Genetic Risk Score clinical trials
The registry lists 53 studies for Genetic Risk Score across more than 10 countries. 35 are recruiting or about to start. 6 of them are mainly about Genetic Risk Score (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Phase
- Phase 4
- 2
Who runs them
Catholic University of the Sacred Heart (5) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (3) · University of Alabama at Birmingham (2) · Second Xiangya Hospital of Central South University (2) · Harokopio University (2) · National and Kapodistrian University of Athens (2) · VA Office of Research and Development (2) · Massachusetts General Hospital (2)
What is being tested here
Drugs under test in Genetic Risk Score studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Saline Solution | 1 | 0 | 1 |
| Sodium Chloride | 1 | 0 | 1 |
| Metoprolol | 1 | 0 | 1 |
| Rosuvastatin | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 9
- Dec 2026Prediction of Atrial Fibrillation Using Polygenic Risk Score · Seoul St. Mary's Hospital
- Jan 2027Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists. · National and Kapodistrian University of Athens
- Feb 2027Evaluation of Polygenic Risk Score for Epithelial OVarian cancEr Risk Prediction: the PROVE Study · Catholic University of the Sacred Heart
- Apr 2027Non-Invasive Diagnostic Panel for MASLD in Children With Obesity · Kayseri City Hospital
- Jun 2027Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Change in Cardiovascular Health · Massachusetts General Hospital
- Aug 2027Clinical Utility of a Genomic Predictor Test on the Management of Cardiorenal Complications of Type 2 Diabetes · Optithera
- Oct 2027Development of Polygenic Risk Scores in Colon Cancer Patients Through the Study of Ancestry and Diversity in Genetic Maps of the Brazilian Population - ORIGEM Project · D'Or Institute for Research and Education
- Oct 2027Pharmacogenomic Informed Statin Prescribing · VA Office of Research and Development
- Nov 2027Polygenic Risk Score for Optimizing Primary Prevention in Intermediate-Risk Populations · University of Bern
Who these studies take
Of the 22 Genetic Risk Score studies recruiting now, 8 (36%) set no upper age limit and 12 (55%) stop at 75 or younger. 6 (27%) take children under 18. 2 (9%) are for women only and 3 (14%) for men only; 11 (50%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (23%) | 5 (23%) |
| 18 | 12 (55%) | 10 (45%) |
| 30 | 12 (55%) | 10 (45%) |
| 40 | 15 (68%) | 15 (68%) |
| 50 | 15 (68%) | 15 (68%) |
| 65 | 14 (64%) | 14 (64%) |
| 75 | 12 (55%) | 10 (45%) |
| 85 | 8 (36%) | 7 (32%) |
Across all 53 studies, recruiting or not: 43% stop at 75 or younger and 21% at 65; 25% take children; 13% are for women only and 9% for men only; 45% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered1
- Lifestyle Interventions and Genetic Scores for Weight ManagementNov 6, 2026NCT07922005
Studies
Recruiting first, then most recently updated. Showing 50 of 53. Browse all 53 → or search them.
- Pharmacogenomic Informed Statin PrescribingRecruitingNCT06568601Not applicable1 country
- Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic ScoreRecruitingNCT07490067Phase 41 country
- Polygenic Risk Score Implementation and Stratification for Managing Blood PressureRecruitingNCT06962488Not applicable1 country
- Predicting Pre-dementiaRecruitingNCT075161191 country
- Measuring Athlete's Risk of Cardiovascular Events 3 (MARC-3)Enrolling by invitationNCT076254881 country
- Implementing Polygenic Risk Scores for Breast Cancer Prevention: a Feasibility StudyRecruitingNCT06922708Not applicable1 country
- Non-Invasive Diagnostic Panel for MASLD in Children With ObesityNot yet recruitingNCT077313601 country
- Early Prediction of Outcomes Following Optic Neuritis: Development and Acceptability of a Prognostic ToolNot yet recruitingNCT077042941 country
- Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists.RecruitingNCT076534121 country
- Exocrine-Endocrine Pancreatic Crosstalk: Precision Pathways to Reframe Diabetes PathophysiologyNot yet recruitingNCT07670871
- Prediction of Atrial Fibrillation Using Polygenic Risk ScoreRecruitingNCT07641582Not applicable1 country
- Genetic Risk Score of Type 1 Diabetes Mellitus for Progression to Insulin in Diabetic Patients Lack of Predictive Value: a Multicenter Nested Case-control StudyRecruitingNCT076214451 country
- Rapid Engagement for Solutions to Population and Outcomes Through Networked Dialogue for Coronary Heart DiseaseNot yet recruitingNCT07260552
- Diagnostic Value of Exome/ Genome Sequencing, Conventional Methods in Rare Diseases and Familial Tumor SyndromesRecruitingNCT047318571 country
