Epilepsy, Temporal Lobe clinical trials
The registry lists 65 studies for Epilepsy, Temporal Lobe across more than 10 countries. 25 are recruiting or about to start. 48 of them are mainly about Epilepsy, Temporal Lobe (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-26.
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Who runs them
National Institute of Neurological Disorders and Stroke (NINDS) (11) · Central Hospital, Nancy, France (2) · Second Affiliated Hospital, School of Medicine, Zhejiang University (2) · Assistance Publique Hopitaux De Marseille (2) · Duke University (2) · Assiut University (2) · Xijing Hospital (2) · University Hospital, Toulouse (1)
What is being tested here
Drugs under test in Epilepsy, Temporal Lobe studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Ferrosoferric Oxide | 1 | 0 | 1 |
| Lovastatin | 0 | 0 | 1 |
| Escitalopram | 0 | 0 | 1 |
| Amitriptyline | 0 | 0 | 1 |
| Buspirone | 0 | 0 | 1 |
| Naluzotan | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 10
- Nov 2026Low-intensity Focused Ultrasound Pulsation (LIFUP) for Treatment of Temporal Lobe Epilepsy · BrainSonix Inc.
- Dec 2026A Pilot Study to Evaluate the Efficacy and Safety of NaviFUS™ System Neuromodulating Treatment for Patients With Drug Resistant Epilepsy · NaviFUS Corporation
- Jan 2027MRgLITT for mTLE: A PROBE Trial · Beijing Tiantan Hospital
- Feb 2027Localizing Epileptic Networks Using MRI and iEEG · University of Pennsylvania
- Mar 2027Changes in Attentional Control After a Focal Seizure. · University Hospital, Lille
- Mar 2027Intensive Preoperative Speech Rehabilitation in Drug-Resistant Temporal Epilepsy · Assistance Publique Hopitaux De Marseille
- Jun 2027Evaluation of the NaviFUS System in Drug Resistant Epilepsy · Genovate-NaviFUS (Australia) Pty Ltd.
- Jun 2027Pre-operative Mapping of the Anterior Temporal Lobe Using Functional MRI Innovative Techniques in in Drug-resistant Epileptic Patients · Central Hospital, Nancy, France
- Jun 2027A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE) · Neurona Therapeutics
- Oct 2027Pathophysiology, Psycho-emotional and Cognitive Functioning Associated With Tinnitus · Assistance Publique - Hôpitaux de Paris
Who these studies take
Of the 19 Epilepsy, Temporal Lobe studies recruiting now, 6 (32%) set no upper age limit and 9 (47%) stop at 75 or younger. 4 (21%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 5 (26%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (16%) | 3 (16%) |
| 18 | 19 (100%) | 19 (100%) |
| 30 | 19 (100%) | 19 (100%) |
| 40 | 19 (100%) | 19 (100%) |
| 50 | 19 (100%) | 19 (100%) |
| 65 | 16 (84%) | 16 (84%) |
| 75 | 11 (58%) | 11 (58%) |
| 85 | 9 (47%) | 9 (47%) |
Across all 65 studies, recruiting or not: 51% stop at 75 or younger and 45% at 65; 26% take children; 0% are for women only and 0% for men only; 29% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- Overnight TI in TLEOct 16, 2026NCT07434986
Studies
Recruiting first, then most recently updated. Showing 50 of 65. Browse all 65 → or search them.
