 1 | 0 | 2 |
| Plerixafor | 1 | 0 | 2 |
| Tocilizumab | 1 | 0 | 1 |
| Eltrombopag | 1 | 0 | 1 |
| Fibroblast Growth Factor 7 | 1 | 0 | 1 |
| Filgrastim | 1 | 0 | 1 |
Drug classes tested here Alkylating agents 3 open · Antimetabolites 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 6
- Nov 2026Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases · Paul Szabolcs
- Nov 2026Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT · Paul Szabolcs
- Nov 2026Early Check: Expanded Screening in Newborns · RTI International
- Dec 2026Prevalence of Antibodies and Cytokines in Participants With Chronic Granulomatous Disease · Ensoma
- Mar 2027pCCLCHIM-p47 (Lentiviral Vector Transduced CD34 Plus Cells) in Patients With p47 Autosomal Recessive Chronic Granulomatous Disease (AR-CGD) · National Institute of Allergy and Infectious Diseases (NIAID)
- Jul 2027NADPH Oxidase Correction in mRNA-transfected Granulocyte-enriched Cells in Chronic Granulomatous Disease (CGD) · National Institute of Allergy and Infectious Diseases (NIAID)
Who these studies take
Of the 12 Granulomatous Disease, Chronic studies recruiting now, 3 (25%) set no upper age limit and 9 (75%) stop at 75 or younger. 8 (67%) take children under 18. 0 (0%) are for women only and 3 (25%) for men only; 2 (17%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 8 (67%) | 8 (67%) |
| 18 | 9 (75%) | 12 (100%) |
| 30 | 8 (67%) | 11 (92%) |
| 40 | 8 (67%) | 11 (92%) |
| 50 | 7 (58%) | 9 (75%) |
| 65 | 5 (42%) | 7 (58%) |
| 75 | 3 (25%) | 5 (42%) |
| 85 | 3 (25%) | 3 (25%) |
Across all 79 studies, recruiting or not: 56% stop at 75 or younger and 49% at 65; 85% take children; 0% are for women only and 15% for men only; 11% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 14, 2026.
Results posted1
- Immune Disorder HSCT ProtocolOct 27, 2026NCT01821781
Studies
Recruiting first, then most recently updated. Showing 50 of 79. Browse all 79 → or search them.
- Evaluation of Patients With Immune Function AbnormalitiesRecruitingNCT001289731 country
- NADPH Oxidase Correction in mRNA-transfected Granulocyte-enriched Cells in Chronic Granulomatous Disease (CGD)RecruitingNCT05189925Phase 11 country
- Recruitment and Apheresis Collection of Peripheral Blood Hematopoietic Stem Cells, Mononuclear Cells and GranulocytesRecruitingNCT000014051 country
- Base Editing for Mutation Repair in Hematopoietic Stem & Progenitor Cells for X-Linked Chronic Granulomatous DiseaseRecruitingNCT06325709Phase 1/21 country
- pCCLCHIM-p47 (Lentiviral Vector Transduced CD34 Plus Cells) in Patients With p47 Autosomal Recessive Chronic Granulomatous Disease (AR-CGD)Enrolling by invitationNCT06253507Phase 1/21 country
- Lentiviral Gene Therapy for CGDNot yet recruitingNCT03645486Not applicable1 country
- Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease (CGD) With an Alemtuzumab, Busulfan and TBI-based Conditioning Regimen Combined With Cytokine (IL-6, +/- IFN-gamma) AntagonistsRecruitingNCT05463133Phase 1/21 country
- Open-label Gene Therapy Study in p47-CGDRecruitingNCT07826767Phase 1/23 countries
- Part B- G1X-CGD (Lentiviral Vector Transduced CD34+ Cells) in Patients With X-Linked Chronic Granulomatous DiseaseEnrolling by invitationNCT07113743Phase 1/21 country
- Prevalence of Antibodies and Cytokines in Participants With Chronic Granulomatous DiseaseRecruitingNCT066053782 countries
- Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)RecruitingNCT07284641Phase 21 country
- A Study of the Safety and Efficacy of Prime Editing (PM359) in Participants With p47phox Autosomal Recessive Chronic Granulomatous Disease (CGD )Enrolling by invitationNCT06559176Phase 1/23 countries
- Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RICRecruitingNCT045283551 country
- Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency DiseasesEnrolling by invitationNCT01852370Phase 1/21 country
- Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCTRecruitingNCT01962415Phase 21 country
- Combination of Ibuprofen, G-CSF and Plerixafor as Stem Cells Mobilization Regimen in Patients Affected by X-CGDRecruitingNCT03055247Phase 21 country
- Neutrophil Oxidative Burst in Early and Late Onset Pediatric Inflammatory Bowel DiseaseRecruitingNCT061629361 country