- Study of a Polygenic Risk Score to Predict the Risk of Pancreatic Ductal AdenocarcinomaNot yet recruitingNCT07516392Not applicable
- Impact of Disclosing Coronary Artery Disease Polygenic Risk Score on Cardiovascular HealthRecruitingNCT07087431Not applicable1 country
- Genetic Architecture of Natriuretic Peptides and Blood Pressure ResponseNot yet recruitingNCT07118592Not applicable1 country
- Evaluation of Polygenic Risk Score for Epithelial OVarian cancEr Risk Prediction: the PROVE StudyRecruitingNCT069353441 country
- General Population Level Estimation for Type 1 Diabetes Risk in Children During Routine Care DeliveryRecruitingNCT044779281 country
- Personalised HeartCare: Poligenic Risk Scores Disclosure for Cardiovascular PreventionRecruitingNCT06888466Not applicable1 country
- The i4i PRODICT® Study: Evaluation of the i4i PRODICT® Test in Different Ethnic Groups (The i4i PRODICT® Study).RecruitingNCT066365261 country
- DELphi Procedure for Developing Recommendations for the Implementation of Wearable Devices and Polygenic Risk ScoresNot yet recruitingNCT073584811 country
- The Prostate Cancer, Genetic Risk, and Equitable Screening Study (ProGRESS)RecruitingNCT05926102Not applicable1 country
- Polygenic Risk Stratification Combined With mpMRI to Identify Clinically Relevant Prostate CancerRecruitingNCT06398639Not applicable1 country
- Utility and Effectiveness of Polygenic Risk Scoring (PRS) for Coronary Artery Disease (CAD)Enrolling by invitationNCT06542432Not applicable1 country
- Better4All Personalized Intervention Pilot StudyRecruitingNCT07120802Not applicable7 countries
- Feasibility of Innovative Approaches for Personalized Cardiovascular PreventionRecruitingNCT06911294Not applicable1 country
- Better4All Personalized InterventionNot yet recruitingNCT06997510Not applicable7 countries
- Development of Polygenic Risk Scores in Colon Cancer Patients Through the Study of Ancestry and Diversity in Genetic Maps of the Brazilian Population - ORIGEM ProjectEnrolling by invitationNCT069177941 country
- Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center StudyNot yet recruitingNCT066625911 country
- Clinical Utility of a Genomic Predictor Test on the Management of Cardiorenal Complications of Type 2 DiabetesRecruitingNCT06586203Not applicable1 country
- Genome-based Management of Patients in Precision Medicine (Ge-Med) Towards a Genomic Health ProgramRecruitingNCT04760522Not applicable1 country
- Polygenic Risk Score to Predict Weight Loss Intervention in Children With ObesityRecruitingNCT054660971 country
- Genomic and Dietary Aspects in Gastric Cancer RiskNot yet recruitingNCT059340581 country
- Mechanisms of Type 1 Diabetes EndophenotypesRecruitingNCT057648501 country
- Lifestyle Interventions and Genetic Scores for Weight ManagementCompletedNCT07922005Not applicable1 country
- The Genomic Medicine at VA StudyActive, not recruitingNCT04331535Not applicable1 country
- Polygenic Risk Score for Optimizing Primary Prevention in Intermediate-Risk PopulationsActive, not recruitingNCT07039123Not applicable1 country
- Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Change in Cardiovascular HealthActive, not recruitingNCT05819814Not applicable1 country
- A Tailored Polygenic Risk Score for Predicting Progression in Prostate Cancer Under Active SurveillanceCompletedNCT074914061 country
- Polygenic Risk Driven Pragmatic Statin Trial for Heart Disease PreventionActive, not recruitingNCT06820086Phase 41 country
- Genome-wide Association Study of Different Types of Diabetes and Construction of Genetic Risk ScoreCompletedNCT06791330
- Genetic Risk Stratification for Primary Prevention of CAD in Men and Pre & Post-menopausal WomenStatus unknownNCT051698401 country
- Genetic and Non-Genetic Breast Cancer Risk Prediction Evaluation in Indonesian SamplesCompletedNCT055702661 country
- Clinical Implementation of a Polygenic Risk Score (PRS) for Breast CancerCompletedNCT036882041 country
- Understanding Genetic Risk for Alcohol Use DisorderCompletedNCT05143073Not applicable1 country
- OneinSeven Gestational Diabetes Genetic and Socioeconomic Risk StudyStatus unknownNCT047894731 country
- Returning Genome and Metabolome Data to FinTerveys 2017 Participants: P5.fi FinTerveys StudyStatus unknownNCT036501271 country
- Correlation of Genetic Polymorphisms and Clinical Parameters With the Complexity of Coronary Artery DiseaseStatus unknownNCT033152341 country
- Proactive Cardiovascular Prevention Strategy in Subjects With High Genetic RiskStatus unknownNCT04291157Not applicable1 country