- Surgery as a Treatment for Medically Intractable EpilepsyRecruitingNCT012731291 country
- Investigating Epilepsy: Screening and EvaluationRecruitingNCT034788521 country
- Overnight TI in TLERecruitingNCT07434986Not applicable1 country
- Studying Heart Rhythms With a Wearable Sensor to Detect and Predict Seizures in People With EpilepsyNot yet recruitingNCT078355941 country
- Evaluation of the NaviFUS System in Drug Resistant EpilepsyRecruitingNCT05947656Not applicable1 country
- Spatial Scene Recognition Memory in Epilepsy SurgeryRecruitingNCT07580183Not applicable1 country
- Enhanced MRI Imaging in Healthy Participants and Participants With EpilepsyRecruitingNCT06483061Phase 21 country
- PRIME: PReservIng Memory in EpilepsyRecruitingNCT05608408Not applicable1 country
- Changes in Attentional Control After a Focal Seizure.RecruitingNCT064666811 country
- A Pilot Study to Evaluate the Efficacy and Safety of NaviFUS™ System Neuromodulating Treatment for Patients With Drug Resistant EpilepsyRecruitingNCT06492720Not applicable1 country
- Localizing Epileptic Networks Using MRI and iEEGRecruitingNCT04649008Early Phase 11 country
- MRI Volumetry and Diffusion Tensor Imaging in Temporal Lobe EpilepsyNot yet recruitingNCT07384351
- MRgLITT for mTLE: A PROBE TrialRecruitingNCT06720922Not applicable1 country
- A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE)RecruitingNCT06422923Phase 1/21 country
- Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration in Neurological Diseases and Healthy AgingRecruitingNCT072024941 country
- Hippocampal Network Function in EpilepsyEnrolling by invitationNCT06521437Not applicable1 country
- Pre-operative Mapping of the Anterior Temporal Lobe Using Functional MRI Innovative Techniques in in Drug-resistant Epileptic PatientsRecruitingNCT05339438Not applicable1 country
- Pathophysiology, Psycho-emotional and Cognitive Functioning Associated With TinnitusRecruitingNCT04717388Not applicable1 country
- Innovative MRI to Localize the Epileptic ZoneNot yet recruitingNCT06057233
- Transcranial Electrical Stimulation Targeting the Cerebellum for the Treatment of Refractory Temporal Lobe EpilepsyRecruitingNCT06558890Not applicable1 country
- Low-intensity Focused Ultrasound Pulsation (LIFUP) for Treatment of Temporal Lobe EpilepsyEnrolling by invitationNCT02151175Not applicable1 country
- Intensive Preoperative Speech Rehabilitation in Drug-Resistant Temporal EpilepsyRecruitingNCT05609084Not applicable1 country
- Exercise for Brain Regeneration in EpilepsyRecruitingNCT05179083Phase 11 country
- A New Approach in Intensive Care Unit Consciousness Assessment: FIVE ScoreNot yet recruitingNCT060367321 country
- Minimally Invasive Surgical Epilepsy Trial for Temporal Lobe EpilepsyRecruitingNCT05019404Not applicable1 country
- Spatial Memory and Temporal Lobe EpilepsyCompletedNCT06847152Not applicable1 country
- Sphenopalatine Ganglion Nerve Block vs. Elavil for Treatment of Transformed MigrainesTerminatedNCT02090998Phase 41 country
- Stimulation of the Thalamus for Arousal Restoral in Temporal Lobe EpilepsyCompletedNCT04897776Not applicable1 country
- Evaluation of Memory and Forgetting in Patients With EpilepsyCompletedNCT04924933Not applicable1 country
- Treating Deep Seizure Foci With Noninvasive Surface Brain StimulationCompletedNCT02339376Not applicable1 country
- The GABAergic Inhibitory System in Drug Resistant EpilepsyCompletedNCT06789497Not applicable1 country
- Stereotactic Laser Ablation for Temporal Lobe Epilepsy (Slate)CompletedNCT02844465Not applicable1 country
- Autonomic Dysfunction in Temporal Lobe Epilepsy and SUDEPCompletedNCT062698221 country
- Epilepsy Surgery and Cognitive OutcomeCompletedNCT042647801 country
- Investigations of Amygdala Function Using Neurophysiological Recording and StimulationCompletedNCT03958903Not applicable1 country
- Low Frequency Electrical Stimulation of the Fornix in Intractable Mesial Temporal Lobe Epilepsy (MTLE)CompletedNCT02383407Not applicable1 country
- SEEG Guided RF-TC v.s. ATL for mTLE With HSCompletedNCT03941613Not applicable1 country
- Self-modulation of the Sense of Agency by Means of Real-time NeurofeedbackStatus unknownNCT05214833Not applicable1 country
- Closed Loop Auditory Stimulus in Sleep and epilepsYCompletedNCT05159609Not applicable1 country
- Buspirone Therapy for Localized EpilepsyTerminatedNCT01496612Phase 21 country
- EASINESS-TRIAL - Enhancing Safety in Epilepsy SurgeryStatus unknownNCT049522981 country
- Structural Cartography of the Insula in Temporal Epilepsy PatientsStatus unknownNCT048715551 country
- A Deep Learning Framework for Pediatric TLE Detection Using 18F-FDG-PET ImagingCompletedNCT041695811 country
- GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major DepressionCompletedNCT009316191 country
- Language Mapping in Patients With EpilepsyCompletedNCT007061601 country
- Evaluation and Treatment of Patients With EpilepsyTerminatedNCT000138451 country
- Hippocampal and Thalamic DBS for Bilateral Temporal Lobe EpilepsyStatus unknownNCT04164056Phase 41 country
- Biomarkers in Neurodegenerative DiseasesWithdrawnNCT040555321 country
- Subcutaneous EEG in EpilepsyCompletedNCT02946151Not applicable1 country
- Effects of tDCS on Depressive Symptoms of Participants With Temporal Lobe EpilepsyStatus unknownNCT03871842Not applicable1 country