Drug Resistant Epilepsy: all 270 studies

Page 2 of 3. Open to participants first (100), then studies with results posted, then the rest; newest registration first within each.

• Optimal Stimulation Parameters to Disrupt Epileptiform ActivityCompletedNCT06141668Not applicableResults posted
• Electrophysiologic Studies of Cognition in Epilepsy PatientsCompletedNCT05769634Not applicableResults posted
• Modulation of Emotion Perception in Humans Via Amygdala StimulationCompletedNCT05292183Not applicableResults posted
• A Safety Study for Previously Treated Vatiquinone (PTC743) Participants With Inherited Mitochondrial DiseaseCompletedNCT05218655Phase 3Results posted
• Pediatric Language and Memory Mapping in Refractory Epilepsy Using MagnetoencephalographyCompletedNCT04888637Results posted
• Perampanel for the Reduction of Seizure Frequency in Patients With High-grade Glioma and Focal EpilepsyTerminatedNCT04650204Phase 4Results posted
• A Study to Evaluate Efficacy and Safety of Vatiquinone for Treating Mitochondrial Disease in Participants With Refractory EpilepsyTerminatedNCT04378075Phase 2/3Results posted
• A Study to Test the Efficacy and Safety of Padsevonil as Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant EpilepsyTerminatedNCT03739840Phase 3Results posted
• Novel Helmet Design in Patients With SeizuresCompletedNCT03443388Not applicableResults posted
• Study to Test the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adults With Drug-resistant EpilepsyCompletedNCT03373383Phase 2Results posted
• Study to Test the Safety and Efficacy of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant EpilepsyTerminatedNCT03370120Phase 2Results posted
• Feasibility Study on LITT for Medical Refractory EpilepsyTerminatedNCT02820740Not applicableResults posted
• Bioavailability, Safety and Tolerability of Diazepam Nasal Spray Versus Diazepam Rectal Gel (Diastat®)TerminatedNCT02474407Phase 2Results posted
• Arterial Spin Labeling MRI Focal Abnormalities in Refractory EpilepsyCompletedNCT01772654Not applicableResults posted
• Thalidomide Low Threshold in EpilepsyCompletedNCT01061866Phase 1/2Results posted
• P-glycoprotein Inhibition as Adjunct Treatment for Medically Refractory Epilepsy.TerminatedNCT00524134Phase 2/3Results posted
• Occupational Therapy Approach in ARX-Related EpilepsyCompletedNCT07745608Not applicable
• A Multifaceted Assessment of Eating Behaviors, Anthropometric Measurements and Body Composition in Pediatric Patients With Drug-resistant Epilepsy on a Ketogenic Diet and Healthy ChildrenActive, not recruitingNCT07714226
• Ultrasound-Guided Intermediate Cervical Plexus Block for Postoperative Analgesia in Vagus Nerve Stimulation SurgeryCompletedNCT07689617
• Coenzyme Q10 as Adjunctive Therapy in Drug-Resistant EpilepsyCompletedNCT07537283Not applicable
• Study to Evaluate the Relative Bioavailability of a New Formulation of NPT 2042 Soft-Gelatin Capsules Compared to the Original Formulation of NPT 2042CompletedNCT07222878Phase 1
• Trial of Multi-Strain Probiotic Supplementation (Hexbio®) in Malaysian Patients With Drug-Resistant Epilepsy (ProbE)Active, not recruitingNCT07100743Not applicable
• Safety, Tolerability, and Pharmacokinetics (PK) of Single and Multiple Ascending Oral Doses of iQ-007Active, not recruitingNCT06899230Phase 1
• The GABAergic Inhibitory System in Drug Resistant EpilepsyCompletedNCT06789497Not applicable
• Efficacy of Low Glycemic Index Diet Versus Classic Ketogenic Diet in Pediatric Epilepsy TreatmentCompletedNCT06703983Not applicable
• Ketogenic Diet for Prevention of Epileptic Spasms in Infantile Onset Genetic EpilepsiesTerminatedNCT06700811Phase 1
• The Association Between Fever and CDKL5 Deficiency Disorder: a Nationwide SurveyCompletedNCT06663163
• Investigating the Role and Electrophysiological Characteristics of the Human Claustrum Based on SEEGCompletedNCT06575413Not applicable
• Efficacy and Safety Evaluation of Hyperthermic Baths in the Treatment of Seizures in CDKL5 Deficiency DisorderCompletedNCT06447675Not applicable
