Eye Pain clinical trials
The registry lists 31 studies for Eye Pain across more than 10 countries. 7 are recruiting or about to start. 18 of them are mainly about Eye Pain (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-06.
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Who runs them
Nicole Fram M.D. (3) · Sylentis, S.A. (3) · EyeCool Therapeutics, Inc. (2) · Biogen (2) · Novartis Pharmaceuticals (2) · Oculis (2) · Mohsen Pourazizi (1) · Laboratorios Sophia S.A de C.V. (1)
What is being tested here
Drugs under test in Eye Pain studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Acoltremon | 1 | 0 | 1 |
| Clemastine | 1 | 0 | 1 |
| Tivanisiran | 0 | 0 | 3 |
| Dexamethasone | 0 | 0 | 2 |
| SAF312 | 0 | 0 | 2 |
| Omaveloxolone | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3, phase 3 first
- May 2027Phase 3, Multi-Center, Randomized, Double-Masked, Placebo-Controlled Study Assessing the Safety and Efficacy of Urcosimod Ophthalmic Solution in Participants With Neuropathic Corneal Pain (NCP). · Phase 3 · Okyo Pharma Ltd
- Nov 2026A Study to Assess Safety, Tolerability, and Pharmacokinetics of Ascending Concentrations of Topical Ocular BL1332 in Healthy Volunteers · Bausch & Lomb Incorporated
- May 2027Effect of Acoltremon Ophthalmic Solution 0.003% on Tear Production and Symptoms in Patients With Tear Deficiency and Concurrent Neuropathic Corneal Pain · University of South Florida
Who these studies take
Of the 3 Eye Pain studies recruiting now, 1 (33%) set no upper age limit and 1 (33%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 1 (33%) | 1 (33%) |
| 30 | 3 (100%) | 3 (100%) |
| 40 | 3 (100%) | 3 (100%) |
| 50 | 3 (100%) | 3 (100%) |
| 65 | 2 (67%) | 2 (67%) |
| 75 | 2 (67%) | 2 (67%) |
| 85 | 2 (67%) | 2 (67%) |
Across all 31 studies, recruiting or not: 16% stop at 75 or younger and 13% at 65; 6% take children; 0% are for women only and 0% for men only; 23% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 31 of 31. search them.
- Effect of Acoltremon Ophthalmic Solution 0.003% on Tear Production and Symptoms in Patients With Tear Deficiency and Concurrent Neuropathic Corneal PainNot yet recruitingNCT07849803Phase 41 country
- Phase 3, Multi-Center, Randomized, Double-Masked, Placebo-Controlled Study Assessing the Safety and Efficacy of Urcosimod Ophthalmic Solution in Participants With Neuropathic Corneal Pain (NCP).Not yet recruitingNCT07838506Phase 31 country
- A Clinical Study to Determine What Effect the EyeCool Treatment Has on the Eye's Surface Anatomy and Inflammation Response After Being Treated for Having Chronic Ocular Surface Pain (COSP)RecruitingNCT07059754Not applicable1 country
- Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER)RecruitingNCT02521311Phase 21 country
- Efficacy of Quantum Molecular Resonance in Neuropathic Corneal Pain and Corneal Nerve RegenerationRecruitingNCT07174739Not applicable1 country
- Validation of Ocular Pain Questionnaire: Single-center, Prospective Observational StudyNot yet recruitingNCT06656260
- Efficacy and Safety of Topical Cyclosporine 0.05% and Lifitgrast on the Ocular Surface Symptom After Photorefractive Keratectomy in Feiz Hospital, Isfahan, 2024Not yet recruitingNCT06624384Phase 11 country
- A Phase 3 Study Evaluating the Efficacy and Safety of OCS-01 Opthalmic Suspension Compared to Vehicle for the Treatment of Ocular Inflammation and Pain Following Cataract SurgeryTerminatedNCT06128369Phase 31 country
- Alternating and Direct Current Stimulation for Neuropathic Eye PainCompletedNCT05931250Not applicable1 country
- Pilot Study of TENS for Ocular PainCompletedNCT05531643Not applicable1 country
- Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Cataract SurgeryCompletedNCT05626478Phase 41 country
- A Study to Assess Safety, Tolerability, and Pharmacokinetics of Ascending Concentrations of Topical Ocular BL1332 in Healthy VolunteersActive, not recruitingNCT06978244Phase 11 country
- Evaluate the TetraLens, a Tetracaine Releasing Therapeutic Bandage Contact Lens in Patients Undergoing PRK ProcedureCompletedNCT06085352Early Phase 11 country
- Study of the ETX-4143 2.0 Device in Subjects With Eye PainCompletedNCT06479382Not applicable1 country
- A Phase 3 Study Evaluating the Efficacy and Safety of OCS-01 Eyedrops Compared to Vehicle for the Treatment of Ocular Inflammation and Pain Following Cataract SurgeryCompletedNCT05147233Phase 31 country
- RTA 408 Ophthalmic Suspension for the Prevention of Corneal Endothelial Cell Loss Following Cataract Surgery - GUARDCompletedNCT02128113Phase 21 country
- RTA 408 Ophthalmic Suspension for the Treatment of Ocular Inflammation and Pain Following Ocular SurgeryCompletedNCT02065375Phase 21 country
- Cool vs Room-temperature Artificial TearsCompletedNCT05832996Phase 41 country
- Study of Efficacy and Safety of SAF312 Eye Drops in Subjects With Post-operative Corneal Induced Chronic Pain (CICP)CompletedNCT04630158Phase 23 countries
- Multisensory Stimulation in Infants for Eye ExaminationCompletedNCT05830409Not applicable1 country
- Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Corneal Transplant SurgeryCompletedNCT04521140Phase 41 country
- Effect of Trigeminal Nerve Stimulation on Corneal Nerves and Chronic Ocular PainCompletedNCT04648085Not applicable1 country
- Study of SAF312 as an Eye Drop for Treatment of Eye Pain Following Photorefractive Keratectomy (PRK) SurgeryCompletedNCT02961062Phase 21 country
- A Retrospective Review of DEXTENZA 0.4 mg inseRt Following Corneal Transplant or Cataract SurgeryCompletedNCT049759711 country
- Efficacy and Safety of PRO-155 on Inflammation of the Conjunctival Surface in Subjects With Grade I-III Pterygium vs Placebo.CompletedNCT03521791Phase 41 country
- DRy Eye Outcome and Prescription StudyStatus unknownNCT036524151 country
- Evaluation of the Safety, Systemic Pharmacokinetics, and TolerabilityCompletedNCT03063489Phase 11 country
- Dose-finding Study to Assess the Safety and Effect of SYL1001 in Patients With Ocular PainCompletedNCT02455999Phase 22 countries
- Pilot Study to Evaluate SYL1001 Safety and Effect in Patients With Ocular PainCompletedNCT01776658Phase 1/21 country
- Pain Expression in the Perioperative Period of Cataract SurgeryStatus unknownNCT01824927Not applicable1 country
- Study to Evaluate the Ocular Tolerance of SYL1001 in Healthy VolunteersCompletedNCT01438281Phase 11 country