National Institute of Allergy and Infectious Diseases (NIAID): Granulomatous Disease, Chronic trials

The registry lists 30 Granulomatous Disease, Chronic studies with National Institute of Allergy and Infectious Diseases (NIAID) as lead sponsor. 7 are open to participants now and 3 have results posted.

Early Phase 1 4Phase 1 11Phase 2 10Phase 3 2Phase 4 2No phase 8(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Part B- G1X-CGD (Lentiviral Vector Transduced CD34+ Cells) in Patients With X-Linked Chronic Granulomatous DiseaseEnrolling by invitationNCT07113743Phase 1/2
• Base Editing for Mutation Repair in Hematopoietic Stem & Progenitor Cells for X-Linked Chronic Granulomatous DiseaseRecruitingNCT06325709Phase 1/2
• pCCLCHIM-p47 (Lentiviral Vector Transduced CD34 Plus Cells) in Patients With p47 Autosomal Recessive Chronic Granulomatous Disease (AR-CGD)Enrolling by invitationNCT06253507Phase 1/2
• Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease (CGD) With an Alemtuzumab, Busulfan and TBI-based Conditioning Regimen Combined With Cytokine (IL-6, +/- IFN-gamma) AntagonistsRecruitingNCT05463133Phase 1/2
• NADPH Oxidase Correction in mRNA-transfected Granulocyte-enriched Cells in Chronic Granulomatous Disease (CGD)RecruitingNCT05189925Phase 1
• Evaluation of Patients With Immune Function AbnormalitiesRecruitingNCT00128973
• Recruitment and Apheresis Collection of Peripheral Blood Hematopoietic Stem Cells, Mononuclear Cells and GranulocytesRecruitingNCT00001405
• Haploidentical Transplant for People With Chronic Granulomatous Disease Using Post Transplant CyclophosphamideTerminatedNCT02282904Phase 1/2Results posted
• Biochemical Response to Interferon-Gamma in Subjects With Specific Gene Mutation in Chronic Granulomatous DiseaseTerminatedNCT01147042Phase 4Results posted
• Infliximab to Treat Crohn'S-like Inflammatory Bowel Disease in Chronic Granulomatous DiseaseTerminatedNCT00325078Phase 1/2Results posted
• Study to Assess the Use of JSP191 in Matched Unrelated Donor Transplantation for Chronic Granulomatous Disease (CGD)Active, not recruitingNCT05600907Early Phase 1
• Safety and Efficacy of Tofacitinib for Chronic Granulomatous Disease With Inflammatory ComplicationsCompletedNCT05104723Phase 1/2
• Elemental Diet for Treatment of Inflammatory Bowel Disease in Patients With Chronic Granulomatous DiseaseCompletedNCT03983837Phase 2
• Skin Immunity Sample Collection Involving Blisters and BiopsiesWithdrawnNCT03921515Early Phase 1
• Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab, Busulfan and TBI With Post-Transplant CyclophosphamideActive, not recruitingNCT03910452Early Phase 1
• Natural History of Intestinal Inflammation in People With Primary Immune DysregulationsWithdrawnNCT03278912
• Evaluating the Transition From Pediatric to Adult Care Among Adolescents With Chronic Granulomatous DiseaseCompletedNCT02233036
• Analysis of Patients Treated for Chronic Granulomatous Disease Since January 1, 1995CompletedNCT02116764
• Patients Treated for Chronic Granulomatous Disease (CGD) Since 1995Status unknownNCT02082353
• Radiofrequency Ablation for Liver Abscesses From Chronic Granulomatous DiseaseWithdrawnNCT01851460Phase 1
• Non-Invasive Assessment of Atherosclerosis in Patients With CGD and Other Disorders of the Immune SystemCompletedNCT01063309
• Gene Therapy for Chronic Granulomatous DiseaseTerminatedNCT00394316Early Phase 1
• Posaconazole to Treat Invasive Fungal InfectionsCompletedNCT00033982Phase 3
• Treatment of Chronic Granulomatous Disease With Allogeneic Stem Cell Transplantation Versus Standard of CareCompletedNCT00023192Phase 3
• Modified Stem Cell Transplantation Procedure for Treating Chronic Granulomatous DiseaseCompletedNCT00006417Phase 2
• Learning and Behavior Problems in Children With Chronic Granulomatous Disease and Related DisordersCompletedNCT00005933
• Stem Cell Transplant Following Low-Intensity Chemotherapy to Treat Chronic Granulomatous DiseaseCompletedNCT00001765Phase 1
• Gene Therapy for Chronic Granulomatous Diseases - Long-term Follow-upCompletedNCT00001476Phase 1
• A Phase IV Study of Recombinant Human Gamma Interferon in Patients With Chronic Granulomatous Diseases of ChildhoodCompletedNCT00001317Phase 4
• Itraconazole for the Prevention of Fungal Infections in Chronic Granulomatous DiseaseCompletedNCT00001280Phase 2