• Subiculum Electrical Stimulation for Temporal Lobe Epilepsy With Biliteral Hippocampus Sclerosis(SESTB)Active, not recruitingNCT06436547Not applicable
• Effects of Low Glycemic Index Diet in Children With Drug-resistant EpilepsyCompletedNCT06432231Not applicable
• A Study to Determine if BHV-7000 is Effective and Safe in Adults With Idiopathic Generalized Epilepsy With Generalized Tonic-clonic SeizuresTerminatedNCT06425159Phase 2/3
• An Automated Navigation System for Deep Brain Electrode ImplantationActive, not recruitingNCT06396494
• Leucine Enriched Essential Amino Acid Powder as an Add-on to a Classic Ketogenic Diet in Refractory EpilepsyCompletedNCT06387186Phase 1
• A First in hUman Study for Resistant Epilepsy With the Vagus Nerve stimulatiOn Device by syneRgia medicAlCompletedNCT06340802Not applicable
• Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset EpilepsyActive, not recruitingNCT06309966Phase 2/3
• Effects of L-Carnitine on Gastric Emptying in Children With Drug Resistant Epilepsy on Ketogenic DietCompletedNCT06255873Not applicable
• The Effect of Carnitine Supplementation on Cardiac Function and Lipid Profile in Patients With Drug Resistant Epilepsy on Ketogenic DietActive, not recruitingNCT06198803Early Phase 1
• A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset EpilepsyActive, not recruitingNCT06132893Phase 2/3
• IF-MCT 16:8: Investigating the Influence of Intermittent Fasting With and Without MCTs in Patients With Drug-resistant EpilepsyCompletedNCT06013761Not applicable
• Cathodal Transcranial Direct Current Stimulation in Patients With Drug-resistant Focal EpilepsyStatus unknownNCT05951244Not applicable
• Goals for Epilepsy Clinic Visits TrialActive, not recruitingNCT05928598Not applicable
• TDCs to Treat Drug-resistant EpilepsyCompletedNCT05825274Not applicable
• The Mechanism of cTBS Targeting Dentate Nucleus for DRECompletedNCT05809349Not applicable
• Cannabidiol in Children and Young Adults With Rare Disease-associated Severe EpilepsyActive, not recruitingNCT05803434Phase 2
• Add-on Clioquinol in Drug-resistant Childhood Epilepsy: an Exploratory StudyCompletedNCT05727943Phase 2
• Feasibility, Tolerability and Efficacy of the Ketogenic Diet in Children With Drug-resistant Epilepsy in South VietnamCompletedNCT05697887Not applicable
• The Benefit and Safety of Older Generation Anti-Epileptic Drugs (AEDs) in Drug-Resistant Epilepsy ChildrenStatus unknownNCT05697614Phase 4
• Adjunctive Everolimus Treatment of Refractory EpilepsyStatus unknownNCT05613166Phase 2
• MiRNA223 and HMGB1 as Apredictos for Drug Resistant EpilepsyStatus unknownNCT05555537
• Clinical Study Evaluating the Safety of Lactobacillus Probiotic in Children With Drug Resistant EpilepsyCompletedNCT05539287Phase 2
• Safety and Pharmacokinetic Study of NPT 2042 Soft-gelatin Capsules Administered Orally to Healthy Adult SubjectsCompletedNCT05503511Phase 1
• the Safety and Efficacy of N-acetyl Cysteine in Children With Drug-Resistant EpilepsyCompletedNCT05485558Phase 2
• ESIS in Pediatric DREActive, not recruitingNCT05469373
• Physical Excercise Program in Children With Drug-resistant EpilepsyStatus unknownNCT05323682Not applicable
• Thermocoagulation in Drug Resistant Focal EpilepsyActive, not recruitingNCT05248269Not applicable
• Fenfluramine for the Treatment of Different Types of Developmental and Epileptic Encephalopathies: a Pilot Trial Exploring Epileptic and Non-epileptic OutcomesCompletedNCT05232630Phase 4
• Probiotic in Treatment of Adult Patients With Drug-resistant EpilepsyCompletedNCT05160350Phase 4
• cTBS Targeting Cerebellum for Drug-refractory EpilepsyCompletedNCT05042726Not applicable
• Acute and Long Term Effects of VNS on Memory in Patients With Refractory EpilepsyCompletedNCT05031208Not applicable
• The Efficacy of a Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant EpilepsyCompletedNCT05019885Phase 2
• Contribution of Genetics, Non-invasive Methods and Neuropsychology in Focal Cryptogenic EpilepsiesCompletedNCT05015868Not applicable
• NaviFUS™ System Neuromodulating Treatment for Patients With Drug Resistant EpilepsyCompletedNCT04999046Not applicable