- Analysis of Patients Treated for Chronic Granulomatous Disease Since January 1, 1995CompletedNCT021167641 country
- Study of Voicing My CHOiCES as a Tool for Advanced Care Planning in Young Adults With CancerCompletedNCT021080281 country
- Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab, Busulfan and TBI With Post-Transplant CyclophosphamideActive, not recruitingNCT03910452Early Phase 11 country
- Immune Disorder HSCT ProtocolCompletedNCT01821781Phase 21 country
- High Dose Peripheral Blood Stem Cell Transplantation With Post Transplant Cyclophosphamide for Patients With Chronic Granulomatous DiseaseActive, not recruitingNCT02629120Phase 1/21 country
- Study to Assess the Use of JSP191 in Matched Unrelated Donor Transplantation for Chronic Granulomatous Disease (CGD)Active, not recruitingNCT05600907Early Phase 11 country
- Study of EN-374 Gene Therapy in Participants With X-Linked Chronic Granulomatous DiseaseActive, not recruitingNCT06876363Phase 1/22 countries
- Early Check: Expanded Screening in NewbornsActive, not recruitingNCT036552231 country
- Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune DeficienciesActive, not recruitingNCT01652092Not applicable1 country
- Genetic Disorders of Mucociliary Clearance in Nontuberculous Mycobacterial Lung DiseaseCompletedNCT003684461 country
- Safety and Efficacy of Tofacitinib for Chronic Granulomatous Disease With Inflammatory ComplicationsCompletedNCT05104723Phase 1/21 country
- Gene Therapy for X-linked Chronic Granulomatous DiseaseTerminatedNCT02757911Phase 1/21 country
- Gene Therapy for X-linked Chronic Granulomatous Disease (X-CGD)TerminatedNCT01855685Phase 1/21 country
- Elemental Diet for Treatment of Inflammatory Bowel Disease in Patients With Chronic Granulomatous DiseaseCompletedNCT03983837Phase 21 country
- Gene Therapy for Chronic Granulomatous Disease in KoreaWithdrawnNCT00778882Phase 1/21 country
- Baby Detect : Genomic Newborn ScreeningCompletedNCT056874741 country
- Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood CancerTerminatedNCT03333486Phase 21 country
- Study of Gene Therapy Using a Lentiviral Vector to Treat X-linked Chronic Granulomatous DiseaseCompletedNCT02234934Phase 1/21 country
- Skin Immunity Sample Collection Involving Blisters and BiopsiesWithdrawnNCT03921515Early Phase 11 country
- Vitamin D3 For CGD Patients With BCGosis/ItisCompletedNCT03984890Phase 2/31 country
- Whole Blood Biospecimen Collection for Subjects With Chronic Granulomatous Disease (CGD)TerminatedNCT059158971 country
- Safety Study of Gene Modified Donor T Cell Infusion After Stem Cell Transplant for Non-Malignant DiseasesTerminatedNCT02231710Phase 11 country
- Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell TransplantationCompletedNCT03513328Phase 1/21 country
- Natural History of Intestinal Inflammation in People With Primary Immune DysregulationsWithdrawnNCT032789121 country
- Reduced Intensity Conditioning for Hemophagocytic Syndromes or Selected Primary Immune Deficiencies (BMT CTN 1204)CompletedNCT01998633Phase 22 countries
- Patients Treated for Chronic Granulomatous Disease (CGD) Since 1995Status unknownNCT020823532 countries
- Non-Invasive Assessment of Atherosclerosis in Patients With CGD and Other Disorders of the Immune SystemCompletedNCT010633091 country
- Role of Interferon-gamma 1-b (IFN-γ) on Cells of the Innate Immune System: Functional, Biochemical and Gene Expression Studies in Patients With Chronic Granulomatous DiseaseCompletedNCT035488181 country
- Pharmacokinetics of Posaconazole in Children With Chronic Granulomatous Disease (CGD)CompletedNCT00799071Phase 21 country
- Haploidentical Transplant for People With Chronic Granulomatous Disease Using Post Transplant CyclophosphamideTerminatedNCT02282904Phase 1/21 country
- IL-1 Receptor Inhibitor for Granulomatous Complications in Patients With Chronic Granulomatous DiseaseCompletedNCT04136028Early Phase 11 country
- Radiofrequency Ablation for Liver Abscesses From Chronic Granulomatous DiseaseWithdrawnNCT01851460Phase 11 country
- Bone Marrow Transplant With Abatacept for Non-Malignant DiseasesCompletedNCT01917708Phase 11 country