• RNS System RESPONSE StudyTerminatedNCT04839601Not applicable
• Galactose Supplementation for the Treatment of MOGHEStatus unknownNCT04833322Not applicable
• EXPRESON-IN : Intracerebral Recordings of P3a Responses to Expressive Own-namesStatus unknownNCT04810832Not applicable
• Non-interventional Study Describing Healthcare Resource Utilisation and Clinical Outcomes Associated With VNS Therapy in UK.TerminatedNCT04779814
• Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Intractable EpilepsyStatus unknownNCT04771065
• Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal EpilepsyCompletedNCT04770337Not applicable
• Ciprofloxacin in Drug-resistant EpilepsyCompletedNCT04763070Not applicable
• A Study to Evaluate fMRI of Active DBS Stimulation in EpilepsyWithdrawnNCT04753983Not applicable
• Symptoms of Post-traumatic Stress in Adult Drug-resistant EpilepsiesTerminatedNCT04749901Not applicable
• Efficacy, Safety and Pharmacokinetics of ES-481 in Adult Patients With Drug Resistant EpilepsyStatus unknownNCT04714996Phase 2
• Role of the Gut Microbiota in Pediatric EpilepsyStatus unknownNCT04705298Phase 4
• Effectiveness and Safety of Thread Embedding Acupuncture for Drug Resistant EpilepsyStatus unknownNCT04673071Not applicable
• Exercise as Adjunctive Treatment for Refractory EpilepsyTerminatedNCT04607317Not applicable
• Clinical Trial of MgLiTT for Medical Refractory EpilepsyStatus unknownNCT04569071Not applicable
• Cortical Resections in Drug Resistant EpilepsyStatus unknownNCT04553354
• The Potential of a Low Glutamate Diet as a Treatment for Pediatric EpilepsyCompletedNCT04545346Not applicable
• Comparative Study of Dietary and Immunological Management of Refractory Epilepsy in ChildrenStatus unknownNCT04542629Phase 4
• Tele-epic (Telemedicine for Epilepsy Care)Status unknownNCT04496310Not applicable
• Extended Access Program With Lorcaserin For The Treatment of Dravet Syndrome and Other Refractory EpilepsiesNo longer availableNCT04457687
• Study of Safety and Efficacy of MGCND00EP1 as an Add on Treatment in Children and Adolescents With Resistant EpilepsiesWithdrawnNCT04406948Phase 2
• Evaluation of KetofloCompletedNCT04399954Not applicable
• European Non-interventional Study on Refractory Epilepsy With Developmental DelayTerminatedNCT04398667
• MELD as an Adjunct for SEEG TrajectoriesStatus unknownNCT04383028Not applicable
• Effects of Transcranial Direct Current Stimulation (tDCS) for the Treatment of Refractory EpilepsyStatus unknownNCT04325360Not applicable
• Memory Retrieval and Encoding Investigated by Neural StimulationActive, not recruitingNCT04286776Not applicable
• Feasibility of HOBSCOTCH Telehealth Intervention in Refractory EpilepsyStatus unknownNCT04240977Not applicable
• Pilot Trial to Evaluate The Effect of Oral Methylprednisolone on Seizure Frequency in Children With EpilepsyStatus unknownNCT04219995Phase 1/2
• Clinical Utility of Automated Electric Source Imaging in Presurgical EvaluationActive, not recruitingNCT04218812Not applicable
• Deep Brain Stimulation Post Failed Vagal Nerve StimulationCompletedNCT04181229Not applicable
• Drug Resistant Epilepsy: Clinical and Genetic StudyStatus unknownNCT04166305
• REC2Stim as a Treatment for Refractory Epilepsy in the Primary Sensorimotor Cortex.Status unknownNCT04158531Not applicable
• Study to Assess Intracerebroventricular (ICV) Delivery of CT-010 in Subjects With Focal Seizures, With Temporal Lobe Onset With or Without Secondary GeneralizationTerminatedNCT04153175Phase 2
• Long-term Cardiac Monitoring in EpilepsyTerminatedNCT03955432Not applicable
• Outcome Study in Refractory Epilepsy (SOPHIE)CompletedNCT03939507Not applicable
• Novel Network Analysis of Intracranial StereoelectroencephalographyStatus unknownNCT03916848Not applicable
• Voronistat in Pediatric Patients With Drug Resistant EpilepsyStatus unknownNCT03894826Phase 2
• Added Value of Automated Electrical Source Localization (EPILOG PreOp®) to Presurgical Evaluation of Refractory EpilepsyStatus unknownNCT03882151Not applicable

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